Genotypic detection of acyclovir-resistant HSV-1: Characterization of 67 ACV-sensitive and 14 ACV-resistant viruses

Antiviral Research

Volumn 79, Issue 1, 2008, Pages 28-36

  Frobert, Emilie ^a,b   Cortay, Jean Claude ^b   Ooka, Tadamasa ^b   Najioullah, Fatiha ^c   Thouvenot, Danielle ^a,b   Lina, Bruno ^a,b   Morfin, Florence ^a,b  

^a HOSPICES CIVILS DE LYON   (France)

^b UNIVERSITÉ DE LYON   (France)

^c CENTRE HOSPITALIER UNIVERSITAIRE DE FORT DE FRANCE   (France)

Author keywords

ACV resistance; Direct genotyping; Herpes simplex virus; Thymidine kinase gene

Indexed keywords

ACICLOVIR; THYMIDINE KINASE;

ADULT; ARTICLE; CHILD; GENE; GENE DELETION; GENE MUTATION; GENETIC POLYMORPHISM; GENOTYPE; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IMMUNOCOMPROMISED PATIENT; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TK GENE; VIRUS DETECTION;

HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 43049180320     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2008.01.153     Document Type: Article

References (58)

1. G. Andrei R. Snoeck E. De Clercq R. Esnouf P. Fiten G. Opdenakker Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene J. Gen. Virol. 81 2000 639 648
2. M. Arens Clinically relevant sequence-based genotyping of HBV, HCV, CMV, and HIV J. Clin. Virol. 22 2001 11 29
3. N.K. Balasubramaniam V. Veerisetty G.A. Gentry Herpesviral deoxythymidine kinases contain a site analogous to the phosphoryl-binding arginine-rich region of porcine adenylate kinase; comparison of secondary structure predictions and conservation J. Gen. Virol. 71 1990 2979 2987
4. F. Baldanti K.K. Biron G. Gerna Interpreting human cytomegalovirus antiviral drug susceptibility testing: the role of mixed virus populations J. Infect. Dis. 177 1998 823 824
5. J. Bestman-Smith G. Boivin Drug resistance patterns of recombinant herpes simplex virus DNA polymerase mutants generated with a set of overlapping cosmids and plasmids J. Virol. 77 2003 7820 7829
6. J. Bestman-Smith I. Schmit B. Papadopoulou G. Boivin Highly reliable heterologous system for evaluating resistance of clinical herpes simplex virus isolates to nucleoside analogues J. Virol. 75 2001 3105 3110
7. D.G. Brown R. Visse G. Sandhu A. Davies P.J. Rizkallah C. Melitz W.C. Summers M.R. Sanderson Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir Nat. Struct. Biol. 2 1995 876 881
8. D. Chibo A. Mijch R. Doherty C. Birch Novel mutations in the thymidine kinase and DNA polymerase genes of acyclovir and foscarnet resistant herpes simplex viruses infecting an immunocompromised patient J. Clin. Virol. 25 2002 165 170
9. D. Chibo J. Druce J. Sasadeusz C. Birch Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus Antiviral Res. 61 2004 83 91
10. J. Christophers J. Clayton J. Craske R. Ward P. Collins M. Trowbridge G. Darby Survey of resistance of herpes simplex virus to acyclovir in northwest England Antimicrob. Agents Chemother. 42 1998 868 872
11. P. Collins B.A. Larder N.M. Oliver S. Kemp I.W. Smith G. Darby Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir J. Gen. Virol. 70 1989 375 382
12. C. Danve-Szatanek M. Aymard D. Thouvenot F. Morfin G. Agius I. Bertin S. Billaudel B. Chanzy M. Coste-Burel L. Finkielsztejn H. Fleury T. Hadou C. Henquell H. Lafeuille M.E. Lafon A. Le Faou M.C. Legrand L. Maille C. Mengelle P. Morand F. Morinet E. Nicand S. Omar B. Picard B. Pozzetto J. Puel D. Raoult C. Scieux M. Segondy J.M. Seigneurin R. Teyssou C. Zandotti Surveillance network for herpes simplex virus resistance to antiviral drugs: 3-year follow-up J. Clin. Microbiol. 42 2004 242 249
13. G. Darby B.A. Larder M.M. Inglis Evidence that the “active centre” of the herpes simplex virus thymidine kinase involves an interaction between three distinct regions of the polypeptide J. Gen. Virol. 67 1986 753 758
14. A. Ducancelle S. Alain F. Petit M.J. Sanson Le Pors M.C. Mazeron Development and validation of a non-radioactive DNA polymerase assay for studying cytomegalovirus resistance to foscarnet J. Virol. Methods 141 2007 212 215
15. H.J. Field D.M. Coen Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene J. Virol. 60 1986 286 289
16. E. Frobert T. Ooka J.C. Cortay B. Lina D. Thouvenot F. Morfin Herpes simplex virus thymidine kinase mutations associated with resistance to acyclovir: a site-directed mutagenesis study Antimicrob. Agents Chemother. 49 2005 1055 1059
17. E. Frobert T. Ooka J.C. Cortay B. Lina D. Thouvenot F. Morfin Resistance of herpes simplex virus type 1 to acyclovir: thymidine kinase gene mutagenesis study Antiviral Res. 73 2007 147 150
18. A. Gaudreau E. Hill H.H. Balfour Jr. A. Erice G. Boivin Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients J. Infect. Dis. 178 1998 297 303
19. C. Gilbert J. Bestman-Smith G. Boivin Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms Drug Resist. Updat. 5 2002 88 114
20. W. Harris P. Collins R.J. Fenton W. Snowden M. Sowa G. Darby Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to acyclovir J. Gen. Virol. 84 2003 1393 1401
21. E.L. Hill G.A. Hunter M.N. Ellis In vitro and in vivo characterization of herpes simplex virus clinical isolates recovered from patients infected with human immunodeficiency virus Antimicrob. Agents Chemother. 35 1991 2322 2328
22. C.B. Hwang H.J. Chen An altered spectrum of herpes simplex virus mutations mediated by an antimutator DNA polymerase Gene 152 1995 191 193
23. C.B. Hwang K.L. Ruffner D.M. Coen A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance J. Virol. 66 1992 1774 1776
24. A.F. Irmiere M.M. Manos J.G. Jacobson J.S. Gibbs D.M. Coen Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stability Virology 168 1989 210 220
25. E. Kudo H. Shiota T. Naito K. Satake M. Itakura Polymorphisms of thymidine kinase gene in herpes simplex virus type 1: analysis of clinical isolates from herpetic keratitis patients and laboratory strains J. Med. Virol. 56 1998 151 158
26. M. Langlois J.P. Allard F. Nugier M. Aymard A rapid and automated colorimetric assay for evaluating the sensitivity of herpes simplex strains to antiviral drugs J. Biol. Stand. 14 1986 201 211
27. B.A. Larder G. Darby Virus drug-resistance: mechanisms and consequences Antiviral Res. 4 1984 1 42
28. B.A. Larder G. Darby Selection and characterisation of acyclovir-resistant herpes simplex virus type 1 mutants inducing altered DNA polymerase activities Virology 146 1985 262 271
29. B.A. Larder S.D. Kemp G. Darby Related functional domains in virus DNA polymerases EMBO J. 6 1987 169 175
30. A. Lindström J. Odeberg J. Albert Pyrosequencing for detection of lamivudine-resistant hepatitis B virus J. Clin. Microbiol. 42 2004 4788 4795
31. C. McLaren L. Corey C. Dekket D.W. Barry In vitro sensitivity to acyclovir in genital herpes simplex viruses from acyclovir-treated patients J. Infect. Dis. 148 1983 868 875
32. M. Michael J. Fetzer G. Folkers Site-directed mutagenesis of herpes simplex virus type 1 thymidine kinase opposes the importance of amino acid positions 251, 321 and 348 for selective recognition of substrate analogs Biochem. Biophys. Res. Commun. 209 1995 966 973
33. H. Momméja-Marin M. Lafaurie C. Scieux L. Galicier E. Oksenhendler J.M. Molina Herpes simplex virus type 2 as a cause of severe meningitis in immunocompromised adults Clin. Infect. Dis. 37 2003 1527 1533
34. F. Morfin G. Souillet K. Bilger T. Ooka M. Aymard D. Thouvenot Genetic characterization of thymidine kinase from acyclovir-resistant and -susceptible herpes simplex virus type 1 isolated from bone marrow transplant recipients J. Infect. Dis. 182 2000 290 293
35. F. Morfin K. Bilger A. Boucher A. Thiebaut F. Najioullah N. Bleyzac N. Raus S. Bosshard M. Aymard M. Michallet D. Thouvenot HSV excretion after bone marrow transplantation: a 4-year survey J. Clin. Virol. 30 2004 341 345
36. F. Nugier J.N. Colin M. Aymard M. Langlois Occurrence and characterization of acyclovir-resistant herpes simplex virus isolates: report on a two-year sensitivity screening survey J. Med. Virol. 36 1992 1 12
37. R.J. Oram D. Marcellino D. Strauss E. Gustafson C.L. Talarico A.K. Root P.L. Sharma K. Thompson J.D. Fingeroth C. Crumpacker B.C. Herold Characterization of an acyclovir-resistant herpes simplex virus type 2 strain isolated from a premature neonate J. Infect. Dis. 181 2000 1458 1461
38. I. Pavić A. Hartmann A. Zimmermann D. Michel W. Hampl I. Schleyer T. Mertens Flow cytometric analysis of herpes simplex virus type 1 susceptibility to acyclovir, ganciclovir, and foscarnet Antimicrob. Agents Chemother. 41 1997 2686 2692
39. B.D. Pilger R. Perozzo F. Alber C. Wurth G. Folkers L. Scapozza Substrate diversity of herpes simplex virus thymidine kinase. Impact of the kinematics of the enzyme J. Biol. Chem. 274 1999 31967 31973
40. S.L. Sacks R.J. Wanklin D.E. Reece K.A. Hicks K.L. Tyler D.M. Coen Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity? Ann. Intern. Med. 111 1989 893 899
41. S. Safrin E. Palacios B.J. Leahy Comparative evaluation of microplate enzyme-linked immunosorbent assay versus plaque reduction assay for antiviral susceptibility testing of herpes simplex virus isolates Antimicrob. Agents Chemother. 40 1996 1017 1019
42. M. Saijo T. Suzutani E. De Clercq M. Niikura A. Maeda S. Morikawa I. Kurane Genotypic and phenotypic characterization of the thymidine kinase of ACV-resistant HSV-1 derived from an acyclovir-sensitive herpes simplex virus type 1 strain Antiviral Res. 56 2002 253 262
43. M. Saijo T. Suzutani S. Morikawa I. Kurane Genotypic characterization of the DNA polymerase and sensitivity to antiviral compounds of foscarnet-resistant herpes simplex virus type 1 (HSV-1) derived from a foscarnet-sensitive HSV-1 strain Antimicrob. Agents Chemother. 49 2005 606 611
44. I. Schmit G. Boivin Characterization of the DNA polymerase and thymidine kinase genes of herpes simplex virus isolates from AIDS patients in whom acyclovir and foscarnet therapy sequentially failed J. Infect. Dis. 180 1999 487 490
45. J. Sevilla S. Fernández-Plaza M. González-Vicent I. Colmenero J.M. Echevarria A. Pérez M.A. Díaz L. Madero Fatal hepatic failure secondary to acute herpes simplex virus infection J. Pediatr. Hematol. Oncol. 26 2004 686 688
46. R. Stránská A.M. van Loon M. Polman R. Schuurman Application of real-time PCR for determination of antiviral drug susceptibility of herpes simplex virus Antimicrob. Agents Chemother. 46 2002 2943 2947
47. R. Stránská A.M. van Loon M. Polman M.F. Beersma R.G. Bredius A.C. Lankester E. Meijer R. Schuurman Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients Antiviral Ther. 9 2004 565 575
48. R. Stránská R. Schuurman E. Nienhuis I.W. Goedegebuure M. Polman J.F. Weel P.M. Wertheim-Van Dillen R.J. Berkhout A.M. van Loon Survey of acyclovir-resistant herpes simplex virus in the Netherlands: prevalence and characterization J. Clin. Virol. 32 2005 7 18
49. E.M. Swierkosz D.R. Scholl J.L. Brown J.D. Jollick C.A. Gleaves Improved DNA hybridization method for detection of acyclovir-resistant herpes simplex virus Antimicrob. Agents Chemother. 31 1987 1465 1469
50. T.N. Thi C. Deback I. Malet P. Bonnafous Z. Ait-Arkoub H. Agut Rapid determination of antiviral drug susceptibility of herpes simplex virus types 1 and 2 by real-time PCR Antiviral Res. 69 2006 152 157
51. M. Vahey M.E. Nau S. Barrick J.D. Cooley R. Sawyer A.A. Sleeker P. Vickerman S. Bloor B. Larder N.L. Michael S.A. Wegner Performance of the Affymetrix GeneChip HIV PRT 440 platform for antiretroviral drug resistance genotyping of human immunodeficiency virus type 1 clades and viral isolates with length polymorphisms J. Clin. Microbiol. 37 1999 2533 2537
52. J. Vogt R. Perozzo A. Pautsch A. Prota P. Schelling B. Pilger G. Folkers L. Scapozza G.E. Schulz Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography Proteins 41 2000 545 553
53. H. Wen Q. Li Real-time PCR detection of multiple lamivudine-resistant mutations with displacing probes in a single tube J. Clin. Virol. 38 2007 334 340
54. K. Wild T. Bohner G. Folkers G.E. Schulz The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue Protein Sci. 6 1997 2097 2106
55. S.W. Wong A.F. Wahl P.M. Yuan N. Arai B.E. Pearson K. Arai D. Korn M.W. Hunkapiller T.S. Wang Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases EMBO J. 7 1988 37 47
56. D.L. Wyles A. Patel N. Madinger M. Bessesen P.R. Krause A. Weinberg Development of herpes simplex virus disease in patients who are receiving cidofovir Clin. Infect. Dis. 41 2005 676 680
57. A.C. Yeo K.P. Chan G. Kumarasinghe H.K. Yap Rapid detection of codon 460 mutations in the UL97 gene of ganciclovir-resistant cytomegalovirus clinical isolates by real-time PCR using molecular beacons Mol. Cell. Probes 19 2005 389 393
58. J. Zhang D.W. Chung C.K. Tan K.M. Downey E.W. Davie A.G. So Primary structure of the catalytic subunit of calf thymus DNA polymerase delta: sequence similarities with other DNA polymerases Biochemistry 30 1991 11742 11750