Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury: Inhibition of late apoptosis and inflammation

Transplantation

Volumn 75, Issue 3, 2003, Pages 375-382

  De Vries, Bart ^a   Matthijsen, Robert A ^a   Wolfs, Tim G A M ^a   Van Bijnen, Annemarie A J H M ^a   Heeringa, Peter ^b   Buurman, Wim A ^a,c  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C6; COMPLEMENT COMPONENT C9; COMPLEMENT INHIBITOR; COMPLEMENT MEMBRANE ATTACK COMPLEX; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY BB5 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT INHIBITION; CONTROLLED STUDY; DISEASE MODEL; INHIBITION KINETICS; KIDNEY ISCHEMIA; KIDNEY TUBULE; KIDNEY TUBULE EPITHELIUM; MALE; MOUSE; NEPHRECTOMY; NEPHRITIS; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; REPERFUSION INJURY; TISSUE LEVEL;

ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; BLOOD UREA NITROGEN; COMPLEMENT ACTIVATION; COMPLEMENT C5; COMPLEMENT MEMBRANE ATTACK COMPLEX; CREATININE; KIDNEY; MALE; MICE; NEPHRITIS; NEUTROPHILS; REPERFUSION INJURY;

EID: 0037442163     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000044455.05584.2A     Document Type: Article

References (37)

1. Daemen MA, van 't Veer C, Denecker G, et al. Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. J Clin Invest 1999; 104(5): 541.
2. Yaoita H, Ogawa K, Maehara K, et al. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor. Circulation 1998; 97(3): 276.
3. Endres H, Namura S, Skimizu-Sasamata M, et al. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. J Cereb Blood Flow Metab 1998; 18(3): 238.
4. Ikeda H, Suzuki Y, Suzuki M, et al. Apoptosis is a major mode of cell death caused by ischaemia and ischaemia/reperfusion injury to the rat intestinal epithelium. Gut 1998; 42(4): 530.
5. Cursio R, Gugenheim J, Ricci JE, et al. A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis. FASEB J 1999; 13(2): 253.
6. Heinzelmann M, Mercer JM, Passmore JC. Neutrophils and renal failure. Am J Kidney Dis 1999; 34(2): 384.
7. Daemen MA, van de Ven MW, Heineman E, et al. Involvement of endogenous interleukin-10 and tumor necrosis factor-alpha in renal ischemiareperfusion injury. Transplantation 1999; 67(6): 792.
8. De Greef KE, Ysebaert DK, Ghielli M, et al. Neutrophils and acute ischemia-reperfusion injury. J Nephrol 1998; 11(3): 110.
9. Donnahoo KK, Meng X, Ayala A, Cain MP, Harken AH, Meldrum DR. Early kidney TNF-alpha expression mediates neutrophil infiltration and injury after renal ischemia-reperfusion. Am J Physiol 1999; 277: R922.
10. Chandrasekar B, Smith JB, Freeman GL. Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine. Circulation 2001; 103(18): 2296.
11. Miura M, Fu X, Zhang QW, et al. Neutralization of gro-alpha and macrophage inflammatory protein-2 attenuates renal ischemia/reperfusion injury. Am J Pathol 2001; 159(6): 2137.
12. Zhou W, Farrar CA, Abe K, et al. Predominant role for C5b-9 in renal ischemia/reperfusion injury. J Clin Invest 2000; 105(10): 1363.
13. Vakeva AP, Agah A, Rollins SA, et al. Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy. Circulation 1998; 97(22): 2259.
14. Vakeva A, Morgan BP, Tikkanen I, et al. Time course of complement activation and inhibitor expression after ischemic injury of rat myocardium. Am J Pathol 1994; 144(6): 1357.
15. Stein JH, Osgood RW, Barnes JL, et al. The role of complement in the pathogenesis of postischemic acute renal failure. Miner Electrolyte Metab 1985; 11(4): 256.
16. Wada K, Montalto MC, Stahl GL. Inhibition of complement C5 reduces local and remote organ injury after intestinal ischemia/reperfusion in the rat. Gastroenterology 2001; 120(1): 126.
17. Czermak BJ, Sarma V, Bless NM, et al. In vitro and in vivo dependency of chemokine generation on C5a and TNF-alpha. J Immunol 1999; 162(4): 2321.
18. Ivey CL, Williams FM, Collins PD, et al. Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit: evidence for a role for C5a and interleukin-8. J Clin Invest 1995; 95(6): 2720.
19. David S, Biancone L, Caserta C, et al. Alternative pathway complement activation induces proinflammatory activity in human proximal tubular epithelial cells. Nephrol Dial Transplant 1997; 12(1): 51.
20. Kilgore KS, Flory CM, Miller BF, et al. The membrane attack complex of complement induces interleukin-8 and monocyte chemoattractant protein-1 secretion from human umbilical vein endothelial cells. Am J Pathol 1996; 149(3): 953.
21. Cragg MS, Howatt WJ, Bloodworth L, et al. Complement mediated cell death is associated with DNA fragmentation. Cell Death Differ 2000; 7(1): 48.
22. Nauta AJ, Daha MR, Tijsma O, et al. The membrane attack complex of complement induces caspase activation and apoptosis. Eur J Immunol 2002; 32(3): 783.
23. Hughes J, Nangaku M, Alpers CE, et al. C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glomerulonephritis. Am J Physiol 2000; 278(5): F747.
24. Sato T, Van Dixhoorn MG, Prins FA, et al. The terminal sequence of complement plays an essential role in antibody-mediated renal cell apoptosis. J Am Soc Nephrol 1999; 10(6): 1242.
25. Shimizu A, Masuda Y, Kitamura H, et al. Complement-mediated killing of mesangial cells in experimental glomerulonephritis: cell death by a combination of apoptosis and necrosis. Nephron 2000; 86(2): 152.
26. Frei Y, Lambris JD, Stockinger B. Generation of a monoclonal antibody to mouse C5 application in an ELISA assay for detection of anti-C5 antibodies. Mol Cell Probes 1987; 1(2): 141.
27. Wang Y, Rollins SA, Madri JA, et al. Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease. Proc Natl Acad Sci USA 1995; 92(19): 8955.
28. Klerx JP, Beukelman CJ, Van Dijk H, et al. Microassay for colorimetric estimation of complement activity in guinea pig, human and mouse serum. J Immunol Methods 1983; 63(2): 215.
29. Vakeva A, Meri S, Lehto T, et al. Activation of the terminal complement cascade in renal infarction. Kidney Int 1995; 47(3): 918.
30. Ichida S, Yuzawa Y, Okada H, et al. Localization of the complement regulatory proteins in the normal human kidney. Kidney Int 1994; 46(1): 89.
31. Jordan JE, Montalto MC, Stahl GL. Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury. Circulation 2001; 104(12): 1413.
32. Buerke M, Schwertz H, Seitz W, et al. Novel small molecule inhibitor of c1s exerts cardioprotective effects in ischemia-reperfusion injury in rabbits. J Immunol 2001; 167(9): 5375.
33. Guo RF, Huber-Lang M, Wang X, et al. Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis. J Clin Invest 2000; 106(10): 1271.
34. Farkas I, Baranyi L, Liposits ZS, et al. Complement C5a anaphylatoxin fragment causes apoptosis in TGW neuroblastoma cells. Neuroscience 1998; 86(3): 903.
35. Serrao KL, Fortenberry JD, Owens ML, et al. Neutrophils induce apoptosis of lung epithelial cells via release of soluble Fas ligand. Am J Physiol 2001; 280(2): L298.
36. Yang JJ, Preston GA, Pendergraft WF, et al. Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants. Am J Pathol 2001; 158(2): 581.
37. Park P, Haas M, Cunningham PN, et al. Inhibiting the complement system does not reduce injury in renal ischemia reperfusion. J Am Soc Nephrol 2001; 12(7): 1383.