Synthesis and activity of tetrapeptidic HTLV-I protease inhibitors possessing different P3-cap moieties

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 10, 2008, Pages 5795-5802

  Zhang, Meihui ^a,b   Nguyen, Jeffrey Tri ^a   Kumada, Henri Obadja ^a   Kimura, Tooru ^a   Cheng, Maosheng ^b   Hayashi, Yoshio ^a,c   Kiso, Yoshiaki ^a  

^a Center for Frontier Research in Medicinal Science   (Japan)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Aspartic protease inhibitor; ATL; HIV 1; HTLV I

Indexed keywords

KNI 10161; KNI 10166; KNI 10247; KNI 10516; KNI 10570; KNI 10571; KNI 10572; KNI 10573; KNI 10574; KNI 10575; KNI 10614; KNI 10615; KNI 10616; KNI 10617; KNI 10618; KNI 10633; KNI 10634; KNI 10651; KNI 10652; KNI 10673; PROTEINASE INHIBITOR; TETRAPEPTIDE;

ANTIVIRAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN T CELL LEUKEMIA VIRUS 1; IC 50; NONHUMAN; SPASTIC PARAPLEGIA; SPINAL CORD DISEASE; STEREOSPECIFICITY; T CELL LEUKEMIA; VIRUS INHIBITION;

ASPARTIC ENDOPEPTIDASES; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HIV PROTEASE; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OLIGOPEPTIDES; PROTEASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 43749120718     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.055     Document Type: Article

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