Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): Spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice

Journal of Neuroscience

Volumn 18, Issue 4, 1998, Pages 1408-1418

  Schwab, Markus H ^a   Druffel Augustin, Silke ^b   Gass, Peter ^a   Jung, Martin ^a   Klugmann, Matthias ^b   Bartholomae, Angelika ^a   Rossner, Moritz J ^a   Nave, Klaus Armin ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Basic helix loop helix proteins; Forebrain development; Homologous recombination; NDRF; NeuroD; Neuronal differentiation factors; NEX 1

Indexed keywords

HELIX LOOP HELIX PROTEIN;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; FETUS; FOREBRAIN; GENE DISRUPTION; GENE EXPRESSION; GENETIC RECOMBINATION; MOUSE; NERVE CELL DIFFERENTIATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL;

EID: 0032519872     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-04-01408.1998     Document Type: Article

References (8)

1. Aghajanian GK, Bloom FE (1967) The formation of synaptic junctions in developing rat brain: a quantitative electron microscopic study. Brain Res 6:716-727.
2. Akazawa C, Sasai Y, Nakanishi S, Kageyama R (1992) Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system. J Biol Chem 267:21879-21885.
3. Akazawa C, Ishibashi M, Shimizu C, Nakanishi S, Kageyama R (1995) A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. J Biol Chem 270:8730-8738.
4. Bartholomae A, Nave KA (1994) NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons. Mech Dev 48:217-228.
5. Bartholomae A, Schwab MH, Schrama L, Gass P, Nave KA (1995) The brain-specific helix-loop-helix protein NEX-1: a neuronal activator of GAP-43? Soc Neurosci Abstr 21:1290.
6. Basi GS, Jacobson RD, Virag I, Schilling J, Skene JH (1987) Primary structure and transcriptional regulation of GAP-43, a protein associated with nerve growth. Cell 49:785-791.
7. Begley CG, Lipkowitz S, Gobel V, Mahon KA, Bertness V, Green AR, Gough NM, Kirsch IR (1992) Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system. Proc Natl Acad Sci USA 89:38-42.
8. Braun T, Arnold HH (1995) Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development. EMBO J 14:1176-1186.