Chipping at large, potent human T-cell leukemia virus type 1 protease inhibitors to uncover smaller, equipotent inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 12, 2007, Pages 3276-3280

  Kimura, Tooru ^a   Nguyen, Jeffrey Tri ^a   Maegawa, Hikoichiro ^a   Nishiyama, Keiji ^a   Arii, Yasuhiro ^a   Matsui, Yasuko ^a   Hayashi, Yoshio ^a   Kiso, Yoshiaki ^a  

^a Center for Frontier Research in Medicinal Science   (Japan)

Author keywords

Adult T cell leukemia; Human immunodeficiency virus; Human T cell leukemia virus; Protease inhibitor

Indexed keywords

3 AMINO 2 HYDROXY 4 PHENYLBUTYRIC ACID; KNI 10102; KNI 10103; KNI 10104; KNI 10105; KNI 10108; KNI 10109; KNI 10110; KNI 10112; KNI 10116; KNI 10127; KNI 10128; KNI 10129; KNI 10130; KNI 10131; KNI 10132; KNI 10138; KNI 10140; KNI 10146; KNI 10147; KNI 10148; KNI 10149; KNI 10150; KNI 10151; KNI 10153; KNI 10156; KNI 10157; KNI 10161; KNI 10162; KNI 10166; OCTAPEPTIDE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DISEASE SEVERITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN T CELL LEUKEMIA VIRUS 1; NONHUMAN; STRUCTURE ACTIVITY RELATION; T CELL LEUKEMIA; VIRUS INHIBITION;

ADULT; CHRONIC DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV PROTEASE INHIBITORS; HUMANS; LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED; MODELS, MOLECULAR; MOLECULAR WEIGHT; OLIGOPEPTIDES;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 34249289725     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.04.019     Document Type: Article

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