Site-directed mutagenesis of conserved charged residues in the helical region of the human C5a receptor: Arg206 determines high-affinity binding sites of C5a receptor

European Journal of Biochemistry

Volumn 235, Issue 1-2, 1996, Pages 82-90

  Raffetseder, Ute ^a   Röper, Detlef ^b   Mery, Laurence ^c   Gietz, Claudia ^a   Klos, Andreas ^a   Grötzinger, Joachim ^b   Wollmer, Axel ^b   Boulay, François ^c   Köhl, Jörg ^a   Bautsch, Wilfried ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c CEA GRENOBLE   (France)

Author keywords

C5a receptor; Guanine nucleotide binding regulatory protein coupling; Receptor structure; Site directed mutagenesis

Indexed keywords

COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; XENOPUS;

ANIMALS; ANTIGENS, CD; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; COMPLEMENT C5A; CONSERVED SEQUENCE; ELECTROCHEMISTRY; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, ANAPHYLATOXIN C5A; RECEPTORS, COMPLEMENT;

EID: 0030047563     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.00082.x     Document Type: Article

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