Catabolic attacks of membrane-bound angiotensin-converting enzyme on the N-terminal part of species-specific amyloid-β peptides

European Journal of Pharmacology

Volumn 588, Issue 1, 2008, Pages 18-25

  Sun, Xiaoou ^a,b   Becker, Matthias ^a   Pankow, Kristin ^a   Krause, Eberhard ^a   Ringling, Martina ^a   Beyermann, Michael ^a   Maul, Bjoern ^a   Walther, Thomas ^b   Siems, Wolf Eberhard ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Alzheimer's disease; Amyloid peptide (A ); Angiotensin converting enzyme (ACE); Catalytic domains of ACE; Neprilysin (NEP)

Indexed keywords

AMINO ACID; AMYLOID BETA PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; ENZYME DEGRADATION; HAMSTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; SPECIES DIFFERENCE;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ANIMALS; CATALYSIS; CELL LINE; CELL MEMBRANE; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; CRICETINAE; CRICETULUS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE FRAGMENTS; PEPTIDES; PEPTIDYL-DIPEPTIDASE A; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 44249110915     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.03.058     Document Type: Article

References (40)

1. Araujo M.C., Melo R.L., Cesari M.H., Juliano M.A., Juliano L., and Carmona A.K. Peptidase specificity characterization of C- and N-terminal catalytic sites of angiotensin I-converting enzyme. Biochemistry 39 (2000) 8519-8525
2. Atwood C.S., Moir R.D., Huang X., Scarpa R.C., Bacarra N.M., Romano D.M., Hartshorn M.A., Tanzi R.E., and Bush A.I. Dramatic aggregation of Alzheimer Ab by Cu II is induced by conditions representing physiological acidosis. J. Biol. Chem. 273 (1998) 12817-12826
3. Barnes N.M., Cheng C.H., Costall B., Naylor R.J., Williams T.J., and Wischik C.M. Angiotensin converting enzyme is increased in temporal cortex from patients with Alzheimer's disease. Eur. J. Pharmacol. 200 (1991) 289-292
4. Binevski P.V., Sizova E.A., Pozdnev V.F., and Kost O.A. Evidence for the negative cooperativity of the two active sites within bovine somatic angiotensin-converting enzyme. FEBS Letters, 550 (2003) 84-88
5. Bush A.I., Pettingell W.H., Multhaup G., d Paradis M., Vonsattel J.P., Gusella J.F., Beyreuther K., Masters C.L., and Tanzi R.E. Rapid induction of Alzheimer Ab amyloid formation by zinc. Science 265 (1994) 1464-1467
6. Bush A.I. The metallobiology of Alzheimer's disease. Trends Neurosci. 26 (2003) 207-214
7. Chauhan N.B., and Siegel G.J. Efficacy of anti-Aβ antibody isotypes used for intracerebroventricular immunization in TgCRND8. Neurosci. Lett. 375 (2005) 143-147
8. Danilov S., Jaspard E., Churakova T., Towbin H., Savoie F., Wei L., and Alhenc-Gelas F. Structure-function analysis of angiotensin I-converting enzyme using monoclonal antibodies. Selective inhibition of the amino-terminal active site. J. Biol. Chem. 269 (1994) 26806-26814
9. Deddish P.A., Marcic B., Jackman H.L., Wang H.Z., Skidgel R.A., and Erdos E.G. N-domain-specific substrate and C-domain inhibitors of angiotensin-converting enzyme angiotensin-1-7 and keto-ACE. Hypertension 31 (1998) 912-917
10. Eckman E.A., Adams S.K., Troendle F.J., Stodola B.A., Kahn M.A., Fauq A.H., Xiao H.D., Bernstein K.E., and Eckman C.B. Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme. J. Biol. Chem. 281 (2006) 30471-30478
11. Friedland J., and Silverstein E. A sensitive fluorimetric assay for serum angiotensin-converting enzyme. Amer. J. Clin. Pathol. 66 (1976) 416-424
12. Hardy J., and Selkoe D.J. The amyloid hypothesis of Alzheimer's disease, progress and problems on the road to therapeutics. Science 297 (2002) 353-356
13. Hemming M.L., and Selkoe D.J. Amyloid β-protein is degraded by cellular angiotensin-converting enzyme ACE and elevated by an ACE inhibitor. J. Biol. Chem. 280 (2005) 37644-37650
14. Howell S., Nalbantoglu J., and Crine P. Neutral endopeptidase can hydrolyze beta-amyloid 1-40 but shows no effect on beta-amyloid precursor protein metabolism. Peptides 16 (1995) 647-652
15. Hu J., Igarashi A., Kamata M., and Nakagawa H. Angiotensin-converting enzyme degrades Alzheimer amyloid β-peptide Aβ; retards Aβ aggregation, deposition, fibril formation; and inhibits cytotoxicity. J. Biol. Chem. 276 (2001) 47863-47868
16. Iwata N., Tsubuki S., Takaki Y., Watanabe K., Sekiguchi M., Hosoki E., Kawashima-Morishima M., Lee H.J., Hama E., Sekine-Aizawa Y., and Saido T.C. Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma, suppression leads to biochemical and pathological deposition. Nat. Med. 6 (2000) 143-150
17. Jalil J.E., Ocaranza M.P., Oliveti C., Cordova S., Godoy I., Chamorro G., Braun S., Fardella C., Michel J.B., and Lavandero S. Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in humans. J. Hum. Hypertens. 18 (2004) 119-125
18. Janek K., Behlke J., Zipper J., Fabian H., Georgalis Y., Beyermann M., Bienert M., and Krause E. Water-soluble beta-sheet models which self-assemble into fibrillar structures. Biochemistry 38 (1999) 8246-8252
19. Jaspard E., Wie L., and Alhenc-Gelas F. Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme kininase 11. J. Biol. Chem. 268 (1993) 9496-9503
20. Kehoe P.G., Russ C., McIlory S., Williams H., Holmans P., Holmes C., Liolitsa D., Vahidassr D., Powell J., McGleenon B., Liddell M., Plomin R., Dynan K., Williams N., Neal J., Cairns N.J., Wilcock G., Passmore P., Lovestone S., Williams J., and Owen M.J. Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. Nat. Gen. 21 (1999) 71-72
21. 18O-labeling and tandem mass spectrometry. Rapid Commun. Mass. Spectrom. 19 (2005) 2259-2271
22. Kozin S.A., Zirah S., Rebuffat S., Hoa G.H., and Debey P. Zinc binding to Alzheimer's Abeta 1-16 peptide results in stable soluble complex. Biochem. Biophys. Res. Commun. 285 (2001) 959-964
23. Liu S.T., Howlett G., and Barrow C.J. Histidine-13 is a crucial residue in the zinc Ion-induced aggregation of the Aβ peptide of Alzheimer's disease. Biochemistry 38 (1999) 9373-9378
24. Maul B., Siems W.E., Hoehe M.R., Grecksch G., Bader M., and Walther T. Alcohol consumption is controlled by angiotensin II. FASEB J. 15 (2001) 1640-1642
25. Miura T., Suzuki K., Kohata N., and Takeuchi H. Metal binding modes of Alzheimer's amyloid, peptide in insoluble aggregates and soluble complexes. Biochemistry 39 (2000) 7024-7031
26. Mohajeri M.H., Gaugler M.N., Martinez J., Tracy J., Li H., Crameri A., Kuehnle K., Wollmer M.A., and Nitsch R.M. Anti-amyloid activity of neprilysin in plaque-bearing mouse models of Alzheimer's disease. FEBS Lett. 562 (2004) 16-21
27. Morris B.J., Zee R.Y., and Schrader A.P. Different frequencies of angiotensin-converting enzyme genotypes in older hypertensive individuals. J. Clin. Invest. 94 (1994) 1085-1089
28. Oba R., Igarashi A., Kamata M., Nagata K., Takano S., and Nakagawa H. The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid β-peptide. Europ. J. Neurosci. 21 (2005) 733-740
29. Rice G.I., Thomas D.A., Grant P.J., Turner A.J., and Hooper N.M. Evaluation of angiotensin-converting enzyme ACE, its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem. J. 383 (2004) 45-51
30. Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P., and Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 86 (1990) 1343-1346
31. Rousseau A., Michaud A., Chauvet M.T., Lenfant M., and Corvol P. The hemoregulatory peptide N-Acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin-converting enzyme. J. Biol. Chem. 270 (1995) 3656-3661
32. Saido T.C., and Iwata N. Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy. Neurosci. Res. 54 (2006) 235-253
33. Vaughan D.W., and Peters A. The structure of neuritic plaque in the cerebral cortex of aged rats. J. Neuropathol. Exp. Neurol. 40 (1981) 472-487
34. Wang D.S., Dickson D.W., and Malter J.S. β-Amyloid degradation and Alzheimer's disease. J. Biomed. Biotechnol. 2006 (2006) 58406-5807
35. Wei L., Alhenc-Gelas F., Corvol P., and Clauser E. The two homologous domains of human angiotensin I-converting enzyme are both catalytically active. J. Biol. Chem. 266 (1991) 9002-9008
36. Wei L., Clauser E., Alhenc-Gelas F., and Corvol P. The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors. J. Biol. Chem. 267 (1992) 13398-13405
37. Yang D.S., McLaurin J., Qin K., Westaway D., and Fraser P.E. Examining the zinc binding site of the amyloid-b peptide. Eur. J. Biochem. 267 (2000) 6692-6698
38. Yang J.D., Feng G., Zhang J., Lin Z.X., Shen T., Breen G., St Clair D., and He L. Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han Chinese. Neurosci. Lett. 295 (2000) 41-44
39. Yasojima K., Akiyama H., McGeer E.G., and McGeer P.L. Reduced neprilysin in high plaque areas of Alzheimer brain, a possible relationship to deficient degradation of β-amyloid peptide. Neurosci. Lett. 297 (2001) 97-100
40. Zirah S., Kozin S.A., Mazur A.K., Blond A., Cheminant M., Segalas-Milazzo I., Debey P., and Rebuffat S. Structural changes of region 1-16 of the Alzheimer disease amyloid β-peptide upon zinc binding and in vitro aging. J. Biol. Chem. 281 (2006) 2151-2161