Inhibition of cholesterol transport into skin cells in cultures by phytosterol-loaded microemulsion

Chemistry and Physics of Lipids

Volumn 153, Issue 2, 2008, Pages 109-118

  Rozner, S ^a   Verkhovski, L ^a   Nissimov, Y ^a   Aserin, A ^a   Vilensky, R ^b   Danino, D ^b   Zouboulis, C C ^c,d   Milner, Y ^a   Garti, N ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c DESSAU MEDICAL CENTER   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Incorporation; Keratinocyte cells; Metabolism; Microemulsion; Phytosterols; Skin cultures

Indexed keywords

CHOLESTEROL; NANOMATERIAL; PHYTOSTEROL; WATER OIL CREAM;

ARTICLE; CELL TRANSPORT; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; ENDOSOME; HUMAN; HUMAN CELL; KERATINOCYTE; LIGHT SCATTERING; LIPID ANALYSIS; MICROEMULSION; PRIORITY JOURNAL; SKIN CELL; TRANSMISSION ELECTRON MICROSCOPY;

CELL SURVIVAL; CELLS, CULTURED; CHOLESTADIENOLS; CHOLESTEROL; CRYOELECTRON MICROSCOPY; EMULSIONS; HUMANS; KERATINOCYTES; MICROSCOPY, ELECTRON, TRANSMISSION; PHYTOSTEROLS; SITOSTEROLS;

EID: 43049178202     PISSN: 00093084     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chemphyslip.2008.02.017     Document Type: Article

References (52)

1. Bellare J.R., Davis H.T., Scriven L.E., and Talmon Y. Controlled environment vitrification system-an improved sample preparation technique. J. Electron Microsc. Tech. 10 (1988) 87-111
2. Bligh E.G., and Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37 (1959) 911-917
3. Bolzinger M.A., Briançon S., Pelletier J., Fessi H., and Chevalier Y. Percutaneous release of caffeine from microemulsion, emulsion and gel dosage forms. Eur. J. Pharmaceut. Biopharmaceut. 68 (2008) 446-451
4. Boukamp P., Petrussevska R.T., Breitkreutz D., Hornung J., Markham A., and Fusenig N.E. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106 (1988) 761-771
5. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
6. Cassidy D.M., Lee C.M., Laker M.F., and Kealey T. Lipogenesis in isolated human sebaceous glands. FEBS Lett. 200 (1986) 173-176
7. Cho E.C., Lim H.J., Shim J., Kim J., and Chang I.S. Improved stability of liposome in oil/water emulsion by association of amphiphilic polymer with liposome and its effect on bioactive skin permeation. Colloids Surf., A. 299 (2007) 160-168
8. Danino D., Bernheim-Groswasser A., and Talmon Y. Digital cryogenic transmission electron microscopy: an advanced tool for direct imaging of complex fluids. Colloids Surf., A. 183 (2001) 113-122
9. De Paepe K., Roseeuw D., and Rogiers V. Repair of acetone- and sodium lauryl sulphate-damaged human skin barrier function using topically applied emulsions containing barrier lipids. J. Eur. Acad. Dermatol. Venereol. 16 (2002) 587-594
10. Downie M.M.T., Sanders D.A., Maier L.M., Stock D.M., and Kealey T. Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. Br. J. Dermatol. 151 (2004) 766-775
11. Edelson P.J., and Duncan R.A. Lowry and Bradford assays for protein. In: Adams D.O., Edelson P.J., and Koren H.S. (Eds). Methods Stud. Mononucl. Phagocytes (1981), Academic Press, New York, NY 337-343
12. Elsayed M.M.A., Abdallah O.Y., Naggar V.F., and Khalafallah N.M. Lipid vesicles for skin delivery of drugs: reviewing three decades of research. Int. J. Pharm. 332 (2007) 1-16
13. Fang J.Y., Hwang T.L., and Huang Y.L. Liposomes as vehicles for enhancing drug delivery via skin routes. Curr. Nanosci. 2 (2006) 55-70
14. Feingold K.R., Man M.Q., Menon G.K., Cho S.S., Brown B.E., and Elias P.M. Cholesterol synthesis is required for cutaneous barrier function in mice. J. Clin. Invest. 86 (1990) 1738-1745
15. Field F.J., and Mathur S.N. β-sitosterol: esterification by intestinal acylcoenzyme A-cholesterol acyltransferase (ACAT) and its effect on cholesterol esterification. J. Lipid Res. 24 (1983) 409-417
16. Freinkel R.K., and Aso K. Esterification of cholesterol by epidermis. Biochim. Biophys. Acta. 239 (1971) 98-102
17. Garti N., Amar-Yuli I., Spernath A., and Hoffman R.E. Transitions and loci of solubilization of nutraceuticals in U-type nonionic microemulsions studied by self-diffusion NMR. Phys. Chem. Chem. Phys. 6 (2004) 2968-2976
18. Hoffmann R. Enzymology of the hair follicle. Eur. J. Dermatol. 4 (2001) 296-300
19. Homan, R., 2004. Dual inhibitors of cholesteryl ester and wax ester synthesis for sebaceous gland disorders. US Patent No. 6,730,703.
20. Ikeda I., Matsuoka R., Hamada T., Mistui K., Imabayashi S., Uchino A., Sato M., Kuwano E., Itamura T., Yamada K., Tanaka K., and Imaizumi K. Cholesterol esterase accelerates intestinal cholesterol absorption. Biochim. Biophys. Acta 1571 (2002) 34-44
21. Ishi H., and Mikami N. Recovery effects of water holding capacity on the scaly skin by cholesterol derivatives. J. SCCJ. 30 (1996) 195-201
22. Jiang Y.J., Kim P., Eliat P.M., and Feingold K.R. LXR and PPAR activators stimulate cholesterol sulforansferase type 2 isoform 1b in human keratinocytes. J. Lipid Res. 46 (2005) 2657-2666
23. Jiang Y.J., Lu B., Kim P., Eliat P.M., and Feingold K.R. Regulation of ABCA1 expression in human keratinocytes and murine epidermis. J. Lipid Res. 47 (2006) 2248-2258
24. Jones P.J.H., Ntanios F.Y., Raeini-Sarjaz M., and Vanstone C.A. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am. J. Clin. Nutr. 69 (1999) 1144-1150
25. Kaneko E., Matsuda M., Yamada Y., Tachibana Y., Shimomura I., and Makishima M. Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. J. Biol. Chem. 278 (2003) 36091-36098
26. Kogan A., and Garti N. Microemulsions as transdermal drug delivery vehicles. Adv. Colloid Interface Sci. 123-126 (2006) 369-385
27. Kreilgaard M., Pedersen E.J., and Jaroszewski J.W. NMR characterization and transdermal drug delivery potential of microemulsion systems. J. Controlled Release 69 (2000) 421-433
28. Maggini M., Raschetti R., Traversa G., Bianchi C., Caffari B., Da Cas R., and Panei P. The cerivastatin withdrawal crisis: a "post-mortem" analysis. Health Policy 69 (2004) 151-157
29. Manuela V., Perugini P., Gagliardi S., Conti B., Genta I., Modena T., and Pavanetto F. Topical application of lignans and phytosterols in seborrhoic skin. J. Appl. Cosmetol. 24 (2006) 123-129
30. Moghadasian M.H., Godin D.V., McManus B.M., and Frohlich J.J. Lack of regression of atherosclerotic lesions in phytosterol-treated apo E-deficient mice. Life Sci. 64 (1999) 1029-1036
31. Mora M.P., Tourne-Peteilh C., Charveron M., Fabre B., Milon A., and Muller I. Optimisation of plant sterols incorporation in human keratinocyte plasma membrane and modulation of membrane fluidity. Chem. Phys. Lipids 101 (1999) 255-265
32. Mora-Ranjeva M.P., Charveron M., Fabre B., Milon A., and Muller I. Incorporation of phytosterols in human keratinocytes. Consequences on UVA-induced lipid peroxidation and calcium ionophore-induced prostaglandin release. Chem. Phys. Lipids 141 (2006) 216-224
33. Ostlund Jr. R.E. Phytosterols in human nutrition. Annu. Rev. Nutr. 22 (2002) 533-549
34. Panchagnula R., Desu H., Jain A., and Khandavilli S. Feasibility studies of dermal delivery of paclitaxel with binary combinations of ethanol and isopropyl myristate: role of solubility, partitioning and lipid bilayer perturbation. Farmaco 60 (2005) 894-899
35. Ponec M., Pas M.F.W., Havekes L., Boonstra J., Mommaas A.M., and Vermeer B.J. LDL receptors in keratinocytes. J. Invest. Dermatol. 98 (1992) 50S-56S
36. Pritchard P.H., Li M., Zamfir C., Lukic T., Novak E., and Moghadasiam M.H. Comparison of cholesterol-lowering efficacy and anti-atherogenic properties of hydrogenated versus non-hydrogenated (Phytrol™) tall oil-derived phytosterols in apo E-deficient mice. Cardiovasc. Drugs Ther. 17 (2003) 443-449
37. Rozner S., Aserin A., Wachtel J.E., and Garti N. Competitive solubilization of cholesterol and phytosterols in nonionic microemulsions. J. Colloid Interface Sci. 315 (2007) 637-647
38. Schurer N.Y., and Elias P.M. The biochemistry and function of stratum corneum lipids. Adv. Lipid Res. 24 (1991) 27-56
39. Sintov A.C., and Shapiro L. New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo. J. Controlled Release 95 (2004) 173-183
40. Smythe C.D.W., Greenall M., and Kealey T. The activity of HMG-CoA reductase and acetyl-CoA carboxylase in human aprocrin sweat glands, sebaceous gland, and hair follicles is regulated by phosphorylation and by exogenous cholesterol. J. Invest. Dermatol. 111 (1998) 139-148
41. Spernath A., and Aserin A. Microemulsions as carriers for drugs and nutraceuticals. Adv. Colloid Interface Sci. 128 (2006) 47-64
42. Spernath A., Aserin A., Ziserman L., Danino D., and Garti N. Phosphatidylcholine embedded microemulsions: physical properties and improved Caco-2 cell permeability. J. Controlled Release 119 (2007) 279-290
43. Spernath A., Yaghmur A., Aserin A., Hoffman R.E., and Garti N. Self-diffusion nuclear magnetic resonance, microstructure transitions, and solubilization capacity of phytosterols and cholesterol in Winsor IV food-grade microemulsions. J. Agric. Food Chem. 51 (2003) 2359-2364
44. Teichmann A., Heuschkel S., Jacobi U., Presse G., Neubert R.H.H., Sterry W., and Lademann J. Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream. Eur. J. Pharmaceut. Biopharmaceut. 67 (2007) 699-706
45. Thiboutot D., Jabara S., McAllister J.M., Sivarajah A., Gilliland K., Cong Z., and Clawson G. Human skin in a steroidologenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis normal sebocytes and an imozfaliced seboycyte cell line (SEB-1). J. Invest. Dermatol. 120 (2003) 905-914
46. Trautwein E.A., Duchateau G.S.M.J.E., Lin Y., Mel'nikov S.M., Molhuizen H.O.F., and Ntanios F.Y. Proposed mechanisms of cholesterol-lowering action of plant sterols. Eur. J. Lipid Sci. Technol. 105 (2003) 171-185
47. Trommer H., and Neubert R.H.H. Overcoming the stratum corneum: the modulation of skin penetration. Skin Pharmacol. Physiol. 19 (2006) 106-121
48. Van de Loosdrecht A.A., Nennie E., Ossenkoppele G.J., Beelen R.H., and Langenhuijsen M.M.A.C. Cell mediated cytotoxicity against U 937 cells by human monocytes and macrophages in a modified colorimetric MTT assay-a methodological study. J. Immunol. Methods 141 (1991) 15-22
49. Wang X., Brégégère F., Frušić-Zlotkin M., Feinmesser M., Michel B., and Milner Y. Possible apoptotic mechanism in epidermal cell acantholysis induced by Pemphigus vulgaris autoimmunoglobulins. Apoptosis 9 (2004) 131-143
50. Zettersten E.M., Ghadially R., Feingold K.R., Crumrine D., and Elias P.M. Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin. J. Am. Acad. Dermatol. 37 (1997) 403-408
51. Zouboulis C.C. Human sebocyte cultures are an appropriate model for studying sebaceous gland function at the cellular level. In: Van Neste D., and Randall V.A. (Eds). Hair Research for the Next Millennium (1996), Elsevier Science Pub. Co., Amsterdam, Netherland 387-392
52. Zouboulis C.C., Seltmann H., Neitzel H., and Orfanos C.E. Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). J. Invest. Dermatol. 113 (1999) 1011-1020