A human homolog of mouse Lbh gene, hLBH, expresses in heart and activates SRE and AP-1 mediated MAPK signaling pathway

Molecular Biology Reports

Volumn 35, Issue 2, 2008, Pages 179-187

  Ai, Jianping ^a   Wang, Yuequn ^a   Tan, Kunrong ^a   Deng, Yun ^a   Luo, Na ^a   Yuan, Wuzhou ^a   Wang, Zequn ^a   Li, Yongqing ^a   Wang, Ying ^a   Mo, Xiaoyang ^a   Zhu, Chuanbing ^a   Yin, Zhaochu ^a   Liu, Mingyao ^a   Wu, Xiushan ^a  

^a HUNAN NORMAL UNIVERSITY   (China)

Author keywords

AP 1; Gene regulation; hLBH; SRE; Transcription factor

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR LBH;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA BINDING MOTIF; DNA LIBRARY; GENE DELETION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY; SERUM RESPONSIVE ELEMENT; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CERCOPITHECUS AETHIOPS; CONSERVED SEQUENCE; COS CELLS; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOME, HUMAN; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MOLECULAR SEQUENCE DATA; MYOCARDIUM; NUCLEAR PROTEINS; PHYLOGENY; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY, AMINO ACID; SERUM RESPONSE ELEMENT; SUBCELLULAR FRACTIONS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

DANIO RERIO;

EID: 44049103798     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-007-9068-4     Document Type: Article

References (22)

1. Wu X (2002) Molecular mechanism of heart development. Hunan Publishing House, Changsha
2. Wu X, Park M, Golden K, Axelrod JD, Bodmer R (1996) The wingless signaling pathway is directly involved in Drosophila heart development. Dev Biol 177:104-116
3. Wu X, Golden K, Bodmer R (1995) Heart development in Drosophila requires the polarity gene wingless. Dev Biol 169:619-628
4. Briegel KJ, Joyner AL (2001) Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development. Dev Biol 233:291-304
5. Briegel KJ, Baldwin HS, Epstein JA, Joyner AL (2005) Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh. Development 132:3305-3316
6. Whitmarsh AJ, Davis RJ (2000) Regulation of transcription factor function by phosphorylation. Cell mol Life Sci 57:1172-1183
7. Aggeli IS, Gaitanaki C, Lazou A, Beis I (2002) Hyperosmotic and thermal stresses activate p38-MAPK in the perfused amphibian heart. J Exp Biol 205:443-454
8. Tanoue T, Nishida E (2003) Molecular recognitions in the MAP kinase cascades. Cell Signal 15:455-462
9. Zhu Y, Wang Y, Xia C, Li D, Li Y, Zeng W, Yuan W, Liu H, Zhu C, Wu X, Liu M (2004) WDR26, a novel G-beta-like protein, suppresses MAPK signaling pathway. J Cell Biochem 93:579-587
10. Huang C, Wang Y, Li D, Li Y, Luo J, Yuan W, Ou Y, Zhu C, Zhang Y, Wang Z, Wu X, Liu M (2004) Inhibition of transcriptional activities of AP-1 and c-Jun by a new zinc-finger protein ZNF394. Biochem Biophys Res Commun 320:1298-1305
11. Wang Y, Li Y, Zeng W, Zhu C, Xiao J, Yuan W, Wang Y, Cai Z, Zhou J, Liu M, Wu X (2004) IXL, a new subunit of the mammalian mediator complex, functions as a transcriptional suppressor. Biochem Biophys Res Commun 325:1330-1338
12. Wang Y, Li Y, Qi X, Yuan W, Ai J, Zhu C, Cao L, Yang H, Liu F, Wu X, Liu M (2004) TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1. Biochem Biophys Res Commun 323:9-16
13. Reszka AA, Seger R, Diltz CD, Krebs EG, Fischer EH (1995) Association of mitogen-activated protein kinase with the microtubule cytoskeleton. Proc Natl Acad Sci USA 92:8881-8885
14. English J, Pearson G, Wilsbacher J, Swantek J, Karandikar M, Xu S, Cobb MH (1999) New insights into the control of MAP kinase pathways. Exp Cell Res 253:255-270
15. Pawson T, Nash P (2000) Protein-protein interactions define specificity in signal transduction. Genes Dev 4:1027-1047
16. Treisman R (1996) Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol 8:205-215
17. Gille H, Kortenjann M, Thomae O, Moomaw C, Slaughter C, Cobb MH, Shaw PE (1995) ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J 14(5):951-962
18. Kyriakis JM, Avruch J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807-869
19. Fantz DA, Jacobs D, Glossip D, Kornfeld K (2001) Docking sites on substrate proteins direct extracellular signal regulated kinase to phosphorylate specific residues. J Biol Chem 276:27256-27265
20. Sharrocks AD, Yang SH, Galanis A (2000) Docking domains and substrate-specificity determination for MAP kinases. Trends Biochem Sci 25:448-453
21. Yang SH, Whitmarsh AJ, Davis RJ, Sharrocks AD (1998) Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1. EMBO J 17:1740-1749
22. Buchwalter G, Gross C, Wasylyk B (2004) Ets ternary complex transcription factors. Gene 324:1-14