Effects of hexarelin against acid-independent and acid-dependent ulcerogens in the rat

Peptides

Volumn 25, Issue 12, 2004, Pages 2163-2170

  Sibilia, V ^a   Torsello, A ^b   Pagani, F ^a   Rapetti, D ^a   Lattuada, N ^a   Locatelli, V ^b   Bulgarelli, I ^b   Guidobono, F ^a   Netti, C ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Gastric ulcer; Ghrelin; GHS R antagonist; Hexarelin; Nitric oxide synthase

Indexed keywords

ALCOHOL; GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR ANTAGONIST; HEXARELIN; HORMONE RECEPTOR BLOCKING AGENT; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG EFFECT; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH ACID; STOMACH INJURY; STOMACH ULCER;

ANIMALS; ETHANOL; GASTRIC MUCOSA; INDOMETHACIN; INJECTIONS, INTRAVENTRICULAR; INJECTIONS, SUBCUTANEOUS; MALE; NERVE TISSUE PROTEINS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; OLIGOPEPTIDES; PEPTIDE HORMONES; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER;

EID: 9644278248     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2004.08.001     Document Type: Article

References (37)

1. R. Adami, E. Maraggi-Uberti, and C. Turba Pharmacological research of gefarnate, a new synthetic isoprenoid with antiulcer activity Int Pharmacodyn Ther. 147 1964 113 118
2. E. Arvat, M. Maccario, L. Di Vito, F. Broglio, A. Benso, and C. Gottero Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone J Clin Endocr Metab 86 2001 1169 1174
3. W.A. Banks, M. Tschop, S.M. Robinson, and M.L. Heiman Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure J Pharmacol Exp Ther 302 2002 822 827
4. K. Bech, C.P. Hoventhal, F. Gottrup, and D. Andersen Dopaminergic and beta-adrenergic effects on gastric antral motility Scand J Gastroenterol 89 1984 65 70
5. V. Bodart, M. Febbraio, A. Demers, N. McNicoll, P. Pohankova, and A. Perreault CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart Circ Res 90 2002 844 849
6. C.H. Cho Current roles of nitric oxide in gastrointestinal disorders J Physiol Paris 95 2001 253 256
7. P. Chomczynski, and N. Sacchi Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction Anal Biochem 162 1987 156 159
8. Chow JYC, L. Ma, and C.H. Cho Effect of cigarette smoke on ethanol-induced gastric mucosal lesions: the role of nitric oxide and neutrophils Eur J Pharmacol 342 1998 253 260
9. R. Clancy, B. Varenika, W. Huang, L. Ballou, M. Attur, and A.R. Amin Nitric oxide synthase/COX cross-talk: nitric oxide activates COX-1 but inhibits COX-2-derived prostaglandin production J Immunol 165 2000 1582 1587
10. L. Franco, and D. Doria Nitric oxide enhances prostaglandin production in ethanol-induced gastric mucosal injury in rats Eur. J. Pharmacol. 348 1998 247 256
11. K. Fujino, A. Inui, A. Asakawa, N. Kihara, M. Fujimura, and M. Fujimiya Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats J. Physiol. 550 2003 227 240
12. E. Ghigo, E. Arvat, and F. Camanni Orally active growth hormone secretagogues: state of the art and clinical perspectives Ann. Med. 30 1998 159 168
13. X.M. Guan, H. Yu, O.C. Palyha, K.K. McKee, S.D. Feighner, and D.J. Sirinathsinghji Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Mol Brain Res. 48 1997 23 29
14. F. Guidobono, M. Coluzzi, F. Pagani, A. Pecile, and C. Netti Amylin given by central and peripheral ruotes inhibits acid gastric secretion Peptides 15 1994 699 702
15. A.K. Hewson, and S.L. Dickson Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats J. Neuroendocrinol. 12 2000 1047 1049
16. A.D. Howard, S.D. Feighner, D.F. Cully, J.P. Arena, P.A. Liberator, and C.I. Rosenblum A receptor in pituitary and hypothalamus that functions in growth hormone release Science 273 1996 974 977
17. S. Kawano, and S. Tsuji Role of mucosal blood flow: a conceptional review in gastric mucosal injury and protection J. Gastroenterol. Hepatol. 15 Suppl 2000 D1 D6
18. M. Kojima, H. Hosoda, H. Matsuo, and K. Kangawa Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor Trends Endocrin. Metab. 12 2001 118 122
19. S.J. Konturek Role of growth factors in gastroduedenal protection and healing of peptic ulcers Gastroenterol. Clin. N. Am. 19 1990 41 65
20. M.J. Martin, E. Marhuenda, C. Perez-Guerrero, and J.M. Franco Antiulcer effect of naringin on gastric lesions induced by ethanol in rats Pharmacology 49 1994 144 150
21. K.K. McKee, O.C. Palyha, S.D. Feighner, D.L. Hreniuk, C.P. Tan, and M.S. Phillips Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors Mol. Endocrinol. 11 1997 415 423
22. W.A. Mersereau, and E.J. Hinchey Relationship between the gastric mioelectric and mechanical activity in the genesis of ulcers in indomethacin-insulin-treated rats Dig. Dis. Sci. 33 1988 200 208
23. G. Muccioli, C. Ghe, M.C. Ghigo, M. Papotti, E. Arvat, and M.F. Boghen Specific receptors for synthetic GH secretagogues in human brain and pituitary gland J. Endocrinol. 157 1998 99 106
24. G. Muccioli, M. Papotti, H. Ong, R. Deghenghi, M.F. Boghen, and M.H.L. Nilsson Presence of specific receptors for synthetic growth hormone secretagogues in the human heart Arc. Pharm. 358 Suppl 2 1998 R549
25. G. Muccioli, M. Tschop, M. Papotti, R. Deghenghi, M. Heiman, and E. Ghigo Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity Eur. J. Pharmacol. 440 2002 235 254
26. H. Ong, V. Bodart, N. McNicoll, D. Lamontagne, and J.F. Bouchard Binding sites for growth hormone-releasing peptides Growth Horm. IGF Res. 8 Suppl B 1998 137 140
27. M. Papotti, C. Ghe, P. Cassoni, F. Catapano, R. Deghenghi, and E. Ghigo Growth hormone secretagogue binding sites in peripheral human tissues J. Clin. Endocr. Metab. 85 2000 3803 3807
28. T.L. Peeters Central and peripheral mechanisms by which ghrelin regulates gut motility J. Physiol. pharmacol. 54 2003 95 103
29. K.J. Price, P.J. Hanson, and BJ.R. Whittle Localization of constitutive isoforms of nitric oxide synthase in the gastric glandular mucosa of the rat Cell Tissue Res. 285 1996 157 163
30. A. Robert, J.E. Nezamis, C. Lancaster, and A.J. Hanchar Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 77 1979 433 443
31. C. Scarpignato Nonsteroidal anti-inflammatory drugs: how do they damage gastroduodenal mucosa? Dig. Dis. 13 Suppl 1 1995 9 39
32. V. Sibilia, F. Pagani, F. Guidobono, V. Locatelli, A. Torsello, and R. Deghenghi Evidence for a central inhibitory role of growth hormone secretagogues and ghrelin on gastric acid secretion in conscious rats Neuroendocrinology 75 2002 92 97
33. V. Sibilia, G. Rindi, F. Pagani, D. Rapetti, V. Locatelli, and A. Torsello Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action Endocrinology 144 2003 353 359
34. A. Torsello, E. Bresciani, G. Rossoni, R. Avallone, G. Tulipano, and D. Cocchi Ghrelin plays a minor role in the physiological control of cardiac function in the rat Endocrinology 144 2003 1787 1792
35. A. Torsello, R. Grilli, M. Luoni, M. Guidi, M.C. Ghigo, and W.B. Wehrenberg Mechanism of action of hexarelin Growth hormone releasing activity in the rat. Eur. J. Endocrinol. 135 1996 481 488
36. A. Torsello, V. Locatelli, M.R. Melis, S. Succu, M.S. Spano, and R. Deghenghi Differential orexigenic effects of hexarelin and its analogs in the rat hypothalamus: indication for multiple growth hormone secretagogue receptor subtypes Neuroendocrinology 72 2000 327 332
37. B.J.R. Whittle Nitric oxide in gastrointestinal physiology and pathology L.R. Johnson The physiology of the gastrointestinal tract 1994 Raven New York 267 294