Influence of ABCB1 gene polymorphisms and P-glycoprotein activity on cyclosporine pharmacokinetics in peripheral blood mononuclear cells in healthy volunteers

Drug Metabolism Letters

Volumn 2, Issue 2, 2008, Pages 76-82

  Ansermot, Nicolas ^a   Rebsamen, Michela ^a   Chabert, Jocelyne ^a   Fathi, Marc ^a   Gex Fabry, Marianne ^a   Daali, Youssef ^a   Besson, Marie ^a   Rossier, Michel ^a   Rudaz, Serge ^b   Hochstrasser, Denis ^a,b   Dayer, Pierre ^a   Desmeules, Jules ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

ABCB1; Cyclosporine; P glycoprotein; PBMCs; Pharmacogenetics; Pharmacokinetics; TDM

Indexed keywords

ADENINE; CD4 ANTIGEN; CD8 ANTIGEN; CYCLOSPORIN A; CYTOSINE; GENOMIC DNA; GLYCOPROTEIN P; GUANINE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; TYROSINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA EXTRACTION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; GENE ACTIVITY; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE DRUG DOSE; SINGLE NUCLEOTIDE POLYMORPHISM; TIME TO MAXIMUM PLASMA CONCENTRATION; VOLUNTEER;

ADMINISTRATION, ORAL; ADULT; AREA UNDER CURVE; CALCINEURIN; CYCLOSPORINE; HALF-LIFE; HAPLOTYPES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LEUKOCYTES, MONONUCLEAR; MALE; P-GLYCOPROTEIN; POLYMORPHISM, SINGLE NUCLEOTIDE; TISSUE DISTRIBUTION;

EID: 43449113913     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231208784040951     Document Type: Article

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