Potential contraceptive use of epididymal proteins: Immunization of male rats with epididymal protein DE inhibits sperm fusion ability

Biology of Reproduction

Volumn 59, Issue 5, 1998, Pages 1029-1036

  Ellerman, Diego A ^a   Brantúa, Verónica S ^a   Martínez, Silvina Pérez ^a   Cohen, Débora J ^a   Conesa, Daniela ^a   Cuasnicú, Patricia S ^a  

^a INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTRACEPTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FERTILIZATION; IMMUNIZATION; MALE; MALE FERTILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SPERMATOZOON CAPACITATION; SPERMATOZOON MOTILITY;

ANIMALS; ANTIBODIES; CONTRACEPTION, IMMUNOLOGIC; EPIDIDYMAL SECRETORY PROTEINS; EPIDIDYMIS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNIZATION; MALE; METALLOPROTEINS; RATS; RATS, WISTAR; SPERM CAPACITATION; SPERM MOTILITY; SPERM-OVUM INTERACTIONS; SPERMATOZOA; TESTICULAR HORMONES;

EID: 0031738499     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod59.5.1029     Document Type: Article

References (43)

1. Naz RK, Sacco A, Singh O, Pal R, Talwar GP. Development of contraceptive vaccines for humans using antigens derived from gametes (spermatozoa and zona pellucida) and hormones (human chorionic gonadotrophin): current status. Hum Reprod Update 1995; 1:1-18.
2. Diekman AB, Herr JC. Sperm antigens and their use in the development of an immunocontraceptive. Am J Reprod Immunol 1997; 37: 111-117.
3. Cooper TG. The Epididymis, Sperm Maturation and Fertilization. Heidelberg: Springer Verlag; 1986.
4. Bedford JM. Sperm dynamics in the epididymis. In: Asch RH, Balmaceda JP, Johnson I (eds.), Gamete Physiology. Norwell, MA: Serono Symposia; 1990: 53-68.
5. Moore HDM. The influence of the epididymis on human and animal sperm maturation and storage. Hum Reprod 1996; 11:103-110.
6. Orgebin-Crist MC, Fournier-Delpech S. Sperm-egg interaction. Evidence for maturational changes during epididymal transit. J Androl 1982; 3:429-433.
7. Cuasnicú PS, González Echeverría F, Piazza A, Blaquier JA. Addition of androgens to cultured hamster epididymis increases zona recognition by immature spermatozoa. J Reprod Fertil 1984; 70:541-547.
8. Cuasnicú PS, González Echeverría F, Piazza A, Piñeiro L, Blaquier JA. Epididymal proteins mimic the androgenic effect on zona pellucida recognition by immature hamster spermatozoa. J Reprod Fertil 1984; 71:427-431.
9. Boué F, Bérubé B, De Lamirande E, Gagnon C, Sullivan R. Human sperm-zona pellucida interaction is inhibited by an antiserum against a hamster sperm protein. Biol Reprod 1994; 51:577-587.
10. Sanjurjo C, Dawidowsky AR, Cameo MS, González Echeverría F, Blaquier JA. Participation of human epididymal sperm coating antigens in fertilization. J Androl 1990; 11:476-483.
11. Rochwerger L, Cohen DJ, Cuasnicú PS. Mammalian sperm-egg fusion: the rat egg has complementary sites for a sperm protein that mediates gamete fusion. Dev Biol 1992; 153:83-90.
12. Cameo MS, Blaquier JA. Androgen-controlled specific proteins in rat epididymis. J Endocrinol 1976; 69:317-324.
13. Kohane AC, González Echeverría F, Piñeiro L, Blaquier JA. Interaction of proteins of epididymal origin with spermatozoa. Biol Reprod 1980; 23:737-742.
14. Kohane AC, Cameo MS, Piñeiro L, Garberi JC, Blaquier JA. Distribution and site of production of specific proteins in the rat epididymis. Biol Reprod 1980; 23:181-187.
15. Rochwerger L, Cuasnicú PS. Redistribution of a rat sperm epididymal glycoprotein after in vivo and in vitro capacitation. Mol Reprod Dev 1992; 31:34-41.
16. Cohen DJ, Munuce MJ, Cuasnicú PS. Mammalian sperm-egg fusion: the development of rat oolemma fusibility during oogenesis involves the appearance of binding sites for sperm protein "DE". Biol Reprod 1996; 55:200-206.
17. Cuasnicú PS, Conesa D, Rochwerger L. Potential contraceptive use of an epididymal protein that participates in fertilization. In: Alexander NJ, Griffin D, Spieler JM, Waites GMH (eds.), Gamete Interaction. Prospects for Immunocontraception. New York: Wiley-Liss; 1990: 143-153.
18. Pérez Martínez S, Conesa D, Cuasnicú PS. Potential contraceptive use of epididymal proteins: evidence for the participation of specific antibodies against rat epididymal protein DE in male and female fertility inhibition. J Reprod Immunol 1995; 29:31-45.
19. Garberi JC, Kohane AC, Cameo MS, Blaquier JA. Isolation and characterization of specific rat epididymal proteins. Mol Cell Endocrinol 1979; 13:73-82.
20. Garberi JC, Fontana JD, Blaquier JA. Carbohydrate composition of specific rat epididymal protein. Int J Androl 1982; 5:619-626.
21. Kohane AC, Piñeiro L, Blaquier JA. Androgen-controlled synthesis of specific protein in the rat epididymis. Endocrinology 1983; 112: 1590-1596.
22. Kaplan R, Kraicer PF. Effect of elevated calcium concentration on fertilization of rat oocytes in vitro. Gamete Res 1978; 1:281-285.
23. Rumke P. The origin of immunoglobulins in semen. Clin Exp Immunol 1974; 17:287-297.
24. Parr MB, Parr EL. Immunohistochemical localization of secretory component and immunoglobulin A in the urogenital tract of the male rodent. J Reprod Fertil 1989; 85:115-124.
25. Meinertz H, Linnet L, Wolf H, Hjort T. Antisperm antibodies on epididymal spermatozoa. Am J Reprod Immunol 1991; 25:158-162.
26. Stern JE, Gardner S, Quirk D, Wira CR. Secretory immune system of the male reproductive tract: effects of dihydrotestosterone and estradiol on IgA and secretory component levels. J Reprod Fertil 1992; 22:73-85.
27. Zouari R, De Almeida M. Effect of sperm-associated antibodies on human sperm ability to bind to zona pellucida and to penetrate zona-free hamster oocytes. J Reprod Immunol 1993; 24:175-186.
28. Wolf JP, De Almeida M, Ducot B, Rodrigues D, Jouannet P. High levels of sperm-associated antibodies impair human sperm-oolemma interaction after subzonal insemination. Fertil Steril 1995; 63:584-590.
29. Hill JA, Cohen J, Anderson DJ. The effects of lymphokines and monokines on human sperm fertilizing ability in the zona-free hamster egg penetration test. Am J Obstet Gynecol 1989; 160:1154-1159.
30. Naz RK, Chatuverdi MM, Aggarwal BB. Role of cytokines and protooncogens in sperm cell function: relevance to immunologic infertility. Am J Reprod Immunol 1994; 32:26-37.
31. Dimitrov D, Petrovská M. Effects of products of activated immune cells and recombinant cytokines on spontaneous and ionophore-induced acrosome reaction. Am J Reprod Immunol 1996; 36:150-156.
32. Weininger RB, Fisher S, Rifkin J, Bedford JM. Experimental studies on the passage of specific IgG to the lumen of the rabbit epididymis. J Reprod Fertil 1982; 66:251-258.
33. Lee CG, Zhang J, Wong E, Chow SN, Yang Y, Leung W. Sex differences of antifertility effect by passively immunized monoclonal sperm antibodies. Am J Reprod Immunol Microbiol 1987; 13:9-14.
34. Naz RK, Bhargava KK. Antibodies to sperm surface fertilization antigen (FA-1): their specificities and site of interaction with sperm in the male genital tract. Mol Reprod Dev 1990; 26:175-183.
35. Bérubé B, Sullivan R. Inhibition of in vivo fertilization by active immunization of male hamsters against a 26-kDa sperm glycoprotein. Biol Reprod 1994; 51:1255-1263.
36. Pöllänen P, Cooper TG. Vascular permeability to effectors of the immune system in the male rat reproductive tract at puberty. J Reprod Immunol 1995; 28:85-109.
37. Pöllänen P, Saari T, Yeung CH, Cooper TG. Regulation of the transport of immunoglobulin G into the male rat reproductive tract. J Reprod Immunol 1995; 28:111-135.
38. Hinton BT, Howards SS. Permeability characteristics of the epithelium in the rat caput epididymis. J Reprod Fertil 1981; 63:95-99.
39. Cuasnicú PS, González Echeverría F, Piazza A, Blaquier JA. Antibody against epididymal glycoprotein blocks fertilizing ability in rats. J Reprod Fertil 1984; 72:467-471.
40. Linnet L, Suominen JJ. A comparison of eight techniques for the evaluation of the auto-immune response to spermatozoa after vasectomy. J Reprod Immunol 1982; 4:133-144.
41. Haas GG Jr, D'Cruz OJ, DeBault LE. Comparison of the indirect immunobead, radiolabeled, and immunofluorescence assays for the immunoglobulin G serum antibodies to human sperm. Fertil Steril 1991; 55:377-388.
42. Hayashi M, Fujimoto S, Takano H, Ushiki T, Abe K, Ishikura H, Yoshida M, Kirchhoff C, Ishibashi T, Kasahara M. Characterization of a human glycoprotein with potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1). Genomics 1996; 32:367-374.
43. Kratzschmar J, Haendler B, Eberspaecher U, Roosterman D, Donner P, Schleuning WD. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1. CRISP-2 and CRISP-3. Eur J Biochem 1996; 236:827-836.