Adaptive cytoprotection mediated by prostaglandin I2 is attributable to sensitization of CGRP-containing sensory nerves

Gastroenterology

Volumn 120, Issue 1, 2001, Pages 134-143

  Boku, Katsuharu ^a   Ohno, Takashi ^a   Saeki, Takeo ^a   Hayashi, Hiromi ^a   Hayashi, Izumi ^a   Katori, Makoto ^a   Murata, Takahiko ^a   Narumiya, Shuh ^a   Saigenji, Kastunori ^a   Majima, Masataka ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CALCITONIN GENE RELATED PEPTIDE; INDOMETACIN; IRRITANT AGENT; PROSTACYCLIN; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTANOID RECEPTOR; PROTEIN INHIBITOR; SODIUM CHLORIDE;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME IMMUNOASSAY; KNOCKOUT MOUSE; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN SECRETION; RAT; SENSITIZATION; SENSORY NERVE; STOMACH MUCOSA INJURY;

EID: 0035170744     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2001.20916     Document Type: Article

References (51)

1. Cytoprotection and prostaglandins
2. Gastrointestinal cytoprotection by prostaglandins
3. Mild irritants prevent gastric necrosis through prostaglandin formation. Histological study
4. Prevention by mild irritants of gastric necrosis produced in rats by sodium taurocholate
5. Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins
6. Evidence that adaptive cytoprotection in rats is not mediated by prostaglandins
7. Cytoprotection of canine gastric mucosa by prostacyclin: Possible mediation by increased mucosal blood flow
8. Neural emergency system in the stomach
9. Calcitonin gene-related peptide and substance P in afferents to the upper gastrointestinal tract in the rat
10. Sensory substance P innervation of the stomach and pancreas. Demonstration of capsaicin-sensitive sensory neurons in the rat by combined immunohistochemistry and retrograde tracing
11. Topographical distribution of neuropeptide-containing nerve fibers in the rat stomach: A quantitative analysis using antibodies against protein gene product 9.5 and gastric mucins
12. Neural and non-neural origin of calcitonin gene-related peptide in the gastric mucosa
13. Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons
14. Capsaicin-sensitive afferent neurons involved in gastric mucosal protection
15. Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of gastric mucosa
16. Intragastric capsaicin protects against aspirin-induced lesion formation and bleeding in the rat gastric mucosa
17. Afferent nerve-mediated protection against deep mucosal damage in the rat stomach
18. Neuropeptide control of rat gastric mucosal blood flow: Increase by calcitonin gene-related peptide and vasoactive intestinal polypeptide, but not substance P and neurokinin A
19. Possible role of endogenous prostaglandins against ethanol injury in rat stomach
20. Interaction of substance P and leukotriene C4 in ethanol-induced mucosal injury of rat stomach
21. 4 in microcirculation during ethanol-induced gastric mucosal injury in rat
22. 4 in ethanol-induced gastric mucosal injury in rat
23. Capsaicin prevents ethanol-induced gastric lesion by suppression of constriction of collecting venules in rats: A study using intravital microscopy
24. Suppression of myoelectrical activity of gastric smooth muscle by endogenous gastric prostaglandin E2
25. Prostaglandins and the mechanism of analgesia produced by aspirin-like drugs
26. Altered pain perception and inflammatory response in mice lacking prostacycline receptor
27. Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3
28. 2 generation after administration of mild hyperosmotic saline solution into gastric lumen
29. Role of endogenous substance P in ethanol-induced mucosal damage in rat stomach
30. Capsaicin-induced calcitonin gene-related peptide release from isolated rat stomach measured with a new chemiluminescent enzyme immunoassay
31. Mechanism of prevention by capsaicin of ethanol-induced gastric mucosal injury: A study using intravital microscopy
32. Human alpha-calcitonin generelated peptide-(8-37) as an antagonist of exogenous and endogenous calcitonin gene-related peptide
33. Antagonistic effect of human alpha-CGRP [8-37] on the in vivo regional haemodynamic action of human alpha-CGRP
34. Pharmacological characterization of CGRP1 receptor subtype in vascular system of the rat: Studies with hCGRP fragments and analogs
35. A calcitonin gene-related peptide (CGRP) antagonist (CGRP8-37) inhibits microvascular responses induced by CGRP and capsaicin in skin
36. 2
37. Potentiation of bradykinin-induced nociceptive response by arachidonate metabolites in dogs
38. Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat
39. Facilitation by endogenous prostaglandins of capsaicin-induced cytoprotection in the rat stomach through EP2 receptor subtype
40. Preventive action of capsaicin in ethanol-induced mucosal injury in rat stomach is not due to released substance P, but to calcitonin gene related peptide
41. 2 release in healthy and alcoholic subjects after ethanol stimulation
42. 2 and glutathione after intragastric 96% ethanol treatment in rats
43. Effect of 10% ethanol and sofalcon on prostaglandin E2 content, mucous gel thickness, and experimental ulcer in the stomach of developing rats
44. Increased resistance of the rat gastric mucosa to hemorrhagic damage after exposure to an irritant
45. Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats
46. Immunocytochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the rat stomach
47. The regional distribution and cellular localization of mRNA encoding rat prostacyclin synthase
48. In situ hybridization studies of prostacyclin receptor mRNA expression in various mouse organs
49. The preventive mechanism of hyperosmotic saline against the ethanol-induced gastric mucosal injury
50. Eicosanoids and the gastrointestinal tract
51. Impaired duodenal bicarbonate secretion and mucosal integrity in mice lacking prostaglandin E-receptor subtype EP3