Oxidized low density lipoprotein activates peroxisome proliferator- activated receptor-α(PPARα) and PPARγ through MAPK-dependent COX-2 expression in macrophages

Journal of Biological Chemistry

Volumn 283, Issue 15, 2008, Pages 9852-9862

  Taketa, Kayo ^a   Matsumura, Takeshi ^a   Yano, Miyuki ^a   Ishii, Norio ^a   Senokuchi, Takafumi ^a   Motoshima, Hiroyuki ^a   Murata, Yusuke ^a   Kim Mitsuyama, Shokei ^a   Kawada, Teruo ^b   Itabe, Hiroyuki ^c   Takeya, Motohiro ^a   Nishikawa, Takeshi ^a   Tsuruzoe, Kaku ^a   Araki, Eiichi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c SHOWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; BODY FLUIDS; CYTOLOGY; FATTY ACIDS; NUCLEIC ACIDS; RNA;

ATHEROSCLEROTIC LESIONS; BINDING CASSETTE TRANSPORTERS; CHEMOATTRACTANT; CYCLOOXYGENASE; DOCOSAHEXAENOIC ACIDS; LINOLEIC; LONG CHAIN FATTY ACIDS; LOW DENSITIES; MELOXICAM; MRNA EXPRESSIONS; OVEREXPRESSION; P38 MAPK; PEROXISOME PROLIFERATOR- ACTIVATED RECEPTORS; PROTEIN EXPRESSIONS; SMALL INTERFERENCE RNAS;

MACROPHAGES;

ABC TRANSPORTER A1; ARACHIDONIC ACID; CYCLOOXYGENASE 2; DOCOSAHEXAENOIC ACID; LINOLEIC ACID; LONG CHAIN FATTY ACID; LOW DENSITY LIPOPROTEIN; MELOXICAM; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; OLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN J2; SMALL INTERFERING RNA; 15 DEOXYPROSTAGLANDIN J2; 15-DEOXYPROSTAGLANDIN J2; APOLIPOPROTEIN E; DRUG DERIVATIVE; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANESULFONAMIDE; NITROBENZENE DERIVATIVE; OXIDIZED LOW DENSITY LIPOPROTEIN; PROSTAGLANDIN D2; PROSTAGLANDIN SYNTHASE INHIBITOR; PTGS2 PROTEIN, HUMAN; PTGS2 PROTEIN, MOUSE; SULFONAMIDE; THIAZINE DERIVATIVE; THIAZOLE DERIVATIVE; UNSATURATED FATTY ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; DOSE RESPONSE; ENZYME ACTIVATION; GENE OVEREXPRESSION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; PATHOLOGY; PERITONEUM MACROPHAGE; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; FATTY ACIDS, UNSATURATED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIPOPROTEINS, LDL; MACROPHAGES, PERITONEAL; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NITROBENZENES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PPAR ALPHA; PPAR GAMMA; PROSTAGLANDIN D2; RNA, MESSENGER; SULFONAMIDES; THIAZINES; THIAZOLES;

EID: 44349186200     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M703318200     Document Type: Article

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