Novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3) / cardiotrophin-like cytokine (CLC) - A novel gp130 cytokine with pleiotropic functions

Cytokine and Growth Factor Reviews

Volumn 15, Issue 5, 2004, Pages 325-336

  Vlotides, George ^a,b   Zitzmann, Kathrin ^a   Stalla, Gunter K ^b   Auernhammer, Christoph J ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

CLC; CLF 1; CNTF; Gp130; Jak STAT; NNT 1 BSF 3; SOCS

Indexed keywords

B CELL STIMULATING FACTOR 3; CARDIOTROPHIN LIKE CYTOKINE; CILIARY NEUROTROPHIC FACTOR RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOKINE; CYTOKINE RECEPTOR; GLYCOPROTEIN GP 130; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPHIN 1; PROTEIN KINASE C; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CELL STIMULATION; COMPLEX FORMATION; CYTOKINE RELEASE; ENZYME ACTIVATION; GENE CONTROL; GENE EXPRESSION; HUMAN; IMMUNOMODULATION; MOLECULAR CLONING; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD; CYTOKINE RECEPTOR GP130; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE GLYCOPROTEINS; SIGNAL TRANSDUCTION;

EID: 4344625249     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2004.04.002     Document Type: Review

References (69)

1. Heinrich P.C., Behrmann I., Haan S., Hermanns H.M., Muller-Newen G., Schaper F. Principles of interleukin (IL)-6-type cytokine signaling and its regulation. Biochem. J. 374:2003;1-20
2. Taga T. gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 15:1997;797-819
3. Heinrich P.C., Behrmann I., Müller-Newen G., Schaper F., Graeve L. Interleukin-6-type cytokine signaling through the gp130/Jak/STAT pathway. Biochem. J. 334:1998;297-314
4. Lindberg R.A., Juan T.S., Welcher A.A., Sun Y., Cupples R., Guthrie B., et al. Cloning and characterization of a specific receptor for mouse oncostatin M. Mol. Cell Biol. 18:1998;3357-3367
5. Tanaka M., Hara T., Copeland N.G., Gilbert D.J., Jenkins N.A., Miyajima A. Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit. Blood. 93:1999;804-815
6. Wang Y., Robledo O., Kinzie E., Blanchard F., Richards C., Miyajima A., et al. Receptor subunit-specific action of oncostatin M in hepatic cells and its modulation by leukemia inhibitory factor. J. Biol. Chem. 18275:2000;25273-25285
7. Naka T., Nishimoto N., Kishimoto T. The paradigm of IL-6: from basic science to medicine. Arthritis Res. 4(Suppl. 3):2002;S233-S242
8. Starr R., Willson T.A., Viney E.M., Murray L.J., Rayner J.R., Jenkins B.J., et al. A family of cytokine-inducible inhibitors of signaling. Nature. 387:1997;917-921
9. Endo T.A., Masuhara M., Yokouchi M., Suzuki R., Sakamoto H., Mitsui K., et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature. 387:1997;921-924
10. Naka T., Narazaki M., Hirata M., Matsumoto T., Minamoto S., Aono A., et al. Structure and function of a new STAT-induced STAT inhibitor. Nature. 387:1997;924-928
11. Auernhammer C.J., Melmed S. The central role of SOCS-3 in integrating the neuro-immunoendocrine interface. J. Clin. Invest. 108:2001;1735-1740
12. Cooney R,N. Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway. Shock. 17:2002;83-90
13. Fujimoto M., Naka T. Regulation of cytokine signaling by SOCS family molecules. Trends Immunol. 24:2003;659-666
14. Narazaki M., Fujimoto M., Matsumoto T., Morita Y., Saito H., Kajita T., et al. Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling. Proc. Natl. Acad. Sci. U.S.A. 95:1998;13130-13134
15. Suzuki R., Sakamoto H., Yasukawa H., Masuhara M., Wakioka T., Sasaki A., et al. CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells. Oncogene. 17:1998;2271-2278
16. Yasukawa H., Misawa H., Sakamoto H., Masuhara M., Sasaki A., Wakioka T., et al. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18:1999;1309-1320
17. Nicholson S.E., Willson T.A., Farley A., Starr R., Zhang J.G., Baca M., et al. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 18:1999;375-385
18. Nicholson S.E., DeSouza D., Fabri L.J., Corbin J., Willson T.A., Zhang J.G., et al. Suppressor of cytokine signalling-3 preferentially binds to the SHP-2 binding site on the shared cytokine receptor subunit gp130. Proc. Natl. Acad. Sci. U.S.A. 97:2000;6493-6498
19. Hansen J.A., Lindberg K., Hilton D.J., Nielsen J.H., Billestrup N. Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins. Mol. Endocrinol. 13:1999;1832-1843
20. Schmitz J., Weissenbach M., Haan S., Heinrich P.C., Schaper F. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J. Biol. Chem. 275:2000;12848-12856
21. Kile B.T., Schulman B.A., Alexander W.S., Nicola N.A., Martin H.M., Hilton D.J. The SOCS box: a tale of destruction and degradation. Trends Biochem. Sci. 27:2002;235-241
22. Senaldi G., Varnum B.C., Sarmiento U., Starnes C., Lile J., Scully S., et al. Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. Proc. Natl. Acad. Sci. U.S.A. 96:1999;11458-11463
23. Shi Y., Wang W., Yourey P.A., Gohari S., Zukauskas D., Zhang J., et al. Computational EST database analysis identifies a novel member of the neuropoietic cytokine family. Biochem. Biophys. Res. Commun. 262:1999;132-138
24. Pennica D., Wood W.I., Chien K.R. Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp130 dependent pathways. Cytokine Growth Factor Rev. 7:1996;81-91
25. Giovannini M., Romo A.J., Evans G.A. Chromosomal localization of the human ciliary neurotrophic factor gene (CNTF) to 11q12 by fluorescence in situ hybridization. Cytogenet. Cell Genet. 63:1993;62-63
26. Vlotides G., Zitzmann K., Hengge S., Engelhardt D., Stalla G.K., Auernhammer C.J. Expression of novel neurotrophin-1/B-cell stimulating factor-3 (NNT-1/BSF-3) in murine pituitary folliculostellate TtT/GF cells: pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide-induced stimulation of NNT-1/BSF-3 is mediated by protein kinase A, protein kinase C, and extracellular-signal-regulated kinase1/2 pathways. Endocrinology. 145:2004;716-727
27. Uemura A., Takizawa T., Ochiai W., Yanagisawa M., Nakashima K., Taga T. Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of STAT3. Cytokine. 18:2002;1-7
28. Forger N.G., Prevette D., deLapeyriere O., de Bovis B., Wang S., Bartlett P., et al. Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo. J. Neurosci. 23:2003;8854-8858
29. Elson G.C., Lelievre E., Guillet C., Chevalier S., Plun-Favreau H., Froger J., et al. CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. Nat. Neurosci. 3:2000;867-872
30. Plun-Favreau H., Elson G., Chabbert M., Froger J., deLapeyriere O., Lelievre E., et al. The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine. EMBO J. 20:2001;1692-1703
31. Elson G.C.A., Graber P., Losberger C., Herren S., Gretener D., Menoud L.N., et al. Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family. J. Immunol. 161:1998;1371-1379
32. Alexander W.S., Rakar S., Robb L., Farley A., Willson T.A., Zhang J.G., et al. Suckling defect in mice lacking the soluble haemopoietin receptor NR6. Curr. Biol. 9:1999;605-608
33. Robinson R.C., Grey L.M., Staunton D., Vankelecom H., Vernallis A.B., Moreau J.F., et al. The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding. Cell. 77:1994;1101-1116
34. McDonald N.Q., Panayotatos N., Hendrickson W.A. Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. EMBO J. 14:1995;2689-2699
35. Senaldi G., Stolina M., Guo J., Faggioni R., McCabe S., Kaufman S.A., et al. Regulatory effects of novel neurotrophin-1/b cell-stimulating factor-3 (cardiotrophin-like cytokine) on B cell function. J. Immunol. 168:2002;5690-5698
36. Davis S., Aldrich T.H., Stahl N., Pan L., Taga T., Kishimoto T., et al. LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science. 260:1993;1805-1808
37. Inoue K., Matsumoto H., Koyama C., Shibata K., Nakazato Y., Ito A. Establishment of a folliculo-stellate-like cell line from a murine thyrotropic pituitary tumor. Endocrinology. 131:1992;3110-3116
38. Arimura A. Perspectives on pituitary adenylate cyclase activating polypeptide (PACAP) in the neuroendocrine, endocrine, and nervous systems. Jpn. J. Physiol. 48:1998;301-331
39. Arimura A., Shioda S. Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors: neuroendocrine and endocrine interaction. Front Neuroendocrinol. 16:1995;53-88
40. Vaudry D., Gonzalez B.J., Basille M., Yon L., Fournier A., Vaudry H. Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions. Pharmacol. Rev. 52:2000;269-324
41. Laburthe M., Couvineau A. Molecular pharmacology and structure of VPAC receptors for VIP and PACAP. Regul. Pept. 108:2002;165-173
42. Kallen K.J., Grotzinger J., Lelievre E., Vollmer P., Aasland D., Renne C., et al. Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6. J. Biol. Chem. 274:1999;11859-11867
43. Auernhammer C.J., Isele N.B., Kopp F.B., Spoettl G., Cengic N., Weber M.M., et al. Novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) stimulates corticotroph function via a signal transducer and activator of transcription-dependent mechanism negatively regulated by suppressor of cytokine signaling-3. Endocrinology. 144:2003;1202-1210
44. Lelievre E., Plun-Favreau H., Chevalier S., Froger J., Guillet C., Elson G.C., et al. Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. J. Biol. Chem. 276:2001;22476-22484
45. Guillet C., Lelievre E., Plun-Favreau H., Froger J., Chabbert M., Hermann J., et al. Functionally active fusion protein of the novel composite cytokine CLC/soluble CNTF receptor. Eur. J. Biochem. 269:2002;1932-1941
46. Burger R., Bakker F., Guenther A., Baum W., Schmidt-Arras D., Hideshima T., et al. Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival. Br. J. Haematol. 123:2003;869-878
47. Auernhammer CJ, Kopp FB, Vlotides G, Dorn F, Isele NB, Spoettl G, et al. Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells - redundancy or specifity of neuroimmunoendocrine modulators? Neuroimmunomodulation 2004, in press.
48. Kim H., Baumann H. Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells. Mol. Cell Biol. 19:1999;5326-5338
49. Schiemann W.P., Bartoe J.L., Nathanson N.M. Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated stimulation of mitogen-activated protein kinase. Evidence for participation of multiple signaling pathways which converge at Ras. J. Biol. Chem. 272:1997;16631-16636
50. Gu H., Pratt J.C., Burakoff S.J., Neel B.G. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Mol Cell. 2:1998;729-740
51. Sendtner M., Carroll P., Holtmann B., Hughes R.A., Thoenen H. Ciliary neurotrophic factor. J. Neurobiol. 25:1994;1436-1453
52. Arakawa Y., Sendtner M., Thoenen H. Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines. J. Neurosci. 10:1990;3507-3515
53. Curtis R., Adryan K.M., Zhu Y., Harkness P.J., Lindsay R.M., DiStefano P.S. Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury. Nature. 365:1993;253-255
54. Oppenheim R.W., Prevette D., Haverkamp L.J., Houenou L., Yin Q.W., McManaman J. Biological studies of a putative avian muscle-derived neurotrophic factor that prevents naturally occurring motoneuron death in vivo. J. Neurobiol. 24:1993;1065-1079
55. Sendtner M., Schmalbruch H., Stockli K.A., Carroll P., Kreutzberg G.W., Thoenen H. Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature. 358:1992;502-504
56. Mitsumoto H., Ikeda K., Holmlund T., Greene T., Cedarbaum J.M., Wong V., et al. The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease. Ann. Neurol. 36:1994;142-148
57. Helgren M.E., Squinto S.P., Davis H.L., Parry D.J., Boulton T.G., Heck C.S., et al. Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle. Cell. 76:1994;493-504
58. Guillet C., Auguste P., Mayo W., Kreher P., Gascan H. Ciliary neurotrophic factor is a regulator of muscular strength in aging. J. Neurosci. 19:1999;1257-1262
59. Masu Y., Wolf E., Holtmann B., Sendtner M., Brem G., Thoenen H. Disruption of the CNTF gene results in motor neuron degeneration. Nature. 365:1993;27-32
60. Takahashi R., Yokoji H., Misawa H., Hayashi M., Hu J., Deguchi T. A null mutation in the human CNTF gene is not causally related to neurological diseases. Nat. Genet. 7:1994;79-84. (erratum in: Nat Genet 1994;7:215)
61. DeChiara T.M., Vejsada R., Poueymirou W.T., Acheson A., Suri C., Conover J.C., et al. Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell. 83:1995;313-322
62. Lesser S.S., Lo D.C. CNTF II, I presume? Nat. Neurosci. 3:2000;851-852
63. Akira S., Taga T., Kishimoto T. Interleukin-6 in biology and medicine. Adv. Immunol. 54:1993;1-78
64. Arzt E. gp130 cytokine signaling in the pituitary gland: a paradigm for cytokine-neuro-endocrine pathways. J. Clin. Invest. 108:2001;1729-1733
65. Benigni F., Fantuzzi G., Sacco S., Sironi M., Pozzi P., Dinarello C.A., et al. Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1. Blood. 87:1996;1851-1854
66. Auernhammer C.J., Melmed S. Leukemia-inhibitory factor-neuroimmune modulator of endocrine function. Endocr. Rev. 21:2000;313-345
67. Lam K.S. Vasoactive intestinal peptide in the hypothalamus and pituitary. Neuroendocrinology. 53(Suppl. 1):1991;45-51
68. Nussdorfer G.G., Bahcelioglu M., Neri G., Malendowicz L.K. Secretin, glucagon, gastric inhibitory polypeptide, parathyroid hormone, and related peptides in the regulation of the hypothalamus-pituitary-adrenal axis. Peptides. 21:2000;309-324
69. Derouet D, Rousseau F, Alfonsi F, Froger J, Hermann J, Barbier F, et al. Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor. Proc Natl Acad Sci USA 2004;101:4827-32.