Enhancing the effect of secreted cyclophilin B on immunosuppressive activity of cyclosporine

Transplantation

Volumn 65, Issue 8, 1998, Pages 1076-1084

  Denys, Agnès ^a   Allain, Fabrice ^a   Masy, Eric ^b,c   Dessaint, Jean Paul ^b   Spik, Geneviève ^a  

^a UNIV LILLE   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c CENTRE HOSPITALIER DE VALENCIENNES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN B; CYCLOSPORIN A;

ARTICLE; DOSE RESPONSE; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SENSITIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN SECRETION; T LYMPHOCYTE ACTIVATION; TARGET CELL;

ADULT; AMINO ACID ISOMERASES; BLOTTING, WESTERN; CARRIER PROTEINS; CYCLOPHILINS; CYCLOSPORINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTES; FEMALE; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; KINETICS; MALE; MIDDLE AGED; PEPTIDYLPROLYL ISOMERASE; REFERENCE VALUES;

EID: 0032571873     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199804270-00012     Document Type: Article

References (33)

1. Borel JF, Feurer C, Gubler HU, Stähelin H. Biological effects of cyclosporin A: a new antilymphocytic agent. Agents Actions 1974; 6: 468.
2. Borel JF. Pharmacology of cyclosporin (Sandimmune). Pharmacol Rev 1989; 42: 260.
3. Schreiber SL. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 1991; 251: 283.
4. Handschumacher RE, Harding MW, Rice J, Drugge RJ, Speicher DW. Cyclophilin: a specific cytosolic binding protein for cyclosporin A. Science 1984; 226: 544.
5. Haendler B, Hofer-Warbinek R, Hofer E. Complementary DNA for human T-cell cyclophilin. EMBO J 1987; 6: 947.
6. Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991; 66: 807.
7. Jain J, McCaffrey PG, Miner Z, et al. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 1993; 365: 352.
8. Liu J, Albers MW, Wandless TJ, et al. Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phophatase activity. Biochemistry 1992; 31: 3896.
9. Fruman DA, Klee CB, Bierer BE, Burakoff SJ. Calcineurin phosphatase activity in T-lymphocytes is inhibited by FK506 and cyclosporin A. Proc Natl Acad Sci USA 1992; 89: 3686.
10. Galat A, Metcalfe SM. Peptidylproline cis/trans isomerases. Prog Biophys Mol Biol 1995; 63: 67.
11. Kay JE. Structure-function relationships in the FK506-binding protein (FKBP) family of peptidylprolyl cis-trans isomerases. Biochem J 1996; 314: 361.
12. Harding MW, Handschumacher RE, Speicher DW. Isolation and aminoacid sequence of cyclophilin. J Biol Chem 1986; 261: 8547.
13. Hasel KW, Glass JR, Godbout M, Sutcliffe JG. An endoplasmic reticulum-specific cyclophilin. Mol Cell Biol 1991; 11: 3483.
14. Arber S, Krause KH, Caroni P. S-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin. J Cell Biol 1992; 116: 113.
15. Spik G, Haendler B, Delmas O, et al. A novel secreted cyclophilin-like protein (SCYLP). J Biol Chem 1991; 266: 10735.
16. Allain F, Boutillon C, Mariller C, Spik G. Selective assay for CyPA and CyPB in human blood using highly specific antipeptides antibodies. J Immunol Methods 1995; 178: 113.
17. Fischer G. Peptidyl-prolyl cis/trans isomerases and their effectors. Angew Chem Int Ed Engl 1994; 33: 1415.
18. Klintmalm G, Säwe J, Ringden O, von Bahr C, Magnusson A. Cyclosporin plasma levels in renal transplant patients: association with renal toxicity and allograft rejection. Transplantation 1985; 39: 132.
19. Sander B, Brigati C, Möller E. Inhibition of in vitro alloreactivity by cyclosporin A: evidence for an interindividual variation in sensitivity. Scand J Immunol 1986; 23: 435.
20. Povlsen JV, Rasmussen A, Madsen M, Lamm LU. Ciclosporininduced immunosuppression in vitro: variation in sensitivity and binding capacity. Scand J Immunol 1990; 32: 45.
21. Masy E, Labalette-Houache M, Dessaint JP. Individual susceptibility to cyclosporine: possible involvement of the CD28/CD80 (B7/BB1) pathway. Transplant Proc 1994; 50: 271.
22. Lindholm A. Factors influencing the pharmacokinetics of cyclosporin in man. Ther Drug Monit 1991; 13: 465.
23. Foxwell BMJ, Hiestand PC, Wenger R, Ryffel B. A comparison of cyclosporin binding by cyclophilin and calmodulin and the identification of a novel 45 kD cyclosporin-binding phosphoprotein in Jurkat cells. Transplantation 1988; 46: 35.
24. Foxwell BMJ, Woerly G, Husi H, et al. Identification of several cyclosporin binding proteins in lymphoid and non-lymphoid cells in vivo. Biochim Biophys Acta 1992; 1138: 115.
25. Allain F, Denys A, Spik G. Characterization of surface binding sites for cyclophilin B on a human tumor T-cell line. J Biol Chem 1994; 269: 16537.
26. Allain F, Denys A, Spik G. Cyclophilin B mediates cyclosporin A incorporation in human blood T-lymphocytes through the specific binding of complexed drug to the cell surface. Biochem J 1996; 317: 565.
27. Denys A, Allain F, Foxwell B, Spik G. Distribution of cyclophilin B binding sites in the subsets of human peripheral blood lymphocytes. Immunology 1997; 91: 609.
28. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose. Proc Natl Acad Sci USA 1979; 76: 4350.
29. Batiuk TD, Pazderka F, Enns J, De Castro L, Halloran PF. Cyclosporine inhibition of leukocyte calcineurin is much less in whole blood than in culture medium. Transplantation 1995; 61: 158.
30. Price ER, Jin M, Lim D, Pati S, Walsh CT, McKeon FD. Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A. Proc Natl Acad Sci USA 1994; 91: 3931.
31. Shirakata Y, Kobayashi M, Ohtsuka K, et al. Inhibitory effect of plasma FKBP12 on immunosuppressive activity of FK506. Transplantation 1995; 60: 1582.
32. Sherry B, Yarlett N, Strupp A, Cerami A. Identification of cyclophilin as a proinflammatory secretory product of lipopolysaccharide-activated macrophages. Proc Natl Acad Sci USA 1992; 89: 3511.
33. Xu Q, Leiva MC, Fischkoff SA, Handschumacher RE, Lyttle CR. Leukocyte chemotactic activity of cyclophilin. J Biol Chem 1992; 267: 11968.