Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses

European Journal of Pharmacology

Volumn 586, Issue 1-3, 2008, Pages 306-312

  Tsuchida, Hiroshi ^a   Takahashi, Sakiko ^a   Nosaka, Emi ^a   Mukaiyama, Osamu ^a   Yamashita, Makoto ^a   Morimoto, Kiyoshi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Capsaicin; Cough; CS 003; Neurokinin; Tachykinin; Triple neurokinin receptor antagonist

Indexed keywords

1 [2 [(3,4 DICHLOROPHENYL) 4 (3,4,5 TRIMETHOXYBENZOYL)MORPHOLIN 2 YL]ETHYL]SPIRO[BENZO[C]THIOPHENE 1 (3H) 4' PIPERIDINE]OXIDE; CAPSAICIN; CITRIC ACID; CS 003; INOSITOL PHOSPHATE; N BENZYL N2 [4 HYDROXY 1 [(1 METHYL 1H INDOL 3 YL)CARBONYL]PROLYL] N METHYL 3 (2 NAPHTHYL)ALANINAMIDE; NEUROKININ; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ 3 RECEPTOR; NEUROKININ 3 RECEPTOR ANTAGONIST; NEUROKININ A; NEUROKININ B; SAREDUTANT; SB 223956; SUBSTANCE P; TACHYKININ RECEPTOR; TACHYKININ RECEPTOR ANTAGONIST;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRONCHOSPASM; COUGHING; DRUG EFFICACY; GUINEA PIG; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; TRACHEAL VASCULAR HYPERPERMEABILITY; VASCULAR DISEASE;

ANIMALS; BRONCHI; CAPILLARY PERMEABILITY; CAPSAICIN; CERCOPITHECUS AETHIOPS; CITRIC ACID; COS CELLS; COUGH; CYCLIC S-OXIDES; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HUMANS; INDOLES; INOSITOL PHOSPHATES; MALE; MOLECULAR SEQUENCE DATA; MORPHOLINES; NEUROKININ A; NEUROKININ B; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; RECEPTORS, NEUROKININ-3; SUBSTANCE P; TRACHEA;

EID: 43549094665     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.02.056     Document Type: Article

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