Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 51, 2005, Pages 18332-18337

  Li, Mi ^a,b   Laco, Gary S ^c,e   Jaskolski, Mariusz ^d   Rozycki, Jan ^c   Alexandratos, Jerry ^a   Wlodawer, Alexander ^a   Gustchina, Alla ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d ADAM MICKIEWICZ UNIVERSITY   (Poland)

^e LAKE ERIE COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

Author keywords

Inhibitor; Leukemia; Retroviral protease

Indexed keywords

AMPRENAVIR; ANTINEOPLASTIC AGENT; INDINAVIR; MONOCLONAL ANTIBODY; NELFINAVIR; PROTEINASE; RITONAVIR; SAQUINAVIR; VIRUS PROTEIN; ZIDOVUDINE;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG DESIGN; DRUG TARGETING; GENETIC CONSERVATION; HUMAN T CELL LEUKEMIA VIRUS; HUMAN T CELL LEUKEMIA VIRUS 1; LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; RETROVIRUS; STRUCTURE ANALYSIS; VIRUS RESISTANCE;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; ANTINEOPLASTIC AGENTS; ASPARTIC ENDOPEPTIDASES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURAL HOMOLOGY, PROTEIN;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 29444452604     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509335102     Document Type: Article

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