메뉴 건너뛰기




Volumn 18, Issue 4, 2004, Pages 895-913

Antibody therapy for chronic lymphocytic leukemia: A promising new modality

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; CALCIUM CHANNEL; CD20 ANTIGEN; CD52 ANTIGEN; CYCLOPHOSPHAMIDE; FLUDARABINE; RITUXIMAB;

EID: 4344691429     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hoc.2004.04.008     Document Type: Review
Times cited : (13)

References (98)
  • 2
    • 0033572883 scopus 로고    scopus 로고
    • The American College of Surgeons Commission on Cancer and the American Cancer Society. The National Cancer Data Base report on age, gender, treatment, and outcomes of patients with chronic lymphocytic leukemia
    • Diehl L.F., Karnell L.H., Menck H.R. The American College of Surgeons Commission on Cancer and the American Cancer Society. The National Cancer Data Base report on age, gender, treatment, and outcomes of patients with chronic lymphocytic leukemia. Cancer. 86:1999;2684-2692
    • (1999) Cancer , vol.86 , pp. 2684-2692
    • Diehl, L.F.1    Karnell, L.H.2    Menck, H.R.3
  • 3
    • 0029981025 scopus 로고    scopus 로고
    • National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment
    • Cheson B.D., Bennett J.M., Grever M., Kay N., Keating M.J., O'Brien S., et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood. 87:1996;4990-4997
    • (1996) Blood , vol.87 , pp. 4990-4997
    • Cheson, B.D.1    Bennett, J.M.2    Grever, M.3    Kay, N.4    Keating, M.J.5    O'Brien, S.6
  • 4
    • 0034667624 scopus 로고    scopus 로고
    • Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1
    • Burger J.A., Tsukada N., Burger M., Zvaifler N.J., Dell'Aquila M., Kipps T.J. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood. 96:2000;2655-2663
    • (2000) Blood , vol.96 , pp. 2655-2663
    • Burger, J.A.1    Tsukada, N.2    Burger, M.3    Zvaifler, N.J.4    Dell'Aquila, M.5    Kipps, T.J.6
  • 5
    • 0034523170 scopus 로고    scopus 로고
    • Update on the biology of chronic lymphocytic leukemia
    • Bannerji R., Byrd J.C. Update on the biology of chronic lymphocytic leukemia. Curr Opin Oncol. 12:2000;22-29
    • (2000) Curr Opin Oncol , vol.12 , pp. 22-29
    • Bannerji, R.1    Byrd, J.C.2
  • 6
    • 0017751562 scopus 로고
    • A clinical staging system for chronic lymphocytic leukemia: Prognostic significance
    • Binet J.L., Lepoprier M., Dighiero G., Charron D., D'Athis P., Vaugier G., et al. A clinical staging system for chronic lymphocytic leukemia: prognostic significance. Cancer. 40:1977;855-864
    • (1977) Cancer , vol.40 , pp. 855-864
    • Binet, J.L.1    Lepoprier, M.2    Dighiero, G.3    Charron, D.4    D'Athis, P.5    Vaugier, G.6
  • 8
    • 0024319910 scopus 로고
    • Fludarabine: A new agent with major activity against chronic lymphocytic leukemia
    • Keating M.J., Kantarjian H., Talpaz M., Redman J., Koller C., Barlogie B., et al. Fludarabine: a new agent with major activity against chronic lymphocytic leukemia. Blood. 74:1989;19-25
    • (1989) Blood , vol.74 , pp. 19-25
    • Keating, M.J.1    Kantarjian, H.2    Talpaz, M.3    Redman, J.4    Koller, C.5    Barlogie, B.6
  • 10
    • 15844368449 scopus 로고    scopus 로고
    • Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia. The French Cooperative Group on CLL
    • Johnson S., Smith A.G., Loffler H., Osby E., Juliusson G., Emmerich B., et al. Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia. The French Cooperative Group on CLL. Lancet. 347:1996;1432-1438
    • (1996) Lancet , vol.347 , pp. 1432-1438
    • Johnson, S.1    Smith, A.G.2    Loffler, H.3    Osby, E.4    Juliusson, G.5    Emmerich, B.6
  • 11
    • 0035889147 scopus 로고    scopus 로고
    • Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients
    • Leporrier M., Chevret S., Cazin B., Boudjerra N., Feugier P., Desablens B., et al. Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients. Blood. 98:2001;2319-2325
    • (2001) Blood , vol.98 , pp. 2319-2325
    • Leporrier, M.1    Chevret, S.2    Cazin, B.3    Boudjerra, N.4    Feugier, P.5    Desablens, B.6
  • 12
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai K.R., Peterson B.L., Appelbaum F.R., Kolitz J., Elias L., Shepherd L., et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med. 343:2000;1750-1757
    • (2000) N Engl J Med , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3    Kolitz, J.4    Elias, L.5    Shepherd, L.6
  • 13
    • 0027168420 scopus 로고
    • Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes
    • Bubien J.K., Zhou L.J., Bell P.D., Frizzell R.A., Tedder T.F. Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. J Cell Biol. 121:1993;1121-1132
    • (1993) J Cell Biol , vol.121 , pp. 1121-1132
    • Bubien, J.K.1    Zhou, L.J.2    Bell, P.D.3    Frizzell, R.A.4    Tedder, T.F.5
  • 14
    • 0345196590 scopus 로고    scopus 로고
    • CD20 is physically and functionally coupled to MHC class II and CD40 on human B cell lines
    • Leveille C., Al-Daccak R., Mourad W. CD20 is physically and functionally coupled to MHC class II and CD40 on human B cell lines. Eur J Immunol. 29:1999;65-74
    • (1999) Eur J Immunol , vol.29 , pp. 65-74
    • Leveille, C.1    Al-Daccak, R.2    Mourad, W.3
  • 15
    • 79960971501 scopus 로고    scopus 로고
    • High levels of soluble CD20 (sCD20) in patients with non-Hodgkin's lymphoma (NHL): Correlation with clinical behavior and contrast with patients with Hodgkin's disease (HD)
    • Vose J.M., Giles F.J., Manshouri T., Bociek G., Bierman P.J., Armitage J.O., et al. High levels of soluble CD20 (sCD20) in patients with non-Hodgkin's lymphoma (NHL): correlation with clinical behavior and contrast with patients with Hodgkin's disease (HD). Blood. 98:2001;767a
    • (2001) Blood , vol.98
    • Vose, J.M.1    Giles, F.J.2    Manshouri, T.3    Bociek, G.4    Bierman, P.J.5    Armitage, J.O.6
  • 16
    • 0036182539 scopus 로고    scopus 로고
    • Emerging information on the use of rituximab in chronic lymphocytic leukemia
    • Keating M.J., O'Brien S., Albitar M. Emerging information on the use of rituximab in chronic lymphocytic leukemia. Semin Oncol. 29(Suppl 2):2002;70-74
    • (2002) Semin Oncol , vol.29 , Issue.SUPPL. 2 , pp. 70-74
    • Keating, M.J.1    O'Brien, S.2    Albitar, M.3
  • 17
    • 0038446696 scopus 로고    scopus 로고
    • Circulating CD20 is detectable in the plasma of patients with chronic lymphocytic leukemia and is of prognostic significance
    • Manshouri T., Do K.A., Wang X., Giles F.J., O'Brien S.M., Saffer H.L., et al. Circulating CD20 is detectable in the plasma of patients with chronic lymphocytic leukemia and is of prognostic significance. Blood. 101:2003;2507-2513
    • (2003) Blood , vol.101 , pp. 2507-2513
    • Manshouri, T.1    Do, K.A.2    Wang, X.3    Giles, F.J.4    O'Brien, S.M.5    Saffer, H.L.6
  • 18
    • 0346103809 scopus 로고    scopus 로고
    • Rituximab: Converging mechanisms of action in non-Hodgkin's lymphoma?
    • Eisenbeis C.F., Caligiuri M.A., Byrd J.C. Rituximab: converging mechanisms of action in non-Hodgkin's lymphoma? Clin Cancer Res. 9:2003;5810-5812
    • (2003) Clin Cancer Res , vol.9 , pp. 5810-5812
    • Eisenbeis, C.F.1    Caligiuri, M.A.2    Byrd, J.C.3
  • 19
    • 0036464611 scopus 로고    scopus 로고
    • The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: Evidence of caspase activation and apoptosis induction
    • Byrd J.C., Kitada S., Flinn I.W., Aron J.L., Pearson M., Lucas D., et al. The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction. Blood. 99:2002;1038-1043
    • (2002) Blood , vol.99 , pp. 1038-1043
    • Byrd, J.C.1    Kitada, S.2    Flinn, I.W.3    Aron, J.L.4    Pearson, M.5    Lucas, D.6
  • 20
    • 0037082469 scopus 로고    scopus 로고
    • The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cells through a p38 mitogen activated protein-kinase-dependent mechanism
    • Pedersen I.M., Buhl A.M., Klausen P., Geisler C.H., Jurlander J. The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cells through a p38 mitogen activated protein-kinase- dependent mechanism. Blood. 99:2002;1314-1319
    • (2002) Blood , vol.99 , pp. 1314-1319
    • Pedersen, I.M.1    Buhl, A.M.2    Klausen, P.3    Geisler, C.H.4    Jurlander, J.5
  • 21
    • 0842264005 scopus 로고    scopus 로고
    • Fc gamma RIIIa and Fc gamma RIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia
    • Farag S.S., Flinn I.W., Modali R., Lehman T.A., Young D., Byrd J.C. Fc gamma RIIIa and Fc gamma RIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia. Blood. 103:2004;1472-1474
    • (2004) Blood , vol.103 , pp. 1472-1474
    • Farag, S.S.1    Flinn, I.W.2    Modali, R.3    Lehman, T.A.4    Young, D.5    Byrd, J.C.6
  • 22
    • 0038518572 scopus 로고    scopus 로고
    • Apoptotic-regulatory and complement-protecting protein expression in chronic lymphocytic leukemia: Relationship to in vivo rituximab resistance
    • Bannerji R., Kitada S., Flinn I.W., Pearson M., Young D., Reed J.C., et al. Apoptotic-regulatory and complement-protecting protein expression in chronic lymphocytic leukemia: relationship to in vivo rituximab resistance. J Clin Oncol. 21:2003;1466-1471
    • (2003) J Clin Oncol , vol.21 , pp. 1466-1471
    • Bannerji, R.1    Kitada, S.2    Flinn, I.W.3    Pearson, M.4    Young, D.5    Reed, J.C.6
  • 23
    • 0345337254 scopus 로고    scopus 로고
    • Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program
    • McLaughlin P., Grillo-Lopez A.J., Link B.K., Levy R., Czuczman M.S., Williams M.E., et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol. 16:1998;2825-2833
    • (1998) J Clin Oncol , vol.16 , pp. 2825-2833
    • McLaughlin, P.1    Grillo-Lopez, A.J.2    Link, B.K.3    Levy, R.4    Czuczman, M.S.5    Williams, M.E.6
  • 24
    • 0032931320 scopus 로고    scopus 로고
    • IDEC-C2B8 anti-CD20 (rituximab) immunotherapy in patients with low-grade non-Hodgkin's lymphoma and lymphoproliferative disorders: Evaluation of response on 48 patients
    • Nguyen D.T., Amess J.A., Doughty H., Hendry L., Diamond L.W. IDEC-C2B8 anti-CD20 (rituximab) immunotherapy in patients with low-grade non-Hodgkin's lymphoma and lymphoproliferative disorders: evaluation of response on 48 patients. Eur J Haematol. 62:1999;76-82
    • (1999) Eur J Haematol , vol.62 , pp. 76-82
    • Nguyen, D.T.1    Amess, J.A.2    Doughty, H.3    Hendry, L.4    Diamond, L.W.5
  • 25
    • 0033214207 scopus 로고    scopus 로고
    • Cytokine-release syndrome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8)
    • Winkler U., Jensen M., Manzke O., Schulz H., Diehl V., Engert A. Cytokine-release syndrome in patients with B-cell chronic lymphocytic leukemia and high lymphocyte counts after treatment with an anti-CD20 monoclonal antibody (rituximab, IDEC-C2B8). Blood. 94:1999;2217-2224
    • (1999) Blood , vol.94 , pp. 2217-2224
    • Winkler, U.1    Jensen, M.2    Manzke, O.3    Schulz, H.4    Diehl, V.5    Engert, A.6
  • 26
    • 0035469851 scopus 로고    scopus 로고
    • Rituximab therapy of patients with B-cell chronic lymphocytic leukemia
    • Huhn D., von Schilling C., Wilhelm M., Ho A.D., Hallek M., Kuse R., et al. Group GCLLS Rituximab therapy of patients with B-cell chronic lymphocytic leukemia. Blood. 98:2001;1326-1331
    • (2001) Blood , vol.98 , pp. 1326-1331
    • Huhn, D.1    Von Schilling, C.2    Wilhelm, M.3    Ho, A.D.4    Hallek, M.5    Kuse, R.6
  • 27
    • 0036757311 scopus 로고    scopus 로고
    • Standard-dose anti-CD20 antibody rituximab has efficacy in chronic lymphocytic leukaemia: Results from a Nordic multicentre study
    • Itala M., Geisler C.H., Kimby E., Juvonen E., Tjonnfjord G., Karlsson K., et al. Standard-dose anti-CD20 antibody rituximab has efficacy in chronic lymphocytic leukaemia: results from a Nordic multicentre study. Eur J Haematol. 69:2002;129-134
    • (2002) Eur J Haematol , vol.69 , pp. 129-134
    • Itala, M.1    Geisler, C.H.2    Kimby, E.3    Juvonen, E.4    Tjonnfjord, G.5    Karlsson, K.6
  • 28
    • 0038811776 scopus 로고    scopus 로고
    • Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: A phase II trial of the Minnie Pearl Cancer Research Network
    • Hainsworth J.D., Litchy S., Barton J.H., Houston G.A., Hermann R.C., Bradof J.E., et al. Single-agent rituximab as first-line and maintenance treatment for patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase II trial of the Minnie Pearl Cancer Research Network. J Clin Oncol. 21:2003;1746-1751
    • (2003) J Clin Oncol , vol.21 , pp. 1746-1751
    • Hainsworth, J.D.1    Litchy, S.2    Barton, J.H.3    Houston, G.A.4    Hermann, R.C.5    Bradof, J.E.6
  • 31
    • 0036125566 scopus 로고    scopus 로고
    • Level of CD20 expression and efficacy of rituximab treatment in patients with resistant or relapsing B-cell prolymphocytic leukemia and B-cell chronic lymphocytic leukemia
    • Perz J., Topaly J., Fruehauf S., Hensel M., Ho A.D. Level of CD20 expression and efficacy of rituximab treatment in patients with resistant or relapsing B-cell prolymphocytic leukemia and B-cell chronic lymphocytic leukemia. Leuk Lymphoma. 43:2002;149-151
    • (2002) Leuk Lymphoma , vol.43 , pp. 149-151
    • Perz, J.1    Topaly, J.2    Fruehauf, S.3    Hensel, M.4    Ho, A.D.5
  • 32
    • 7844225540 scopus 로고    scopus 로고
    • Association of serum rituximab (IDEC-C2B8) concentration and anti-tumor response in the treatment of recurrent low-grade or follicular non-Hodgkin's lymphoma
    • Berinstein N.L., Grillo-Lopez A.J., White C.A., Bence-Bruckler I., Maloney D., Czuczman M.S., et al. Association of serum rituximab (IDEC-C2B8) concentration and anti-tumor response in the treatment of recurrent low-grade or follicular non-Hodgkin's lymphoma. Ann Oncol. 9:1998;995-1001
    • (1998) Ann Oncol , vol.9 , pp. 995-1001
    • Berinstein, N.L.1    Grillo-Lopez, A.J.2    White, C.A.3    Bence-Bruckler, I.4    Maloney, D.5    Czuczman, M.S.6
  • 33
    • 0034468409 scopus 로고    scopus 로고
    • High-dose rituximab therapy in chronic lymphocytic leukemia
    • Keating M.J., O'Brien S. High-dose rituximab therapy in chronic lymphocytic leukemia. Semin Oncol. 27(Suppl 12):2000;86-90
    • (2000) Semin Oncol , vol.27 , Issue.SUPPL. 12 , pp. 86-90
    • Keating, M.J.1    O'Brien, S.2
  • 35
    • 0035871445 scopus 로고    scopus 로고
    • Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity
    • Byrd J.C., Murphy T., Howard R.S., Lucas M.S., Goodrich A., Park K., et al. Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol. 19:2001;2153-2164
    • (2001) J Clin Oncol , vol.19 , pp. 2153-2164
    • Byrd, J.C.1    Murphy, T.2    Howard, R.S.3    Lucas, M.S.4    Goodrich, A.5    Park, K.6
  • 36
    • 0033016566 scopus 로고    scopus 로고
    • Rituximab therapy in hematologic malignancy patients with circulating blood tumor cells: Association with increased infusion-related side effects and rapid blood tumor clearance
    • Byrd J.C., Waselenko J.K., Maneatis T.J., Murphy T., Ward F.T., Monahan B.P., et al. Rituximab therapy in hematologic malignancy patients with circulating blood tumor cells: association with increased infusion-related side effects and rapid blood tumor clearance. J Clin Oncol. 17:1999;791-795
    • (1999) J Clin Oncol , vol.17 , pp. 791-795
    • Byrd, J.C.1    Waselenko, J.K.2    Maneatis, T.J.3    Murphy, T.4    Ward, F.T.5    Monahan, B.P.6
  • 37
    • 0031664666 scopus 로고    scopus 로고
    • Rapid tumor lysis in a patient with B-cell chronic lymphocytic leukemia and lymphocytosis treated with an anti-CD20 monoclonal antibody (IDEC-C2B8, rituximab)
    • Jensen M., Winkler U., Manzke O., Diehl V., Engert A. Rapid tumor lysis in a patient with B-cell chronic lymphocytic leukemia and lymphocytosis treated with an anti-CD20 monoclonal antibody (IDEC-C2B8, rituximab). Ann Hematol. 77:1998;89-91
    • (1998) Ann Hematol , vol.77 , pp. 89-91
    • Jensen, M.1    Winkler, U.2    Manzke, O.3    Diehl, V.4    Engert, A.5
  • 38
    • 0042236333 scopus 로고    scopus 로고
    • Rituximab herapy for CLL
    • Lin T.S. L.M., Byrd J.C. Rituximab herapy for CLL. Semin Oncol. 30(4):2003;483-492
    • (2003) Semin Oncol , vol.30 , Issue.4 , pp. 483-492
    • Lin, T.S.L.M.1    Byrd, J.C.2
  • 39
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from Cancer and Leukemia Group B 9712 (CALGB 9712)
    • Byrd J.C., Peterson B.L., Morrison V.A., Park K., Jacobson R., Hoke E., et al. Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood. 101:2003;6-14
    • (2003) Blood , vol.101 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3    Park, K.4    Jacobson, R.5    Hoke, E.6
  • 40
    • 0003228854 scopus 로고    scopus 로고
    • Combination chemo-antibody therapy with fludarabine (F), cyclophosphamide (C) and rituximab (R) achieves a high CR rate in previously untreated chronic lymphocytic leukemia (CLL)
    • Keating M.J., O'Brien S., Lerner S., Giles F.J., Andreeff M., Cortes J., et al. Combination chemo-antibody therapy with fludarabine (F), cyclophosphamide (C) and rituximab (R) achieves a high CR rate in previously untreated chronic lymphocytic leukemia (CLL). Blood. 96:2000;514a
    • (2000) Blood , vol.96
    • Keating, M.J.1    O'Brien, S.2    Lerner, S.3    Giles, F.J.4    Andreeff, M.5    Cortes, J.6
  • 41
    • 0036839469 scopus 로고    scopus 로고
    • Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia
    • Schulz H., Klein S.K., Rehwald U., Reiser M., Hinke A., Knauf W.U., et al. Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia. Blood. 100:2002;3115-3120
    • (2002) Blood , vol.100 , pp. 3115-3120
    • Schulz, H.1    Klein, S.K.2    Rehwald, U.3    Reiser, M.4    Hinke, A.5    Knauf, W.U.6
  • 42
    • 0036839469 scopus 로고    scopus 로고
    • Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia
    • Schulz H., Klein S.K., Rehwald U., Reiser M., Hinke A., Knauf W.U., et al. Group GCS Phase 2 study of a combined immunochemotherapy using rituximab and fludarabine in patients with chronic lymphocytic leukemia. Blood. 100:2002;3115-3120
    • (2002) Blood , vol.100 , pp. 3115-3120
    • Schulz, H.1    Klein, S.K.2    Rehwald, U.3    Reiser, M.4    Hinke, A.5    Knauf, W.U.6
  • 43
    • 14344252714 scopus 로고    scopus 로고
    • Chemoimmunotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) improves complete response (CR), remission duration and survival as initial therapy of chronic lymphocytic leukemia (CLL)
    • Keating M.J., O'Brien S., Lerner S., Wierda W., Kantarjian H. Chemoimmunotherapy with fludarabine (F), cyclophosphamide (C), and rituximab (R) improves complete response (CR), remission duration and survival as initial therapy of chronic lymphocytic leukemia (CLL). J Clin Oncol. 22(14S):2004;573
    • (2004) J Clin Oncol , vol.22 , Issue.14 S , pp. 573
    • Keating, M.J.1    O'Brien, S.2    Lerner, S.3    Wierda, W.4    Kantarjian, H.5
  • 44
    • 0036165916 scopus 로고    scopus 로고
    • CD38 expression and secondary 17p deletion are important prognostic factors in chronic lymphocytic leukaemia
    • Chevallier P., Penther D., Avet-Loiseau H., Robillard N., Ifrah N., Mahe B., et al. CD38 expression and secondary 17p deletion are important prognostic factors in chronic lymphocytic leukaemia. Br J Haematol. 116:2002;142-150
    • (2002) Br J Haematol , vol.116 , pp. 142-150
    • Chevallier, P.1    Penther, D.2    Avet-Loiseau, H.3    Robillard, N.4    Ifrah, N.5    Mahe, B.6
  • 45
    • 0028987180 scopus 로고
    • P53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias
    • Dohner H., Fischer K., Bentz M., Hansen K., Benner A., Cabot G., et al. p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias. Blood. 85:1995;1580-1589
    • (1995) Blood , vol.85 , pp. 1580-1589
    • Dohner, H.1    Fischer, K.2    Bentz, M.3    Hansen, K.4    Benner, A.5    Cabot, G.6
  • 46
    • 0031791801 scopus 로고    scopus 로고
    • Secondary abnormalities of chromosome 6q in B-cell chronic lymphocytic leukemia: A sequential study of karyotypic instability in 51 patients
    • Finn W.G., Kay N.E., Kroft S.H., Church S., Peterson L.C. Secondary abnormalities of chromosome 6q in B-cell chronic lymphocytic leukemia: a sequential study of karyotypic instability in 51 patients. Am J Hematol. 59:1998;223-229
    • (1998) Am J Hematol , vol.59 , pp. 223-229
    • Finn, W.G.1    Kay, N.E.2    Kroft, S.H.3    Church, S.4    Peterson, L.C.5
  • 47
    • 0025077558 scopus 로고
    • Correlation of chromosome abnormalities with laboratory features and clinical course in B-cell chronic lymphocytic leukaemia
    • Oscier D.G., Stevens J., Hamblin T.J., Pickering R.M., Lambert R., Fitchett M. Correlation of chromosome abnormalities with laboratory features and clinical course in B-cell chronic lymphocytic leukaemia. Br J Haematol. 76:1990;352-358
    • (1990) Br J Haematol , vol.76 , pp. 352-358
    • Oscier, D.G.1    Stevens, J.2    Hamblin, T.J.3    Pickering, R.M.4    Lambert, R.5    Fitchett, M.6
  • 48
    • 0035679122 scopus 로고    scopus 로고
    • Analysis of clonal B-cell CD38 and immunoglobulin variable region sequence status in relation to clinical outcome for B-chronic lymphocytic leukaemia
    • Jelinek D.F., Tschumper R.C., Geyer S.M., Bone N.D., Dewald G.W., Hanson C.A., et al. Analysis of clonal B-cell CD38 and immunoglobulin variable region sequence status in relation to clinical outcome for B-chronic lymphocytic leukaemia. Br J Haematol. 115:2001;854-861
    • (2001) Br J Haematol , vol.115 , pp. 854-861
    • Jelinek, D.F.1    Tschumper, R.C.2    Geyer, S.M.3    Bone, N.D.4    Dewald, G.W.5    Hanson, C.A.6
  • 49
    • 0027436745 scopus 로고
    • P53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression
    • el Rouby S., Thomas A., Costin D., Rosenberg C.R., Potmesil M., Silber R., et al. p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression. Blood. 82:1993;3452-3459
    • (1993) Blood , vol.82 , pp. 3452-3459
    • El Rouby, S.1    Thomas, A.2    Costin, D.3    Rosenberg, C.R.4    Potmesil, M.5    Silber, R.6
  • 50
    • 17744410949 scopus 로고    scopus 로고
    • P53 expression in B-cell chronic lymphocytic leukemia: A marker of disease progression and poor prognosis
    • Cordone I., Masi S., Mauro F.R., Soddu S., Morsilli O., Valentini T., et al. p53 expression in B-cell chronic lymphocytic leukemia: a marker of disease progression and poor prognosis. Blood. 91:1998;4342-4349
    • (1998) Blood , vol.91 , pp. 4342-4349
    • Cordone, I.1    Masi, S.2    Mauro, F.R.3    Soddu, S.4    Morsilli, O.5    Valentini, T.6
  • 51
    • 0028172868 scopus 로고
    • P53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies
    • Wattel E., Preudhomme C., Hecquet B., Vanrumbeke M., Quesnel B., Dervite I., et al. p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood. 84:1994;3148-3157
    • (1994) Blood , vol.84 , pp. 3148-3157
    • Wattel, E.1    Preudhomme, C.2    Hecquet, B.3    Vanrumbeke, M.4    Quesnel, B.5    Dervite, I.6
  • 52
    • 0032079746 scopus 로고    scopus 로고
    • Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: Correlations with in vitro and in vivo chemoresponses
    • Kitada S., Andersen J., Akar S., Zapata J.M., Takayama S., Krajewski S., et al. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. Blood. 91:1998;3379-3389
    • (1998) Blood , vol.91 , pp. 3379-3389
    • Kitada, S.1    Andersen, J.2    Akar, S.3    Zapata, J.M.4    Takayama, S.5    Krajewski, S.6
  • 53
    • 0035437138 scopus 로고    scopus 로고
    • P53 dysfunction in B-cell chronic lymphocytic leukemia: Inactivation of ATM as an alternative to TP53 mutation
    • Pettitt A.R., Sherrington P.D., Stewart G., Cawley J.C., Taylor A.M., Stankovic T. p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation. Blood. 98:2001;814-822
    • (2001) Blood , vol.98 , pp. 814-822
    • Pettitt, A.R.1    Sherrington, P.D.2    Stewart, G.3    Cawley, J.C.4    Taylor, A.M.5    Stankovic, T.6
  • 54
    • 0033513587 scopus 로고    scopus 로고
    • Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia
    • Stankovic T., Weber P., Stewart G., Bedenham T., Murray J., Byrd P.J., et al. Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia. Lancet. 353:1999;26-29
    • (1999) Lancet , vol.353 , pp. 26-29
    • Stankovic, T.1    Weber, P.2    Stewart, G.3    Bedenham, T.4    Murray, J.5    Byrd, P.J.6
  • 55
    • 0036096157 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage
    • Stankovic T., Stewart G.S., Fegan C., Biggs P., Last J., Byrd P.J., et al. Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage. Blood. 99:2002;300-309
    • (2002) Blood , vol.99 , pp. 300-309
    • Stankovic, T.1    Stewart, G.S.2    Fegan, C.3    Biggs, P.4    Last, J.5    Byrd, P.J.6
  • 56
    • 0034614551 scopus 로고    scopus 로고
    • Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway
    • Genini D., Budihardjo I., Plunkett W., Wang X., Carrera C.J., Cottam H.B., et al. Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway. J Biol Chem. 275:2000;29-34
    • (2000) J Biol Chem , vol.275 , pp. 29-34
    • Genini, D.1    Budihardjo, I.2    Plunkett, W.3    Wang, X.4    Carrera, C.J.5    Cottam, H.B.6
  • 57
    • 0034669944 scopus 로고    scopus 로고
    • Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
    • Genini D., Adachi S., Chao Q., Rose D.W., Carrera C.J., Cottam H.B., et al. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood. 96:2000;3537-3543
    • (2000) Blood , vol.96 , pp. 3537-3543
    • Genini, D.1    Adachi, S.2    Chao, Q.3    Rose, D.W.4    Carrera, C.J.5    Cottam, H.B.6
  • 58
    • 0037228952 scopus 로고    scopus 로고
    • Interphase cytogenetic abnormalities in chronic lymphocytic leukemia may predict response to rituximab
    • Byrd J., Smith L., Hackbarth M., Flinn I., Young D., Proffitt J., et al. Interphase cytogenetic abnormalities in chronic lymphocytic leukemia may predict response to rituximab. Cancer Res. 63:2003;36-38
    • (2003) Cancer Res , vol.63 , pp. 36-38
    • Byrd, J.1    Smith, L.2    Hackbarth, M.3    Flinn, I.4    Young, D.5    Proffitt, J.6
  • 59
    • 0034501632 scopus 로고    scopus 로고
    • Campath-1H monoclonal antibody therapy
    • Flynn J.M., Byrd J.C. Campath-1H monoclonal antibody therapy. Curr Opin Oncol. 12:2000;574-581
    • (2000) Curr Opin Oncol , vol.12 , pp. 574-581
    • Flynn, J.M.1    Byrd, J.C.2
  • 60
    • 0020591822 scopus 로고
    • Removal of T cells from bone marrow for transplantation: A monoclonal antilymphocyte antibody that fixes human complement
    • Hale G., Bright S., Chumbley G., Hoang T., Metcalf D., Munro A.J., et al. Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement. Blood. 62:1983;873-882
    • (1983) Blood , vol.62 , pp. 873-882
    • Hale, G.1    Bright, S.2    Chumbley, G.3    Hoang, T.4    Metcalf, D.5    Munro, A.J.6
  • 61
    • 0024204319 scopus 로고
    • Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H
    • Hale G., Dyer M.J., Clark M.R., Phillips J.M., Marcus R., Riechmann L., et al. Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H. Lancet. 2:1988;1394-1399
    • (1988) Lancet , vol.2 , pp. 1394-1399
    • Hale, G.1    Dyer, M.J.2    Clark, M.R.3    Phillips, J.M.4    Marcus, R.5    Riechmann, L.6
  • 64
    • 0031790767 scopus 로고    scopus 로고
    • Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52-deficient cells
    • Rowan W., Tite J., Topley P., Brett S.J. Cross-linking of the CAMPATH-1 antigen (CD52) mediates growth inhibition in human B- and T-lymphoma cell lines, and subsequent emergence of CD52-deficient cells. Immunology. 95:1998;427-436
    • (1998) Immunology , vol.95 , pp. 427-436
    • Rowan, W.1    Tite, J.2    Topley, P.3    Brett, S.J.4
  • 65
    • 0021813140 scopus 로고
    • Reactivity of rat monoclonal antibody CAMPATH-1 with human leukaemia cells and its possible application for autologous bone marrow transplantation
    • Hale G., Swirsky D., Waldmann H., Chan L.C. Reactivity of rat monoclonal antibody CAMPATH-1 with human leukaemia cells and its possible application for autologous bone marrow transplantation. Br J Haematol. 60:1985;41-48
    • (1985) Br J Haematol , vol.60 , pp. 41-48
    • Hale, G.1    Swirsky, D.2    Waldmann, H.3    Chan, L.C.4
  • 66
    • 0028352208 scopus 로고
    • Immunohistochemical analysis of CDw52 antigen expression in non-Hodgkin's lymphomas
    • Salisbury J.R., Rapson N.T., Codd J.D., Rogers M.V., Nethersell A.B. Immunohistochemical analysis of CDw52 antigen expression in non-Hodgkin's lymphomas. J Clin Pathol. 47:1994;313-317
    • (1994) J Clin Pathol , vol.47 , pp. 313-317
    • Salisbury, J.R.1    Rapson, N.T.2    Codd, J.D.3    Rogers, M.V.4    Nethersell, A.B.5
  • 67
    • 0031027623 scopus 로고    scopus 로고
    • Subcutaneous CAMPATH-1H in fludarabine-resistant/relapsed chronic lymphocytic and B-prolymphocytic leukaemia
    • Bowen A.L., Zomas A., Emmett E., Matutes E., Dyer M.J., Catovsky D. Subcutaneous CAMPATH-1H in fludarabine-resistant/relapsed chronic lymphocytic and B-prolymphocytic leukaemia. Br J Haematol. 96:1997;617-619
    • (1997) Br J Haematol , vol.96 , pp. 617-619
    • Bowen, A.L.1    Zomas, A.2    Emmett, E.3    Matutes, E.4    Dyer, M.J.5    Catovsky, D.6
  • 68
    • 4344630062 scopus 로고    scopus 로고
    • Multicenter study of Campath-1H in patients with chronic lymphocytic leukemia (B-CLL) refractory to fludarabine
    • Keating M.J., Byrd J.C., Rai K., Flinn I., Jain V., Binet L., et al. Group C-Hcs Multicenter study of Campath-1H in patients with chronic lymphocytic leukemia (B-CLL) refractory to fludarabine. Blood. 96:2000;722a
    • (2000) Blood , vol.96
    • Keating, M.J.1    Byrd, J.C.2    Rai, K.3    Flinn, I.4    Jain, V.5    Binet, L.6
  • 69
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
    • Keating M.J., Flinn I., Jain V., Binet J.-L., Hillmen P., Byrd J.C., et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study. Blood. 99:2002;3554-3561
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3    Binet, J.-L.4    Hillmen, P.5    Byrd, J.C.6
  • 70
    • 0029937765 scopus 로고    scopus 로고
    • Humanized CD52 monoclonal antibody Campath-1H as first-line treatment in chronic lymphocytic leukaemia
    • Osterborg A., Fassas A.S., Anagnostopoulos A., Dyer M.J., Catovsky D., Mellstedt H. Humanized CD52 monoclonal antibody Campath-1H as first-line treatment in chronic lymphocytic leukaemia. Br J Haematol. 93:1996;151-153
    • (1996) Br J Haematol , vol.93 , pp. 151-153
    • Osterborg, A.1    Fassas, A.S.2    Anagnostopoulos, A.3    Dyer, M.J.4    Catovsky, D.5    Mellstedt, H.6
  • 71
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia: European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia
    • Osterborg A., Dyer M.J., Bunjes D., Pangalis G.A., Bastion Y., Catovsky D., et al. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia: European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia. J Clin Oncol. 15:1997;1567-1574
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3    Pangalis, G.A.4    Bastion, Y.5    Catovsky, D.6
  • 72
    • 79960971484 scopus 로고    scopus 로고
    • Efficacy and safety of alemtuzumab (Campath-1H) in refractory B-CLL patients treated on a compassionate basis
    • Rai K.R., Coutre S., Rizzieri D., Gribben J.G., Flinn I., Rabinowe S., et al. Group CS Efficacy and safety of alemtuzumab (Campath-1H) in refractory B-CLL patients treated on a compassionate basis. Blood. 98:2001;365a
    • (2001) Blood , vol.98
    • Rai, K.R.1    Coutre, S.2    Rizzieri, D.3    Gribben, J.G.4    Flinn, I.5    Rabinowe, S.6
  • 73
    • 0036683449 scopus 로고    scopus 로고
    • Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)
    • Lundin J., Kimby E., Bjorkholm M., Broliden P.A., Celsing F., Hjalmar V., et al. Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL). Blood. 100:2002;768-773
    • (2002) Blood , vol.100 , pp. 768-773
    • Lundin, J.1    Kimby, E.2    Bjorkholm, M.3    Broliden, P.A.4    Celsing, F.5    Hjalmar, V.6
  • 75
    • 0036076178 scopus 로고    scopus 로고
    • Safety and efficacy of subcutaneous Campath-1H for treating residual disease in patients with chronic lymphocytic leukemia responding to fludarabine
    • Montillo M., Cafro A.M., Tedeschi A., Brando B., Oreste P., Veronese S., et al. Safety and efficacy of subcutaneous Campath-1H for treating residual disease in patients with chronic lymphocytic leukemia responding to fludarabine. Haematologica. 87:2002;695-700
    • (2002) Haematologica , vol.87 , pp. 695-700
    • Montillo, M.1    Cafro, A.M.2    Tedeschi, A.3    Brando, B.4    Oreste, P.5    Veronese, S.6
  • 76
    • 0037860441 scopus 로고    scopus 로고
    • A phase II trial of fludarabine followed by alemtuzumab (Campath-1H) in previously untreated chronic lymphocytic leukemia (CLL) Patients with Active Disease: Cancer and Leukemia Group B (CALGB) study 19901
    • Rai K.R., Peterson B., Larson R.A. A phase II trial of fludarabine followed by alemtuzumab (Campath-1H) in previously untreated chronic lymphocytic leukemia (CLL) Patients with Active Disease: Cancer and Leukemia Group B (CALGB) study 19901. Blood. 101:2002;205a
    • (2002) Blood , vol.101
    • Rai, K.R.1    Peterson, B.2    Larson, R.A.3
  • 77
    • 0344236261 scopus 로고    scopus 로고
    • Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia
    • O'Brien S., Kantarjan H.M., Thomas D.A., Cortes J., Giles F.J., Wierda W.G., et al. Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia. Cancer. 98(12):2003;2657-2663
    • (2003) Cancer , vol.98 , Issue.12 , pp. 2657-2663
    • O'Brien, S.1    Kantarjan, H.M.2    Thomas, D.A.3    Cortes, J.4    Giles, F.J.5    Wierda, W.G.6
  • 78
    • 2942540231 scopus 로고    scopus 로고
    • High efficacy but considerable toxicity of campath-1H consolidation therapy in CLL patients responding to fludarabine: Results of a randomized phase III trial
    • Wendtner C.M., Fingerle-Rowson G., Jaeger G., Campe H., Engert A., Doehner H., et al. High efficacy but considerable toxicity of campath-1H consolidation therapy in CLL patients responding to fludarabine: results of a randomized phase III trial. Proc Am Soc Clin Oncol. 2003
    • (2003) Proc Am Soc Clin Oncol
    • Wendtner, C.M.1    Fingerle-Rowson, G.2    Jaeger, G.3    Campe, H.4    Engert, A.5    Doehner, H.6
  • 79
    • 0035075989 scopus 로고    scopus 로고
    • A phase II multicenter study of Campath-1H antibody in previously treated patients with nonbulky non-Hodgkin's lymphoma
    • Khorana A., Bunn P., McLaughlin P., Vose J., Stewart C., Czuczman M.S. A phase II multicenter study of Campath-1H antibody in previously treated patients with nonbulky non-Hodgkin's lymphoma. Leuk Lymphoma. 41:2001;77-87
    • (2001) Leuk Lymphoma , vol.41 , pp. 77-87
    • Khorana, A.1    Bunn, P.2    McLaughlin, P.3    Vose, J.4    Stewart, C.5    Czuczman, M.S.6
  • 80
    • 0030300084 scopus 로고    scopus 로고
    • Immunosuppressive toxicity of CAMPATH1H monoclonal antibody in the treatment of patients with recurrent low grade lymphoma
    • Tang S.C., Hewitt K., Reis M.D., Berinstein N.L. Immunosuppressive toxicity of CAMPATH1H monoclonal antibody in the treatment of patients with recurrent low grade lymphoma. Leuk Lymphoma. 24:1996;93-101
    • (1996) Leuk Lymphoma , vol.24 , pp. 93-101
    • Tang, S.C.1    Hewitt, K.2    Reis, M.D.3    Berinstein, N.L.4
  • 81
    • 0031757274 scopus 로고    scopus 로고
    • CAMPATH-1H monoclonal antibody in therapy for previously treated low-grade non-Hodgkin's lymphoma: A phase II multicenter study. European Study Group of CAMPATH-1H Treatment in Low-Grade Non-Hodgkin's Lymphoma
    • Lundin J., Osterborg A., Brittinger G., Crowther D., Dombret H., Engert A., et al. CAMPATH-1H monoclonal antibody in therapy for previously treated low-grade non-Hodgkin's lymphoma: a phase II multicenter study. European Study Group of CAMPATH-1H Treatment in Low-Grade Non-Hodgkin's Lymphoma. J Clin Oncol. 16:1998;3257-3263
    • (1998) J Clin Oncol , vol.16 , pp. 3257-3263
    • Lundin, J.1    Osterborg, A.2    Brittinger, G.3    Crowther, D.4    Dombret, H.5    Engert, A.6
  • 82
    • 0029666221 scopus 로고    scopus 로고
    • Repopulation of blood lymphocyte sub-populations in rheumatoid arthritis patients treated with the depleting humanized monoclonal antibody, CAMPATH-1H
    • Brett S., Baxter G., Cooper H., Johnston J.M., Tite J., Rapson N. Repopulation of blood lymphocyte sub-populations in rheumatoid arthritis patients treated with the depleting humanized monoclonal antibody, CAMPATH-1H. Immunology. 88:1996;13-19
    • (1996) Immunology , vol.88 , pp. 13-19
    • Brett, S.1    Baxter, G.2    Cooper, H.3    Johnston, J.M.4    Tite, J.5    Rapson, N.6
  • 83
    • 0029824828 scopus 로고    scopus 로고
    • Campath-1G impairs human natural killer (NK) cell-mediated cytotoxicity
    • Condiotti R., Nagler A. Campath-1G impairs human natural killer (NK) cell-mediated cytotoxicity. Bone Marrow Transplant. 18:1996;713-720
    • (1996) Bone Marrow Transplant , vol.18 , pp. 713-720
    • Condiotti, R.1    Nagler, A.2
  • 84
    • 0027853686 scopus 로고
    • Effects of CAMPATH-1 antibodies on the functional activity of monocytes and polymorphonuclear neutrophils
    • Fabian I., Flidel O., Gadish M., Kletter Y., Slavin S., Nagler A. Effects of CAMPATH-1 antibodies on the functional activity of monocytes and polymorphonuclear neutrophils. Exp Hematol. 21:1993;1522-1527
    • (1993) Exp Hematol , vol.21 , pp. 1522-1527
    • Fabian, I.1    Flidel, O.2    Gadish, M.3    Kletter, Y.4    Slavin, S.5    Nagler, A.6
  • 85
    • 4344710500 scopus 로고    scopus 로고
    • Peripheral blood dendritic cells express CD52 and are depleted in vivo by treatment with Campath-1H
    • Buggins A.G.S., Mufti G.J., Fishlock K., Arno M., Hale G., Waldmann H., et al. Peripheral blood dendritic cells express CD52 and are depleted in vivo by treatment with Campath-1H. Blood. 98:2001;366a
    • (2001) Blood , vol.98
    • Buggins, A.G.S.1    Mufti, G.J.2    Fishlock, K.3    Arno, M.4    Hale, G.5    Waldmann, H.6
  • 86
    • 0032535279 scopus 로고    scopus 로고
    • Improving the outcome of bone marrow transplantation by using CD52 monoclonal antibodies to prevent graft-versus-host disease and graft rejection
    • Hale G., Zhang M.J., Bunjes D., Prentice H.G., Spence D., Horowitz M.M., et al. Improving the outcome of bone marrow transplantation by using CD52 monoclonal antibodies to prevent graft-versus-host disease and graft rejection. Blood. 92:1998;4581-4590
    • (1998) Blood , vol.92 , pp. 4581-4590
    • Hale, G.1    Zhang, M.J.2    Bunjes, D.3    Prentice, H.G.4    Spence, D.5    Horowitz, M.M.6
  • 87
    • 0033949148 scopus 로고    scopus 로고
    • CD52 antibodies for prevention of graft-versus-host disease and graft rejection following transplantation of allogeneic peripheral blood stem cells
    • Hale G., Jacobs P., Wood L., Fibbe W.E., Barge R., Novitzky N., et al. CD52 antibodies for prevention of graft-versus-host disease and graft rejection following transplantation of allogeneic peripheral blood stem cells. Bone Marrow Transplant. 26:2000;69-76
    • (2000) Bone Marrow Transplant , vol.26 , pp. 69-76
    • Hale, G.1    Jacobs, P.2    Wood, L.3    Fibbe, W.E.4    Barge, R.5    Novitzky, N.6
  • 88
    • 0005950282 scopus 로고    scopus 로고
    • Randomized trial of early versus delayed GM-CSF with Campath-1H: Preliminary feasibility and correlative biologic studies results
    • Flinn I.W., Sickler J., Lucas M., Buj V., Waymer S., Shinn C., et al. Randomized trial of early versus delayed GM-CSF with Campath-1H: preliminary feasibility and correlative biologic studies results. Blood. 96:2000;838a
    • (2000) Blood , vol.96
    • Flinn, I.W.1    Sickler, J.2    Lucas, M.3    Buj, V.4    Waymer, S.5    Shinn, C.6
  • 89
    • 0038351661 scopus 로고    scopus 로고
    • Filgrastim and alemtuzumab (Campath-1H) for refractory chronic lymphocytic leukemia: High frequency of cytomegalovirus disease and delayed neutropenia
    • Lin T.S., Flinn I.W., Lucas M.S., Sickler J., Moran M., Porcu P., et al. Filgrastim and alemtuzumab (Campath-1H) for refractory chronic lymphocytic leukemia: high frequency of cytomegalovirus disease and delayed neutropenia. Blood. 100:2002;802a
    • (2002) Blood , vol.100
    • Lin, T.S.1    Flinn, I.W.2    Lucas, M.S.3    Sickler, J.4    Moran, M.5    Porcu, P.6
  • 90
    • 0037085770 scopus 로고    scopus 로고
    • Campath-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia
    • Kennedy B., Rawstron A., Carter C., Ryan M., Speed K., Lucas G., et al. Campath-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia. Blood. 99:2002;2245-2247
    • (2002) Blood , vol.99 , pp. 2245-2247
    • Kennedy, B.1    Rawstron, A.2    Carter, C.3    Ryan, M.4    Speed, K.5    Lucas, G.6
  • 91
    • 79960970604 scopus 로고    scopus 로고
    • Phase I study of rituximab and Campath-1H in patients with relapsed or refractory chronic lymphocytic leukemia
    • Nabhan C., Tallman M.S., Riley M.B., Fitzpatrick J., Gordon L.I., Gartenhaus R., et al. Phase I study of rituximab and Campath-1H in patients with relapsed or refractory chronic lymphocytic leukemia. Blood. 98:2003;365a
    • (2003) Blood , vol.98
    • Nabhan, C.1    Tallman, M.S.2    Riley, M.B.3    Fitzpatrick, J.4    Gordon, L.I.5    Gartenhaus, R.6
  • 92
    • 0038724252 scopus 로고    scopus 로고
    • Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies
    • Faderl S., Thomas D.A., O'Brien S., Garcia-Manero G., Kantarjian H.M., Giles F.J., et al. Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies. Blood. 101:2003;3413-3415
    • (2003) Blood , vol.101 , pp. 3413-3415
    • Faderl, S.1    Thomas, D.A.2    O'Brien, S.3    Garcia-Manero, G.4    Kantarjian, H.M.5    Giles, F.J.6
  • 93
    • 0037103272 scopus 로고    scopus 로고
    • Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia
    • Lin K., Sherrington P.D., Dennis M., Matrai Z., Cawley J.C., Pettitt A.R. Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia. Blood. 100:2002;1404-1409
    • (2002) Blood , vol.100 , pp. 1404-1409
    • Lin, K.1    Sherrington, P.D.2    Dennis, M.3    Matrai, Z.4    Cawley, J.C.5    Pettitt, A.R.6
  • 94
    • 1242291417 scopus 로고    scopus 로고
    • Genomic aberrations, p53 abnormalities, and IgV mutation: Relationship to disease evolution, resistance to therapy, and clinical course of CLL
    • Stilgenbauer S. Genomic aberrations, p53 abnormalities, and IgV mutation: relationship to disease evolution, resistance to therapy, and clinical course of CLL. Leuk Lymphoma. 62(2):2000;76-82
    • (2000) Leuk Lymphoma , vol.62 , Issue.2 , pp. 76-82
    • Stilgenbauer, S.1
  • 95
    • 0037850927 scopus 로고    scopus 로고
    • Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy
    • Sturm I., Bosanquet A.G., Hermann S., Guner D., Dorken B., Daniel P.T. Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy. Cell Death Differ. 10:2003;477-484
    • (2003) Cell Death Differ , vol.10 , pp. 477-484
    • Sturm, I.1    Bosanquet, A.G.2    Hermann, S.3    Guner, D.4    Dorken, B.5    Daniel, P.T.6
  • 96
    • 0037228952 scopus 로고    scopus 로고
    • Interphase cytogenetic abnormalities in chronic lymphocytic leukemia may predict response to rituximab
    • Byrd J.C., Smith L., Hackbarth M.L., Flinn I.W., Young D., Proffitt J.H., et al. Interphase cytogenetic abnormalities in chronic lymphocytic leukemia may predict response to rituximab. Cancer Res. 63:2003;36-38
    • (2003) Cancer Res , vol.63 , pp. 36-38
    • Byrd, J.C.1    Smith, L.2    Hackbarth, M.L.3    Flinn, I.W.4    Young, D.5    Proffitt, J.H.6
  • 97
    • 0037043653 scopus 로고    scopus 로고
    • Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy
    • Stilgenbauer S., Dohner H. Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p53 gene mutation and resistance to chemotherapy. N Engl J Med. 347:2002;452-453
    • (2002) N Engl J Med , vol.347 , pp. 452-453
    • Stilgenbauer, S.1    Dohner, H.2
  • 98
    • 11144357657 scopus 로고    scopus 로고
    • Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
    • Lozanski G., Heerema N.A., Flinn I.W., Smith L., Harbison J., Webb J., et al. Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood. 103:2004;3278-3281
    • (2004) Blood , vol.103 , pp. 3278-3281
    • Lozanski, G.1    Heerema, N.A.2    Flinn, I.W.3    Smith, L.4    Harbison, J.5    Webb, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.