Feasibility studies of dermal delivery of paclitaxel with binary combinations of ethanol and isopropyl myristate: Role of solubility, partitioning and lipid bilayer perturbation

Farmaco

Volumn 60, Issue 11-12, 2005, Pages 894-899

  Panchagnula, Ramesh ^a   Desu, Hariraghuram ^a   Jain, Amit ^a   Khandavilli, Sateesh ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Dermal delivery; FT IR; Paclitaxel; Push pull effect

Indexed keywords

ALCOHOL; LIPID; MYRISTIC ACID ISOPROPYL ESTER; PACLITAXEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; DRUG TRANSPORT; EPIDERMIS CELL; HYDROPHILICITY; INFRARED SPECTROSCOPY; LIPID BILAYER; LIPID SOLUBILITY; LIPOPHILICITY; MISCIBILITY; NONHUMAN; PROBABILITY; RAT; SKIN EPITHELIUM; SKIN PENETRATION; SKIN PERMEABILITY;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; DERMIS; DIFFUSION; EPIDERMIS; ETHANOL; FEASIBILITY STUDIES; LIPID BILAYERS; MYRISTATES; PACLITAXEL; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; SKIN; SKIN ABSORPTION; SOLUBILITY; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TIME FACTORS; VEHICLES;

EID: 27744549679     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.farmac.2005.07.004     Document Type: Article

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