A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8

Science

Volumn 301, Issue 5640, 2003, Pages 1725-1728

  Kim, Peter W ^a,b   Sun, Zhen Yu J ^b   Blacklow, Stephen C ^c   Wagner, Gerhard ^b   Eck, Michael J ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; TERNARY SYSTEMS;

CELL CORECEPTORS;

CELL CULTURE;

CD4 ANTIGEN; CD8 ANTIGEN; LEUCINE; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; ZINC;

BIOLOGY; ZINC;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL MATURATION; COMPLEX FORMATION; CYTOPLASM; ENDOCYTOSIS; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE; T LYMPHOCYTE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; CALORIMETRY; CYTOPLASM; DIMERIZATION; DIPEPTIDES; HUMANS; HYDROPHOBICITY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; T-LYMPHOCYTES; ZINC;

EID: 0141654999     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1085643     Document Type: Article

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28. We thank S. Harrison for critical comments on the manuscript. M.J.E. is a recipient of a Scholar Award from the Leukemia and Lymphoma Society. S.C.B. is a Pew Scholar in the Biomedical Sciences and an Established investigator of the American Heart Association. This work was supported in part by NIH grants CA080942 (M.J.E.), A137581 (G.W.), and HL61001 (S.C.B.). Atomic coordinates have been deposited in the Protein Data Bank with accession numbers 1Q68 (for CD4-Lck) and 1Q69 (for CD8-Lck).