Narrow substrate specificity and sensitivity toward ligand-binding site mutations of human T-cell leukemia virus type 1 protease

Journal of Biological Chemistry

Volumn 279, Issue 26, 2004, Pages 27148-27157

  Kádas, János ^a   Weber, Irene T ^b   Bagossi, Péter ^a   Miklóssy, Gabriella ^a   Boross, Péter ^a   Oroszlan, Stephen ^c   Tözsér, József ^a,d  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b GEORGIA STATE UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; ENZYMES; MUTAGENESIS; VIRUSES;

LEUKEMIA; SUBSTRATE SPECIFICITY;

BIOCHEMISTRY;

AMINO ACID; HUMAN T CELL LEUKEMIA VIRUS 1 PROTEASE; INDINAVIR; OLIGOPEPTIDE; PEPTIDE; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL BOND; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN T CELL LEUKEMIA VIRUS 1; HYDROLYSIS; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; RETROVIRUS; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ASPARTIC ENDOPEPTIDASES; BINDING SITES; HIV PROTEASE; HIV-1; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEOCAPSID; OLIGOPEPTIDES; PROTEASE INHIBITORS; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN T-LYMPHOTROPIC VIRUS 1; RNA VIRUSES; UNIDENTIFIED RETROVIRUS;

EID: 3042648441     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M401868200     Document Type: Article

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