Structural basis for redox regulation of Yap1 transcription factor localization

Nature

Volumn 430, Issue 7002, 2004, Pages 917-921

  Wood, Matthew J ^a   Storz, Gisela ^a   Tjandra, Nica ^b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; CYTOLOGY; HYDROPHOBICITY; OXYGEN;

DISULPHIDE BONDS; NUCLEAR EXPORT SIGNALS (NES);

GENES;

REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR YAP1; UNCLASSIFIED DRUG;

BIOLOGY; GENETICS;

ALPHA HELIX; ARTICLE; CARBOXY TERMINAL SEQUENCE; DISULFIDE BOND; GENE EXPRESSION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; CELL EXTRACTS; CELL NUCLEUS; CONSERVED SEQUENCE; CYTOPLASM; DISULFIDES; GENE EXPRESSION REGULATION, FUNGAL; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; OXIDATION-REDUCTION; POINT MUTATION; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

NES; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 4344562921     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02790     Document Type: Article

References (29)

1. Kuge, S., Jones, N. & Nomoto, A. Regulation of yAP-1 nuclear localization in response to oxidative stress. EMBO J. 16, 1710-1720 (1997).
2. 2 stimulon in Saccharomyces cerevisiae. J. Biol. Chem. 273, 22480-22489 (1998).
3. Gasch, A. P. et al. Genomic expression programs in the response of yeast cells to environmental changes. Mol. Biol. Cell 11, 4241-4257 (2000).
4. Yan, C., Lee, L. H. & Davis, L. I. Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor. EMBO J. 17, 7416-7429 (1998).
5. Isoyama, T., Murayama, A., Nomoto, A. & Kuge, S. Nuclear import of the yeast AP-1-like transcription factor Yap1p is mediated by transport receptor Pse1p, and this import step is not affected by oxidative stress. J. Biol. Chem. 276, 21863-21869 (2001).
6. Coleman, S. T., Epping, E. A., Steggerda, S. M. & Moye-Rowley, W. S. Yap1p activates gene transcription in an oxidant-specific fashion. Mol. Cell. Biol. 19, 8302-8313 (1999).
7. Wood, M. J., Andrade, E. C. & Storz, G. The redox domain of the Yap1p transcription factor contains two disulfide bonds. Biochemistry 42, 11982-11991 (2003).
8. 2 sensing through oxidation of the Yap1 transcription factor. EMBO J. 19, 5157-5166 (2000).
9. 2 receptor and redox-transducer in gene activation. Cell 111, 471-481 (2002).
10. Demarest, S. J. et al. Mutual synergistic folding in recruitment of CBP/p300 by p 160 nuclear receptor coactivators. Nature 415, 549-553 (2002).
11. Choi, H. et al. Structural basis of the redox switch in the OxyR transcription factor. Cell 105, 103-113 (2001).
12. Graumann, J. et al. Activation of the redox-regulated molecular chaperone Hsp33-a two-step mechanism. Structure (Camb) 9, 377-387 (2001).
13. Vijayalakshmi, J., Mukhergee, M. K., Graumann, J., Jakob, U. & Saper, M. A. The 2.2 A crystal structure of Hsp33: a heat shock protein with redox-regulated chaperone activity. Structure (Camb) 9, 367-375 (2001).
14. Kaffman, A. & O'Shea, E. K. Regulation of nuclear localization: a key to a door. Annu. Rev. Cell Dev. Biol. 15, 291-339 (1999).
15. Kau, T. R., Way, J. C. & Silver, P. A. Nuclear transport and cancer: from mechanism to intervention. Nature Rev. Cancer 4, 106-117 (2004).
16. Zhu, J. et al. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. Cell 93, 851-861 (1998).
17. Clore, G. M. et al. High-resolution structure of the oligomerization domain of p53 by multidimensional NMR. Science 265, 386-391 (1994).
18. Stommel, J. M. et al. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J. 18, 1660-1672 (1999).
19. Kim, P. W., Sun, Z. Y., Blacklow, S. C., Wagner, G. & Eck, M. J. A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science 301, 1725-1728 (2003).
20. Sikorski, R. S. & Hieter, P. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27 (1989).
21. Suzuki, M., Youle, R. J. & Tjandra, N. Structure of Bax: coregulation of dimer formation and intracellular localization. Cell 103, 645-654 (2000).
22. Delaglio, F. et al. NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J. Biomol. NMR 6, 277-293 (1995).
23. Garrett, D. S., Powers, R., Gronenborn, A. M. & Clore, G. M. A common-sense approach to peak picking in 2-dimensional, 3-dimensional, and 4-dimensional spectra using automatic computer-analysis of contour diagrams. J. Magn. Reson. 95, 214-220 (1991).
24. Clore, G. M. & Gronenborn, A. M. Multidimensional heteronuclear nuclear magnetic resonance of proteins. Methods Enzymol. 239, 349-363 (1994).
25. Cavanagh, J., Fairbrother, W. J., Palmer, A. G. & Skelton, N. J. Protein NMR Spectroscopy: Principles and Practice (Academic, San Diego, 1995).
26. Cornilescu, G., Delaglio, F. & Bax, A. Protein backbone angle restraints from searching a database for chemical shift and sequence homology. J. Biomol. NMR 13, 289-302 (1999).
27. Hansen, M. R., Mueller, L. & Pardi, A. Tunable alignment of macromolecules by filamentous phage yields dipolar coupling interactions. Nature Struct. Biol. 5, 1065-1074 (1998).
28. 13C couplings in the structure determination of magnetically oriented macromolecules in solution. Nature Struct. Biol. 4, 732-738 (1997).
29. Schwieters, C. D., Kuszewski, J. J., Tjandra, N. & Clore, G. M. The Xplor-NIH NMR molecular structure determination package. J. Magn. Reson. 160, 65-73 (2003).