β-catenin signalling in mesenchymal islet-derived precursor cells

Cell Proliferation

Volumn 41, Issue 3, 2008, Pages 474-491

  Ikonomou, L ^a   Geras Raaka, E ^a   Raaka, B M ^a   Gershengorn, M C ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 BROMOINDIRUBIN 3' OXIME; BETA CATENIN; ENZYME INHIBITOR; SMALL INTERFERING RNA;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL GROWTH; CELL MEMBRANE; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MESENCHYME CELL; PANCREAS ISLET CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION;

BETA CATENIN; BIOLOGICAL MARKERS; CELL NUCLEUS; CELL PROLIFERATION; EPITHELIUM; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; MESODERM; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STEM CELLS; TRANSCRIPTION, GENETIC; WNT PROTEINS;

EID: 43749088220     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/j.1365-2184.2008.00527.x     Document Type: Article

References (62)

1. Aberle H, Bauer A, Stappert J, Kispert A, Kemler R (1997) beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 16, 3797 3804.
2. Atouf F, Park CH, Pechhold K, Ta M, Choi Y, Lumelsky NL (2007) No evidence for mouse pancreatic β-Cell epithelial-mesenchymal transition in vitro. Diabetes 56, 699 702.
3. Bach JF (1994) Insulin-dependent diabetes-mellitus as an autoimmune-disease. Endocr. Rev. 15, 516 542.
4. Boland GM, Perkins G, Hall DJ, Tuan RS (2004) Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J. Cell. Biochem. 93, 1210 1230.
5. Chase LG, Ulloa-Montoya F, Kidder BL, Verfaillie CM (2007) Islet-derived fibroblast-like cells are not derived via epithelial-mesenchymal transition from Pdx-1 or insulin-positive cells. Diabetes 56, 3 7.
6. Cho HH, Kim YJ, Kim SJ, Kim JH, Bae YC, Ba B, Jung JS (2006) Endogenous Wnt signaling promotes proliferation and suppresses osteogenic differentiation in human adipose derived stromal cells. Tissue Eng. 12, 111 121.
7. Cong F, Schweizer L, Chamorro M, Varmus H (2003) Requirement for a nuclear function of beta-catenin in Wnt signaling. Mol. Cell. Biol. 23, 8462 8470.
8. Davani B, Ikonomou L, Raaka BM, Geras-Raaka E, Morton RA, Marcus-Samuels B, Gershengorn MC (2007) Human islet-derived precursor cells are mesenchymal stromal cells that differentiate and mature to hormone-expressing cells in vivo. Stem Cells 25, 3215 3222.
9. Dessimoz J, Bonnard C, Huelsken J, Grapin-Botton A (2005) Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development. Curr. Biol. 15, 1677 1683.
10. Etheridge SL, Spencer GJ, Heath DJ, Genever PG (2004) Expression profiling and functional analysis of Wnt signaling mechanisms in mesenchymal stem cells. Stem Cells 22, 849 860.
11. Filali M, Cheng NL, Abbott D, Leontiev V, Engelhardt JF (2002) Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter. J. Biol. Chem. 277, 33398 33410.
12. Gao R, Ustinov J, Korsgren O, Otonkoski T (2005) In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells. Diabetologia 48, 2296 2304.
13. George SJ, Beeching CA (2006) Cadherin: catenin complex: a novel regulator of vascular smooth muscle cell behaviour. Atherosclerosis 188, 1 11.
14. Gershengorn MC, Geras-Raaka E, Hardikar AA, Raaka BM (2005) Are better islet cell precursors generated by epithelial-to-mesenchymal transition? Cell Cycle 4, 380 382.
15. Gershengorn MC, Hardikar AA, Wei CJ, Geras-Raaka E, Marcus-Samuels B, Raaka BM (2004) Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells. Science 306, 2261 2264.
16. Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C (1998) Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391, 357 362.
17. Gonzalez-Sancho JM, Aguilera O, Garcia JM, Pendas-Franco N, Pena C, Cal S, de Herreros AG, Bonilla F, Munoz A (2005) The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer. Oncogene 24, 1098 1103.
18. Gregory CA, Singh H, Perry AS, Prockop DJ (2003) The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow. J. Biol. Chem. 278, 28067 28078.
19. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW (1998) Identification of c-MYC as a target of the APC pathway. Science 281, 1509 1512.
20. Heiser PW, Lau J, Taketo MM, Herrera PL, Hebrok M (2006) Stabilization of beta-catenin impacts pancreas growth. Development 133, 2023 2032.
21. Heller RS, Klein T, Ling ZD, Heimberg H, Katoh M, Madsen OD, Serup P (2003) Expression of Wnt, frizzled, sFRP, and DKK genes in adult human pancreas. Gene Expr. 11, 141 147.
22. Hermann M, Pirkebner D, Draxl A, Berger P, Untergasser G, Margreiter R, Hengster P (2007) Dickkopf-3 is expressed in a subset of adult human pancreatic beta cells. Histochem. Cell Biol. 127, 513 521.
23. Hou R, Liu L, Anees S, Hiroyasu S, Sibinga NES (2006) The Fat1 cadherin integrates vascular smooth muscle cell growth and migration signals. J. Cell Biol. 173, 417 429.
24. Huber MA, Kraut N, Beug H (2005) Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 17, 548 558.
25. Jamora C, Dasgupta R, Kocieniewski P, Fuchs E (2003) Links between signal transduction, transcription and adhesion in epithelial bud development. Nature 422, 317 322.
26. Kayali AG, Flores LE, Lopez AD, Kutlu B, Baetge E, Kitamura R, Hao E, Beattie GM, Hayek A (2007) Limited capacity of human adult islets expanded in vitro to redifferentiate into insulin-producing β-cells. Diabetes 56, 703 708.
27. Lechner A, Nolan AL, Blacken RA, Habener JF (2005) Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue. Biochem. Biophys. Res. Commun. 327, 581 588.
28. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 (T) (-Delta Delta C) method. Methods 25, 402 408.
29. Logan CY, Nusse R (2004) The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20, 781 810.
30. Lu ZM, Ghosh S, Wang ZY, Hunter T (2003) Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell 4, 499 515.
31. Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XZP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, Greengard P (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem. Biol. 10, 1255 1266.
32. Monga SPS, Mars WM, Pediaditakis P, Bell A, Mule K, Bowen WC, Wang X, Zarnegar R, Michalopoulos GK (2002) Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after met-ss-catenin dissociation in hepatocytes. Cancer Res. 62, 2064 2071.
33. Morali OG, Delmas V, Moore R, Jeanney C, Thiery JP, Larue L (2001) IGF-II induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition. Oncogene 20, 4942 4950.
34. Morton RA, Geras-Raaka E, Wilson LM, Raaka BM, Gershengorn MC (2007) Endocrine precursor cells from mouse islets are not generated by epithelial-to-mesenchymal transition of mature beta cells. Mol. Cell. Endocrinol. 270, 87 93.
35. Muller T, Bain G, Wang X, Papkoff J (2002) Regulation of epithelial cell migration and tumor formation by beta-catenin signaling. Exp. Cell Res. 280, 119 133.
36. Murtaugh LC, Law AC, Dor Y, Melton DA (2005) beta-Catenin is essential for pancreatic acinar but not islet development. Development 132, 4663 4674.
37. Mussmann R, Geese M, Harder F, Kegel S, Andag U, Lomow A, Burk U, Onichtchouk D, Dohrmann C, Austen M (2007) Inhibition of GSK3 promotes replication and survival of pancreatic beta cells. J. Biol. Chem. 282, 12030 12037.
38. Nelson WJ, Nusse R (2004) Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303, 1483 1487.
39. Niida A, Hiroko T, Kasai M, Furukawa Y, Nakamura Y, Suzuki Y, Sugano S, Akiyama T (2004) DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway. Oncogene 23, 8520 8526.
40. Nir T, Dor Y (2005) How to make pancreatic beta cells - prospects for cell therapy in diabetes. Curr. Opin. Biotechnol. 16, 524 529.
41. Novak A, Hsu SC, Leung-Hagesteijn C, Radeva G, Papkoff J, Montesano R, Roskelley C, Grosschedl R, Dedhar S (1998) Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proc. Natl. Acad. Sci. USA 95, 4374 4379.
42. Nowak SJ, Corces VG (2004) Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation. Trends Genet. 20, 214 220.
43. Oloumi A, McPhee T, Dedhar S (2004) Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase. Biochim. Biophys. Acta 1691, 1 15.
44. Ouziel-Yahalom L, Zalzman M, Anker-Kitai L, Knoller S, Bar Y, Glandt M, Herold K, Efrat S (2006) Expansion and redifferentiation of adult human pancreatic islet cells. Biochem. Biophys. Res. Commun. 341, 291 298.
45. Papadopoulou S, Edlund H (2005) Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function. Diabetes 54, 2844 2851.
46. Quasnichka H, Slater SC, Beeching CA, Boehm M, Sala-Newby GB, George SJ (2006) Regulation of smooth muscle cell proliferation by beta-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression. Circ. Res. 99, 1329 1337.
47. Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, Erickson RL, MacDougald OA (2000) Inhibition of adipogenesis by Wnt signaling. Science 289, 950 953.
48. Rulifson IC, Karnik SK, Heiser PW, Ten Berge D, Chen HN, Gu XY, Taketo MM, Nusse R, Hebrok M, Kim SK (2007) Wnt signaling regulates pancreatic beta cell proliferation. Proc. Natl. Acad. Sci. USA 104, 6247 6252.
49. Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH (2004) Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat. Med. 10, 55 63.
50. Scholzen T, Gerdes J (2000) The Ki-67 protein: from the known and the unknown. J. Cell. Physiol. 182, 311 322.
51. 1 gene is a target of the beta-catenin/LEF-1 pathway. Proc. Natl. Acad. Sci. USA 96, 5522 5527.
52. Slusarski DC, Corces VG, Moon RT (1997) Interaction of Wnt and a frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 390, 410 413.
53. Song L, Webb NE, Song YJ, Tuan RS (2006) Identification and functional analysis of candidate genes regulating mesenchymal stem cell self-renewal and multipotency. Stem Cells 24, 1707 1718.
54. 1 in colon carcinoma cells. Nature 398, 422 426.
55. Thiery JP, Sleeman JP (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 7, 131 142.
56. Tian E, Zhan FH, Walker R, Rasmussen E, Ma YP, Barlogie B, Shaughnessy JD (2003) The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N. Engl. J. Med. 349, 2483 2494.
57. Uglow EB, Slater S, Sala-Newby GB, Aguilera-Garcia CM, Angelini GD, Newby AC, George SJ (2003) Dismantling of cadherin-mediated cell-cell contacts modulates smooth muscle cell proliferation. Circ. Res. 92, 1314 1321.
58. Wang XH, Xiao Y, Mou YS, Zhao Y, Blankesteijn WM, Hall JL (2002) A role for the beta-catenin/T-cell factor signaling cascade in vascular remodeling. Circ. Res. 90, 340 347.
59. Weinberg N, Ouziel-Yahalom L, Knoller S, Efrat S, Dor Y (2007) Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic β-cells. Diabetes 56, 1299 1304.
60. Wells JM, Esni F, Boivin GP, Aronow BJ, Stuart W, Combs C, Sklenka A, Leach SD, Lowy AM (2007) Wnt/beta-catenin signaling is required for development of the exocrine pancreas. BMC Dev. Biol. 7, 4.
61. Willert J, Epping M, Pollack J, Brown P, Nusse R (2002) A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC Dev. Biol. 2, 8.
62. Zhang T, Otevrel T, Gao ZQ, Gao ZP, Ehrlich SM, Fields JZ, Boman BM (2001) Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. Cancer Res. 61, 8664 8667.