Targeting the replication of adenoviral gene therapy vectors to lung cancer cells: The importance of the adenoviral E1b-55kD gene

Human Gene Therapy

Volumn 10, Issue 4, 1999, Pages 579-590

  Hay, John G ^a   Shapiro, Neil ^a   Sauthoff, Harald ^a   Heitner, Sheila ^a   Phupakdi, Wipanee ^a   Rom, William N ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; VIRUS DNA; VIRUS PROTEIN; VIRUS VECTOR;

ADENOVIRUS; ARTICLE; CANCER CELL CULTURE; DNA REPLICATION; GENE DELETION; GENE MUTATION; GENE THERAPY; HUMAN; HUMAN CELL; LUNG CANCER; LUNG FIBROBLAST; VIRUS REPLICATION;

ADENOVIRIDAE; ADENOVIRUS E1B PROTEINS; BASE SEQUENCE; CELL SURVIVAL; CYTOPATHOGENIC EFFECT, VIRAL; DNA PRIMERS; DNA REPLICATION; GENE THERAPY; GENES, VIRAL; GENETIC VECTORS; HUMANS; LUNG NEOPLASMS; TUMOR SUPPRESSOR PROTEIN P53; VIRUS REPLICATION;

ADENOVIRIDAE; DNA VIRUSES;

EID: 0033105423     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950018652     Document Type: Article

References (48)

1. AMERICAN CANCER SOCIETY. (1996). Cancer Facts and Figures - 1996. (American Cancer Society, Atlanta).
2. BABISS, L.E., and GINSBERG, H.S. (1984). Adenovirus type 5 early region 1b gene product is required for efficient shutoff of host protein synthesis. J. Virol. 50, 202-212.
3. BISCHOFF, J.R., KIRN, D.H., WILLIAMS, A., HEISE, C., HORN, S., MUNA, M., NG, L., NYE, J.A., SAMPSON-JOHANNES, A., FATTAEY, A., and MCCORMICK, F. (1996). An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 274, 373-376.
4. CAAMANO, J., RUGGERI, B., MOMIKl, S., SICKLER, A., ZHANG, S.Y., and KLEIN-SZANTO, A.J. (1991). Detection of p53 in primary lung tumors and nonsmall cell lung carcinoma cell lines. Am. J. Pathol. 139, 839-845.
5. CULVER, K.W., RAM, Z., WALLBRIDGE, S., ISHII, H., OLDFIELD, E.H., and BLAESE, R.M. (1992). In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256, 1550-1552.
6. DOBBELSTEIN, M., ROTH, J., KIMBERLY, W.T., LEVINE, A.J., and SHENK, T. (1997). Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence. EMBO J. 16, 4276-4284.
7. FESSLER, S.P., and YOUNG, C.S. (1998). Control of adenovirus early gene expression during the late phase of infection. J. Virol. 72, 4049-4056.
8. GABLER, S., SCHUTT, H., GROITL, P., WOLF, H., SHENK, T., and DOBNER, T. (1998). E1B 55-kilodalton-associated protein: A cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAs. J. Virol. 72, 7960-7971.
9. GOODRUM, F.D., and ORNELLES, D.A. (1997). The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle. J. Virol. 71, 548-561.
10. GRAHAM, F.L., SMILEY, J., RUSSELL, W.C., and NAIRN, R. (1977). Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36, 59-74.
11. HALL, A.R., DIX, B.R., O'CARROLL, S.J., and BRAITHWAITE, A.W. (1998). p53-dependent cell death/apoptosis is required for a productive adenovirus infection. Nature Med. 4, 1068-1072.
12. HARBOUR, J.W., LAI, S.L., WHANG-PENG, J., GAZDAR, A.F., MINNA, J.D., and KAYE, F.J. (1988). Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science 241, 353-357.
13. HAUPT, Y., MAYA, R., KAZAZ, A., and OREN, M. (1997). Mdm2 promotes the rapid degradation of p53. Nature (London) 387, 296-299.
14. HEISE, C., SAMPSON-JOHANNES, A., WILLIAMS, A., MCCORMICK, F., VON HOFF, D.D., and KIRN, D.H. (1997). ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nature Med 3, 639-645.
15. HONG, J.S., and ENGLER, J.A. (1991). The amino terminus of the adenovirus fiber protein encodes the nuclear localization signal. Virology 185, 758-767.
16. KAO, C.C., YEW, P.R., and BERK, A.J. (1990). Domains required for an in vitro association between the cellular p53 and the adenovirus 2 E1B 55K proteins. Virology 179, 806-814.
17. KINOSHITA, I., DOSAKA-AKITA, H., MISHINA, T., AKIE, K., NISHI, M., HIROUMI, H., HOMMURA, F., and KAWAKAMI, Y. (1996). Altered p16INK4 and retinoblastoma protein status in nonsmall cell lung cancer: Potential synergistic effect with altered p53 protein on proliferative activity. Cancer Res. 56, 5557-5562.
18. KUBBUTAT, M.H., JONES, S.N., and VOUSDEN, K.H. (1997). Regulation of p53 stability by Mdm2. Nature (London) 387, 299-303.
19. KULJU, K.S., and LEHMAN, J.M. (1995). Increased p53 protein associated with aging in human diploid fibroblasts. Exp. Cell Res. 217, 336-345.
20. LAI, S.L., BRAUCH, H., KNUTSEN, T., JOHNSON, B.E., NAU, M.M., MITSUDOMI, T., TSAI, C.M., WHANG-PENG, J., ZBAR, B., KAYE, F.J., and GAZDAR, A.F. (1995). Molecular genetic characterization of neuroendocrine lung cancer cell lines. Anticancer Res. 15, 225-232.
21. LEACH, F.S., TOKINO, T., MELTZER, P., BURRELL, M., OLINER, J.D., SMITH, S., HILL, D.E., SIDRANSKY, D., KINZLER, K.W., and VOGELSTEIN, B. (1993). p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res. 53, 2231-2234.
22. LEVINE, A.J. (1997). p53, the cellular gatekeeper for growth and division. Cell 88, 323-331.
23. MARCHETTI, A., BUTTITTA, F., PELLEGRINI, S., MERLO, G., CHELLA, A., ANGELETTI, C.A., and BEVILACQUA, G. (1995). mdm2 gene amplification and overexpression in non-small cell lung carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations. Diagn. Mol. Pathol. 4, 93-97.
24. MARINO, P., PAMPALLONA, S., PREATONI, A., CANTONI, A., and INVERNIZZI, F. (1994). Chemotherapy vs supportive care in advanced non-small-cell lung cancer. Results of a meta-analysis of the literature. Chest 106, 861-865.
25. MITTEREDER, N., MARCH, K.L., and TRAPNELL, B.D. (1996). Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. J. Virol. 70, 7498-7509.
26. MULSHINE, J.L., JOHNSON, B.E., GAZDAR, A.F., SHAW, G.L., KRAMER, B.S., MITSUDOMI, T., MINNA, J.D., PASS, H., PHELPS, R., GHOSH, B., et al. (1994). Integrated clinical and basic studies related to circumventing non-small cell lung cancer drug resistance. Lung Cancer 10, S73-S81.
27. NEVINS, J.R. (1992). E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science 258, 424-429.
28. NON-SMALL CELL LUNG CANCER STUDY GROUP. (1995). Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomized clinical trials. Br. Med. J. 311, 899-909.
29. O'CONNOR, P.M., JACKMAN, J., BAE, I., MYERS, T.G., FAN, S., MUTOH, M., SCUDIERO, D.A. MONKS, A., SAUSVILLE, E.A., WEINSTEIN, J.N., FRIEND, S., FORNACE, A.J., JR., and KOHN, K.W. (1997). Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res. 57, 4285-4300.
30. PASS, H., MITCHEL, J., JOHNSON, D., and TURRISI, A. (1996). Lung Cancer: Principles and Practice (Lippincott-Raven, Philadelphia).
31. PERRY, M.E., and LEVINE, A.J. (1993). Tumor-suppressor p53 and the cell cycle. Curr. Opin. Genet. Dev. 3, 50-54.
32. PHELPS, R.M., JOHNSON, B.E., IHDE, D.C., GAZDAR, A.F., CARBONE, D.P., MCCLINTOCK, P.R., LINNOILA, R.I., MATTHEWS, M.J., BUNN, P.A., JR., CARNEY, D., MINNA, J.D., and MULSHINE, J.L. (1996). NCI-Navy Medical Oncology Branch cell line data base. J. Cell Biochem. Suppl. 24, 32-91.
33. PILDER, S., MOORE, M., LOGAN, J., and SHENK, T. (1986). The adenovirus E1b-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs. Mol. Cell. Biol. 6, 470-476.
34. RIDGWAY, P.J., HALL, A.R., MYERS, C.J., and BRAITHWAITE, A.W. (1997). p53/E1b58kDa complex regulates adenovirus replication. Virology 237, 404-413.
35. ROTH, J., DOBBELSTEIN, M., FREEDMAN, D.A., SHENK, T., and LEVINE, A.J. (1988). Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus Rev protein. EMBO J. 17, 554-564.
36. SALGIA, R., and SKARIN, A.T. (1998). Molecular abnormalities in lung cancer. J. Clin. Oncol. 16, 1207-1217.
37. SCHEFFNER, M., MUNGER, K., BYRNE, J.C., and HOWLEY, P.M. (1991). The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proc. Natl. Acad. Sci. U.S.A. 88, 5523-5527.
38. SHAPIRO, G.I., EDWARDS, C.D., EWEN, M.E., and ROLLINS, B.J. (1998). p16INK4A participates in a G1 arrest checkpoint in response to DNA damage. Mol. Cell. Biol. 18, 378-387.
39. SHENK, T. (1996). Adenovirudae. In Fundamental Virology, B.N. Fields, D.M. Knipe and P.M. Howley, eds. (Lippincott-Raven, Philadelphia) pp. 979-1016.
40. SHERR, C.J. (1996). Cancer cell cycles. Science 274, 1672-1677.
41. TALIS, A.L., HUIBREGTSE, J.M., and HOWLEY, P.M. (1998). The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells. J. Biol. Chem. 273, 6439-6445.
42. TEODORO, J.G., HALLIDAY, T., WHALEN, S.G., TAKAYESU, D., GRAHAM, F.L., and BRANTON, P.E. (1994). Phosphorylation at the carboxy terminus of the 55-kilodalton adenovirus type 5 E1B protein regulates transforming activity. J. Virol. 68, 776-786.
43. TRAPNELL, B.C., CHU, C.S., PAAKKO, P.K., BANKS, T.C., YOSHIMURA, K., FERRANS, V.J., CHERNICK, M.S., and CRYSTAL, R.G. (1991). Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis. Proc. Natl. Acad. Sci. U.S.A. 88, 6565-6569.
44. WEINBERG, R.A. (1995). The retinoblastoma protein and cell cycle control. Cell 81, 323-330.
45. WHYTE, P., BUCHKOVICH, K.J., HOROWITZ, J.M., FRIEND, S.H., RAYBUCK, M., WEINBERG, R.A., and HARLOW, E. (1988). Association between an oncogene and an anti-oncogene: The adenovirus E1A proteins bind to the retinoblastoma gene product. Nature (London) 334, 124-129.
46. WHYTE, P., WILLIAMSON, N.M., and HARLOW, E. (1989). Cellular targets for transformation by the adenovirus E1A proteins. Cell 56, 67-75.
47. YEW, P.R., and BERK, A.J. (1992). Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature (London) 357, 82-85.
48. ZHANG, Y., and SCHNEIDER, R.J. (1994). Adenovirus inhibition of cell translation facilitates release of virus particles and enhances degradation of the cytokeratin network. J. Virol. 68, 2544-2555.