Variable effect of ghrelin administration on pancreatic development in young rats. role of insulin-like growth factor-1

Journal of Physiology and Pharmacology

Volumn 56, Issue 4, 2005, Pages 555-570

  Dembinski A ^a   Warzecha, Z ^a   Ceranowicz, P ^a   Bielanski W ^a   Cieszkowski, J ^a   Dembinski M ^a   Pawlik, W W ^a   Kuwahara, A ^b   Kato, I ^c   Konturek, P C ^d  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b UNIVERSITY OF SHIZUOKA   (Japan)

^c Yanaihara Institute Inc   (Japan)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Amylase; Food intake; Ghrelin; Pancreas

Indexed keywords

AMYLASE; DNA; GHRELIN; GROWTH HORMONE; SOMATOMEDIN C;

ADOLESCENT; AGE DISTRIBUTION; AMYLASE BLOOD LEVEL; AMYLASE RELEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DNA CONTENT; DNA SYNTHESIS; FOOD INTAKE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE RELEASE; MALE; NEWBORN; NONHUMAN; ORGAN WEIGHT; ORGANOGENESIS; PANCREAS BLOOD FLOW; PANCREAS DEVELOPMENT; PANCREAS ISLET ALPHA CELL; PERINATAL PERIOD; PUBERTY; RAT; SPECIES COMPARISON; SUCKLING; WEANING;

AMYLASES; ANIMALS; ANIMALS, NEWBORN; ANIMALS, SUCKLING; BODY WEIGHT; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; GHRELIN; INSULIN-LIKE GROWTH FACTOR I; MALE; PANCREAS; PEPTIDE HORMONES; RATS; RATS, WISTAR; WEANING;

EID: 31144477853     PISSN: 08675910     EISSN: 08675910     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone releasing acylated peptide from stomach. Nature 1999; 402: 656-660.
2. Date Y, Kojima M, Hosoda H et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000; 141: 4255-4261.
3. Ariyasu H, Takaya K, Tagami, T et al. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 2001; 86: 4753-4758.
4. Gnanapavan S, Kola B, Bustin SA et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002; 87: 2988-2991.
5. Kojima M, Hosoda H, Matsuo H, Kangawa K. Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol Metab 2001; 12: 118-122.
6. Bowers CY, Momany F, Reynolds GA, Hong A. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 1984; 114: 1537-1545.
7. Smith RG, Pong SS, Hickey G et al. Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland. Recent Prog Horm Res 1996; 51: 261-285.
8. Wren AM, Small CJ, Abbott CR et al. Ghrelin causes hyperphagia and obesity in rats. Diabetes 2001; 50: 2540-2547.
9. Shimbara T, Mondal MS, Kawagoe T et al. Central administration of ghrelin preferentially enhances fat ingestion. Neurosci Lett 2004; 369: 75-79.
10. Wren AM, Seal LJ, Cohen MA et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 2001; 86: 5992-5995.
11. Shiiya, T., Nakazato, M., Mizuta et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 2002; 87: 240-244.
12. Shimizu Y, Nagaya N, Isobe T et al. Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res 2003; 9: 774-8.
13. Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001; 50: 707-709.
14. Bellone S, Castellino N, Broglio F et al. Ghrelin secretion in childhood is refractory to the inhibitory effect of feeding. J Clin Endocrinol Metab 2004; 89: 1662-1665.
15. Saito ES, Kaiya H, Takagi T et al. Chicken ghrelin and growth hormone-releasing peptide-2 inhibit food intake of neonatal chicks. Eur J Pharmacol 2002; 453: 75-79.
16. Egido EM, Rodriguez-Gallardo J, Silvestre RA, Marco J. Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion. Eur J Endocrinol 2002; 146: 241-244.
17. Reimer MK, Pacini G, Ahren B. Dose-dependent inhibition by ghrelin of insulin secretion in the mouse. Endocrinology 2003; 144: 916-921.
18. Broglio F, Benso A, Castiglioni C et al. The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects. J Clin Endocrinol Metab 2003; 88: 1537-1542.
19. Date Y, Nakazato M, Hashiguchi S et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes 2002; 51: 124-129.
20. Lee HM, Wang G, Englander EW, Kojima M, Greeley GH Jr. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 2002; 143: 185-190.
21. Zhang W, Chen M, Chen X, Segura BJ, Mulholland MW. Inhibition of pancreatic protein secretion by ghrelin in the rat. J Physiol 2001; 537: 231-236.
22. Dembiński A, Warzecha Z, Ceranowicz P et al Ghrelin attenuates the development of acute pancreatitis in rat. J Physiol Pharmacol 2003; 54: 561-573.
23. Konturek PC, Brzozowski T, Pajdo R et al. Ghrelin - a new gastroprotective factor in gastric mucosa. J Physiol Pharmacol 2004; 55: 325-336.
24. Wierup N, Svensson H, Mulder H, Sundler F. The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul Pept 2002; 107: 63-69.
25. Konturek SJ, Szlachcic A, Dembiński A, Warzecha Z, Jaworek J, Stachura J. Nitric oxide in pancreatic secretion and hormone-induced pancreatitis in rats. Int J Pancreatol 1994; 15: 19-28.
26. Warzecha Z, Dembiński A, Ceranowicz P et al. IGF-1 stimulates production of interleukin-10 and inhibits development of caerulein-induced pancreatitis. J Physiol Pharmacol 2003; 54: 575-590.
27. Giles KW, Myers A. An improvement diphenylamine method for the estimation of deoxyribonucleic acid. Nature 1965; 206: 93.
28. Konturek SJ, Konturek JW, Pawlik T, Brzozowski T. Brain-gut axis and its role in the control of food intake. J Physiol Pharmacol 2004; 55: 137-154.
29. Banks WA, Tschöp M, Robinson SM, Heiman ML. Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther 2002; 302: 822-827.
30. Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Wakabayashi I. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and agouti-related protein mRNA levels and body weight in rats. Diabetes 2001; 50: 2438-2443.
31. Toshinai K, Date Y, Murakami N et al. Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology 2003; 144: 1506-1512.
32. Plant TM, Shahab M. Neuroendocrine mechanisms that delay and initiate puberty in higher primates. Physiol Behav 2002; 77: 717-722.
33. Blogowska A, Rzepka-Gorska I, Krzyzanowska-Swiniarska B. Is neuropeptide Y responsible for constitutional delay of puberty in girls? A preliminary report. Gynecol Endocrinol 2004; 19: 22-25.
34. McDonald JK, Lumpkin MD, Samson WK, McCann SM. Neuropeptide Y affects secretion of luteinizing hormone and growth hormone in ovariectomized rats. Proc Natl Acad Sci USA 1985; 82: 561-564.
35. Korbonits M, Little JA, Forsling ML et al. The effect of growth hormone secretagogues and neuropeptide Y on hypothalamic hormone release from acute rat hypothalamic explants. J Neuroendocrinol 1999; 11: 521-528.
36. Fölsch UR. Regulation of pancreatic growth. Clin Gastroenterol 1984; 13: 679-699.
37. Konturek SJ, Dembiński A, Warzecha Z et al. Antagonism of receptors for bombesin, gastrin and cholecystokinin in pancreatic secretion and growth. Digestion 1991; 48: 89-97.
38. Webster PD, Singh M, Tucker PC, Black O. Effects of fasting and feeding on the pancreas. Gastroenterology 1972; 62: 600-605.
39. Zapf J, Froesch ER. Insulin-like growth factors/somatomedins: structure, secretion, biological actions and physiological role. Horm Res 1986; 24: 121-130.
40. Roth J, Glick SM, Yalow RS, Berson SA. Hypoglycemia: a potent stimulus to secretion of growth hormone. Science 1963; 140: 987-988.
41. Roth J, Glick SM, Yalow RS, Berson SA. Secretion of human growth hormone: physiologic and experimental modification. Metabolism 1963; 12: 577-579.
42. Greenwood FC, Landon J. Growth hormone secretion in response to stress in man. Nature 1966; 210: 540-541.
43. Schalch DS. The influence of physical stress and exercise on growth hormone and insulin secretion in man. J Lab Clin Med 1967; 69: 256-269.
44. Ho KK, O'Sullivan AJ, Hoffman DM. Metabolic actions of growth hormone in man. Endocr J 1996; 43 Suppl: S57-S63.
45. Rennie MJ. Claims for the anabolic effects of growth hormone: a case of the emperor's new clothes? Br J Sports Med 2003; 37: 100-105.
46. Fanelli C, Calderone S, Epifano L et al. Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans. J Clin Invest 1993; 92: 1617-1622.
47. Glenn KC, Rose KS, Krivi GG. Somatotropin antagonism of insulin-stimulated glucose utilization in 3T3-L1 adipocytes. J Cell Biochem 1988; 37: 371-383.
48. Saito ES, Kaiya H, Tachibana T et al. Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing factor system in neonatal chicks. Regul Pept 2005; 125: 201-208.
49. Schmid DA, Held K, Ising M, Uhr M, Weikel JC, Steiger A. Ghrelin stimulates appetite, imagination of food, GH, ACTH, and cortisol, but does not affect leptin in normal controls. Neuropsychopharmacology 2005; 30: 1187-1192.
50. Wren AM, Small CJ, Fribbens CV et al. The hypothalamic mechanisms of the hypophysiotropic action of ghrelin. Neuroendocrinology 2002; 76: 316-324.