Fine mapping and single nucleotide polymorphism association results of candidate genes for asthma and related phenotypes

Human Mutation

Volumn 18, Issue 4, 2001, Pages 327-336

  Immervoll, Thomas ^a,c   Loesgen, Sabine ^a   Dtsch, Gabriele ^a   Gohlke, Henning ^a   Herbon, Nicole ^a   Klugbauer, Sabine ^a   Dempfle, Astrid ^a   Bickebller, Heike ^a   Becker Follmann, Johannes ^a   Rschendorf, Franz ^a   Saar, Kathrin ^b   Reis, Andre ^b   Wichmann, H Erich ^b   Wjst, Matthias ^b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

Association analysis; Asthma; EDN1; Fine mapping; IL10; IL4; LTA; MALDI TOF MS; Multifactorial disease; NOS1; SNP; TNFB

Indexed keywords

ENDOTHELIN 1; GENE PRODUCT; IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 4; LYMPHOTOXIN; NITRIC OXIDE SYNTHASE; PROTEIN EDN1; PROTEIN NOS1; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; ASTHMA; CAUCASIAN; CHILD; CHROMOSOMAL LOCALIZATION; CHROMOSOME 11P; CHROMOSOME 12Q; CHROMOSOME 2P; CHROMOSOME 5Q; CHROMOSOME 6P; CHROMOSOME 7P; CHROMOSOME 9Q; EOSINOPHIL; GENE MAPPING; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC VARIABILITY; HUMAN; HUMAN CELL; INFANT; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ASTHMA; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN; ENDOTHELIN-1; EOSINOPHILS; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXONS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-10; INTERLEUKIN-4; INTRONS; LEUKOCYTE COUNT; LINKAGE (GENETICS); LYMPHOTOXIN-ALPHA; MICROSATELLITE REPEATS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 0034815155     PISSN: 10597794     EISSN: None     Source Type: Journal    
DOI: 10.1002/humu.1194     Document Type: Article

References (45)

1. Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms
2. Standardization of spirometry - 1987 Update
3. Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations
4. A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid)
5. Interleukin-10 regulation in normal subjects and patients with asthma
6. Cytokines in symptomatic asthma airways
7. Standardization of bronchial inhalation challenge procedures
8. A genome-wide search for asthma susceptibility loci in ethnically diverse populations
9. A genome-wide search for quantitative trait loci underlying asthma
10. A comprehensive genetic map of the human genome based on 5,264 microsatellites
11. Genome screen for asthma and related phenotypes in the French EGEA study
12. Neuronal NO synthase (NOS1) is a major candidate gene for asthma
13. Endothelin-1-induced increases in microvascular permeability in isolated, perfused rat lungs requires leukocytes and plasma
14. Current status of the asthma and allergy database
15. In vivo administration of insulin like growth factor-I stimulates primary B lymphopoiesis and enhances lymphocyte recovery after bone marrow transplantation
16. The transmission/disequilibrium test and parental-genotype reconstruction: The reconstruction-combined transmission/disequilibrium test
17. Using exact p-values to compare the power between the reconstruction-combined transmission/disequilibrium test and the sib transmission/disequilibrium test
18. The HLA gene complex and genetic susceptibility to disease
19. Complete multipoint sib-pair analysis of qualitative and quantitative traits
20. Parametric and nonparametric linkage analysis: A unified multipoint approach
21. The role of NF-Y and IRF-2 in the regulation of human IL-4 gene expression
22. Cloning and characterization of the human leukotriene A4 hydrolase gene
23. Subregional mapping of 13 single-copy genes on the long arm of chromosome 12 by fluorescence in situ hybridization
24. A simple salting out procedure for extracting DNA from human nucleated cells
25. Interleukin-10
26. Endothelin-1 stimulates arachidonate 15-lipoxygenase activity and oxygen radical formation in the rat distal lung
27. Evidence for linkage of chromosome q15-q24. 1 markers to high total serum IgE concentrations in children of the German multicenter allergy study
28. Genome-wide search for asthma susceptibility loci in a founder population. The collaborative study on the genetics of asthma
29. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population
30. Platelet-activating factor
31. Genetics of atopy and asthma: The rationale behind promoter-based candidate gene studies (IL-4 and IL-10)
32. Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines
33. Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice
34. Mammalian nitric oxide synthases
35. IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice
36. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage
37. Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia
38. The association between baseline lung function and bronchial responsiveness to methacholine
39. Endothelin: New discoveries and rapid progress in the clinic
40. Linkage of asthma to markers on chromosome 12 in a sample of 240 families using quantitative phenotype scores
41. Collaborative study on the genetics of asthma in Germany
42. An Internet linkage and mutation database for the complex phenotype asthma
43. A genome-wide search for linkage to asthma. German asthma genetics group
44. Major genes regulating total serum immunoglobulin E levels in families with asthma
45. Significant evidence for linkage of mite-sensitive childhood asthma to chromosome q31-q33 near the interleukin 12 B locus by a genome-wide search in Japanese families