Lipopolysaccharide-induced NF-κB activation and cytokine release in human alveolar macrophages is PKC-independent and TK- and PC-PLC-dependent

American Journal of Respiratory Cell and Molecular Biology

Volumn 18, Issue 3, 1998, Pages 384-391

  Carter, Aaron Brent ^a   Monick, Martha M ^b   Hunninghake, Gary W ^b  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; CARRIER PROTEIN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE BINDING PROTEIN; LIPOPOLYSACCHARIDE-BINDING PROTEIN; MEMBRANE PROTEIN; PHOSPHATIDYLCHOLINE SPECIFIC PHOSPHOLIPASE C; PHOSPHATIDYLCHOLINE-SPECIFIC PHOSPHOLIPASE C; PHOSPHOLIPASE C; PROTEIN KINASE C; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; HUMAN; IMMUNOLOGY; LUNG ALVEOLUS MACROPHAGE; METABOLISM; MIDDLE AGED; PROTEIN BINDING; SECRETION; SIGNAL TRANSDUCTION;

ACUTE-PHASE PROTEINS; ADOLESCENT; ADULT; CARRIER PROTEINS; CYTOKINES; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NF-KAPPA B; PHOSPHOLIPASE C; PROTEIN BINDING; PROTEIN KINASE C; RESPIRATORY DISTRESS SYNDROME, ADULT; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032013322     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.18.3.2972     Document Type: Article

References (34)

1. Chollet-Martin, S., B. Jourdain, C. Gibert, C. Elbim, J. Chastre, and M. A. Gougerot-Pocidalo. 1996. Interactions between neutrophils and cytokines in blood and alveolar spaces during ARDS. Am. J. Respir. Crit. Care Med. 153:594-601.
2. Goodman, R. B., R. M. Strieter, D. P. Martin, K. P. Steinherg, J. A. Milberg, R. J. Maunder, S. L. Kunkel, A. Walz, L. D. Hudson, and T. R. Martin. 1996. Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 154:602-611.
3. Baughman, R. P., K. L. Gunther, M. C. Rashkin, D. A. Keeton, and E. N. Pattishall. 1996. Changes in the inflammatory response of the lung during acute respiratory distress syndrome: prognostic indicators. Am. J. Respir. Crit. Care Med. 154:76-81.
4. Shakhov, A. N., M. A. Collart, P. Vassalli, S. A. Nedospasov, and C. V. Jongeneel. 1990. κB-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor gene in primary macrophages. J. Exp. Med. 171:35-47.
5. Goldfeld, A. E., J. L. Strominger, and C. Doyle. 1991. Human tumor necrosis factor α gene regulation in phorbol ester stimulated T and B cells lines. J. Exp. Med. 174:73-81.
6. Shimizu, H., K. Mitomo, T. Watanabe, S. Okamoto, and K. Yamamoto. 1989. Involvement of the NF-κB-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines. Mol. Cell. Biol. 10:561-568.
7. Collart, M. A., P. Baeuerle, and P. Vassalli. 1990. Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four κB-like motifs and of constitutive and inducible forms of NF-κB. Mol. Cell. Biol. 10:1498-1506.
8. Libermann, T. A., and D. Baltimore. 1990. Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol. Cell. Biol. 10: 2327-2334.
9. Zhang, Y., J. Lin, and J. Vilcek. 1990. Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a κB-like sequence. Mol. Cell. Biol. 10:3818-3823.
10. Yan, S. F., I. Tritto, D. Pinsky, H. Liao, J. Huang, G. Fuller, J. Brett, L. May, and D. Stern. 1995. Induction of interleukin-6 (IL-6) by hypoxia in vascular cells: central role of the binding for nuclear factor-IL-6. J. Biol. Chem. 270:11463-11471.
11. Matsusaka, T., K. Fujikawa, Y. Nishio, N. Mukaida, K. Matsushima, T. Kishimoto, and S. Akira. 1993. Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc. Natl. Acad. Sci. USA 90:10193-10197.
12. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141-179.
13. Kunsch, C., R. K. Lang, C. A. Rosen, and M. F. Shannon. 1494. Synergistic transcriptional activation of the IL-8 gene by NF-κB p65 (Rel A) and NF-IL-6. J. Immunol. 153:153-164.
14. Finco, T. S., and A. S. Baldwin. 1995. Mechanistic aspects of NF-κB regulation: the emerging role of phosphorylation and proteolysis. Immunity 3: 263-272.
15. Schwartz, M. D., E. E. Moore, F. A. Moore, R. Shenkar, P. Moine, J. B. Haenel, and E. Abraham. 1996. Nuclear factor-κB is activated in alveolar macrophages from patients with acute respiratory distress syndrome. Crit. Care Med. 24:1285-1292.
16. Shapira, L., S. Takashiba, C. Champagne, S. Amar, and T. E. Van Dyke. 1944. Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide-induced TNF-α and IL-1β production by human monocytes. J. Immunol. 153:1818-1824.
17. Muller, G., M. Ayoub, P. Storz, J. Rennecke, D. Fabbro, and K. Pfizenmaier. 1995. PKC ζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid. EMBO J. 14: 1961-1969.
18. Geng, Y., B. Zhang, and M. Lotz. 1993. Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes. J. Immunol. 151:6692-6700.
19. Anderson, M. T., F. J. T. Staal, C. Gilter, L. A. Herzenberg, and L. A. Herzenberg. 1994. Separation of oxidant-initiated and redox-regulated steps in the NF-κB signal transduction pathway. Proc. Natl. Acad. Sci. USA 91:11527-11531.
20. Delude, R. L., M. J. Fenton, R. Savedra, P. Perera, S. N. Vogel, R. Thieringer, and D. T. Golenbock. 1494. CD14-mediated translocation of nuclear factor-κB induced by lipopolysaccharide does not require tyrosine kinase activity. J. Biol. Chem. 269:22253-22260.
21. Yoza, B. K., J. Y. Q. Hu, and C. E. McCall. 1996. Protein-tyrosine kinase activation is required for lipopolysaccharide induction of interleukin I and NFκB activation, but not NFκB nuclear translocation. J. Biol. Chem. 271: 18306-18309.
22. Schutze, S., K. Potthoff, T. Machleidt, D. Berkovic, K. Wiegmann, and M. Kronke. 1992. TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyclin breakdown. Cell 71:765-776.
23. Wiegmann, K., S. Schutze, T. Machleidt, D. Witte, and M. Kronke. 1994. Functional dichotomy of neutral and acidic sphingomyclinases in tumor necrosis factor signaling. Cell 78:1005-1015.
24. Yang, Z., M. Costanzo, D. W. Golde, and R. N. Kolesnick. 1993. Tumor necrosis factor activation of the sphingomyclin pathway signals nuclear factor κB translocation in intact HL-60 cells. J. Biol. Chem. 268:20520-20523.
25. Arenzana-Seisdedos, F., B. Fernandez, I. Dominguez J. M. Jacque, D. Thomas, M. Diaz-Meco, J. Moscat, and J. L. Virelizier. 1993. Phosphatidylcholine hydrolysis activates NF-κB and increases human immunodeficiency virus replication in human monocytes and T lymphocytes. J. Virol. 67:6546-6604.
26. Tschaikowsky, K. 1994. Protein kinase C inhibitors suppress LPS-induced TNF production in alveolar macrophages and in whole blood: the role of encapsulation into liposomes. Biochim. Biophys. Acta 1222:113-121.
27. Nishimura, H., and I. A. Simpson. 1994. Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and CLUT4 glucose transporters in rat adipose cells. Biochem. J. 302:271-277.
28. Weinstein, S. L., C. H. June, and A. L. DeFranco. 1993. Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14. J. Immunol. 151:3829-3838.
29. Weinstein, S. L., J. S. Sanghera, K. Lemke, A. L. DeFranco, and S. L. Pelech. 1992. Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J. Biol. Chem. 267:14955-14962.
30. Han, J., J. Lee, P. S. Tobias, and R. J. Ulevitch. 1993. Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. J. Biol. Chem. 268:25009-25014.
31. Baeuerle, P. A., and D. Baltimore. 1996. NF-κB: ten years later. Cell 87:13-20.
32. Machleidt, T., B. Kramer, D. Adam, B. Neumann, S. Schutze, K. Wiegmann, and M. Kronke. 1996. Function of the p55 tumor necrosis factor receptor "death domain" mediated by phosphatidylcholine-specific phospholipase C. J. Exp. Med. 184:725-733.
33. Joseph, C. K., H. Byun, R. Bittman, and R. N. Kolesnick. 1993. Substrate recognition by ceramide-activated protein kinase: evidence that kinase activity is proline-directed. J. Biol. Chem. 268:20002-20006.
34. Hannun, Y. A. 1996. Functions of ceramide in coordinating cellular responses to stress. Science 274:1855-1859.