Structure of the complement factor 5a receptor-ligand complex studied by disulfide trapping and molecular modeling

Journal of Biological Chemistry

Volumn 283, Issue 12, 2008, Pages 7763-7775

  Hagemann, Ian S ^a   Miller, Daniel L ^a   Klco, Jeffery M ^a   Nikiforovich, Gregory V ^a   Baranski, Thomas J ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Campus Box 8127 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; FLOW INTERACTIONS; MOLECULAR MODELING; MOLECULAR ORIENTATION; THREE DIMENSIONAL;

ANAPHYLATOXIN; COUPLED RECEPTORS; DISULFIDE TRAPPING; DYNAMIC EQUILIBRIUMS; EXTRACELLULAR LOOPS; FUNCTIONAL INTERACTIONS; G PROTEINS; INTERMOLECULAR INTERACTIONS; LIGAND COMPLEXES; LIGAND MOLECULES; N TERMINUSES; NOVEL TECHNIQUES; RANDOM MUTAGENESISES; RECEPTOR CONFORMATIONS; RELATIVE ORIENTATIONS; THREE-DIMENSIONAL MODELS;

LIGANDS;

COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A RECEPTOR; CYSTEINE; DISULFIDE; G PROTEIN COUPLED RECEPTOR; LIGAND; COMPLEMENT C5A RECEPTOR, HUMAN; COMPLEMENT RECEPTOR; MEMBRANE PROTEIN; MULTIPROTEIN COMPLEX; RECOMBINANT PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; FUNGAL STRAIN; MOLECULAR MODEL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SPIN TRAPPING; STRUCTURE ANALYSIS; TECHNIQUE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING;

COMPLEMENT C5A; DISULFIDES; HUMANS; IMAGING, THREE-DIMENSIONAL; MEMBRANE PROTEINS; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; MUTAGENESIS; RECEPTORS, COMPLEMENT; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 43149124854     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709467200     Document Type: Article

References (38)

1. Bockaert, J., and Pin, J. P. (1999) EMBO J. 18, 1723-1729
2. Fredriksson, R., and Schioth, H. B. (2005) Mol. Pharmacol. 67, 1414-1425
3. Drews, J. (2000) Science 287, 1960-1964
4. Fan, Q. R., and Hendrickson, W. A. (2005) Nature 433, 269-277
5. Ji, T. H., Grossmann, M., and Ji, I. (1998) J. Biol. Chem. 273, 17299-17302
6. Gerard, N. P., and Gerard, C. (1991) Nature 349, 614-617
7. Allegretti, M., Moriconi, A., Beccari, A. R., Di Bitondo, R., Bizzarri, C., Bertini, R., and Colotta, F. (2005) Curr. Med. Chem. 12, 217-236
8. Siciliano, S. J., Rollins, T. E., DeMartino, J., Konteatis, Z., Malkowitz, L., Van Riper, G., Bondy, S., Rosen, H., and Springer, M. S. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 1214-1218
9. Mollison, K. W., Mandecki, W., Zuiderweg, E. R., Fayer, L., Fey, T. A., Krause, R. A., Conway, R. G., Miller, L., Edalji, R. P., Shallcross, M. A., Lane, B., Fox, J. L., Greer, J., and Carter, G. W. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 292-296
10. DeMartino, J. A., Van Riper, G., Siciliano, S. J., Molineaux, C. J., Konteatis, Z. D., Rosen, H., and Springer, M. S. (1994) J. Biol. Chem. 269, 14446-14450
11. Chen, Z., Zhang, X., Gonnella, N. C., Pellas, T. C., Boyar, W. C., and Ni, F. (1998) J. Biol. Chem. 273, 10411-10419
12. Hagemann, I. S., Narzinski, K. D., Floyd, D. H., and Baranski, T. J. (2006) J. Biol. Chem. 281, 36783-36792
13. Mery, L., and Boulay, F. (1993) Eur. J. Haematol. 51, 282-287
14. Mery, L., and Boulay, F. (1994) J. Biol. Chem. 269, 3457-3463
15. Gerber, B. O., Meng, E. C., Dotsch, V., Baranski, T. J., and Bourne, H. R. (2001) J. Biol. Chem. 276, 3394-3400
16. Higginbottom, A., Cain, S. A., Woodruff, T. M., Proctor, L. M., Madala, P. K., Tyndall, J. D., Taylor, S. M., Fairlie, D. P., and Monk, P. N. (2005) J. Biol. Chem. 280, 17831-17840
17. Kawai, M., Quincy, D. A., Lane, B., Mollison, K. W., Or, Y. S., Luly, J. R., and Carter, G. W. (1992) J. Med. Chem. 35, 220-223
18. DeMartino, J. A., Konteatis, Z. D., Siciliano, S. J., Van Riper, G., Underwood, D. J., Fischer, P. A., and Springer, M. S. (1995) J. Biol. Chem. 270, 15966-15969
19. Kolakowski, L. F., Jr., Lu, B., Gerard, C., and Gerard, N. P. (1995) J. Biol. Chem. 270, 18077-18082
20. Baranski, T. J., Herzmark, P., Lichtarge, O., Gerber, B. O., Trueheart, J., Meng, E. C., Iiri, T., Sheikh, S. P., and Bourne, H. R. (1999) J. Biol. Chem. 274, 15757-15765
21. Dohlman, H. G., and Thorner, J. W. (2001) Annu. Rev. Biochem. 70, 703-754
22. Brown, A. J., Dyos, S. L., Whiteway, M. S., White, J. H., Watson, M. A., Marzioch, M., Clare, J. J., Cousens, D. J., Paddon, C., Plumpton, C., Romanos, M. A., and Dowell, S. J. (2000) Yeast 16, 11-22
23. Klco, J. M., Wiegand, C. B., Narzinski, K., and Baranski, T. J. (2005) Nat. Struct. Mol. Biol. 12, 320-326
24. Nikiforovich, G. V., and Marshall, G. R. (2003) Biochemistry 42, 9110-9120
25. Nikiforovich, G. V., and Marshall, G. R. (2005) Biophys. J. 89, 3780-3789
26. Matsumoto, M. L., Narzinski, K., Kiser, P. D., Nikiforovich, G. V., and Baranski, T. J. (2007) J. Biol. Chem. 282, 3105-3121
27. Finch, A. M., Vogen, S. M., Sherman, S. A., Kirnarsky, L., Taylor, S. M., and Sanderson, S. D. (1997) J. Med. Chem. 40, 877-884
28. Vogen, S. M., Finch, A. M., Wadi, S. K., Thatcher, J., Monk, P. N., Taylor, S. M., and Sanderson, S. D. (1999) J. Pept. Res. 53, 8-17
29. Zuiderweg, E. R., Nettesheim, D. G., Mollison, K. W., and Carter, G. W. (1989) Biochemistry 28, 172-185
30. Zhang, X., Boyar, W., Galakatos, N., and Gonnella, N. C. (1997) Protein Sci. 6, 65-72
31. Bubeck, P., Grotzinger, J., Winkler, M., Kohl, J., Wollmer, A., Klos, A., and Bautsch, W. (1994) Eur. J. Biochem. 219, 897-904
32. Toth, M. J., Huwyler, L., Boyar, W. C., Braunwalder, A. F., Yarwood, D., Hadala, J., Haston, W. O., Sills, M. A., Seligmann, B., and Galakatos, N. (1994) Protein Sci. 3, 1159-1168
33. Cain, S. A., Coughlan, T., and Monk, P. N. (2001) Biochemistry 40, 14047-14052
34. Cain, S. A., Higginbottom, A., and Monk, P. N. (2003) Biochem. Pharmacol. 66, 1833-1840
35. Raffetseder, U., Roper, D., Mery, L., Gietz, C., Klos, A., Grotzinger, J., Wollmer, A., Boulay, F., Kohl, J., and Bautsch, W. (1996) Eur. J. Biochem. 235, 82-90
36. Geva, A., Lassere, T. B., Lichtarge, O., Pollitt, S. K., and Baranski, T. J. (2000) J. Biol. Chem. 275, 35393-35401
37. Klco, J. M., Nikiforovich, G. V., and Baranski, T. J. (2006) J. Biol. Chem. 281, 12010-12019
38. Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G., Thian, F. S., Kobilka, T. S., Choi, H. J., Kuhn, P., Weis, W. I., Kobilka, B. K., and Stevens, R. C. (2007) Science 318, 1258-1265