Role of leptin in farm animals: A review

Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine

Volumn 51, Issue 4, 2004, Pages 157-166

  Macajova M ^a   Lamosova D ^a   Zeman, M ^a,b  

^a INSTITUTE OF CHEMISTRY   (Slovakia)

^b Physics and Informatics   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

LEPTIN;

ADIPOSE TISSUE; ANIMAL; BLOOD; DOMESTIC ANIMAL; METABOLISM; REVIEW;

ADIPOSE TISSUE; ANIMALS; ANIMALS, DOMESTIC; LEPTIN;

EID: 4344639254     PISSN: 0931184X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1439-0442.2004.00619.x     Document Type: Review

References (116)

1. Ahima, R. S., D. Prabakaran, C. Mantzoros, D. Qu, B. Lowell, E. Maratos Flier, and J. S. Flier, 1996: Role of leptin in the neuroendocrine response to fasting. Nature 382, 250-252.
2. Ahima, R. S., C. Bjorbaek, S. Y. Osei, and J. S. Flier, 1999: Regulation of neuronal and glial proteins by leptin: implications for brain development. Endocrinology 140, 2755-2762.
3. Amstalden, M., M. R. Garcia, S. W. Williams, R. L. Stanko, S. E. Nizielski, C. D. Morrison, D. H. Keisler, and G. L. Williams, 2000: Leptin gene expression, circulating leptin, and luteinizing hormone pulsatility are acutely responsive to short-term fasting in prepubertal heifers: relationship to circulating insulin and insulin-like growth factor-I. Biol. Reprod. 63, 127-133.
4. Amstalden, M., M. R. Garcia, R. L. Stanko, S. E. Nizielski, C. D. Morrison, D. H. Keisler, and G. L. Williams, 2002: Central infusion of recombinant ovine leptin normalizes plasma insulin and stimulates a novel hypersecretion of luteinizing hormone after short-term fasting in mature beef cows. Biol. Reprod. 66, 1555-1561.
5. Antczak, M., and J. Van Blerkom, 1997: Oocyte influence on early development: the regulatory proteins leptin and STAT3 are polarized in mouse and human oocytes and differentially distributed within the cells of the preimplantation stage embryo. Mol. Hum. Reprod. 3, 1067-1086.
6. Apter, D., T. L. Butzow, G. A. Laughlin, and S. S. Yen, 1993: Gonadotropin-releasing hormone pulse generator activity during pubertal transition in girls: pulsatile and diurnal patterns of circulating gonadotropins. J. Clin. Endocrinol. Metab. 76, 940-949.
7. Ashwell, C. M., S. M. Czerwinski, D. M. Brocht, and J. P. McMurtry, 1999a: Hormonal regulation of leptin expression in broiler chickens. Am. J. Physiol. 276, 226-232.
8. Ashwell, C. M., J. P. McMurtry, X. H. Wang, Y. Zhou, and R. Vasilatos-Younken, 1999b: Effects of growth hormone and pair-feeding on leptin mRNA expression in liver and adipose tissue. Domest. Anim. Endocrinol. 17, 77-84.
9. Bado, A., S. Levasseur, S. Attoub, S. Kermogant, and J. P. Laigneau, 1998: The stomach is a source of leptin. Nature 394, 790-793.
10. Barb, C. R., X. Yan, M. J. Azain, R. R. Kraeling, G. B. Rampacek, and T. G. Ramsay, 1998: Recombinant porcine leptin reduces feed intake and stimulates growth hormone secretion in swine. Domest. Anim. Endocrinol. 15, 77-86.
11. Benomar, Y., N. Rideau, S. Crochet, M. Derouet, and M. Taouis, 2003: Leptin fully suppresses acetylcholine induced insulin secretion and is reversed by tolbutamide in isolated perfused chicken pancreas. Horm. Metab. Res. 35, 81-85.
12. Bjorbaek, C., S. Uotani, B. de Silva, and J. S. Flier, 1997: Divergent signaling capacities of the long and short isoforms of the leptin. J. Biol. Chem. 272, 32686-32695.
13. Bjorbaek, C., J. K. Elmquist, P. Michl, R. S. Ahima, and A. van Bueren, 1998: Expression of leptin receptor isoforms in rat brain microvessels. Endocrinology 139, 3485-3491.
14. Block, S. S., W. R. Butler, R. A. Ehrhardt, A. W. Bell, M. E. Van Amburgh, and Y. R. Boisclair, 2001: Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance. J. Endocrinol. 171, 339-348.
15. Block, S. S., R. P. Rhoads, D. E. Bauman, M. A. McGuire, B. A. Crooker, J. M. Griinari, T. R. Mackle, W. J. Weber, R. A. Ehrhardt, M. E. Van Amburgh, and Y. R. Boisclair, 2003: Demonstration of a role for insulin in the regulation of leptin in lactating dairy cows. J. Dairy Sci. 86, 3508-3515.
16. Boden, G., X. Chen, J. W. Kolaczynski, and M. Polansky, 1997: Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects. J. Clin. Invest. 100, 1107-1113.
17. Bornstein, S., I. Plavnik, and Y. Lev, 1984: Body weight and/or fatness as potential determinants of the onset of egg production in broiler breeder hens. Br. Poult. Sci. 25, 323-341.
18. Bungo, T., M. Shimojo, Y. Masuda, T. Tachibanab, S. Tanaka, K. Sugahara, and M. Furuse, 1999: Intraventricular administration of mouse leptin does not reduce food intake in the chicken. Brain Res. 817, 196-198.
19. Carro, E., R. Senaris, R. Considine, F. Casanueva, and C. Dieguez, 1997: Regulation of in vivo growth hormone secretion by leptin. Endocrinology 138, 2203-2206.
20. Carro, E., L. Seoane, R. Senaris, F. Casanueva, and C. Dieguez, 2000: Leptin increases in vivo GH responses to GHRH and GHRP-6 in food-deprived rats. Eur. J. Endocrinol. 142, 66-70.
21. Casabiell, X., V. Pineiro, M. A. Tome, R. Peino, C. Dieguez, and F. F. Casnueva, 1997: Presence of leptin in colostrum and/or breast milk from lactating mothers: a potential role in the regulation of neonatal food intake. J. Clin. Endocrinol. Metab. 82, 4270-4273.
22. Casanueva, F. F., and C. Dieguez, 1999: Neuroendocrine regulation and actions of leptin. Front. Neuroendocrinol. 20, 317-363.
23. Castracane, V. D., R. R. Kraemer, M. A. Franken, G. R. Kraemer, and T. Gimpel, 1998: Serum leptin concentration in women: effect of age, obesity, and estrogen administration. Fertil. Steril. 70, 472-477.
24. Chehab, F. F., M. E. Lim, and R. H. Lu, 1996: Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet. 12, 318-320.
25. Chehab, F. F., K. Mounzih, R. H. Lu, and M. E. Lim, 1997: Early onset of reproductive function in normal female mice treated with leptin. Science 275, 88-90.
26. Chelikani, P. K., J. D. Ambrose, D. H. Keisler, and J. J. Kennelly, 2004: Effect of short-term fasting on plasma concentrations of leptin and other hormones and metabolites in dairy cattle. Domest. Anim. Endocrinol. 26, 33-48.
27. Cheung, C. C., J. E. Thornton, J. L. Kuijper, D. S. Weigle, D. K. Clifton, and D. A. Steiner, 1997: Leptin is a metabolic gate for the onset of puberty in the female rat. Endocrinology 138, 855-858.
28. Cinti, S., R. C. Frederich, M. C. Zingaretti, R. DeMatteis, J. S. Flier, and B. B. Lowell, 1997: Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue. Endocrinology 138, 797-804.
29. Cioffi, J. A., J. Van Blerkom, M. Antczak, A. Shafer, S. Wittmer, and H. R. Snodgrass, 1997: The expression of leptin and its receptors in pre-ovulatory human follicles. Mol. Hum. Reprod. 3, 467-472.
30. Clement, K., C. Vaisse, N. Lahlou, S. Cabrol, V. Pelloux, D. Cassuto, M. Gourmelen, C. Dina, and J. Chambaz, 1998: A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392, 398-401.
31. Considine, R. V., and J. F. Caro, 1997: Leptin and the regulation of body weight. Int. J. Biochem. Cell Biol. 29, 1255-1272.
32. Czaja, K., M. Lakomy, W. Sienkiewicz, J. Kaleczyc, Z. Pidsudko, C. R. Barb, G. B. Rampacek, and R. R. Kraeling, 2002: Distribution of neurons containing leptin receptors in the hypothalamus of the pig. Biochem. Biophys. Res. Commun. 298, 333-337.
33. DeMatteis, R., K. Dashtipour, A. Ognibene, and S. Cinti, 1998: Localization of leptin receptor splice variants in mouse peripheral tissues by immunohistochemistry. Proc. Nutr. Soc. 57, 441-448.
34. Denbow, D. M., S. Meade, A. Robertson, J. P. McMurtry, M. Richards, and Ch. Ashwell, 2000: Leptin-induced decrease in food intake in chickens. Physiol. Behav. 69, 359-362.
35. Doyon, C., G. Drouin, V. L. Trudeau, and T. W. Moon, 2001: Molecular evolution of leptin. Gen. Comp. Endocrinol. 124, 188-198.
36. Dridi, S., N. Raver, E. E. Gussakovsky, M. Derouet, M. Picard, A. Gertler, and M. Taouis, 2000: Biological activities of recombinant chicken leptin C4S analog compared with unmodified leptins. Am. J. Physiol. 279, 116-123.
37. Dyer, C. J., J. M. Simmons, R. L. Matteri, and D. H. Keisler, 1997a: Leptin receptor mRNA is expressed in ewe anterior pituitary and adipose tissue and is differentially expressed in hypothalamic regions of well-fed and feed-restricted ewes. Domest. Anim. Endocrinol. 14, 119-128.
38. Dyer, C. J., J. M. Simmons, R. L. Matteri, and D. H. Keisler, 1997b: Effects of an intravenous injection of NPY on leptin and NPY-Y1 receptor mRNA expression in ovine adipose tissue. Domest. Anim. Endocrinol. 14, 325-333.
39. Elmquist, J. K., C. Bjorbaek, J. S. Ahima, J. S. Flier, and C. B. Saper, 1998: Distribution of leptin receptor mRNA isoforms in the rat brain. J. Comp. Neurol. 395, 535-547.
40. Escobar-Morreale, H. F., F. Escobar del Rey, and G. Morreale de Escobar, 1997: Thyroid hormones influence serum leptin concentrations in the rat. Endocrinology 138, 4485-4488.
41. Fehmann, H. C., C. Peiser, and H. P. Bode, 1997: Leptin: a potent inhibitor of insulin secretion. Peptides 18, 1267-1273.
42. Fei, H., H. J. Okano, C. Li, G. H. Lee, and C. Zhao, 1997: Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl Acad. Sci. U S A 94, 7001-7005.
43. Finn, P. D., M. J. Cunningham, K. Y. F. Pau, H. G. Spies, D. K. Clifton, and R. A. Steiner, 1998: The stimulatory effect of leptin on the neuroendocrine reproductive axis of the monkey. Endocrinology 139, 4652-4662.
44. Frederich, R. C., A. Hamann, S. Anderson, B. Lollman, B. B. Lowell, and J. S. Flier, 1995: Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 1, 1311-1314.
45. Friedman, J. M., and J. L. Halaas, 1998: Leptin and the regulation of body weight in mammals. Nature 395, 763-770.
46. Friedman-Einat, M., T. Boswell, G. Horev, and P. Sharp, 1999: The chicken leptin gene: has it been cloned? Gen. Comp. Endocrinol. 115, 354-363.
47. Frühbeck, G., M. Aguado, and J. A. Martinez, 1997: In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin. Biochem. Biophys. Res. Commun. 240, 590-594.
48. Gainsford, T., T. A. Willson, D. Metcalf, E. Handman, C. McFarlane, A. Ng, N. A. Nicola, W. S. Alexander, and D. J. Hilton, 1996: Leptin can induce proliferation, differentiation, and functional activation of hematopoietic cells. Proc. Natl Acad. Sci. USA 93, 14564-14568.
49. Grunfeld, C., C. Zhao, J. Fuller, and A. Pollack, 1996: Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J. Clin. Invest. 97, 2152-2157.
50. Hakansson, M. L., H. Brown, N. Ghilardi, R. C. Skoda, and B. Meister, 1998: Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J. Neurosci. 18, 559-572.
51. Harris, R. B. S., T. G. Ramsay, S. R. Smith, and R. C. Bruch, 1996: Early and late stimulation of ob mRNA expression in mealfed and overfed rats. J. Clin. Invest. 97, 2020-2026.
52. Heidler, B., H. Sauerwein, U. Heintges, J. Aurich, W. Pohl, and C. Aurich, 2002: Metabolic profiles and plasma leptin concentrations in lactating and non-lactating mares. Theriogenology 58, 557-561.
53. Hoggard, N., L. Hunter, J. Duncan, and L. Wiliams, 1997: Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. PNAS 94, 11073-11078.
54. Hoggard, N., L. Hunter, P. Trayhurn, P. Williams, S. W. Mercer, 1998: Leptin and reproduction. Proc. Nutr. Soc. 57, 421-427.
55. Horev, G., P. Einat, T. Aharoni, Y. Eshdat, and M. Friedman-Einat, 2000: Molecular cloning and properties of the chicken leptin-receptor (CLEPR) gene. Mol. Cell. Endocrinol. 162, 95-106.
56. Huang, L., Z. Wang, and C. Li, 2001: Modulation of circulating leptin levels by its soluble receptor. J. Biol. Chem. 276, 6343-6349.
57. Ishii, S., T. Shibasaki, T. Murakami, K. Shima, and I. Wakabayashi, 2000: Response of leptin mRNA to 24-h food deprivation and refeeding is influenced by age in rats. Regul. Pept. 92, 45-50.
58. Kaira, S. P., M. G. Dube, S. Pu, B. Xu, T. L. Horvath, and P. S. Kaira, 1999: Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocrinol. Rev. 20, 68-100.
59. Kamohara, S., R. Burcelin, and J. L. Halaas, 1997: Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 389, 374-377.
60. Karlsson, C., K. Lindell, E. Svensson, C. Bergh, P. Lind, and H. Billig, 1997: Expression of functional leptin receptors in the human ovary. J. Clin. Endocrinol. Metab. 82, 4144-4148.
61. Keisler, D. H., J. A. Daniel, and C. D. Morrison, 1999: The role of leptin in nutritional status and reproductive function. J. Reprod. Fertil. Suppl. 54, 425-435.
62. Lamošová, D., and M. Zeman, 2001: Effect of leptin and insulin on chick embryonic muscle cells and hepatocytes. Physiol. Res, 50, 183-189.
63. Lamošová, D., M. Máčajová, M. Zeman, Š. Mózeš, and D. Ježová, 2003: Effect of in ovo leptin administration on development of Japanese quail. Physiol. Res. 52, 201-209.
64. Lewandowski, K., R. Horn, C. J. O'Callaghan, D. Dunlop, G. F. Medley, and P. O'Hare, 1999: Free leptin, bound leptin, and soluble leptin receptor in normal and diabetic pregnancies. J. Clin. Endocrinol. Metab. 84, 300-306.
65. Li, H., M. Matheny, and M. J. Scarpace, 1997: Beta 3-adrenergic-mediated suppression of leptin gene expression in rats. Am. J. Physiol. 272, 1031-1036.
66. Licinio, J., A. B. Negrao, C. Mantzoros, V. Kaklamani, M. L. Wong, P. B. Bongiorno, and A. Mulla, 1998: Synchronicity of frequently-sampled 24-hour concentrations of circulating leptin, luteninizing hormone, and estradiol in healthy woman. Proc. Natl Acad. Sci. USA 95, 2541-2546.
67. Lord, G. M., G. Matarese, J. K. Howard, J. R. Baker, S. R. Bloom, and L. I. Lechler, 1998: Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394, 897-901.
68. Lostao, M. P., E. Urdaneta, and E. Martinez-Anso, 1998: Presence of leptin receptors in rat small intestine and leptin effects on sugar absorption. FEBS Lett. 423, 302-306.
69. Máčajová, M., D. Lamošová, and M. Zeman, 2002: Role of leptin in Japanese quail development. Acta Vet. Brno 71, 473-479.
70. Máčajová, M., D. Lamošová, and M. Zeman, 2003: Physiological effects of leptin, insulin and triamcinolone on adult male Japanese quail. Acta Vet. Brno 72, 515-522.
71. McCann, S., M. Kimura, A. Walczewska, S. Karanth, V. Rettori, and W. Yu, 1998: Hypothalamic control of FSH and LH by FSH-RF, LHRH, cytokines, leptin and nitric oxide. Neuroimmunomodulation 5, 193-202.
72. McMurtry, J., C. Ashwell, and M. Richards, 2000: Hormonal and developmental regulation of leptin gene expression in the chicken. In: Gupta, D. (ed.) Proceedings the 7th International Symposium on Avian Endocrinology, Varanasi, India.
73. McShane, T. M., T. May, J. L. Miner, and D. H. Keisler, 1992: Central actions of neuropeptide Y may provide aneuromodulatory link between nutrition and reproduction. Biol. Reprod. 46, 1151-1157.
74. Madej, T., M. S. Boguski, and S. H. Bryant, 1995: Threading analysis suggest that the obese gene product may be a helical cytokine. FEBS Lett. 373, 13-18.
75. Magni, P., R. Vettor, C. Pagano, A. Calcagno, E. Beretta, E. Messi, M. Zanisi, L. Martini, and M. Motta, 1999: Expression of a leptin receptor in immortalized gonadotropin-releasing hormone-secreting neurons. Endocrinology 140, 1581-1585.
76. Masuzaki, H., Y. Ogawa, and N. Sagawa, 1997: Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat. Med. 3, 1029-1033.
77. Mercer, J., N. Hoggard, L. Williams, C. Lawrence, L. Hannah, and P. Trayhurn, 1996: Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 387, 113-116.
78. Mercer, J. G., K. M. Moar, D. V. Rayner, P. Trayhurn, and N. Hoggard, 1997: Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold exposed lean mice. FEBS Lett. 402, 185-188.
79. Meyer, C., D. Robson, N. Rackovsky, V. Nadkarni, and J. Gerich, 1997: Role of the kidney in human leptin metabolism. Am. J. Physiol. E273, 903-907.
80. Mistry, A. M., A. Swick, and D. R. Romsos, 1999: Leptin alters metabolic rates before acquisition of its anorectic effect in developing neonatal mice. Am. J. Physiol. R277, 742-747.
81. Morash, B., L. Johnstone, and C. Leopold, 2000: The regulation of leptin gene expression in the C6 glioblastoma cell line. Mol. Cell. Endocrinol. 165, 97-105.
82. Morash, B., D. Wilkinson, P. Murphy, E. Ur, and M. Wilkinson, 2001: Developmental regulation of leptin gene expression in rat brain and pituitary. Mol. Cell. Endocrinol. 185, 151-159.
83. Morrison, C. D., J. A. Daniel, B. J. Holmberg, J. Djiane, N. Raver, A. Gertler, and D. H. Keisler, 2001: Central infusion of leptin into well-fed and undernourished ewe lambs: effects on feed intake and serum concentrations of growth hormone and luteinizing hormone. J. Endocrinol. 168, 317-324.
84. Morton, N. M., V. Emilsson, Y. L. Liu, and M. A. Cawthorne, 1998: Leptin action in intestinal cells. J. Biol. Chem. 273, 26194-26201.
85. Nagatani, S., Y. Zeng, D. H. Keisler, D. L. Foster, and C. A. Jaffe, 2000: Leptin regulates pulsatile luteinizing hormone and growth hormone secretion in the sheep. Endocrinology 141, 3965-3975.
86. Ohkubo, T., M. Tanaka, and K. Nakashima, 2000: Structure and tissue distribution of chicken leptin receptor mRNA. Biochim. Biophys. Acta 1491, 303-308.
87. Roh, S.-G., I. J. Clarke, R.-W. Xu, J. W. Goding, K. Loneragan, and C. Chen, 1998: The in vitro effect of leptin on basal and growth hormone-releasing hormone-stimulated growth hormone secretion from the ovine pituitary gland. Neuroendocrinology 68, 361-364.
88. Rosebrough, R. W., J. P. McMurtry, and R. Vasilatos-Younken, 1991: Effect of pulsatile or continuous administration of pituitary-derived chicken growth hormone (pcGH) on lipid metabolism in broiler pullets. Comp. Biochem. Physiol. 99, 207-214.
89. Saladin, R., P. De-Vos, M. Guerre-Millo, and A. Leturge, 1995: Transient increase in obese gene expression after food intake or insulin administration. Nature 377, 527-529.
90. Sato, K., M. Nishida, T. Takahashi, and Y. Akiba, 2000: Nutritional Regulation of Leptin Expression in Adipose Tissues of Broiler Chickens, Vol. XXI. World's Poultry Congress, Montreal, p. 27.
91. Scacchi, M., A. Pincelli, and F. Cavagnini, 1999: Growth hormone in obesity. Int. J. Obes. 23, 260-271.
92. Schwartz, M. V., R. J. Seeley, and L. A. Campfield, 1996: Identification of leptin action in rat hypothalamus. J. Clin. Invest. 98, 1101-1106.
93. Shimon, I., X. Yan, D. A. Magoffin, T. C. Friedman, and S. Melmed, 1998: Intact leptin receptor is selectively expressed in human fetal pituitary and pituitary adenomas and signals human fetal pituitary growth hormone secretion. J. Clin. Endocrinol. Metab. 83, 4059-4064.
94. Sierra-Honigmann, M. R., A. K. Nath, C. Murakami, G. Garcia-Cardena, A. Papapetropoulos, W. C. Sessa, and L. A. Madge, 1998: Biological action of leptin as an angiogenic factor. Science 281, 1683-1686.
95. Simon, J., B. Chevalier, M. Derouet, and B. Leclerq, 1991: Normal number and kinase activity of insulin receptors in liver of genetically fat chickens. J. Nutr. 121, 379-385.
96. Slieker, L. J., K. W. Sloop, P. L. Surface, A. Kriaucinaus, and F. LaQuier, 1996: Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J. Biol. Chem. 271, 5301-5304.
97. Smith, J. L., and L. G. Sheffield, 2002: Production and regulation of leptin in bovine mammary epithelial cells. Domest. Anim. Endocrinol. 22, 145-154.
98. Smith, G. D., L. M. Jackson, and D. L. Foster, 2002: Leptin regulation of reproductive function and fertility. Theriogenology 57, 73-86.
99. Spicer, L. J., and C. C. Francisco, 1998: Adipose obese gene product, leptin, inhibits bovine ovarian thecal cell steroidogenesis. Biol. Reprod. 58, 207-212.
100. Stein, T. P., T. O. Scholl, M. D. Schluter, and C. M. Schroeder, 1998: Plasma leptin influences gestational weight gain and postpartum weight retention. Am. J. Clin. Nutr. 68, 1236-1240.
101. Stephens, T. W., M. Basinski, P. K. Bristow, J. M. Bue-Vallesky, S. G. Burgett, and L. Craft, 1995: The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530-532.
102. Strobel, A., T. Issad, L. Camoin, M. Ozata, and A. D. Strosberg, 1998: Aleptin missense mutation associated with hypogonadism and morbid obesity. Nat. Genet. 18, 213-215.
103. Tamura, T., R. Goldenberg, K. Johnston, and S. Cliver, 1998: Serum leptin concentrations during pregnancy and their relationship to fetal growth. Obstet. Gynecol. 91, 389-395.
104. Tanabe, K., S. Okuya, Y. Tanizawa, A. Matsumoto, and Y. Oka, 1997: Leptin induces proliferation of pancreatic β-cell line MIN6 through activation of mitogen-activated protein kinase. Biochem. Biophys. Res. Commun. 241, 765-768.
105. Tannenbaum, G. S., W. Gurd, and M. Lapointe, 1998: Leptin is a potent stimulator of spontaneous pulsatile growth hormone (GH) secretion and the GH response to GH-releasing hormone. Endocrinology 139, 3871-3875.
106. Taouis, M., J. W. Chen, C. Daviaud, J. Upont, M. Derouet, and J. Simon, 1998: Cloning the chicken leptin gene. Gene 208, 239-242.
107. Tartaglia, L. A., M. Dembski, X. Weng, N. Deng, J. Culpepper, R. Devos, G. J. Richards, L. A. Campfield, F. T. Clark, and J. Deeds, 1995: Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263-1271.
108. Tsuchiya, T., H. Shimizu, T. Horie, and M. Mori, 1999: Expression of leptin receptor in lung: leptin as a growth factor. Eur. J. Pharmacol. 365, 273-279.
109. Van der Kroon, P. H. W., and G. J. A. Speijers, 1979: Brain deviations in adult obese-hyperglycemic mice (ob/ob). Metabolism 28, 1-3.
110. Wang, Q., C. Bing, K. Al-Barazanji, D. E. Mossakowaska, X. M. Wang, D. L. McBay, W. A. Neville, M. Taddayon, L. Pickavane, S. Dryden, M. E. A. Thomas, M. T. McHale, E. S. Gloyer, S. Wilson, R. Buckingham, J. R. S. Arch, P. Trayhurn, and G. Williams, 1997: Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat. Diabetes 46, 335-341.
111. Wang, J., R. Liu, M. Hawkins, N. Barzalai, and L. Rossetti, 1998a: A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 393, 684-688.
112. Wang, X. H., J. R. Day, J. L. Beard, Y. Zhou, and R. Vasilatos-Younken, 1998b: Evidence for mediation of the depressive effect of growth hormone on voluntary feed intake by neuropeptide Y and monoamines. Poult. Sci. 77, 1-33.
113. Wauters, M., R. V. Considine, and L. F. Van Gaal, 2000: Human leptin: from an adipocyte hormone to an endocrine mediator. Eur. J. Endocrinol. 143, 293-311.
114. Williams, G. L., M. Amstalden, M. R. Garcia, R. L. Stanko, S. E. Nizielski, C. D. Morrison, and D. H. Keisler, 2002: Leptin and its role in the central regulation of reproduction in cattle. Domest. Anim. Endocrinol. 23, 339-349.
115. Yu, W. H., M. Kimura, A. Walczewska, S. Karanth, and S. M. McCann, 1997: Role of leptin in hypothalamic-pituitary function. Proc. Natl Acad. Sci. U S A 94, 1023-1028.
116. Zhang, Y., R. Proenca, M. Maffei, M. Barrone, L. Leopold, and J. M. Friedman, 1994: Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432.