Cell depletion due to diphtheria toxin fragment A after Cre-mediated recombination

Molecular and Cellular Biology

Volumn 24, Issue 17, 2004, Pages 7636-7642

  Brockschnieder, Damian ^a   Lappe Siefke, Corinna ^a,b   Goebbels, Sandra ^b   Boesl, Michael R ^a,c   Nave, Klaus Armin ^b   Riethmacher, Dieter ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^c MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; DIPHTHERIA TOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BACTERIAL GENE; CELL LOSS; CELL SPECIFICITY; CELL TYPE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEGENERATIVE DISEASE; DEVELOPMENTAL DISORDER; DT A GENE; EMBRYO; GENE EXPRESSION; GENE LOCUS; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; IN VIVO STUDY; LIVER; LIVER CELL; NONHUMAN; OLIGODENDROGLIA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROMOTER REGION; PYRAMIDAL NERVE CELL; TRANSGENIC MOUSE;

ANIMALIA; BACTERIA (MICROORGANISMS); EUKARYOTA; MUS MUSCULUS;

EID: 4344684040     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.17.7636-7642.2004     Document Type: Article

References (40)

1. Amiel, J., and S. Lyonnet. 2001. Hirschsprung disease, associated syndromes, and genetics: a review. J. Med. Genet. 38:729-739.
2. Argos, P., A. Landy, K. Abremski, J. B. Egan, E. Haggard-Ljungquist, R. H. Hoess, M. L. Kahn, B. Kalionis, S. V. Narayana, L. S. Pierson III, et al. 1986. The integrase family of site-specific recombinases: regional similarities and global diversity. EMBO J. 5:433-440.
3. Awatramani, R., P. Soriano, J. J. Mai, and S. Dymecki. 2001. An Flp indicator mouse expressing alkaline phosphatase from the ROSA26 locus. Nat. Genet. 29:257-259.
4. Bartholoma, A., and K. A. Nave. 1994. NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons. Mech. Dev. 48:217-228.
5. Chandross, K. J., R. I. Cohen, P. Paras, Jr., M. Gravel, P. E. Braun, and L. D. Hudson. 1999. Identification and characterization of early glial progenitors using a transgenic selection strategy. J. Neurosci. 19:759-774.
6. Collier, R. J. 1975. Diphtheria toxin: mode of action and structure. Bacteriol. Rev. 39:54-85.
7. Collier, R. J. 2001. Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century. Toxicon 39:1793-1803.
8. Davis, B. R., and G. Zauli. 1995. Effect of human immunodeficiency virus infection on haematopoiesis. Bailliere's Clin. Haematol. 8:113-130.
9. de Waegh, S. M., V. M. Lee, and S. T. Brady. 1992. Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells. Cell 68:451-463.
10. Farley, F. W., P. Soriano, L. S. Steffen, and S. M. Dymecki. 2000. Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28:106-110.
11. Foran, D. R., and A. C. Peterson. 1992. Myelin acquisition in the central nervous system of the mouse revealed by an MBP-LacZ transgene. J. Neurosci. 12:4890-4897.
12. Friedrich, G., and P. Soriano. 1991. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5:1513-1523.
13. Grieshammer, U., M. Lewandoski, D. Prevette, R. W. Oppenheim, and G. R. Martin. 1998. Muscle-specific cell ablation conditional upon Cre-mediated DNA recombination in transgenic mice leads to massive spinal and cranial motoneuron loss. Dev. Biol. 197:234-247.
14. Hoess, R. H., M. Ziese, and N. Sternberg. 1982. P1 site-specific recombination: nucleotide sequence of the recombining sites. Proc. Natl. Acad. Sci. USA 79:3398-3402.
15. Horcher, M., A. Souabni, and M. Busslinger. 2001. Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis. Immunity 14:779-790.
16. Kellendonk, C., C. Opherk, K. Anlag, G. Schutz, and F. Tronche. 2000. Hepatocyte-specific expression of Cre recombinase. Genesis 26:151-153.
17. Klinge, O. 1973. Cytologic and histologic aspects of toxically induced liver reactions. Curr. Top. Pathol. 58:91-116.
18. Lakso, M., B. Sauer, B. Mosinger, Jr., E. J. Lee, R. W. Manning, S. H. Yu, K. L. Mulder, and H. Westphal. 1992. Targeted oncogene activation by site-specific recombination in transgenic mice. Proc. Natl. Acad. Sci. USA 89:6232-6236.
19. Lappe-Siefke, C., S. Goebbels, M. Gravel, E. Nicksch, J. Lee, P. E. Braun, I. R. Griffiths, and K. A. Nave. 2003. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat. Genet. 33:366-374.
20. Lewandoski, M. 2001. Conditional control of gene expression in the mouse. Nat. Rev. Genet. 2:743-755.
21. Lobe, C. G., K. E. Koop, W. Kreppner, H. Lomeli, M. Gertsenstein, and A. Nagy. 1999. Z/AP, a double reporter for cre-mediated recombination. Dev. Biol. 208:281-292.
22. Lozano, A. M., A. E. Lang, W. D. Hutchison, and J. O. Dostrovsky. 1998. New developments in understanding the etiology of Parkinson's disease and in its treatment. Curr. Opin. Neurobiol. 8:783-790.
23. Mallet, V. O., C. Mitchell, J. E. Guidotti, P. Jaffray, M. Fabre, D. Spencer, D. Arnoult, A. Kahn, and H. Gilgenkrantz. 2002. Conditional cell ablation by tight control of caspase-3 dimerization in transgenic mice. Nat. Biotechnol. 20:1234-1239.
24. Mao, X., Y. Fujiwara, and S. H. Orkin. 1999. Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc. Natl. Acad. Sci. USA 96:5037-5042.
25. Messing, A., R. R. Behringer, J. P. Hammang, R. D. Palmiter, R. L. Brinster, and G. Lemke. 1992. P0 promoter directs expression of reporter and toxin genes to Schwann cells of transgenic mice. Neuron 8:507-520.
26. Nagy, A. 2000. Cre recombinase: the universal reagent for genome tailoring. Genesis 26:99-109.
27. Palmiter, R. D., R. R. Behringer, C. J. Quaife, F. Maxwell, I. H. Maxwell, and R. L. Brinster. 1987. Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell 50:435-443.
28. Pasparakis, M., M. Schmidt-Supprian, and K. Rajewsky. 2002. IκB kinase signaling is essential for maintenance of mature B cells. J. Exp. Med. 196:743-752.
29. Rickert, R. C., J. Roes, and K. Rajewsky. 1997. B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 25:1317-1318.
30. Riethmacher, D., E. Sonnenberg-Riethmacher, V. Brinkmann, T. Yamaai, G. R. Lewin, and C. Birchmeier. 1997. Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature 389:725-730.
31. Rinkenberger, J. L., and S. J. Korsmeyer. 1997. Errors of homeostasis and deregulated apoptosis. Curr. Opin. Genet. Dev. 7:589-596.
32. Saito, M., T. Iwawaki, C. Taya, H. Yonekawa, M. Noda, Y. Inui, E. Mekada, Y. Kimata, A. Tsuru, and K. Kohno. 2001. Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat. Biotechnol. 19:746-750.
33. Schwab, M. H., A. Bartholomae, B. Heimrich, D. Feldmeyer, S. Druffel-Augustin, S. Goebbels, F. J. Naya, S. Zhao, M. Frotscher, M. J. Tsai, and K. A. Nave. 2000. Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus. J. Neurosci. 20:3714-3724.
34. Schwab, M. H., S. Druffel-Augustin, P. Gass, M. Jung, M. Klugmann, A. Bartholomae, M. J. Rossner, and K. A. Nave. 1998. Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice. J. Neurosci. 18:1408-1418.
35. Shimizu, C., C. Akazawa, S. Nakanishi, and R. Kageyama. 1995. MATH-2, a mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal, is specifically expressed in the nervous system. Eur. J. Biochem. 229:239-248.
36. Soriano, P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21:70-71.
37. Sprinkle, T. J. 1989. 2′,3′-cyclic nucleotide 3′-phosphodiesterase, an oligodendrocyte-Schwann cell and myelin-associated enzyme of the nervous system. Crit. Rev. Neurobiol. 4:235-301.
38. Stobrawa, S. M., T. Breiderhoff, S. Takamori, D. Engel, M. Schweizer, A. A. Zdebik, M. R. Bosl, K. Ruether, H. Jahn, A. Draguhn, R. Jahn, and T. J. Jentsch. 2001. Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus. Neuron 29:185-196.
39. Yuan, X., R. Chittajallu, S. Belachew, S. Anderson, C. J. McBain, and V. Gallo. 2002. Expression of the green fluorescent protein in the oligodendrocyte lineage: a transgenic mouse for developmental and physiological studies. J. Neurosci. Res. 70:529-545.
40. Zambrowicz, B. P., A. Imamoto, S. Fiering, L. A. Herzenberg, W. G. Kerr, and P. Soriano. 1997. Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc. Natl. Acad. Sci. USA 94:3789-3794.