Crystal structural analysis of protein-protein interactions drastically destabilized by a single mutation

Protein Science

Volumn 17, Issue 6, 2008, Pages 1055-1065

  Urakubo, Yoshiaki ^a   Ikura, Teikichi ^a,b   Ito, Nobutoshi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Barnase; Barstar; Mutation; Protein protein interaction; Water mediated interaction

Indexed keywords

ALANINE; ASPARTIC ACID; BARNASE; BARSTAR; HYDROGEN; MUTANT PROTEIN; WATER;

AMINO ACID SUBSTITUTION; ARTICLE; CRYSTAL STRUCTURE; HYDRATION; HYDROGEN BOND; MOLECULAR DYNAMICS; MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; SIMULATION; STRUCTURE ANALYSIS; WATER TRANSPORT; WILD TYPE; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; KINETICS; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS;

EID: 44349192157     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.073322508     Document Type: Article

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