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1
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2942710089
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Systemic lupus erythematosus
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Edited by Theofilopoulos A, Bona C. Gordon and Breach, Harwood Academic Publishers
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Tsokos GC, Boumpas DT: Systemic lupus erythematosus. In: Molecular Pathology of Autoimmunity. Edited by Theofilopoulos A, Bona C. Gordon and Breach, Harwood Academic Publishers; 2001:255-281.
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Molecular Pathology of Autoimmunity
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Tsokos, G.C.1
Boumpas, D.T.2
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2
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0022533156
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Oncogene expression in autoimmune and normal peripheral blood mononuclear cells
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Klinman, D.M.1
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Honda, M.3
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3
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0023743861
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Activated T lymphocytes in the peripheral blood of patients with systemic lupus erythematosus induce B cells to produce immunoglobulin
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Inghirami G, Simon J, Balow JE, et al.: Activated T lymphocytes in the peripheral blood of patients with systemic lupus erythematosus induce B cells to produce immunoglobulin. Clin Exp Rheumatol 1988, 6:269-276.
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Immune cell signaling defects in lupus: Activation, anergy and death
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Tsokos GC, Liossis SN: Immune cell signaling defects in lupus: activation, anergy and death. Immunol Today 1999, 20:119.
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Tsokos, G.C.1
Liossis, S.N.2
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0029862632
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Immunopathogenesis and spectrum of infections in systemic lupus erythematosus
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Iliopoulos AG, Tsokos GC: Immunopathogenesis and spectrum of infections in systemic lupus erythematosus. Semin Arthritis Rheum 1996, 25:318.
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Iliopoulos, A.G.1
Tsokos, G.C.2
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1642495711
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Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus
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Kang I, Quan T, Nolasco H, et al.: Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus. J Immunol 2004, 172:1287-1294.
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Kang, I.1
Quan, T.2
Nolasco, H.3
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7
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1542619236
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Cloned human TCR from patients with autoimmune disease can respond to two structurally distinct autoantigens
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De Silva-Udawatta M, Kumar SR, Greidinger EL, et al.: Cloned human TCR from patients with autoimmune disease can respond to two structurally distinct autoantigens. J Immunol 2004, 172:3940-3947. This article explores TCR plasticity in SLE. TCR from lupus T cells specific for one autoantigen is shown also to cross-react with another distinct autoantigen. This concept can help explain the epitope spreading seen in many autoimmune conditions.
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J Immunol
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De Silva-Udawatta, M.1
Kumar, S.R.2
Greidinger, E.L.3
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8
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0032036481
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Altered pattern of TcR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus: Deficient expression of the T cell receptor zeta chain
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Liossis S-NC, Ding XZ, Dennis GJ, et al.: Altered pattern of TcR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus: deficient expression of the T cell receptor zeta chain. J Clin Invest 1998, 101:1448-1457.
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Liossis, S.-N.C.1
Ding, X.Z.2
Dennis, G.J.3
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9
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0037111374
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Defective production of functional 98-kDa form of elf-1 is responsible for the decreased expression of TCR-æ chain in patients with systemic lupus erythematosus
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Juang Y-T, Tenbrock K, Nambiar MP, et al.: Defective production of functional 98-kDa form of elf-1 is responsible for the decreased expression of TCR-æ chain in patients with systemic lupus erythematosus. J Immunol 2002, 169:6048-6055.
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J Immunol
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Juang, Y.-T.1
Tenbrock, K.2
Nambiar, M.P.3
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10
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0041929387
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TCR zeta mRNA with an alternatively spliced 3′-untranslated region detected in systemic lupus erythematosus patients leads to the down-regulation of TCR zeta and TCR/CD3 complex
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Tsuzaka K, Fukuhara I, Setoyama Y, et al.: TCR zeta mRNA with an alternatively spliced 3′-untranslated region detected in systemic lupus erythematosus patients leads to the down-regulation of TCR zeta and TCR/CD3 complex. J Immunol 2003, 171:2496-2503.
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J Immunol
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Tsuzaka, K.1
Fukuhara, I.2
Setoyama, Y.3
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11
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0036164354
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Abnormal expression of various molecular forms and distribution of T cell receptor zeta chain in patients with systemic lupus erythematosus
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Nambiar MP, Enyedy EJ, Fisher CU, et al.: Abnormal expression of various molecular forms and distribution of T cell receptor zeta chain in patients with systemic lupus erythematosus. Arthritis Rheum 2002, 46:163-174.
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(2002)
Arthritis Rheum
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Nambiar, M.P.1
Enyedy, E.J.2
Fisher, C.U.3
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12
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0037653244
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Increased ubiquitination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus
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Jury EC, Kabouridis PS, Abba A, et al.: Increased ubiquitination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum 2003, 48:1343-1354.
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(2003)
Arthritis Rheum
, vol.48
, pp. 1343-1354
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Jury, E.C.1
Kabouridis, P.S.2
Abba, A.3
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13
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0034744286
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Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus
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Enyedy EJ, Nambiar MP, Liossis SN, et al.: Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus. Arthritis Rheum 2001, 44:1114-1121.
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(2001)
Arthritis Rheum
, vol.44
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Enyedy, E.J.1
Nambiar, M.P.2
Liossis, S.N.3
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14
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0037446543
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The FcR gamma subunit and Syk kinase replace the CD3 zeta-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells
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Krishnan S, Warke VG, Nambiar MP, et al.: The FcR gamma subunit and Syk kinase replace the CD3 zeta-chain and ZAP-70 kinase in the TCR signaling complex of human effector CD4 T cells. J Immunol 2003, 170:4189. The FcRγ-chain substitutes the ζ-chain in TCR effector T cells, resulting in signaling through the TCR that can be 100-fold increased. This observation may help explain the heightened calcium response in the lupus T cell that is TCR ζ-chain-deficient.
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(2003)
J Immunol
, vol.170
, pp. 4189
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Krishnan, S.1
Warke, V.G.2
Nambiar, M.P.3
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15
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2942586874
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Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus
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in press
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Krishnan S, Nambiar MP, Warke VG, et al.: Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus. J Immunol 2004, in press.
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(2004)
J Immunol
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Krishnan, S.1
Nambiar, M.P.2
Warke, V.G.3
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16
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0038342830
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Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus
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Nambiar MP, Fisher CU, Warke VG, et al.: Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus. Arthritis Rheum 2003, 48:1948-1955.
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(2003)
Arthritis Rheum
, vol.48
, pp. 1948-1955
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Nambiar, M.P.1
Fisher, C.U.2
Warke, V.G.3
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17
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1042290323
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Induction of costimulation of human CD4 T cells by tumor necrosis factor-related apoptosis-inducing ligand: Possible role in T cell activation in systemic lupus erythematosus
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Tsai HF, Lai JJ, Chou AH, et al.: Induction of costimulation of human CD4 T cells by tumor necrosis factor-related apoptosis-inducing ligand: possible role in T cell activation in systemic lupus erythematosus. Arthritis Rheum 2004, 50:629-639.
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(2004)
Arthritis Rheum
, vol.50
, pp. 629-639
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Tsai, H.F.1
Lai, J.J.2
Chou, A.H.3
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18
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1342267617
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Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus
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Liu MF, Wang CR, Fung LL, et al.: Decreased CD4+CD25+ T cells in peripheral blood of patients with systemic lupus erythematosus. Scand J Immunol 2004, 59:198-202.
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(2004)
Scand J Immunol
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, pp. 198-202
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Liu, M.F.1
Wang, C.R.2
Fung, L.L.3
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19
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0346969979
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CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis
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Liu Z, Xu X, Hsu HC, et al.: CII-DC-AdTRAIL cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced arthritis. J Clin Invest 2003, 112:1332-1341.
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J Clin Invest
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Liu, Z.1
Xu, X.2
Hsu, H.C.3
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20
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10744221539
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Roles of CCR2 and CXCR3 in the T cell-mediated response occurring during lupus flares
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Amoura Z, Combadiere C, Faure S, et al.: Roles of CCR2 and CXCR3 in the T cell-mediated response occurring during lupus flares. Arthritis Rheum 2003, 48:3487-3496.
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(2003)
Arthritis Rheum
, vol.48
, pp. 3487-3496
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Amoura, Z.1
Combadiere, C.2
Faure, S.3
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21
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1542379705
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CXCR3 is involved in tubulointerstitial injury in human glomerulonephritis
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Segerer S, Banas B, Wornle M, et al.: CXCR3 is involved in tubulointerstitial injury in human glomerulonephritis. Am J Pathol 2004, 164:635-649.
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Am J Pathol
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Segerer, S.1
Banas, B.2
Wornle, M.3
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0034874277
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Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation
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Flier J, Boorsma DM, van Beek PJ, et al.: Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation. J Pathol 2001, 194:398-405.
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J Pathol
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Flier, J.1
Boorsma, D.M.2
Van Beek, P.J.3
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23
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0037289364
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Defective activity of ERK-1 and ERK-2 mitogen-activated protein kinases in peripheral blood T lymphocytes from patients with systemic lupus erythematosus: Potential role of altered coupling of Ras guanine nucleotide exchange factor hSos to adapter protein Grb2 in lupus T cells
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Cedeno S, Cifarelli DF, Blasini AM, et al.: Defective activity of ERK-1 and ERK-2 mitogen-activated protein kinases in peripheral blood T lymphocytes from patients with systemic lupus erythematosus: potential role of altered coupling of Ras guanine nucleotide exchange factor hSos to adapter protein Grb2 in lupus T cells. Clin Immunology 2003, 106:41-49.
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Clin Immunology
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Cedeno, S.1
Cifarelli, D.F.2
Blasini, A.M.3
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24
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0036291454
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Deficient protein kinase a in systemic lupus erythematosus: A disorder of T lymphocyte signal transduction
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Kammer GM: Deficient protein kinase a in systemic lupus erythematosus: a disorder of T lymphocyte signal transduction. Ann N Y Acad Sci 2002, 968:96-105.
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Kammer, G.M.1
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25
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0141920615
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Protein kinase A regulatory subunit type II beta directly interacts with and suppresses CREB transcriptional activity in activated T cells
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Elliott MR, Tolnay M, Tsokos GC, et al.: Protein kinase A regulatory subunit type II beta directly interacts with and suppresses CREB transcriptional activity in activated T cells. J Immunol 2003, 171:3636-3644.
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Elliott, M.R.1
Tolnay, M.2
Tsokos, G.C.3
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26
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2942618491
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Down-regulation of IL-2 production in T Lymphocytes by phosphorylated protein kinase A-RIIβ
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in press
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Elliott MR, Shanks RA, Brooks JW, et al.: Down-regulation of IL-2 production in T Lymphocytes by phosphorylated protein kinase A-RIIβ. J Immunol 2004, in press.
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J Immunol
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Elliott, M.R.1
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Brooks, J.W.3
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27
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0036264363
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Electroporation-mediated gene transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activity
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Herndon TM, Juang Y-T, Solomou E, et al.: Electroporation-mediated gene transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activity. Clin Immunol 2002, 103:145-153.
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Clin Immunol
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Herndon, T.M.1
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Solomou, E.3
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0035869333
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Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus
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Solomou EE, Juang Y-T, Gourley MF, et al.: Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus. J Immunol 2001, 166:4216-4222.
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Solomou, E.E.1
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29
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0037108487
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Antisense cyclic adenosine 5′-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus
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Tenbrock K, Juang Y-T, Gourley MF, et al.: Antisense cyclic adenosine 5′-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus. J Immunol 2002, 169:4147-4152.
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Tenbrock, K.1
Juang, Y.-T.2
Gourley, M.F.3
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4344718846
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cAMP response element modulator is responsible for the decreased expression of c-fos and AP-1 binding in T cells from patients with systemic lupus erythematosus
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in press
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Kyttaris VC, Juang Y-T, Tenbrock K, et al.: cAMP response element modulator is responsible for the decreased expression of c-fos and AP-1 binding in T cells from patients with systemic lupus erythematosus. J Immunol 2004, in press.
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J Immunol
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Kyttaris, V.C.1
Juang, Y.-T.2
Tenbrock, K.3
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31
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1942454327
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Human lupus T cells resist inactivation and escape death by upregulating COX-2
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Xu L, Zhang L, Yi Y, et al.: Human lupus T cells resist inactivation and escape death by upregulating COX-2. Nat Med 2004, 10:411-415. A novel mechanism through which lupus T cells escape AICD and anergy is explored in this article. T cells from patients with SLE upregulate COX-2 on activation. Blocking that molecule with celecoxib induced apoptosis that was associated with increased Fas signaling.
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Combining Fas mutation with interleukin-2 deficiency prevents colitis and lupus: Implicating interleukin-2 for autoreactive T cell expansion and Fas ligand for colon epithelial cell death
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Xiao S, Sung SS, Fu SM, et al.: Combining Fas mutation with interleukin-2 deficiency prevents colitis and lupus: implicating interleukin-2 for autoreactive T cell expansion and Fas ligand for colon epithelial cell death. J Biol Chem 2003, 278:52730-52738.
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Xiao, S.1
Sung, S.S.2
Fu, S.M.3
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1342282319
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The centromeric region of chromosome 7 from MRL mice (Lmb3) is an epistatic modifier of Fas for autoimmune disease expression
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Kong PL, Morel L, Croker BP, et al.: The centromeric region of chromosome 7 from MRL mice (Lmb3) is an epistatic modifier of Fas for autoimmune disease expression. J Immunol 2004, 172:2785-2794.
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J Immunol
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Kong, P.L.1
Morel, L.2
Croker, B.P.3
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34
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1642540587
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Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis
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Waters ST, McDuffie M, Bagavant H, et al.: Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis. J Exp Med 2004, 199:255-264.
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Waters, S.T.1
McDuffie, M.2
Bagavant, H.3
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0037443547
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The cyclic adenosine 5′-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism
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Tenbrock K, Juang Y-T, Tolnay M, et al.: The cyclic adenosine 5′-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism. J Immunol 2003, 170:2971-2976.
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Tolnay, M.3
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Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse
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Mishra N, Reilly CM, Brown DR, et al.: Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. J Clin Invest 2003, 111:539-552.
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Mishra, N.1
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