Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells

European Journal of Medicinal Chemistry

Volumn 43, Issue 6, 2008, Pages 1160-1170

  Seo, Jai Woong ^a   Srisook, Ekaruth ^a   Son, Hyo Jin ^b   Hwang, Onyou ^b   Cha, Young Nam ^c   Chi, Dae Yoon ^a  

^a Inha University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Inha University School of Medicine   (South Korea)

Author keywords

Nitric oxide; Nitric oxide synthase; Tetrahydrobiopterin; Tetrahydroisoquinoline

Indexed keywords

2 ACETYL 1 BENZYL 7 HYDROXY 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 ACETYL 1 CYCLOBUTYL 7 HYDROXY 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 ACETYL 1 CYCLOPROPYL 7 HYDROXY 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 ACETYL 1 ETHYL 7 HYDROXY 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 ACETYL 7 HYDROXY 1 ISOBUTYL 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 ACETYL 7 HYDROXY 1 ISOPROPYL 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 ACETYL 7 HYDROXY 6 METHOXY 1 METHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 ACETYL 7 HYDROXY 6 METHOXY 1 PHENYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 ACETYL 7 HYDROXY 6 METHOXY 1 PROPYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 BUTYL 7 HYDROXY 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 CYCLOHEXYLCARBONYL 7 HYDROXY 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 CYCLOHEXYLMETHYL 7 HYDROXY 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 2 ETHYLCARBONYL 7 HYDROXY 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 7 HYDROXY 2 ISOBUTYLCARBONYL 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 7 HYDROXY 2 ISOPROPYLCARBONYL 6 METHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 7 HYDROXY 6 METHOXY 2 PROPYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 7 HYDROXY 6 METHOXY 2 PROPYLCARBONYL 1,2,3,4 TETRAHYDROISOQUINOLINE; ALKYL GROUP; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MONOMER; NITRIC OXIDE; TETRAHYDROBIOPTERIN; TETRAHYDROISOQUINOLINE; TETRAHYDROISOQUINOLINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DIMERIZATION; DRUG DESIGN; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; INHIBITION KINETICS; MICROGLIA; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; MICE; MICROGLIA; NITRIC OXIDE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 44349188538     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.09.009     Document Type: Article

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