Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: A quantitative proteomic analysis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 16, 2008, Pages 6069-6074

  Steen, Judith A J ^a   Steen, Hanno ^a   Georgi, Ann ^b   Parker, Kenneth ^c   Springer, Michael ^b   Kirchner, Marc ^d   Hamprecht, Fred ^d   Kirschner, Marc W ^b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cell cycle arrest; Mass spectrometry; Prometaphase; Stable isotope free quantitation

Indexed keywords

ANAPHASE PROMOTING COMPLEX; ANTIMITOTIC AGENT; MONASTROL; NOCODAZOLE; PACLITAXEL; VINCRISTINE; ANAPHASE-PROMOTING COMPLEX; PROTEIN SUBUNIT; PYRIMIDINE DERIVATIVE; THIOKETONE; UBIQUITIN PROTEIN LIGASE;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; HELA CELL; HUMAN; HUMAN CELL; ISOTOPE FREE QUANTITATION OF THE EXTENT OF MODIFICATION; MASS SPECTROMETRY; MITOSIS INHIBITION; PRIORITY JOURNAL; PROMETAPHASE; PROTEOMICS; QUANTITATIVE ANALYSIS; STOICHIOMETRY; DRUG EFFECT; METABOLISM; METHODOLOGY; MITOSIS SPINDLE; PHOSPHORYLATION;

ANTIMITOTIC AGENTS; HELA CELLS; HUMANS; MASS SPECTROMETRY; MITOTIC SPINDLE APPARATUS; NOCODAZOLE; PACLITAXEL; PHOSPHORYLATION; PROMETAPHASE; PROTEIN SUBUNITS; PROTEOMICS; PYRIMIDINES; THIONES; UBIQUITIN-PROTEIN LIGASE COMPLEXES; VINCRISTINE;

EID: 43149125189     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0709807104     Document Type: Article

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