Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: Evidence for a second phosphotyrosine substrate recognition pocket

Journal of Biological Chemistry

Volumn 280, Issue 9, 2005, Pages 8180-8187

  Villa, Fabrizio ^a   Deak, Maria ^a   Bloomberg, Graham B ^b   Alessi, Dario E ^a   Van Aalten, Daan M F ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CATALYSIS; CRYSTAL STRUCTURE; ENZYMES; INSULIN; MUTAGENESIS; PHOSPHATES; TUMORS;

COLORECTAL CANCER; GROWTH FACTOR; MUTANTS; PROTEIN-TYROSINE PHOSPHATASE-L1 (PTPL1);

ENZYME KINETICS;

GROWTH FACTOR RECEPTOR; INSULIN; INSULIN RECEPTOR; PEPTIDE; PHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE L1; SOLVENT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; COLORECTAL CARCINOMA; CRYSTAL STRUCTURE; DOWN REGULATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME REGULATION; INSULIN METABOLISM; MUTATION; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN INTERACTION; PROTEIN MODIFICATION; RECEPTOR SENSITIVITY; SIGNAL TRANSDUCTION; SOLVENT EFFECT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; CLONING, MOLECULAR; COLORECTAL NEOPLASMS; CRYSTALLOGRAPHY, X-RAY; DNA; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDES; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 14844304321     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M412211200     Document Type: Article

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