Experimental haemophilic synovitis: Rationale and development of a murine model of human factor VIII deficiency

Haemophilia

Volumn 10, Issue 3, 2004, Pages 280-287

  Valentino, Leonard A ^a   Hakobyan, N ^a   Kazarian, T ^a   Jabbar, K J ^a   Jabbar, A A ^a  

^a RUSH MEDICAL COLLEGE   (United States)

Author keywords

Haemophilia; Joint; Mouse model; Synovitis

Indexed keywords

BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; HEMOSIDERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHROPATHY; ARTICLE; BLOOD COMPONENT; BLUNT TRAUMA; CELL HYPERPLASIA; CONTROLLED STUDY; HEMARTHROSIS; HEMOPHILIA A; HEMOPHILIA B; HISTOPATHOLOGY; HYPERTROPHY; IMMOBILIZATION; INFLAMMATORY DISEASE; INTERMETHOD COMPARISON; KNEE ARTHRITIS; KNEE INJURY; MICROSCOPY; MORBIDITY; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SYNOVIOCYTE; SYNOVITIS; SYNOVIUM; ULTRASTRUCTURE; WEIGHT REDUCTION;

EID: 2342538377     PISSN: 13518216     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2516.2004.00899.x     Document Type: Article

References (23)

1. Rodriguez-Merchan EC. Pathogenesis, early diagnosis, and prophylaxis for chronic hemophilic synovitis. Clin Orthop 1997; 343: 6-11.
2. Soreff J, Blomback M. Arthropathy in children with severe hemophilia A. Acta Paediatr Scand 1980; 69: 667-73.
3. Aledort LM, Haschmeyer RH, Pettersson H. A longitudinal study of orthopaedic outcomes for severe factor VIII-deficient haemophiliacs. The Orthopaedic Outcome Study Group. J Intern Med 1994; 236: 391-9.
4. Mannucci PM, Mendolicchio L, Gringeri A. Use of prophylaxis to prevent complications of hemophilia. Adv Exp Med Biol 2001; 489: 59-64.
5. Lusher JM. Prophylaxis in children with hemophilia: is it the optimal treatment? Thromb Haemost 1997; 78: 726-9.
6. Manco-Johnson MJ, Nuss R, Geraghty S, Funk S, Kilcoyne R. Results of secondary prophylaxis in children with severe hemophilia. Am J Hematol 1994; 47: 113-7.
7. Van Creveld S. Prophylaxis of joint hemorrhages in hemophilia. Acta Haematol 1971; 45: 120-7.
8. Ahlberg A. Treatment and prophylaxis of arthropathy in severe hemophilia. Clin Orthop 1967; 53: 135-46.
9. Lofqvist T et al. Haemophilia prophylaxis in young patients - a long-term follow-up. J Intern Med 1997; 241: 395-400.
10. Funk M, Schmidt H, Escuriola-Ettingshausen C, Pons S, Dzinaj T, Weimer C, et al. Radiological and orthopedic score in pediatric hemophilic patients with early and late prophylaxis. Ann Hematol 1998; 77: 171-4.
11. Rodriguez-Merchan EC. Effects of hemophilia on articulations of children and adults. Clin Orthop 1996; 328: 7-13.
12. Bi L, Lawler AM, Antonarakis SE, High KA, Gearhart JD, Kazazian, HH, Jr. Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A. Nat Genet 1995; 10: 119-21.
13. Bi L, Sarkar R, Naas T, Lawler AM, Pain J, Shumaker SL, et al. Further characterization of factor VIII-deficient mice created by gene targeting: RNA and protein studies. Blood 1996; 88: 3446-50.
14. Wiedel JD. Arthroscopic synovectomy of the knee in hemophilia: 10-15 year follow-up. Clin Orthop 1996; 328: 46-53.
15. Dunn AL, Busch MT, Wyly JB, Abshire TC. Radionuclide synovectomy for hemophilic arthropathy: a comprehensive review of safety and efficacy and recommendation for a standardized treatment protocol. Thromb Haemost 2002; 87: 383-93.
16. Stein H, Duthie RB. The pathogenesis of chronic haemophilic arthropathy. J Bone Jt Surg Br 1981; 63: 601-9.
17. Swanton MC. Hemophilic arthropathy in dogs. Lab Invest 1959; 8: 1269-995.
18. Madhok R et al. Mechanisms of joint damage in an experimental model of hemophilic arthritis. Arthritis Rheum 1988; 31: 1148-55.
19. Morris CJ, Blake DR, Wainwright AC, Steven MM. Relationship between iron deposits and tissue damage in the synovium: an ultrastructural study. Ann Rheum Dis 1986; 45: 21-6.
20. Blake DR, Hall ND, Bacon PA, Dieppe PA, Halliwell B, Gutteridge JM. The importance of iron in rheumatoid disease. Lancet 1981; 2: 1142-4.
21. Roosendaal G, vianen ME, Wenting MJ, van Rinsum AC, van den Berg HM, Lafeber FP, et al. Iron deposits and catabolic properties of synovial tissue from patients with haemophilia. J Bone Jt Surg Br 1998; 80: 540-5.
22. Nishiya K. Stimulation of human synovial cell DNA synthesis by iron. J Rheumatol 1994; 21: 1802-7.
23. Wen FQ, Jabbar AA, Chen YX, Kazarian T, Patel DA, Valentino LA. c-myc proto-oncogene expression in hemophilic synovitis: in vitro studies of the effects of iron and ceramide. Blood 2002; 100: 912-6.