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Volumn 19, Issue 11, 2004, Pages 1892-1904

Growth hormone attenuates the transcriptional activity of Runx2 by facilitating its physical association with Stat3β

Author keywords

Growth hormone; Osteoblast; Protein protein interaction; Runx2 Cbfa1; Stat3

Indexed keywords

GROWTH HORMONE; MITOGEN ACTIVATED PROTEIN KINASE; PLEIOTROPHIN; STAT 3 BETA PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; GLUTATHIONE TRANSFERASE; LUCIFERASE; MILK PROTEIN; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; STAT5 PROTEIN; TRANSACTIVATOR PROTEIN; TUMOR PROTEIN; TYROSINE;

EID: 16244393552     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.040701     Document Type: Article
Times cited : (41)

References (67)
  • 3
    • 0034657348 scopus 로고    scopus 로고
    • The role of STAT proteins in growth hormone signalling
    • Herrington J, Smit LS, Schwartz J, Carter-Su C 2000 The role of STAT proteins in growth hormone signalling. Oncogene 19:2585-2597.
    • (2000) Oncogene , vol.19 , pp. 2585-2597
    • Herrington, J.1    Smit, L.S.2    Schwartz, J.3    Carter-Su, C.4
  • 6
    • 0035958030 scopus 로고    scopus 로고
    • Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells
    • Lai CF, Chaudhary L, Fausto A, Halstead LR, Ory DS, Avioli LV, Cheng SL 2001 Erk is essential for growth, differentiation, integrin expression, and cell function in human osteoblastic cells. J Biol Chem 276:14443-14450.
    • (2001) J Biol Chem , vol.276 , pp. 14443-14450
    • Lai, C.F.1    Chaudhary, L.2    Fausto, A.3    Halstead, L.R.4    Ory, D.S.5    Avioli, L.V.6    Cheng, S.L.7
  • 7
    • 0035877823 scopus 로고    scopus 로고
    • Sustained activation of the extracellular signal-regulated kinase pathway is required for extracellular calcium stimulation of human osteoblast proliferation
    • Huang Z, Cheng SL, Slatopolsky E 2001 Sustained activation of the extracellular signal-regulated kinase pathway is required for extracellular calcium stimulation of human osteoblast proliferation. J Biol Chem 276:21351-21358.
    • (2001) J Biol Chem , vol.276 , pp. 21351-21358
    • Huang, Z.1    Cheng, S.L.2    Slatopolsky, E.3
  • 9
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B 2002 The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108:17-29.
    • (2002) Cell , vol.108 , pp. 17-29
    • Nakashima, K.1    Zhou, X.2    Kunkel, G.3    Zhang, Z.4    Deng, J.M.5    Behringer, R.R.6    De Crombrugghe, B.7
  • 10
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G 1997 Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell 89:747-754.
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 12
    • 0242655673 scopus 로고    scopus 로고
    • Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation
    • Jimenez MJ, Balbin M, Lopez JM, Alvarez J, Komori T, Lopez-Otin C 1999 Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol Cell Biol 19:4431-4442.
    • (1999) Mol Cell Biol , vol.19 , pp. 4431-4442
    • Jimenez, M.J.1    Balbin, M.2    Lopez, J.M.3    Alvarez, J.4    Komori, T.5    Lopez-Otin, C.6
  • 14
    • 0035341209 scopus 로고    scopus 로고
    • TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
    • Alliston T, Choy L, Ducy P, Karsenty G, Derynck R 2001 TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J 9:2254-2272.
    • (2001) EMBO J , vol.9 , pp. 2254-2272
    • Alliston, T.1    Choy, L.2    Ducy, P.3    Karsenty, G.4    Derynck, R.5
  • 15
    • 0037441529 scopus 로고    scopus 로고
    • Regulation of the osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways
    • Franceschi RT, Xiao G 2003 Regulation of the osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways. J Cell Biochem 88:446-454.
    • (2003) J Cell Biochem , vol.88 , pp. 446-454
    • Franceschi, R.T.1    Xiao, G.2
  • 17
    • 0037016730 scopus 로고    scopus 로고
    • Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation
    • Alonzo R, Selvamurugan N, Karsenty G, Partridge NC 2002 Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation. J Biol Chem 277:816-822.
    • (2002) J Biol Chem , vol.277 , pp. 816-822
    • Alonzo, R.1    Selvamurugan, N.2    Karsenty, G.3    Partridge, N.C.4
  • 18
    • 0028791174 scopus 로고
    • Expression of functional growth hormone receptors in cultured human osteoblast-like cells
    • Nilsson A, Swolin D, Enerback S, Ohlsson C 1995 Expression of functional growth hormone receptors in cultured human osteoblast-like cells. J Clin Endocrinol Metab 80:3483-3488.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3483-3488
    • Nilsson, A.1    Swolin, D.2    Enerback, S.3    Ohlsson, C.4
  • 19
    • 0033783160 scopus 로고    scopus 로고
    • Growth hormone-regulated intracellular signaling in UMR 106 osteosarcoma cells
    • Morales O, Lindgren U, Haldosen LA 2000 Growth hormone-regulated intracellular signaling in UMR 106 osteosarcoma cells. J Bone Miner Res 15:2284-2290.
    • (2000) J Bone Miner Res , vol.15 , pp. 2284-2290
    • Morales, O.1    Lindgren, U.2    Haldosen, L.A.3
  • 22
    • 0030455820 scopus 로고    scopus 로고
    • Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
    • James P, Halladay J, Craig EA 1996 Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144:425-436.
    • (1996) Genetics , vol.144 , pp. 425-436
    • James, P.1    Halladay, J.2    Craig, E.A.3
  • 23
    • 0034820060 scopus 로고    scopus 로고
    • Functional analysis of the Saccharomyces cerevisiae YFR021w/YGR223c/ YPL100w ORF family suggests relations to mitochondrial/peroxisomal functions and amino acid signalling pathways
    • Georgakopoulos T, Koutroubas G, Vakonakis I, Tzermia M, Prokova V, Voutsina A, Alexandraki D 2001 Functional analysis of the Saccharomyces cerevisiae YFR021w/YGR223c/YPL100w ORF family suggests relations to mitochondrial/peroxisomal functions and amino acid signalling pathways. Yeast 18:1155-1171.
    • (2001) Yeast , vol.18 , pp. 1155-1171
    • Georgakopoulos, T.1    Koutroubas, G.2    Vakonakis, I.3    Tzermia, M.4    Prokova, V.5    Voutsina, A.6    Alexandraki, D.7
  • 25
    • 0026501752 scopus 로고
    • A rapid method for localized mutagenesis of yeast genes
    • Muhlrad D, Hunter R, Parker R 1992 A rapid method for localized mutagenesis of yeast genes. Yeast 8:79-82.
    • (1992) Yeast , vol.8 , pp. 79-82
    • Muhlrad, D.1    Hunter, R.2    Parker, R.3
  • 26
    • 0028927556 scopus 로고
    • Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene
    • Ducy P, Karsenty G 1995 Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol Cell Biol 15:1858-1869.
    • (1995) Mol Cell Biol , vol.15 , pp. 1858-1869
    • Ducy, P.1    Karsenty, G.2
  • 27
    • 0025639009 scopus 로고
    • The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter
    • Wagner BJ, Hayes TE, Hoban CJ, Cochran BH 1990 The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter. EMBO J 9:4477-4484.
    • (1990) EMBO J , vol.9 , pp. 4477-4484
    • Wagner, B.J.1    Hayes, T.E.2    Hoban, C.J.3    Cochran, B.H.4
  • 28
    • 0028217452 scopus 로고
    • Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
    • Wakao H, Gouilleux F, Groner B 1994 Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J 13:2182-2191.
    • (1994) EMBO J , vol.13 , pp. 2182-2191
    • Wakao, H.1    Gouilleux, F.2    Groner, B.3
  • 29
    • 0033532158 scopus 로고    scopus 로고
    • Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo
    • Devine JH, Eubank DW, Clouthier DE, Tontonoz P, Spiegelman BM, Hammer RE, Beale EG 1999 Adipose expression of the phosphoenolpyruvate carboxykinase promoter requires peroxisome proliferator-activated receptor gamma and 9-cis-retinoic acid receptor binding to an adipocyte-specific enhancer in vivo. J Biol Chem 274:13604-13612.
    • (1999) J Biol Chem , vol.274 , pp. 13604-13612
    • Devine, J.H.1    Eubank, D.W.2    Clouthier, D.E.3    Tontonoz, P.4    Spiegelman, B.M.5    Hammer, R.E.6    Beale, E.G.7
  • 30
    • 0024494581 scopus 로고
    • Cellular mechanisms in the processing of growth hormone and its receptor
    • Roupas P, Herington AC 1989 Cellular mechanisms in the processing of growth hormone and its receptor. Mol Cell Endocrinol 61:1-12.
    • (1989) Mol Cell Endocrinol , vol.61 , pp. 1-12
    • Roupas, P.1    Herington, A.C.2
  • 31
    • 0035816531 scopus 로고    scopus 로고
    • Growth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysis
    • Zhang Y, Guan R, Jiang J, Kopchick JJ, Black RA, Baumann G, Frank SJ 2001 Growth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysis. J Biol Chem 276:24565-24573.
    • (2001) J Biol Chem , vol.276 , pp. 24565-24573
    • Zhang, Y.1    Guan, R.2    Jiang, J.3    Kopchick, J.J.4    Black, R.A.5    Baumann, G.6    Frank, S.J.7
  • 32
    • 33644986723 scopus 로고    scopus 로고
    • AP kinase signaling cascades and gene expression in osteoblasts
    • Hipskind RA, Bilbe GM 1998 AP kinase signaling cascades and gene expression in osteoblasts. Front Biosci 3:DS04-D816.
    • (1998) Front Biosci , vol.3
    • Hipskind, R.A.1    Bilbe, G.M.2
  • 33
    • 0034708172 scopus 로고    scopus 로고
    • Involvement of ERK in BMP-2 induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1/2
    • Lou J, Tu Y, Li S, Manske PR 2000 Involvement of ERK in BMP-2 induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1/2. Biochem Biophys Res Commun 268:757-762.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 757-762
    • Lou, J.1    Tu, Y.2    Li, S.3    Manske, P.R.4
  • 34
    • 0026361399 scopus 로고
    • Effects of recombinant human insulin-like growth factor I and II (IGF-I/-II) and growth hormone (GH) on the growth of normal adult human osteoblast-like cells and human osteogenic sarcoma cells
    • Scheven BA, Hamilton NJ, Fakkeldij TM, Duursma SA 1991 Effects of recombinant human insulin-like growth factor I and II (IGF-I/-II) and growth hormone (GH) on the growth of normal adult human osteoblast-like cells and human osteogenic sarcoma cells. Growth Regul 1:160-167.
    • (1991) Growth Regul , vol.1 , pp. 160-167
    • Scheven, B.A.1    Hamilton, N.J.2    Fakkeldij, T.M.3    Duursma, S.A.4
  • 35
    • 0027429428 scopus 로고
    • In vitro effects of growth hormone and other hormones on chondrocytes and osteoblast-like cells
    • Saggese G, Federico G, Cinquanta L 1993 In vitro effects of growth hormone and other hormones on chondrocytes and osteoblast-like cells. Acta Paediatr Suppl 82(Suppl 391):54-59.
    • (1993) Acta Paediatr Suppl , vol.82 , Issue.391 SUPPL. , pp. 54-59
    • Saggese, G.1    Federico, G.2    Cinquanta, L.3
  • 36
    • 0345425804 scopus 로고    scopus 로고
    • Growth hormone stimulates tyrosine phosphorylation of focal adhesion kinase (p125(FAK)) and actin stress fiber formation in human osteoblast-like cells, Saos2
    • Takahashi MO, Takahashi Y, Iida K, Okimura Y, Kaji H, Abe H, Chihara K 1999 Growth hormone stimulates tyrosine phosphorylation of focal adhesion kinase (p125(FAK)) and actin stress fiber formation in human osteoblast-like cells, Saos2. Biochem Biophys Res Commun 263:100-106.
    • (1999) Biochem Biophys Res Commun , vol.263 , pp. 100-106
    • Takahashi, M.O.1    Takahashi, Y.2    Iida, K.3    Okimura, Y.4    Kaji, H.5    Abe, H.6    Chihara, K.7
  • 41
    • 0028889335 scopus 로고
    • STAT3 and STAT5B are targets of two different signal pathways activated by hematopoietin receptors and control transcription via separate cytokine response elements
    • Lai CF, Ripperger J, Morella KK, Wang Y, Gearing DP, Horseman ND, Campos SP, Fey GH, Baumann H 1995 STAT3 and STAT5B are targets of two different signal pathways activated by hematopoietin receptors and control transcription via separate cytokine response elements. J Biol Chem 270:23254-23257.
    • (1995) J Biol Chem , vol.270 , pp. 23254-23257
    • Lai, C.F.1    Ripperger, J.2    Morella, K.K.3    Wang, Y.4    Gearing, D.P.5    Horseman, N.D.6    Campos, S.P.7    Fey, G.H.8    Baumann, H.9
  • 43
    • 0029075875 scopus 로고
    • Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3
    • Schaefer TS, Sanders LK, Nathans D 1995 Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3. Proc Natl Acad Sci USA 92:9097-9101.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9097-9101
    • Schaefer, T.S.1    Sanders, L.K.2    Nathans, D.3
  • 45
    • 0037144079 scopus 로고    scopus 로고
    • 1α,25-dihydroxyvitamin D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus kinase (JAK2)/signal transducers and activators of transcription (STAT5) system in osteoblast-like cells
    • Morales O, Faulds MH, Lindgren UJ, Haldosen LA 2002 1α,25- dihydroxyvitamin D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus kinase (JAK2)/signal transducers and activators of transcription (STAT5) system in osteoblast-like cells. J Biol Chem 277:34879-34884.
    • (2002) J Biol Chem , vol.277 , pp. 34879-34884
    • Morales, O.1    Faulds, M.H.2    Lindgren, U.J.3    Haldosen, L.A.4
  • 46
    • 0026770566 scopus 로고
    • Growth hormone activates mitogen-activated protein kinase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes
    • Anderson N 1992 Growth hormone activates mitogen-activated protein kinase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes. Biochem J 284:649-652.
    • (1992) Biochem J , vol.284 , pp. 649-652
    • Anderson, N.1
  • 47
    • 0026700256 scopus 로고
    • Stimulation by growth hormone of MAP kinase activity in 3T3-F442A fibroblasts
    • Campbell G, Pang L, Miyasaka T, Saltiel A, Carter-Su C 1992 Stimulation by growth hormone of MAP kinase activity in 3T3-F442A fibroblasts. J Biol Chem 267:6074-6080.
    • (1992) J Biol Chem , vol.267 , pp. 6074-6080
    • Campbell, G.1    Pang, L.2    Miyasaka, T.3    Saltiel, A.4    Carter-Su, C.5
  • 48
    • 0031764773 scopus 로고    scopus 로고
    • Growth hormone stimulation of the mitogen-activated protein kinase pathway is cell type specific
    • Love DW, Whatmore AJ, Clayton PE, Silva CM 1998 Growth hormone stimulation of the mitogen-activated protein kinase pathway is cell type specific. Endocrinology 139:1965-1971.
    • (1998) Endocrinology , vol.139 , pp. 1965-1971
    • Love, D.W.1    Whatmore, A.J.2    Clayton, P.E.3    Silva, C.M.4
  • 49
    • 0038819062 scopus 로고    scopus 로고
    • Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids
    • Kousteni S, Han L, Chen JR, Almeida M, Plotkin LI, Bellido T, Manolagas SC 2003 Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest 111:1651-1664.
    • (2003) J Clin Invest , vol.111 , pp. 1651-1664
    • Kousteni, S.1    Han, L.2    Chen, J.R.3    Almeida, M.4    Plotkin, L.I.5    Bellido, T.6    Manolagas, S.C.7
  • 50
    • 0036133374 scopus 로고    scopus 로고
    • Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells
    • Xiao G, Gopalakrishnan R, Jiang D, Reith E, Benson MD, Franceschi RT 2002 Bone morphogenetic proteins, extracellular matrix, and mitogen-activated protein kinase signaling pathways are required for osteoblast-specific gene expression and differentiation in MC3T3-E1 cells. J Bone Miner Res 17:101-110.
    • (2002) J Bone Miner Res , vol.17 , pp. 101-110
    • Xiao, G.1    Gopalakrishnan, R.2    Jiang, D.3    Reith, E.4    Benson, M.D.5    Franceschi, R.T.6
  • 51
    • 0034773199 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinases and calcium channels are involved in the proliferative effect of bisphosphonates on osteoblastic cells in vitro
    • Mathov I, Plotkin LI, Sgarlata CL, Leoni J, Bellido T 2001 Extracellular signal-regulated kinases and calcium channels are involved in the proliferative effect of bisphosphonates on osteoblastic cells in vitro. J Bone Miner Res 16:2050-2056.
    • (2001) J Bone Miner Res , vol.16 , pp. 2050-2056
    • Mathov, I.1    Plotkin, L.I.2    Sgarlata, C.L.3    Leoni, J.4    Bellido, T.5
  • 52
    • 0037184027 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2
    • Xiao G, Jiang D, Gopalakrishnan R, Franceschi RT 2002 Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem 277:36181-36187.
    • (2002) J Biol Chem , vol.277 , pp. 36181-36187
    • Xiao, G.1    Jiang, D.2    Gopalakrishnan, R.3    Franceschi, R.T.4
  • 53
    • 0037192760 scopus 로고    scopus 로고
    • Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors
    • Wang FS, Wang CJ, Sheen-Chen SM, Kuo YR, Chen RF, Yang KD 2002 Superoxide mediates shock wave induction of ERK-dependent osteogenic transcription factor (CBFA1) and mesenchymal cell differentiation toward osteoprogenitors. J Biol Chem 277:10931-10937.
    • (2002) J Biol Chem , vol.277 , pp. 10931-10937
    • Wang, F.S.1    Wang, C.J.2    Sheen-Chen, S.M.3    Kuo, Y.R.4    Chen, R.F.5    Yang, K.D.6
  • 55
    • 0036333736 scopus 로고    scopus 로고
    • High bone resorption in adult aging transgenic mice overexpressing Cbfa1/Runx2 in cells of the osteoblastic lineage
    • Geoffroy V, Kneissel M, Fournier B, Boyde A, Matthias P 2002 High bone resorption in adult aging transgenic mice overexpressing Cbfa1/Runx2 in cells of the osteoblastic lineage. Mol Cell Biol 22:6222-6233.
    • (2002) Mol Cell Biol , vol.22 , pp. 6222-6233
    • Geoffroy, V.1    Kneissel, M.2    Fournier, B.3    Boyde, A.4    Matthias, P.5
  • 56
    • 0034055896 scopus 로고    scopus 로고
    • GH and bone - Experimental and clinical studies
    • Ohlsson C, Bengtsson BA, Johannsson G 2000 GH and bone - experimental and clinical studies. Endocr J 47(Suppl):S9-S16.
    • (2000) Endocr J , vol.47 , Issue.SUPPL.
    • Ohlsson, C.1    Bengtsson, B.A.2    Johannsson, G.3
  • 57
    • 0141448883 scopus 로고    scopus 로고
    • Growth hormone regulates osteogenic marker mRNA expression in human periodontal fibroblasts and alveolar bone-derived cells
    • Haase HR, Ivanovski S, Waters MJ, Bartold PM 2003 Growth hormone regulates osteogenic marker mRNA expression in human periodontal fibroblasts and alveolar bone-derived cells. J Periodontal Res 38:366-374.
    • (2003) J Periodontal Res , vol.38 , pp. 366-374
    • Haase, H.R.1    Ivanovski, S.2    Waters, M.J.3    Bartold, P.M.4
  • 61
    • 0034789271 scopus 로고    scopus 로고
    • A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene
    • Zaidi SK, Javed A, Choi JY, van Wijnen AJ, Stein JL, Lian JB, Stein GS 2001 A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene. J Cell Sci 114:3093-3102.
    • (2001) J Cell Sci , vol.114 , pp. 3093-3102
    • Zaidi, S.K.1    Javed, A.2    Choi, J.Y.3    Van Wijnen, A.J.4    Stein, J.L.5    Lian, J.B.6    Stein, G.S.7


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