Contribution of capsaicin-sensitive sensory neurons to stress-induced increases in gastric tissue levels of prostaglandins in rats

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 285, Issue 6 48-6, 2003, Pages

  Harada, Naoaki ^a   Okajima, Kenji ^b   Uchiba, Mitsuhiro ^b   Katsuragi, Takeshi ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Calcitonin gene related peptide; Endothelial cells; Gastric mucosal injury; Neutrophils

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; AMINOGUANIDINE; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE[8-37]; CAPSAICIN; CAPSAZEPINE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; MYELOPEROXIDASE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTACYCLIN; PROSTAGLANDIN E2; RECEPTOR BLOCKING AGENT; VANILLOID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENERVATION; DISEASE EXACERBATION; DRUG EFFECT; DRUG MEGADOSE; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; IMMOBILIZATION STRESS; LEUKOCYTE ACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; RAT; REGULATORY MECHANISM; SENSORY NERVE CELL; STOMACH; STOMACH MUCOSA INJURY; STOMACH PROTECTION; STRESS; TIME; TISSUE LEVEL; WATER IMMERSION;

EID: 0344494799     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00364.2002     Document Type: Article

References (46)

1. Arai I, Hamasaka Y, Futaki N, Takahashi S, Yoshikawa K, Higuchi S, and Otomo S. Effect of NS-398, a new nonsteroidal anti-inflammatory agent, on gastric ulceration and acid secretion in rats. Res Commun Chem Pathol Pharmacol 81: 259-270, 1993.
2. Brzozowski T, Konturek SJ, Sliwowski Z, Pytko-Polonczyk J, Szlachcic A, and Drozdowicz D. Role of capsaicin-sensitive sensory nerves in gastroprotection against acid-independent and acid-dependent ulcerogens. Digestion 57: 424-432, 1996.
3. Bull HA, Hothersall J, Chowdhury N, Cohen J, and Dowd PM. Neuropeptides induce release of nitric oxide from human dermal microvascular endothelial cells. J Invest Dermatol 106: 655-660, 1996.
4. Clancy R, Varenika B, Huang W, Ballou L, Attur M, Amin AR, and Abramson SB. Nitric oxide synthase/COX cross-talk: nitric oxide activates COX-1 but inhibits COX-2-derived prostaglandin production. J Immunol 165: 1582-1587, 2000.
5. Cooper LC, Dial EJ, and Lichtenberger LM. Effect of milk, prostaglandin and antacid in experimentally-induced duodenitis in the rat. Dig Dis Sci 35: 1211-1216, 1990.
6. Crossman D, McEwan J, MacDermot J, MacIntyre I, and Dolley CT. Human calcitonin gene-related peptide activates adenylate cyclase and releases prostacyclin from human umbilical vein endothelial cells. Br J Pharmacol 92: 695-701, 1987.
7. Dray A. Inflammatory mediators of pain. Br J Anaesth 75: 125-131, 1995.
8. Evangelista S and Renzi D. A protective role for calcitonin gene-related peptide in water-immersion stress-induced gastric ulcers in rats. Pharmacol Res 35: 347-350, 1997.
9. Fiske SC. Peptic ulcer disease, cytoprotection, and prostaglandins. Arch Intern Med 148: 2112-2113, 1988.
10. Geppetti P, Tramontana M, Evangelista S, Renzi D, Maggi CA, Fusco BM, and Del Bianco E. Differential effect of neuropeptide release of different concentrations of hydrogen ions on afferent and intrinsic neurons of the rat stomach. Gastroenterology 101: 1505-1511, 1991.
11. Gerritsen ME and Cheli CD. Arachidonic acid and prostaglandin endoperoxide metabolism in isolated rabbit and coronary microvessels and isolated and cultured coronary microvessel endothelial cells. J Clin Invest 72: 1658-1671, 1983.
12. Griffiths MJ, Messent M, MacAllister RJ, and Evans TW. Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br J Pharmacol 110: 963-968, 1993.
13. Hamajima E, Sugiyama S, Hoshino H, Goto H, Tsukamoto Y, and Ozawa T. Effect of FK506, an immunosuppressive agent, on genesis of water-immersion stress-induced gastric lesions in rats. Dig Dis Sci 39: 713-720, 1994.
14. Harada N, Okajima K, Liu W, and Uchiba M. Activated neutrophils impair gastric cytoprotection. Role of neutrophil elastase. Dig Dis Sci 45: 1210-1216, 2000.
15. 2) prevents stress-induced gastric mucosal injury in rats primarily by inhibiting leukocyte activation. Prostaglandins Other Lipid Mediat 57: 291-303, 1999.
16. Harada N, Okajima K, Murakami K, Uchiba M, Tanaka K, Okabe H, and Takatsuki K. Novel role of prostacyclin in stress-induced gastric mucosal lesion formation in rats. J Lab Clin Med 129: 620-626, 1997.
17. Harada N, Okajima K, Uchiba M, and Katsuragi T. Ischemia/reperfusion-induced increase in the hepatic level of prostacyclin is mainly mediated by activation of capsaicin-sensitive sensory neurons in rats. J Lab Clin Med 139: 218-226, 2002.
18. 2. Naunyn Schmiedebergs Arch Pharmacol 341: 308-315, 1990.
19. Holzer P. Neural emergency system in the stomach. Gastroenterology 114: 823-839, 1998.
20. Holzer P. Local microcirculatory reflexes and afferent signaling in response to gastric acid challenge. Gut 47 Suppl 4, iv46-iv48, 2000.
21. Holzer P and Guth PH. Neuropeptide control of rat gastric mucosal blood flow: increase by calcitonin gene-related peptide and vasoactive intestinal polypeptide, but not substance P and neurokinin A. Circ Res 12: 25-31, 1991.
22. Kainoh M, Imai R, Umetsu T, Hattori M, and Nishio S. Prostacyclin and beraprost sodium as suppressors of activated rat polymorphonuclear leukocytes. Bichem Pharmacol 39: 477-484, 1990.
23. Kaneko H, Kaunitz J, and Taché Y. Vagal mechanisms underlying gastric protection induced by chemical activation of raphe pallidus in rats. Am J Physiol Gastrointest Liver Physiol 275: G1056-G1062, 1998.
24. Konturek SJ and Robert A. Cytoprotection of canine gastric mucosa by prostacyclin: possible mediation by increased mucosal blood flow. Digestion 25: 155-163, 1982.
25. 2 on gastric secretion, gastric release, and mucosal blood flow in dogs. Dig Dis Sci 25: 673-679, 1980.
26. Krawisz JE, Sharon P, and Stenson WF. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity: assessment of inflammation in rat and hamster. Gastroenterology 87: 1344-1350, 1984.
27. Kushimoto S, Okajima K, Okabe H, and Binder BR. Role of granulocyte elastase in the formation of hemorrhagic shock-induced gastric mucosal lesions in the rat. Crit Care Med 24: 1041-1046, 1996.
28. Laszlo F, Whittle BJR, and Moncada S. Time-dependent enhancement or inhibition of endotoxin-induced vascular injury in rat intestine by nitric oxide synthase inhibitors. Br J Pharmacol 111: 1309-1315, 1994.
29. Lippe IT, Sametz W, Sabin K, and Holzer P. Inhibitory role of capsaicin-sensitive afferent neurons and nitric oxide in hemostasis. Am J Physiol Heart Circ Physiol 265: H1864-H1868, 1993.
30. Okano J, Shiota G, and Kawasaki H. Protective action of hepatocyte growth factor for acute liver injury caused by D-galactosamine in transgenic mice. Hepatology 26: 1241-1249, 1997.
31. Perkins MN and Campbell EA. Capsazepine reversal of the antinociceptive action of capsaicin in vivo. Br J Pharmacol 107: 329-333, 1992.
32. Redfern JS, Lee E, and Feldman M. Effect of indomethacin on gastric mucosal prostaglandins in human. Correlation with mucosal damage. Gastroenterology 92: 969-977, 1987.
33. Ren J, Gao J, Ojeas H, Lightfoot SA, Kida M, Brewer K, and Harty RF. Involvement of capsaicin-sensitive sensory neurons in stress-induced gastroduodenal mucosal injury in rats. Dig Dis Sci 45: 830-836, 2000.
34. Robert A. Cytoprotection by prostaglandins. Gastroenterology 77: 761-767, 1979.
35. Santucci L, Fiorucci S, Giansanti M, Brunori PM, Di Matteo FM, and Morelli A. Pentoxifylline prevents indomethacin induced acute gastric mucosal damage in rats: role of tumor necrosis factor alpha. Gut 35: 909-915, 1994.
36. Simpson PJ, Mickelson J, Fantone JC, Gallagher KP, and Lucchesi BR. Iloprost inhibits neutrophil function in vitro and in vivo and limits experimental infarct size in canine heart. Circ Res 60: 666-673, 1987.
37. Starkey PM. Elastase and cathepsin G; the serine protease of human neutrophil leukocytes and spleen. In: Proteinases in Mammalian Cells and Tissues, edited by Barret AJ. Amsterdam: Elsevier, 1977, p. 57-89.
38. Sternini C, Reeve JR, and Brecha N. Distribution and characterization of calcitonin gene-related peptide immunoreactivity in the digestive system of normal and capsaicin-treated rats. Gastroenterology 93: 852-862, 1987.
39. Szallasi A and Blumberg PM. Vanilloid receptors: new insights enhance potential as a therapeutic target. Pain 68: 195-208, 1996.
40. Takagi K and Okabe S. The effect of drugs on the production and recovery processes of the stress ulcer. Jpn J Pharmacol 18: 9-17, 1968.
41. Tepperman BL, Besco JM, Kiernan JA, and Soper BD. Relationship between myeloperoxidase activity and the ontogenic response of rat gastric mucosa to ethanol. Can J Physiol Pharmacol 69: 1882-1888, 1991.
42. Wallace JL. Glucocorticoid-induced gastric mucosal damage. Inhibition of leukotriene but not prostaglandin biosynthesis. Prostaglandins 34: 311-3123, 1937.
43. Wallace JL, Keenan CM, and Granger DN. Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am J Physiol Gastrointest Liver Physiol 259: G462-G467, 1990.
44. Weiss SJ and LoBuglio AF. An oxygen-dependent mechanism of neutrophil-mediated cytotoxicity. Blood 55: 1020-1024, 1980.
45. Weiss SJ, Young J, LoBuglio AF, Slivka A, and Nimeh NF. Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells. J Clin Invest 68: 714-721, 1981.
46. Wong K and Freund K. Inhibition of the n-formylmethionyl-leucyl-phenylalanine induced respiratory burst in human neutrophils by adrenergic agonists and prostaglandins of the E series. Can J Physiol Pharmacol 59: 915-920, 1981.