CD38 expression and secondary 17p deletion are important prognostic factors in chronic lymphocytic leukaemia

British Journal of Haematology

Volumn 116, Issue 1, 2002, Pages 142-150

  Garand, Richard ^a   Bataille, Régis ^a   Robillard, Nelly ^a   Avet Loiseau, Hervé ^a   Penther, Dominique ^a   Harousseau, Jean Luc ^b   Mahé, Béatrice ^b   Ifrah, Norbert ^c   Hamidou, Mohamed ^d  

^a Institut de Biologie   (United States)

^b NANTES UNIVERSITY HOSPITAL   (France)

^c Centre Hospitalier Universitaire   (United States)

^d Service de Médecine Interne A   (United States)

Author keywords

17p deletion; CD38; Chronic lymphocytic leukaemia; Cytogenetic diagnosis

Indexed keywords

CD38 ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CHROMOSOME 11Q; CHROMOSOME 13Q; CHROMOSOME 17P; CHROMOSOME ABERRATION; CHROMOSOME DELETION; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; STATISTICAL ANALYSIS; SURVIVAL RATE; TRISOMY 13;

ADP-RIBOSYL CYCLASE; AGED; ANTIGENS, CD; ANTIGENS, CD38; ANTIGENS, DIFFERENTIATION; CHROMOSOME ABERRATIONS; DISEASE-FREE SURVIVAL; FEMALE; GENE DELETION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, CHRONIC; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NAD+ NUCLEOSIDASE; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 0036165916     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0007-1048.2001.3205.x     Document Type: Article

References (39)

1. High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies
2. Proposals for the classification of chronic (mature) B and T lymphoid leukaemias
3. A clinical staging system for chronic lymphocytic leukemia
4. Translocations involving the short arm of chromosome 17 in chronic B-lymphoid disorders: Frequent occurrence of dicentric rearrangements and possible association with adverse outcome
5. The search for genetic clues in chronic lymphocytic leukemia
6. Prognostic implications of CD38 and myeloid-associated markers expression in B-cell
7. National Cancer Institute- sponsored working group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment
8. Regression models and life-tables
9. Further characterization of morphologically defined typical and atypical CLL: A clinical, immunophenotypic, cytogenetic and prognostic study on 390 cases
10. Toward a clinically relevant cytogenetic classification of chronic lymphocytic leukemia and related disorders
11. Ig gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
12. CD38 expression identifies two distinct prognostic subsets in B-chronic lymphocytic leukemia (B-CLL)
13. Genetic abnormalities in chronic lymphocytic leukemia and clinical and prognostic implications
14. 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis
15. Genomic aberrations and survival in chronic lymphocytic leukemia
16. Karyotypic evolution in CLL: Identification of a new subgroup of patients with deletions of 11q and advanced or progressive disease
17. VH gene status but not additional cytogenetic abnormalities predicts clinical outcome with CLL and trisomy 12
18. Trisomy 12 is found in CLL with both typical and atypical immunophenotype and has no prognostic significance
19. Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia
20. Immunoglobulin V genes and CD38 expression in CLL
21. Cytogenetics in chronic lymphocytic leukemia
22. Nonparametric estimation from incomplete observations
23. p53 abnormalities in CLL are associated with excess of prolymphocytes and poor prognosis
24. Sequential FISH studies in B-CLL reveal clonal evolution with the acquisition of deletions involving 6q21, 11q22 and 17p13 (TP53)
25. CD38 expression and Ig VH gene mutation in B-cell chronic lymphocytic leukemia
26. Trisomy 12 defines a group of CLL with atypical morphology: Correlation between cytogenetic, clinical and laboratory features in 544 patients
27. The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL
28. Improvement of the chronic lymphocytic leukemia scoring system with the monoclonal antibody SN8 (CD79b)
29. Mutational status of Ig V (H) genes provides clinically valuable information in B-cell chronic lymphocytic leukemia
30. Prediction of VH gene mutation status in B-CLL using immunophenotyping and trephine histology
31. Cytogenetic and molecular abnormalities in chronic lymphocytic leukemia
32. Atypical lymphocyte morphology: An adverse prognostic factor for disease progression in stage A CLL independent of trisomy 12
33. The mutational status of immunoglobulin V genes is the most important prognostic factor in B-CLL
34. Can CD38 expression act as a surrogate marker for Ig V gene mutational status in B-CLL?
35. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. II. Analysis and examples
36. Clinical staging of chronic lymphocytic leukemia
37. The prognostic significance of 13q14 deletions in chronic lymphocytic leukemia
38. Molecular cytogenetic analysis of B-cell chronic lymphocytic leukemia
39. CD38 expression is a poor predictor for VH gene mutational status and prognosis in chronic lymphocytic leukemia