Development of novel water-soluble photocleavable protective group and its application for design of photoresponsive paclitaxel prodrugs

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 10, 2008, Pages 5389-5397

  Noguchi, Mayo ^a   Skwarczynski, Mariusz ^a   Prakash, Halan ^b   Hirota, Shun ^b,c   Kimura, Tooru ^a   Hayashi, Yoshio ^a,d   Kiso, Yoshiaki ^a  

^a Center for Frontier Research in Medicinal Science   (Japan)

^b NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

O N intramolecular acyl migration; Prodrug of paclitaxel; Taxol; Water soluble photocleavable protective group

Indexed keywords

7 [BIS [2 [[2 (DIMETHYLAMINO)ETHYL]AMINO] 2 OXOETHYL]AMINO] 4 (HYDROXYMETHYL)COUMARIN; 7 [BIS [2 [[2 (DIMETHYLAMINO)ETHYL]AMINO] 2 OXOETHYL]AMINO] 4 [2' O PACLITAXEL)CARBONYLOXYMETHYL]COUMARIN; 7 [BIS [2 [[2 (DIMETHYLAMINO)ETHYL]AMINO] 2 OXOETHYL]AMINO] 4 [[3' N (2' O BENZOYL 3' N DEBENZOYLPACLITAXEL)]CARBONYLOXYMETHYL]COUMARIN; COUMARIN DERIVATIVE; PACLITAXEL; PRODRUG;

AQUEOUS SOLUTION; ARTICLE; DECOMPOSITION; DRUG DESIGN; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; LASER; PHOTODYNAMIC THERAPY; PHOTOSENSITIVITY; TISSUE INJURY; ULTRAVIOLET IRRADIATION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; DRUG DESIGN; LASERS; MOLECULAR CONFORMATION; PACLITAXEL; PHOTOCHEMISTRY; PHOTOLYSIS; PHOTOSENSITIZING AGENTS; PRODRUGS; SOLUBILITY; STEREOISOMERISM; ULTRAVIOLET RAYS; WATER;

EID: 43749100667     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.04.022     Document Type: Article

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