Th1/Th2 cytokine expression and its relationship with tumor growth in B cell non-Hodgkin's lymphoma (NHL)

Leukemia and Lymphoma

Volumn 43, Issue 6, 2002, Pages 1313-1321

  Jones, E A ^a   Pringle, J H ^b   Angel, C A ^a   Rees, R C ^c  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b LEICESTER ROYAL INFIRMARY   (United Kingdom)

^c NONE

Author keywords

B cell; Cytokine; Lymphoma; NHL; Tumor immunity

Indexed keywords

CYCLOPHOSPHAMIDE; CYTOKINE; DOXORUBICIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; PREDNISONE; PROTEIN P35; PROTEIN P40; VINCRISTINE; ANTINEOPLASTIC AGENT; CHOP PROTOCOL; INTERLEUKIN 12P40; PROTEIN SUBUNIT;

ADOLESCENT; ADULT; AGED; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; BONE MARROW TRANSPLANTATION; CANCER GRADING; CANCER RADIOTHERAPY; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL ARTICLE; CLINICAL OBSERVATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; MALE; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TH1 CELL; TH2 CELL; TUMOR GROWTH; TUMOR IMMUNITY; BIOSYNTHESIS; CELL DIVISION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; MORTALITY; MULTIMODALITY CANCER THERAPY; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION; SURVIVAL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CELL DIVISION; COMBINED MODALITY THERAPY; CYCLOPHOSPHAMIDE; CYTOKINES; DOXORUBICIN; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN; INTERLEUKIN-12; LYMPHOMA, B-CELL; LYMPHOMA, HIGH-GRADE; LYMPHOMA, LOW-GRADE; MALE; MIDDLE AGE; PREDNISONE; PROTEIN SUBUNITS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUPPORT, NON-U.S. GOV'T; SURVIVAL ANALYSIS; TH1 CELLS; TH2 CELLS; VINCRISTINE; HUMANS; INTERLEUKIN-12 SUBUNIT P40; MIDDLE AGED;

EID: 0035992311     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190290026385     Document Type: Article

References (43)

1. "Acquisition of lymphokine-producing phenotype by CD4 + T cells"
2. "T helper 2-dominant antilymphoma immune response is associated with fatal outcome"
3. "Prognostic value of intratumoral interferon gamma messenger RNA expression in invasive cervical carcinomas"
4. "The critical role of Th1-dominant immunity in tumor immunology"
5. "Autotumour reactive T-cell clones among tumour-infiltrating T lymphocytes in B-cell non-Hodgkin's lymphomas"
6. "T-cell derived cytokines co-stimulate proliferation of CD40-actiavyed germinal centre as well as follicular lymphoma cells"
7. "Low grade B cell lymphomas of mucosa-associated lymphoid tissue (MALT-type) require Cd40-mediated signaling and Th2-type cytokines for in vitro growth and differentiation"
8. "Requirement for reverse immune surveillance for the growth of germinal center-derived murine lymphomas"
9. "Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes"
10. "Phase I clinical trial of interleukin-12 (IL-12) gene therapy using direct injection of tumors with genetically engineered autologous fibroblasts"
11. "Interleukin-12 therapy of cutaneous T-cell lymphoma induces lesion regression and cytotoxic T-cell responses"
12. "Peripheral burst of tumor-specific cytotoxic T lymphocytes and infiltration of metastatic lesions by memory CD8 + T cells in melanoma patients receiving interleukin 12"
13. "Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production"
14. "Antitumor activity of interleukin 12 in preclinical models"
15. "In vivo therapeutic effects of interleukin-12 against highly metastatic residual lymphoma"
16. "Development of TH1 Cd4 + T cells through IL-12 produced by Listeria-induced macrophages"
17. "Interleukin 12 acts directly on CD4 + T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming"
18. "Role of IL-12 in human B lymphocyte proliferation and differentiation"
19. "Interleukin-12 stimulates B cell growth by inducing IFN-gamma"
20. "Locally IL-4 delivery enhances immune reactivity to murine tumors: Gene therapy in combination with IL-2"
21. "Interleukin 4 retards dissemination of a human B-cell lymphoma in severe combined immunodeficient mice"
22. "Effects of interleukin-4 on the in vitro growth of human lymphoid and plasma cell neoplasms"
23. "Antiproliferative effects of interleukin-4 on freshly isolated non-Hodgkin malignant B-lymphoma cells"
24. "The role of interleukin-4 in the negative regulation of leukemia cell growth"
25. "Liver regeneration: A comparison of in situ hybridization for histone mRNA with bromodeoxyuridine labeling for the detection of S-phase cells"
26. "Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation"
27. "Correlation between apoptosis, proliferation and bcl-2 expression in malignant non-Hodgkin's lymphoma"
28. "Efficient method for preparing normal and tumor tissue for RNA extraction"
29. "Defining protective responses to pathogens: Cytokine profiles in leprosy lesions"
30. "Expression of interleukin 10 in B lymphocytes of different origin"
31. "The human germinal cells, follicular dendritic cells and germinal centre T cells produce B cell-stimulating cytokines"
32. "Cytokines in malignant lymphomas: Review and prospective evaluation"
33. "Interleukin-13 gene expression by malignant and EBV-transformed human B lymphocytes"
34. "Identification of B-cell growth factors (interleukin-14; high molecular weight-B-cell growth factors) in effusion fluids from patients with aggressive B-cell lymphomas"
35. "Lymphokine mRNA expression by transplantable murine B lymphocytic malignancies. Tumor-derived IL-10 as a possible mechanism for modulating the anti-tumor response"
36. "Cytokine gene expression in neoplastic B cells from human mantle cell, follicular and marginal zone lymphomas and in their postulated normal counterparts"
37. "Growth modulation of freshly isolated non-Hodgkin's B-lymphoma cells induced by various cytokines and all trans-retinoic acid"
38. "Modulation of apoptosis with cytokines in B-cell chronic lymphocytic leukaemia"
39. "Human cytokines suppress apoptosis of leukaemic CD5 + B cells and preserve expression of bcl-2"
40. "Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression"
41. "Interleukin-12 expression in human lymphomas and nonneoplastic lymphoid disorders"
42. "IL-12 expression in AIDS-related lymphoma B cell lines"
43. "Interleukin-12 induced cytolytic activity in lymphocytes from recipients of autologous and allogenic stem cell transplants"