Animal models of bleeding and tissue repair

Haemophilia

Volumn 14, Issue SUPPL. 3, 2008, Pages 62-67

  Hoffman, Maureane ^a,b  

^a DURHAM VA MEDICAL CENTER   (United States)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

Haemophilia; Inflammation angiogenesis; Iron; Tissue factor; Wound healing

Indexed keywords

BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; THROMBOPLASTIN;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ARTICLE; BLEEDING; BLEEDING DISORDER; BLEEDING TENDENCY; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; BLOOD CLOTTING FACTOR DEFICIENCY; CELL PROLIFERATION; DISEASE PREDISPOSITION; EXPERIMENTAL MODEL; FIBRIN FORMATION; FIBROBLAST; HEMARTHROSIS; HEMOPHILIA; HEMOPHILIA B; HEMOSTASIS; INFLAMMATION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RECURRENT DISEASE; SINGLE DRUG DOSE; SUBSTITUTION THERAPY; THROMBOCYTE ADHESION; THROMBOCYTE FUNCTION; THROMBOSIS; TISSUE REPAIR; VON WILLEBRAND DISEASE; WOUND HEALING IMPAIRMENT;

ANGIOGENESIS INHIBITORS; ANIMALS; DISEASE MODELS, ANIMAL; EXUDATES AND TRANSUDATES; GRANULATION TISSUE; HEMOPHILIA A; HEMORRHAGE; HUMANS; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; RABBITS; REPRODUCIBILITY OF RESULTS; WOUND HEALING;

EID: 44249102544     PISSN: 13518216     EISSN: 13652516     Source Type: Journal    
DOI: 10.1111/j.1365-2516.2008.01729.x     Document Type: Article

References (47)

1. Kingdon HS, Hassell TM. Hemophilic dog model for evaluating therapeutic effectiveness of plasma protein fractions. Blood 1981; 58: 868-872.
2. Giles AR, Tinlin S, Greenwood R. A canine model of hemophilic (factor VIII:C deficiency) bleeding. Blood 1982; 60: 727-730.
3. Brinkhous KM, Reddick RL, Read MS, Nichols TC, Bellinger DA, Griggs TR. von Willebrand factor and animal models: Contributions to gene therapy, thrombotic thrombocytopenic purpura, and coronary artery thrombosis. Mayo Clin Proc 1991; 66: 733-742.
4. Giles AR. Use of an animal model to evaluate hemophilia therapies. Prog Clin Biol Res 1984; 150: 265-276.
5. Thompson AR, Forrey AW, Gentry PA, Smith KJ, Harker LA. Human factor IX in animals: Kinetics from isolated, radiolabelled protein and platelet destruction following crude concentrate infusions. Br J Haematol 1980; 45: 329-342.
6. Pijnappels MI, Briet E, van der Zwet GT, Huisden R, van Tilburg NH, Eulderink F. Evaluation of the cuticle bleeding time in canine haemophilia A. Thromb Haemost 1986; 55: 70-73.
7. Brooks M, Catalfamo J. Buccal mucosa bleeding time is prolonged in canine models of primary hemostatic disorders. Thromb Haemost 1993; 70: 777-780.
8. Turecek PL, Gritsch H, Richter G, Auer W, Pichler L, Schwarz HP. Assessment of bleeding for the evaluation of therapeutic preparations in small animal models of antibody-induced hemophilia and von Willebrand disease. Thromb Haemost 1997; 77: 591-599.
9. Tranholm M, Kristensen K, Kristensen AT, Pyke C, Rojkjaer R, Persson E. Improved hemostasis with superactive analogs of factor VIIa in a mouse model of hemophilia A. Blood 2003; 102: 3615-3620.
10. Bi L, Lawler AM, Antonarakis SE, High KA, Gearhart JD, Kazazian HH Jr. Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A. Nat Genet 1995; 10: 119-121.
11. Valentino LA, Hakobyan N, Kazarian T, Jabbar KJ, Jabbar AA. Experimental haemophilic synovitis: Rationale and development of a murine model of human factor VIII deficiency. Haemophilia 2004; 10: 280-287.
12. Valentino LA, Hakobyan N. Histological changes in murine haemophilic synovitis: A quantitative grading system to assess blood-induced synovitis. Haemophilia 2006; 12: 654-662.
13. Roy S, Ghadially F. Pathology of experimental haemarthrosis. Ann Rheum Dis 1966; 25: 402-415.
14. Mainardi C, Levine P, Werb Z, Harris E. Proliferative synovitis in hemophilia: Biochemical and morphologic observations. Arthritis Rheum 1978; 21: 137-144.
15. Hakobyan N, Kazarian T, Jabbar AA, Jabbar KJ, Valentino LA. Pathobiology of hemophilic synovitis I: Overexpression of mdm2 oncogene. Blood 2004; 104: 2060-2064.
16. Wen FQ, Jabbar AA, Chen YX, Kazarian T, Patel DA, Valentino LA. c-myc proto-oncogene expression in hemophilic synovitis: In vitro studies of the effects of iron and ceramide. Blood 2002; 100: 912-916.
17. Hoots WK. Pathogenesis of hemophilic arthropathy. Semin Hematol 2006; 43: S18-S22.
18. Abrahams T, Pavlov H, Bansal M, Bullough P. Concentric joints space narrowing of the hip associated with hemosiderotic synovitis (HS) including pigmented villonodular synovitis. Skeletal Radiol 1988; 17: 37-45.
19. France M, Gupta S. Non-haemophilic hemosiderotic synovitis of the shoulder. Clin Orthop 1991; 262: 132-136.
20. Gospodarowicz D, Brown KD, Birdwell CR, Zetter BR. Control of proliferation of human vascular endothelial cells. Characterization of the response of human umbilical vein endothelial cells to fibroblast growth factor, epidermal growth factor, and thrombin. J Cell Biol 1978; 77: 774-788.
21. Maruyama N, Hirano F, Yoshikawa N, Migita K, Eguchi K, Tanaka H. Thrombin stimulates cell proliferation in human fibroblast-like synoviocytes in nuclear factor-kappaB activation and protein kinase C mediated pathway. J Rheumatol 2000; 27: 2777-2785.
22. Bar-Shavit R, Kahn AJ, Mann KG, Wilner GD. Identification of a thrombin sequence with growth factor activity on macrophages. Proc Natl Acad Sci U S A 1986; 83: 976-980.
23. Algermissen B, Sitzmann J, Nurnberg W, Laubscher JC, Henz BM, Bauer F. Distribution and potential biologic function of the thrombin receptor PAR-1 on human keratinocytes. Arch Dermatol Res 2000; 292: 488-495.
24. Wolberg AS. Thrombin generation and fibrin clot structure. Blood Rev 2007; 21: 131-142.
25. Richardson DL, Pepper DS, Kay AB. Chemotaxis for human monocytes by fibrinogen-derived peptides. Br J Haematol 1976; 32: 507-513.
26. Simpson DM, Ross R. The neutrophilic leukocyte in wound repair a study with antineutrophil serum. J Clin Invest 1972; 51: 2009-2023.
27. DiPietro LA. Wound healing: The role of the macrophage and other immune cells. Shock 1995; 4: 233-240.
28. Drew AF, Liu H, Davidson JM, Daugherty CC, Degen JL. Wound-healing defects in mice lacking fibrinogen. Blood 2001; 97: 3691-3698.
29. te Velde EA, Wagenaar GT, Reijerkerk A et al. Impaired healing of cutaneous wounds and colonic anastomoses in mice lacking thrombin-activatable fibrinolysis inhibitor. J Thromb Haemost 2003; 1: 2087-2096.
30. Vinckier F, Vermylen J. Wound healing following dental extractions in rabbits: Effects of tranexamic acid, warfarin anti-coagulation, and socket packing. J Dent Res 1984; 63: 646-649.
31. Hoffman M, Harger A, Lenkowski A, Hedner U, Roberts HR, Monroe DM. Cutaneous wound healing is impaired in hemophilia B. Blood 2006; 108: 3053-3060.
32. Brandstedt S, Olson PS. Effect of defibrinogenation on wound strength and collagen formation. A study in the rabbit. Acta Chir Scand 1980; 146: 483-486.
33. Brandstedt S, Olson PS. Lack of influence on collagen accumulation in granulation tissue with 'delayed'defibrinogenation. A study in the rabbit. Acta Chir Scand 1981; 147: 89-91.
34. Brandstedt S, Rank F, Olson PS. Wound healing and formation of granulation tissue in normal and defibrinogenated rabbits. An experimental model and histological study. Eur Surg Res 1980; 12: 12-21.
35. McDonald A, Hoffman M, Hedner U, Roberts H, Monroe D. Restoring thrombin generation does not normalize cutaneous wound healing in hemophilia. J Thromb Haemost 2007; 5: 1577-1583.
36. Conway EM, Carmeliet P. Molecular mechanisms of blood vessel growth. Cardiovasc Res 2001; 49: 507-521.
37. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 2001; 6: 389-395.
38. Collen A, Koolwijk P, Kroon M, van Hinsbergh VW. Influence of fibrin structure on the formation and maintenance of capillary-like tubules by human microvascular endothelial cells. Angiogenesis 1998; 2: 153-165.
39. McDonald A, Yang K, Roberts HR, Monroe DM, Hoffman M. Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia. Blood 2008; 111: 2046-2048.
40. Drake TA, Morrissey JH, Edgington TS. Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis. Am J Pathol 1989; 134: 1087-1097.
41. Fleck R, Rao L, Rapaport S, Varki N. Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody. Thromb Res 1990; 59: 421-437.
42. Hoffman M, Cooper ST. Thrombin enhances monocyte secretion of tumor necrosis factor and interleukin-1 beta by two distinct mechanisms. Blood Cells Mol Dis 1995; 21: 156-167.
43. Schaud RG, Dunn CJ, Deibel MR, Berger AE, Wunderlich D, Fleming WE. Correlation of leukocyte interleukin-1 production with the stimulation of prostaglandin and tissue factor synthesis by human umbilical vein endothelial cells. Agents Actions 1990; 31: 127-134.
44. Neumann FJ, Ott I, Marx N et al. Effect of human recombinant interleukin-6 and interleukin-8 on monocyte procoagulant activity. Arterioscler Thromb Vasc Biol 1997; 17: 3399-3405.
45. Ryan J, Brett J, Tijberg P, Bach RR, Kisiel W, Stern DM. Tumor necrosis factor-induced endothelial tissue factor is associated with subendothelial matrix vesicles but is not expressed on the apical surface. Blood 1992; 80: 966-974.
46. Chen J, Kasper M, Heck T et al. Tissue factor as a link between wounding and tissue repair. Diabetes, 2005; 54: 2143-2154.
47. Roosendaal GLF. Pathogenesis of haemophilic arthropathy. Haemophilia 2006; 12(Suppl. 3): 117-121.