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Volumn 173, Issue 5, 2004, Pages 3215-3222

Functional analysis of -571 IL-10 promoter polymorphism reveals a repressor element controlled by Sp1

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3;

EID: 4344623872     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.5.3215     Document Type: Article
Times cited : (62)

References (64)
  • 2
    • 0024408824 scopus 로고
    • Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • Fiorentino, D. F., M. W. Bond, and T. R. Mosmann. 1989. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170:2081.
    • (1989) J. Exp. Med. , vol.170 , pp. 2081
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 3
    • 0027232788 scopus 로고
    • + T cell clones and resting T cells: Specific inhibition of IL-2 production and proliferation
    • + T cell clones and resting T cells: specific inhibition of IL-2 production and proliferation. J. Immunol. 150:4754.
    • (1993) J. Immunol. , vol.150 , pp. 4754
    • De Waal Malefyt, R.D.1    Yssel, H.2    De Vries, J.E.3
  • 4
    • 0027204621 scopus 로고
    • Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production
    • Del Prete, G., M. De Carli, F. Almerigogna, M. G. Giudizi, R. Biagiotti, and S. Romagnani. 1993. Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production. J. Immunol. 150:353.
    • (1993) J. Immunol. , vol.150 , pp. 353
    • Del Prete, G.1    De Carli, M.2    Almerigogna, F.3    Giudizi, M.G.4    Biagiotti, R.5    Romagnani, S.6
  • 5
    • 0026094306 scopus 로고
    • Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • de Waal Malefyt, R. D., J. S. Abrams, B. Bennett, C. G. Figdor, and J. E. de Vries. 1991. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:1209.
    • (1991) J. Exp. Med. , vol.174 , pp. 1209
    • De Waal Malefyt, R.D.1    Abrams, J.S.2    Bennett, B.3    Figdor, C.G.4    De Vries, J.E.5
  • 6
    • 0027131207 scopus 로고
    • Predominant role of tumor necrosis factor-α in human monocyte IL-10 synthesis
    • Wanidworanun, C., and W. Strober. 1993. Predominant role of tumor necrosis factor-α in human monocyte IL-10 synthesis. J. Immunol. 151:6853.
    • (1993) J. Immunol. , vol.151 , pp. 6853
    • Wanidworanun, C.1    Strober, W.2
  • 9
    • 0032403697 scopus 로고    scopus 로고
    • Control of immune pathology by regulatory T cells
    • Mason, D., and F. Powrie. 1998. Control of immune pathology by regulatory T cells. Curr. Opin. Immunol. 10:649.
    • (1998) Curr. Opin. Immunol. , vol.10 , pp. 649
    • Mason, D.1    Powrie, F.2
  • 10
    • 0025673971 scopus 로고
    • Interleukin 10, a novel B cell stimulatory factor: Unresponsiveness of X chromosome-linked immunedeficiency B cells
    • Go, N. F., B. E. Castle, R. Barrett, R. Kastelein, W. Dang, T. R. Mosmann, K. W. Moore, and M. Howard. 1990. Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunedeficiency B cells. J. Exp. Med. 172:1625.
    • (1990) J. Exp. Med. , vol.172 , pp. 1625
    • Go, N.F.1    Castle, B.E.2    Barrett, R.3    Kastelein, R.4    Dang, W.5    Mosmann, T.R.6    Moore, K.W.7    Howard, M.8
  • 14
    • 0009719099 scopus 로고
    • IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
    • Fiorentino, D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra. 1991. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol. 147:2815.
    • (1991) J. Immunol. , vol.147 , pp. 2815
    • Fiorentino, D.F.1    Zlotnik, A.2    Mosmann, T.R.3    Howard, M.4    O'Garra, A.5
  • 15
    • 0026530464 scopus 로고
    • IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor
    • Ralph, P., I. Nakoinz, A. Sampson-Johannes, S. Fong, D. Lowe, H. Y. Min, and L. Lin. 1992. IL-10, T lymphocyte inhibitor of human blood cell production of IL-1 and tumor necrosis factor. J. Immunol. 148:808.
    • (1992) J. Immunol. , vol.148 , pp. 808
    • Ralph, P.1    Nakoinz, I.2    Sampson-Johannes, A.3    Fong, S.4    Lowe, D.5    Min, H.Y.6    Lin, L.7
  • 16
    • 0025889036 scopus 로고
    • Macrophage deactivation by interleukin 10
    • Bogdan, C., Y. Vodoyotz, and C. Nathan. 1991. Macrophage deactivation by interleukin 10. J. Exp. Med. 174:1549.
    • (1991) J. Exp. Med. , vol.174 , pp. 1549
    • Bogdan, C.1    Vodoyotz, Y.2    Nathan, C.3
  • 17
    • 0027240219 scopus 로고
    • Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
    • D'Andrea, A., M. Aste-Amezaga, N. M. Vaiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041.
    • (1993) J. Exp. Med. , vol.178 , pp. 1041
    • D'Andrea, A.1    Aste-Amezaga, M.2    Vaiante, N.M.3    Ma, X.4    Kubin, M.5    Trinchieri, G.6
  • 18
    • 0026000892 scopus 로고
    • Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression
    • de Waal Malefyt, R. D., J. Haanen, H. Spits, M. G. Roncarolo, A. te Velde, C. G. Figdor, K. Johnsbn, R. Kastelein, H. Yssel, and J. E. de Vries. 1991. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J. Exp. Med. 174:915.
    • (1991) J. Exp. Med. , vol.174 , pp. 915
    • De Waal Malefyt, R.D.1    Haanen, J.2    Spits, H.3    Roncarolo, M.G.4    Te Velde, A.5    Figdor, C.G.6    Johnsbn, K.7    Kastelein, R.8    Yssel, H.9    De Vries, J.E.10
  • 19
    • 0027320133 scopus 로고
    • Inhibition of Langerhans cell antigen-presenting function by IL-10: A role for IL-10 in induction of tolerance
    • Enk, A. H., V. L. Angeloni, M. C. Udey, and S. I. Katz. 1993. Inhibition of Langerhans cell antigen-presenting function by IL-10: a role for IL-10 in induction of tolerance. J. Immunol. 151:2390.
    • (1993) J. Immunol. , vol.151 , pp. 2390
    • Enk, A.H.1    Angeloni, V.L.2    Udey, M.C.3    Katz, S.I.4
  • 20
    • 0027960758 scopus 로고
    • Maintenance of clonal anergy by endogenously produced IL-10
    • Becker, J. C., C. Czerny, and E. B. Brocker. 1994. Maintenance of clonal anergy by endogenously produced IL-10. Int. Immunol. 6:1605.
    • (1994) Int. Immunol. , vol.6 , pp. 1605
    • Becker, J.C.1    Czerny, C.2    Brocker, E.B.3
  • 21
    • 0028283903 scopus 로고
    • Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils
    • Takanaski, S., R. Nonaka, Z. Xing, P. O'Bryne, J. Dolovich, and M. Jordana. 1994. Interleukin 10 inhibits lipopolysaccharide-induced survival and cytokine production by human peripheral blood eosinophils. J. Exp. Med. 180:711.
    • (1994) J. Exp. Med. , vol.180 , pp. 711
    • Takanaski, S.1    Nonaka, R.2    Xing, Z.3    O'Bryne, P.4    Dolovich, J.5    Jordana, M.6
  • 22
    • 0027171964 scopus 로고
    • IL-10 and viral IL-10 prevent IL-4-induced IgE synthesis by inhibiting the accessory cell function of monocytes
    • Punnonen, J., R. D. Malefyt, P. Van Vlasselaer, J.-F. Gauchat, and J. E. de Vries. 1993. IL-10 and viral IL-10 prevent IL-4-induced IgE synthesis by inhibiting the accessory cell function of monocytes. J. Immunol. 151:1280.
    • (1993) J. Immunol. , vol.151 , pp. 1280
    • Punnonen, J.1    Malefyt, R.D.2    Van Vlasselaer, P.3    Gauchat, J.-F.4    De Vries, J.E.5
  • 23
    • 0032921181 scopus 로고    scopus 로고
    • IL-10-induced anergy in peripheral T cell and reactivation by microenviromental cytokines: Two key steps in specific immunotherapy
    • Akdis, C. A., and K. Blaser. 1999. IL-10-induced anergy in peripheral T cell and reactivation by microenviromental cytokines: two key steps in specific immunotherapy. FASEB J. 13:603.
    • (1999) FASEB J. , vol.13 , pp. 603
    • Akdis, C.A.1    Blaser, K.2
  • 24
    • 0034890907 scopus 로고    scopus 로고
    • Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
    • Akbari, O., R. H. DeKruyff, and D. T, Umtesu. 2001. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. 2:725.
    • (2001) Nat. Immunol. , vol.2 , pp. 725
    • Akbari, O.1    DeKruyff, R.H.2    Umtesu, D.T.3
  • 28
    • 0032445196 scopus 로고    scopus 로고
    • Interleukin-10 and transforming growth factor-β promoter polymorphisms in allergies and asthma
    • Hobbs, K., J. Negri, M. Klinnert, L. J. Rosenwasser, and L. Borish. 1998. Interleukin-10 and transforming growth factor-β promoter polymorphisms in allergies and asthma. Am. J. Respir. Crit. Care Med. 158:1958.
    • (1998) Am. J. Respir. Crit. Care Med. , vol.158 , pp. 1958
    • Hobbs, K.1    Negri, J.2    Klinnert, M.3    Rosenwasser, L.J.4    Borish, L.5
  • 31
    • 0030919267 scopus 로고    scopus 로고
    • Association between polymorphisms at the human IL-10 locus and systemic lupus erythematosus
    • Eskdale, J., P. Wordsworth, S. Bowman, M. Field, and G. Gallagher. 1997. Association between polymorphisms at the human IL-10 locus and systemic lupus erythematosus. Tissue Antigens 49:635.
    • (1997) Tissue Antigens , vol.49 , pp. 635
    • Eskdale, J.1    Wordsworth, P.2    Bowman, S.3    Field, M.4    Gallagher, G.5
  • 32
    • 2942643251 scopus 로고    scopus 로고
    • Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus
    • Mok, C. C., J. S. Lanchbury, D. W. Chan, and C. S. Lau. 1998. Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus. Arthritis Rheum 41:1090.
    • (1998) Arthritis Rheum. , vol.41 , pp. 1090
    • Mok, C.C.1    Lanchbury, J.S.2    Chan, D.W.3    Lau, C.S.4
  • 34
    • 0028386516 scopus 로고
    • Gastrointestinal inflammation: Inflammatory bowel disease in knockout mice
    • MacDonald, T. T. 1994. Gastrointestinal inflammation: inflammatory bowel disease in knockout mice. Curr. Biol. 4:261.
    • (1994) Curr. Biol. , vol.4 , pp. 261
    • MacDonald, T.T.1
  • 35
    • 0032533678 scopus 로고    scopus 로고
    • Cytokine gene polymorphisms associating with severe acute graft-versus-host disease in HLA-identical sibling transplants
    • Middleton, P. G., P. R. Taylor, G. Jackson, S. J. Proctor, and A. M. Dickinson. 1998. Cytokine gene polymorphisms associating with severe acute graft-versus-host disease in HLA-identical sibling transplants. Blood 92:3943.
    • (1998) Blood , vol.92 , pp. 3943
    • Middleton, P.G.1    Taylor, P.R.2    Jackson, G.3    Proctor, S.J.4    Dickinson, A.M.5
  • 37
    • 0026006396 scopus 로고
    • A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation
    • Hagman, J., A. Travis, and R. Grosschedl. 1991. A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation. EMBO J. 10:3409.
    • (1991) EMBO J. , vol.10 , pp. 3409
    • Hagman, J.1    Travis, A.2    Grosschedl, R.3
  • 38
    • 0029833870 scopus 로고    scopus 로고
    • Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter
    • Fitzsimmons, D., W. Hodson, W. Wheat, S. M. Maira, B. Wasylyk, and J. Hagman. 1996. Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter. Genes Dev. 10:2198.
    • (1996) Genes Dev. , vol.10 , pp. 2198
    • Fitzsimmons, D.1    Hodson, W.2    Wheat, W.3    Maira, S.M.4    Wasylyk, B.5    Hagman, J.6
  • 39
    • 0028267289 scopus 로고
    • Differential expression of viral and human interleukin-10 (IL-10) by primary B cell tumors and B cell lines
    • Stewart, J. P., F. G. Behm, J. R. Arrand, and C. M. Rooney. 1994. Differential expression of viral and human interleukin-10 (IL-10) by primary B cell tumors and B cell lines. Virology 200:724.
    • (1994) Virology , vol.200 , pp. 724
    • Stewart, J.P.1    Behm, F.G.2    Arrand, J.R.3    Rooney, C.M.4
  • 40
    • 0034651850 scopus 로고    scopus 로고
    • A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages
    • Brightbill, H. D., S. E. Plevy, R. L. Modlin, and S. T. Smale. 2000. A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages. J. Immunol. 164:1940.
    • (2000) J. Immunol. , vol.164 , pp. 1940
    • Brightbill, H.D.1    Plevy, S.E.2    Modlin, R.L.3    Smale, S.T.4
  • 41
    • 0034234573 scopus 로고    scopus 로고
    • IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3
    • Tone, M., M. J. Powell, Y. Tone, S. A. J. Thompson, and H. Waldmann. 2000. IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3. J. Immunol. 165:286.
    • (2000) J. Immunol. , vol.165 , pp. 286
    • Tone, M.1    Powell, M.J.2    Tone, Y.3    Thompson, S.A.J.4    Waldmann, H.5
  • 42
    • 0026595811 scopus 로고
    • Differential expression of related HLA class II DQ β genes caused by nucleotide variation in transcriptional regulatory elements
    • Shewey, L. M., J. S. Beaty, L. C. Andersen, and G. T. Nepom. 1992. Differential expression of related HLA class II DQ β genes caused by nucleotide variation in transcriptional regulatory elements. J. Immunol. 148:1265.
    • (1992) J. Immunol. , vol.148 , pp. 1265
    • Shewey, L.M.1    Beaty, J.S.2    Andersen, L.C.3    Nepom, G.T.4
  • 43
    • 0027741020 scopus 로고
    • The different level of expression of HLA-DRB1 and -DRB3 genes is controlled by conserved isotypic differences in promoter sequence
    • Emery, P., B. Mach, and W. Reith. 1993. The different level of expression of HLA-DRB1 and -DRB3 genes is controlled by conserved isotypic differences in promoter sequence. Hum. Immunol. 38:137.
    • (1993) Hum. Immunol. , vol.38 , pp. 137
    • Emery, P.1    Mach, B.2    Reith, W.3
  • 44
    • 0035889904 scopus 로고    scopus 로고
    • A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity
    • LeVan, T. D., J. W. Bloom, T. J. Bailey, C. L. Karp, M. Halonen, F. D. Martinez, and D. Vercelli. 2001. A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J. Immunol. 167:5838.
    • (2001) J. Immunol. , vol.167 , pp. 5838
    • LeVan, T.D.1    Bloom, J.W.2    Bailey, T.J.3    Karp, C.L.4    Halonen, M.5    Martinez, F.D.6    Vercelli, D.7
  • 46
    • 0038179307 scopus 로고    scopus 로고
    • The RANTES promoter polymorphism: A genetic risk factor for near-fatal asthma in Chinese children
    • Yao, T., M. Kuo, L. See, L. Chen, D. Yan, L. Ou, C. Shaw, and I. Huang. 2003. The RANTES promoter polymorphism: a genetic risk factor for near-fatal asthma in Chinese children. J. Allergy Clin. Immunol. 111:1285.
    • (2003) J. Allergy Clin. Immunol. , vol.111 , pp. 1285
    • Yao, T.1    Kuo, M.2    See, L.3    Chen, L.4    Yan, D.5    Ou, L.6    Shaw, C.7    Huang, I.8
  • 47
    • 0027999214 scopus 로고
    • Regulation of parathyroid hormone-related protein (PTHrP) gene expression
    • Dittmer, J., A. Gegonne, S. D. Gitlin, J. Ghysdael, and J. N. Brady. 1994. Regulation of parathyroid hormone-related protein (PTHrP) gene expression. J.f Biol. Chem. 269:21428.
    • (1994) J.f Biol. Chem. , vol.269 , pp. 21428
    • Dittmer, J.1    Gegonne, A.2    Gitlin, S.D.3    Ghysdael, J.4    Brady, J.N.5
  • 48
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn, R., J. Lohler, D. M. Rennick, K. Rajeswky, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263.
    • (1993) Cell , vol.75 , pp. 263
    • Kuhn, R.1    Lohler, J.2    Rennick, D.M.3    Rajeswky, K.4    Muller, W.5
  • 49
    • 0029083269 scopus 로고
    • Interleukin-10 gene knock-out mice: A model of chronic inflammation
    • Rennick, D., N. Davidson, and D. Berg. 1995. Interleukin-10 gene knock-out mice: a model of chronic inflammation. Clin. Immunol. Immunopathol. 76:S174.
    • (1995) Clin. Immunol. Immunopathol. , vol.76
    • Rennick, D.1    Davidson, N.2    Berg, D.3
  • 50
    • 0026707402 scopus 로고
    • Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery
    • Kennedy, M. K., D. S. Torrance, K. S. Picha, and K. M. Mohler. 1992. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149:2496.
    • (1992) J. Immunol. , vol.149 , pp. 2496
    • Kennedy, M.K.1    Torrance, D.S.2    Picha, K.S.3    Mohler, K.M.4
  • 52
    • 0035869289 scopus 로고    scopus 로고
    • Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus
    • Gibson, A. W., J. C. Edberg, J. Wu, R. G. J. Westendorp, T. W. J. Huizinga, and R. P. Kimberly. 2001. Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus. J. Immunol. 166:3915.
    • (2001) J. Immunol. , vol.166 , pp. 3915
    • Gibson, A.W.1    Edberg, J.C.2    Wu, J.3    Westendorp, R.G.J.4    Huizinga, T.W.J.5    Kimberly, R.P.6
  • 54
    • 0035992311 scopus 로고    scopus 로고
    • Th1/Th2 cytokine expression and its relationship with tumor growth in B cell non-Hodgkin's lymphoma (NHL)
    • Jones, E. A., J. H. Pringle, C. A. Angel, and R. C. Rees. 2002. Th1/Th2 cytokine expression and its relationship with tumor growth in B cell non-Hodgkin's lymphoma (NHL). Leuk. Lymphoma 43:1313.
    • (2002) Leuk. Lymphoma , vol.43 , pp. 1313
    • Jones, E.A.1    Pringle, J.H.2    Angel, C.A.3    Rees, R.C.4
  • 55
    • 0036901177 scopus 로고    scopus 로고
    • Correlation of serum IL-2, IL-6 and IL-10 levels with International Prognostic Index in patients with aggressive non-Hodgkin's lymphoma
    • Aydin, F., M. Yilmaz, F. Ozdemir, H. Kavgaci, M. N. Yavuz, and A. A. Yavuz. 2002. Correlation of serum IL-2, IL-6 and IL-10 levels with International Prognostic Index in patients with aggressive non-Hodgkin's lymphoma. Am. J. Clin. Oncol. 25:570.
    • (2002) Am. J. Clin. Oncol. , vol.25 , pp. 570
    • Aydin, F.1    Yilmaz, M.2    Ozdemir, F.3    Kavgaci, H.4    Yavuz, M.N.5    Yavuz, A.A.6
  • 56
    • 0037300528 scopus 로고    scopus 로고
    • Polymorphisms in the interleukin 10 gene promoter are associated with susceptibility to aggressive non-Hodgkin's lymphoma
    • Cunningham, L. M., C. Chapman, R, Dunstan, M. C. Bell, and D. J. Joske. 2003. Polymorphisms in the interleukin 10 gene promoter are associated with susceptibility to aggressive non-Hodgkin's lymphoma. Leuk. Lymphoma 44:251.
    • (2003) Leuk. Lymphoma , vol.44 , pp. 251
    • Cunningham, L.M.1    Chapman, C.2    Dunstan, R.3    Bell, M.C.4    Joske, D.J.5
  • 58
  • 59
    • 0034121689 scopus 로고    scopus 로고
    • Systemic lupus erythematosus candidate genes in the Italian population: Evidence for a significant association with interleukin-10
    • D'Alfonso, S., M. Rampi, D. Bocchio, G. Colombo, R. Scorza-Smeraldi, and P. Momigliano-Richardi. 2000. Systemic lupus erythematosus candidate genes in the Italian population: evidence for a significant association with interleukin-10. Arthritis Rheum. 43:120.
    • (2000) Arthritis Rheum. , vol.43 , pp. 120
    • D'Alfonso, S.1    Rampi, M.2    Bocchio, D.3    Colombo, G.4    Scorza-Smeraldi, R.5    Momigliano-Richardi, P.6
  • 60
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • Maloy, K. J., and F. Powrie. 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2:816.
    • (2001) Nat. Immunol. , vol.2 , pp. 816
    • Maloy, K.J.1    Powrie, F.2
  • 64
    • 12244300909 scopus 로고    scopus 로고
    • Interleukin-10 gene promoter region polymorphism is associated with eosinophil count and circulating immunoglobulin E in adult asthma
    • Karjalainen, J., J. Hulkkonen, M. M. Nieminen, H. Huhtala, A. Aromaa, T. Klaukka, and M, Hurme. 2003. Interleukin-10 gene promoter region polymorphism is associated with eosinophil count and circulating immunoglobulin E in adult asthma. Clin. Exp. Allergy 33:78.
    • (2003) Clin. Exp. Allergy , vol.33 , pp. 78
    • Karjalainen, J.1    Hulkkonen, J.2    Nieminen, M.M.3    Huhtala, H.4    Aromaa, A.5    Klaukka, T.6    Hurme, M.7


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