Effect of nafamostat mesilate on pulmonary vascular injury induced by lipopolysaccharide in rats

American Journal of Respiratory and Critical Care Medicine

Volumn 155, Issue 2, 1997, Pages 711-718

  Uchiba, Mitsuhiro ^a   Okajima, Kenji ^a   Murakami, Kazunori ^a   Okabe, Hiroaki ^a   Takatsuki, Kiyoshi ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 7A; COMPLEMENT FACTOR H; LIPOPOLYSACCHARIDE; NAFAMSTAT MESILATE; THROMBIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; BLOOD VESSEL INJURY; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DRUG MECHANISM; HISTOPATHOLOGY; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG BLOOD VESSEL; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEINASE INHIBITION; RAT;

EID: 0031045815     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.155.2.9032217     Document Type: Article

References (45)

1. Bone, R. C., R. Maunder, G. Slotman, H. Silverman, T. M. Hyers, M. D. Kerstein, and J. J. Ursprung. 1989. An early lest of survival in patients with the adult respiratory distress syndrome. Chest 96: 849-851.
2. Bone, R. C., R. Balk, G. Slotman, R. Maunder, H. Silverman, T. M. Hyers, and M. D. Kerstein. 1992. Adult respiratory distress syndrome. Sequence and importance of development of multiple organ failure. Chest 101:320-326.
3. St. John, R. C., and P. M. Dorinsky. 1993. Immunologic therapy for ARDS, septic shock, and multiple organ failure. Chest 103:932-943.
4. Okajima, K., Y. P. Wang, H. Okabe, M. Inoue, and K. Takatsuki. 1991. Role of leukocytes in the activation of intravascular coagulation in patients with septicemia. Am. J. Hematol. 36:265-271.
5. Tate, R. M., and J. E. Repine. 1983. Neutrophils and the adult respiratory distress syndrome. Am. Rev. Respir. Dis. 128:552-559.
6. Okajima, K., M. Uchiba, and K. Murakami. 1995. Nafamostat mesilate. Cardiovasc. Drug. Rev. 13:51-65.
7. Paques, E. P., and J. Romisch. 1991. Comparative study on the in vitro effectiveness of antithrombotic agents. Thromb. Res. 64:11-21.
8. Uchiba, M., K. Okajima, H. Abe, H. Okabe, and K. Takatsuki. 1994. Effect of nafamostat mesilate, a synthetic protease inhibitor, on tissue factor-factor VIIa complex activity. Thromb. Res. 74:155-161.
9. Takahashi, H., S. Takizawa, W. Tatewaki, K. Nagai, K. Wada, M. Hanano, and A. Sibata. 1989. Nafamostat mesilate (FUT-175) in the treatment of patients with disseminated intravascular coagulation. Thromb. Haemost. 62:372.
10. Yoshikawa, T., M. Murakami, Y. Furukawa, H. Kato, S. Takemura, and M. Kondo. 1983. Effects of FUT-175, a new synthetic protease inhibitor on endotoxin-induced disseminated intravascular coagulation in rats. Hemostasis 13:374-378.
11. Bregengaard, C., O. Nordfang, P. Wildgoose, and V. Diness. 1993. Effect of two domain tissue factor pathway inhibitor (2D-TFPI) and inactivated factor VIIa on endotoxin-induced DIC in rabbits. In G. Müller-Berghaus, K. Madlener, M. Blombäck, and J. W. ten Cate, editors. DIC: Pathogenesis, Diagnosis, and Therapy of Disseminated Intravascular Fibrin Formation. Elsevier Science Publishers B. V., Amsterdam. 229-231.
12. Uchiba, M., K. Okajima, K. Murakami, H. Okabe, and K. Takatsuki. 1995. Endotoxin-induced pulmonary vascular injury is mainly mediated by activated neutrophils in rats. Thromb. Res. 78:117-125.
13. Zhang, X., and E. F. Ellis. 1990. Superoxide dismutase reduces permeability and edema induced by hypertension in rats. Am. J. Physiol. 259:H497-H503.
14. Chang, S. W. 1994. Endotoxin-induced pulmonary leukostasis in the rat: role of platelet-activating factor and tumor necrosis factor. J. Lab. Clin. Med. 123:65-72.
15. Chang, S. W., N. Ohara, G. Kuo, and N. F. Voelkel. 1989. Tumor necrosis factor-α induced lung injury is not mediated by platelet-activating factor. Am. J. Physiol. 257:L232-L239.
16. Chang, J. C., and M. Lesser. 1984. Quantitation of leukocytes in bronchoalveolar lavage samples from rats after intravascular injection of endotoxin. Am. Rev. Respir. Dis. 129:72-75.
17. Clauss, A. 1957. Rapid physiological coagulation method for the determination of fibrinogen. Acta Haematol. (Basel) 17:237-246.
18. Osler, A. G., J. H. Strauss, and M. M. Mayer. 1952. Diagnostic complement fixation. Am. J. Syph. 36:140-153.
19. Ford, T. C., and D. Rickwood. 1982. Formation of isotonic Nycodenz gradients for cell separations. Anal. Biochem. 124:293-298.
20. Watabe, S., F. Sendo, S. Kimura, and S. Arai. 1984. Activation of cytotoxic polymorphonuclear leukocytes by in vivo administration of a streptococcal preparation, OK-432. J. Natl. Cancer Inst. 72:1365-1370.
21. Leculier, C., N. Couprie, P. Adeleine, P. Leitienne, A. Francina, and M. Richard. 1993. The effects of high molecular weight- and low molecular weight-heparins on superoxide ion production and degranulation by human polymorphonuclear leukocytes. Thromb. Res. 69: 519-531.
22. Tanaka, H., T. Shimazu, H. Sugimoto, T. Yoshioka, and T. Sugimoto. 1990. A sensitive and specific assay for granulocyte elastase in inflammatory tissue fluid using L-pyroglutamyl-L-prolyl-L-valine-p-nitro-anilide. Clin. Chim. Acta 187:173-180.
23. 2) and hydroxyl radical production by human polymorphonuclear leukocytes. Hepatogastroenterology 39:59-61.
24. Russel-Smith, N. C., R. J. Flower, and D. C. Cardinal. 1981. Measuring platelet and leukocyte aggregation/adhesion responses in very small volumes of whole blood. J. Pharmacol. Methods 6:315-333.
25. Kirchhofer, D., T. B. Tschopp, and H. R. Baumgartner. 1995. Active site-blocked factor VIIa and IXa differentially inhibit fibrin formation in a human ex vivo thrombosis model. Arterioscler. Thromb. Vasc. Biol. 15:1098-1106.
26. Fujii, S., Y. Hitomi, Y. Sajai, N. Ikari, M. Hirado, and M. Niinobe. 1983. Synthetic inhibitors of protease in blood. In N. Katunuma, editor. Proteinase Inhibitors: Medical and Biological Aspects. Japan Scientific Societies Press, Tokyo. 37-44.
27. Bachofen, M., and E. F. Weibel. 1982. Structural alterations of lung parenchyma in the adult respiratory distress syndrome. Clin. Chest Med. 3:35-56.
28. Davie, E. W., K. Fujikawa, and W. Kisiel. 1991. The coagulation cascade: initiation, maintenance, and regulation. Biochemistry 30:10365-10370.
29. Kaplan, J. E., and A. B. Malik. 1987. Thrombin-induced intravascular coagulation: role in vascular injury. Semin. Thromb. Hemost. 13:398-415.
30. Hasegawa, N., A. W. Husari, W. T. Hart, T. G. Kandra, and T. A. Raffin. 1995. Role of the coagulation system in ARDS. Chest 105: 268-277.
31. Brett, J., H. Gerlach, P. Nawroth, S. Steinberg, G. Godman, and D. Stern. 1989. Tumor necrosis factor/cachectin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins. J. Exp. Med. 169:1977-1991.
32. Stephens, K. E., A. Ishizaka, Z. H. Wu, J. W. Larrick, and T. A. Raffin. 1988. Granulocyte depletion prevents tumor necrosis factor-mediated acute lung injury in guinea pigs. Am. Rev. Respir. Dis. 138:1300-1307.
33. Abe, H., K. Okajima, H. Okabe, K. Takatsuki, and B. R. Binder. 1994. Granulocyte proteases and hydrogen peroxide synergistically inactivate thrombomodulin of endothelial cells in vitro. J. Lab. Clin. Med. 123:874-881.
34. Moore, F. D., Jr. 1994. Therapeutic regulation of the complement system in acute injury state. Adv. Immunol. 56:267-299.
35. Rabinovici, R., C. G. Yeh, L. M. Hillegass, D. E. Griswold, M. J. DiMartino, J. E. Vernick, K. L. Fong, and G. Feuerstein. 1992. Role of complement in endotoxin/platelet-activating factor-induced lung injury. J. Immunol. 149:1744-1750.
36. Stevens, J. H., P. O'Hanley, J. M. Shapiro, F. G. Mihm, P. S. Satoh, J. A. Collins, and T. A. Raffin. 1986. Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates. J. Clin. Invest. 77:1812-1816.
37. Naka, Y., H. Hirose, H. Matsuda, S. Nakano, R. Shirakura, A. Kawaguchi, Y. Miyamoto, S. Miyagawa, N. Fukashima, and Y. Kawashima. 1989. Prevention of pulmonary edema in autoperfusing heart-lung preparation by FUT-175 and leukocyte depletion. Transplant. Proc. 21:1353-1356.
38. Kuratani, T., H. Matsuda, Y. Sawa, M. Kaneko, S. Nakano, and Y. Kawashima. 1992. Experimental study in a rabbit model of ischemia-reprefusion lung injury during cardiovascular bypass. J. Thorac. Cardiovasc. Surg. 103:564-568.
39. Rinaldo, J. E., J. H. Dauber, J. Christman, and R. M. Rogers. 1984. Neutrophil alveolitis following endotoxemia. Enhancement by previous exposure to hyperoxia. Am. Rev. Respir. Dis. 130:1065-1071.
40. Meyrick, B., L. C. Berry, Jr., and B. W. Christman. 1995. Response of cultured human pulmonary artery endothelial cells to endotoxin. Am. J. Physiol. 268:L239-L244.
41. Hammerschmidt, D. E., L. J. Weaver, L. D. Hudson, P. R. Craddock, and H. S. Jacob. 1980. Association of complement activation and elevated plasma-C5a with adult respiratory distress syndrome. Lancet 1:947-949.
42. Parsons, P. E., and P. C. Giclas. 1990. The terminal complement complex (sC5b-9) is not specifically associated with the development of the adult respiratory distress syndrome. Am. Rev. Respir. Dis. 141: 98-103.
43. Wachtfogel, Y. T., R. A. Pixley, U. Kucich, W. Abrams, G. Weinbaum, M. Schapira, and R. W. Colman. 1986. Purified plasma factor XIIa aggregates human neutrophils and causes degradation. Blood 67:1731-1737.
44. Schapira, M., E. Despland, C. F. Scott, L. A. Boxer, and R. W. Colman. 1982. Purified human plasma kallikrein aggregates human blood neutrophils. J. Clin. Invest. 69:1199-1202.
45. Cardozo, C., J. Edelman, J. Jaishree, and M. Lesser. 1991. Lipoplysaccharide-induced pulmonary vascular sequestration of polymorphonuclear leukocytes is complement independent. Am. Rev. Respir. Dis. 144:173-178.