Physical and functional interactions between STAT5 and Runx transcription factors

Journal of Biochemistry

Volumn 143, Issue 5, 2008, Pages 695-709

  Ogawa, Shinya ^a   Satake, Masanobu ^b   Ikuta, Koichi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Interleukin 7; Runx; Signal transduction; STAT5; Transcription factor

Indexed keywords

DNA; PROTEIN SH2; STAT5 PROTEIN; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR RUNX3;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DNA BINDING; IMMUNOPRECIPITATION; NONHUMAN; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ANIMALS; CELL LINE; CHO CELLS; CORE BINDING FACTOR ALPHA SUBUNITS; CRICETINAE; CRICETULUS; HUMANS; PROTEIN INTERACTION DOMAINS AND MOTIFS; STAT5 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC;

EID: 43449139993     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvn022     Document Type: Article

References (41)

1. Rekhtman, N., Radparvar, F., Evans, T., and Skoultchi, A.I. (1999) Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev. 13, 1398-1411
2. Zhang, P., Behre, G., Pan, J., Iwama, A., Wara-Aswapati, N., Radomska, H.S., Auron, P.E., Tenen, D.G., and Sun, Z. (1999) Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc. Natl. Acad. Sci. USA 96, 8705-8710
3. Nerlov, C., Querfurth, E., Kulessa, H., and Graf, T. (2000) GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription. Blood 95, 2543-2551
4. Caldenhoven, E., Liden, J., Wissink, S., Van de Stolpe, A., Raaijmakers, J., Koenderman, L., Okret, S., Gustafsson, J.A., and Van der Saag, P.T. (1995) Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids. Mol. Endocrinol. 9, 401-412
5. Scheinman, R.I., Gualberto, A., Jewell, C.M., Cidlowski, J.A., and Baldwin, A.S. Jr. (1995) Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol. Cell. Biol. 15, 943-953
6. De Bosscher, K., Vanden Berghe, W., and Haegeman, G. (2006) Cross-talk between nuclear receptors and nuclear factor κB. Oncogene 25, 6868-6886
7. Leonard, W.J. and O'Shea, J.J. (1998) Jaks and STATs: biological implications. Annu. Rev. Immunol. 16, 293-322
8. Yao, Z., Cui, Y., Watford, W.T., Bream, J.H., Yamaoka, K., Hissong, B.D., Li, D., Durum, S.K., Jiang, Q., Bhandoola, A., Hennighausen, L., and O'Shea, J.J. (2006) Stat5a/b are essential for normal lymphoid development and differentiation. Proc. Natl. Acad. Sci. USA 103, 1000-1005
9. Ye, S.K., Agata, Y., Lee, H.C., Kurooka, H., Kitamura, T., Shimizu, A., Honjo, T., and Ikuta, K. (2001) The IL-7 receptor controls the accessibility of the TCRγ locus by Stat5 and histone acetylation. Immunity 15, 813-823
10. Xu, R., Spencer, V.A., and Bissell, M.J. (2007) Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors. J. Biol. Chem. 282, 14992-14999
11. Stocklin, E., Wissler, M., Gouilleux, F., and Groner, B. (1996) Functional interactions between Stat5 and the glucocorticoid receptor. Nature 383, 726-728
12. Cella, N., Groner, B., and Hynes, N.E. (1998) Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells. Mol. Cell. Biol. 18, 1783-1792
13. Magne, S., Caron, S., Charon, M., Rouyez, M.C., and Dusanter-Fourt, I. (2003) STAT5 and Oct-1 form a stable complex that modulates cyclin D1 expression. Mol. Cell. Biol. 23, 8934-8945
14. Ito, Y. (2004) Oncogenic potential of the RUNX gene family: 'overview'. Oncogene 23, 4198-4208
15. Okuda, T., van Deursen, J., Hiebert, S.W., Grosveld, G., and Downing, J.R. (1996) AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84, 321-330
16. Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R.T., Gao, Y.H., Inada, M., Sato, M., Okamoto, R., Kitamura, Y., Yoshiki, S., and Kishimoto, T. (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755-764
17. Taniuchi, I., Osato, M., Egawa, T., Sunshine, M.J., Bae, S.C., Komori, T., Ito, Y., and Littman, D.R. (2002) Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Cell 111, 621-633
18. Woolf, E., Xiao, C., Fainaru, O., Lotem, J., Rosen, D., Negreanu, V., Bernstein, Y., Goldenberg, D., Brenner, O., Berke, G., Levanon, D., and Groner, Y. (2003) Runx3 and Runx1 are required for CD8T cell development during thymopoiesis. Proc. Natl. Acad. Sci. USA 100, 7731-7736
19. Sato, T., Ohno, S., Hayashi, T., Sato, C., Kohu, K., Satake, M., and Habu, S. (2005) Dual functions of Runx proteins for reactivating CD8 and silencing CD4at the commitment process into CD8 thymocytes. Immunity 22, 317-328
20. Meyers, S., Downing, J.R., and Hiebert, S.W. (1993) Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions. Mol. Cell. Biol. 13, 6336-6345
21. Wang, S., Wang, Q., Crute, B.E., Melnikova, I.N., Keller, S.R., and Speck, N.A. (1993) Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol. Cell. Biol. 13, 3324-3339
22. Ogawa, E., Inuzuka, M., Maruyama, M., Satake, M., Naito-Fujimoto, M., Ito, Y., and Shigesada, K. (1993) Molecular cloning and characterization of PEBP2β, the heterodimeric partner of a novel Drosophila runt-related DNA binding protein PEBP2α. Virology 194, 314-331
23. Kitabayashi, I., Yokoyama, A., Shimizu, K., and Ohki, M. (1998) Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation. EMBO J. 17, 2994-3004
24. Lutterbach, B., Westendorf, J.J., Linggi, B., Isaac, S., Seto, E., and Hiebert, S.W. (2000) A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia. J. Biol. Chem. 275, 651-656
25. Kim, S., Koga, T., Isobe, M., Kern, B.E., Yokochi, T., Chin, Y.E., Karsenty, G., Taniguchi, T., and Takayanagi, H. (2003) Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. Genes Dev. 17, 1979-1991
26. Ziros, P.G., Georgakopoulos, T., Habeos, I., Basdra, E.K., and Papavassiliou, A.G. (2004) Growth hormone attenuates the transcriptional activity of Runx2 by facilitating its physical association with Stat3β. J. Bone Miner. Res. 19, 1892-1904
27. Morita, S., Kojima, T., and Kitamura, T. (2000) Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther. 7, 1063-1066
28. Carleton, M., Ruetsch, N.R., Berger, M.A., Rhodes, M., Kaptik, S., and Wiest, D.L. (1999) Signals transduced by CD3e, but not by surface pre-TCR complexes, are able to induce maturation of an early thymic lymphoma in vitro. J. Immunol. 163, 2576-2585
29. Karasuyama, H., Rolink, A., and Melchers, F. (1988) Recombinant interleukin 2 or 5, but not 3 or 4, induces maturation of resting mouse B lymphocytes and propagates proliferation of activated B cell blasts. J. Exp. Med. 167, 1377-1390
30. Onishi, M., Nosaka, T., Misawa, K., Mui, A.L., Gorman, D., McMahon, M., Miyajima, A., and Kitamura, T. (1998) Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol. Cell. Biol. 18, 3871-3879
31. Kitamura, T., Koshino, Y., Shibata, F., Oki, T., Nakajima, H., Nosaka, T., and Kumagai, H. (2003) Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics. Exp. Hematol. 31, 1007-1014
32. Hayashi, K., Abe, N., Watanabe, T., Obinata, M., Ito, M., Sato, T., Habu, S., and Satake, M. (2001) Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage. J. Immunol. 167, 4957-4965
33. Mili, S., Shu, H.J., Zhao, Y., and Pinol-Roma, S. (2001) Distinct RNP complexes of shuttling hnRNP proteins with pre-mRNA and mRNA: candidate intermediates in formation and export of mRNA. Mol. Cell. Biol. 21, 7307-7319
34. Masui, N., Tani-ichi, S., Maki, K., and Ikuta, K. (2007) Transcriptional activation of mouse TCR Jγ4 germline promoter by STAT5. Mol. Immunol. 45, 849-855
35. Tanaka, T., Tanaka, K., Ogawa, S., Kurokawa, M., Mitani, K., Nishida, J., Shibata, Y., Yazaki, Y., and Hirai, H. (1995) An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms. EMBO J. 14, 341-350
36. Lu, J., Maruyama, M., Satake, M., Bae, S.C., Ogawa, E., Kagoshima, H., Shigesada, K., and Ito, Y. (1995) Subcellular localization of the a and b subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF. Mol. Cell. Biol. 15, 1651-1661
37. Toda, T., Wada, H., Ogawa, S., Tani-ichi, S., and Ikuta, K. (2008) An efficient reporter assay for Stat5-dependent promoters. Anal. Biochem. 372, 250-252
38. Kanno, T., Kanno, Y., Chen, L.F., Ogawa, E., Kim, W.Y., and Ito, Y. (1998) Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor a subunit revealed in the presence of the b subunit. Mol. Cell. Biol. 18, 2444-2454
39. Matsumoto, A., Masuhara, M., Mitsui, K., Yokouchi, M., Ohtsubo, M., Misawa, H., Miyajima, A., and Yoshimura, A. (1997) CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood 89, 3148-3154
40. Wyszomierski, S.L., Yeh, J., and Rosen, J.M. (1999) Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation. Mol. Endocrinol. 13, 330-343
41. Trigueros, C., Hozumi, K., Silva-Santos, B., Bruno, L., Hayday, A.C., Owen, M.J., and Pennington, D.J. (2003) Pre-TCR signaling regulates IL-7 receptor α expression promoting thymocyte survival at the transition from the double-negative to double-positive stage. Eur. J. Immunol. 33, 1968-1977