Possible apoptotic mechanism in epidermal cell acantholysis induced by pemphigus vulgaris autoimmunoglobulins

Apoptosis

Volumn 9, Issue 2, 2004, Pages 131-143

  Wang, X ^a,d   Bregegere F ^a   Frusic Zlotkin M ^a   Feinmesser, M ^b   Michel, B ^c   Milner, Y ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b RABIN MEDICAL CENTER   (Israel)

^c Michel Skin Care Incorporated   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Autoimmune antibodies; Caspase inhibitors; Cell signaling; DISC; FasR

Indexed keywords

CASPASE 3; CASPASE 8; DNA FRAGMENT; FAS ANTIBODY; FAS LIGAND; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 1BETA CONVERTING ENZYME; PEMPHIGUS ANTIBODY; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ACANTHOLYSIS; APOPTOSIS; ARTICLE; CELL CONTACT; CELL LEVEL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EPIDERMIS CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; PEMPHIGUS VULGARIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ACANTHOLYSIS; APOPTOSIS; AUTOANTIBODIES; CASPASES; CELL CULTURE TECHNIQUES; EPIDERMIS; HUMANS; KERATINOCYTES; KINETICS; PEMPHIGUS; SIGNAL TRANSDUCTION;

PEMPHIGUS;

EID: 2942518307     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:APPT.0000018795.05766.1f     Document Type: Article

References (52)

1. Udey MC, Stanley JR. Pemphigus - Diseases of antidesmosomal autoimmunity. JAMA 1999; 282: 572-576.
2. Stanley JR. Update: Structure and function of pemphigus vulgaris antigen. J Dermatol 1997; 24: 741-743.
3. Memar O, Christensen B, Rajaraman S et al. Induction of blister-causing antibodies by a recombinant full-length, but not the extracellular, domain of the pemphigus vulgaris antigen (desmoglein 3). J Immunol 1996; 157: 3171-3177.
4. Amagai M, Tsunoda K, Suzuki H, Nishifuji K, Koyasu S, Nishikawa T. Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus. J Clin Invest 2000; 105: 625-631.
5. Nguyen VT, Ndoye A, Shultz LD, Pittelkow MR, Grando S. Antibodies against keratinocyte antigens other than desmoglein 1 and 3 can induce pemphigus vulgaris-like lesions. J Clin Invest 2000; 106: 1467-1479.
6. Aoyama Y, Owada MK, Kitajima Y. A pathogenic autoantibody, pemphigus vulgans-IgG, induces phosphorylation of desmoglein 3, and its dissociation from plakoglobin in cultured keratinocytes. Eur J Immunol 1999; 29: 2233-2240.
7. Caldelari R, de Bruin A, Baumann D, et al. A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris. J Cell Biol 2001; 153: 823-834.
8. Milner Y, Sagi E, Timberg R, Michel B, Métézeau P, Goldberg M. Binding modes of IgG from pemphigus autoimmune sera onto guinea pig keratinocytes and the fate of bound IgGs. J Cell Physiol 1989; 139: 441-454.
9. Iwatsuki K, Han GW, Fukuti R, et al. Internalization of constitutive desmogleins with the subsequent induction of desmoglein 2 in pemphigus lesions. Br J Dermatol 1999; 140: 35-43.
10. ++ concentration. J Invest Dermatol 1987; 89: 167-171.
11. Schiltz JR, Michel B, Papay R. Pemphigus antibody interaction with human epidermal cells in culture. J Clin Invest 1978; 62: 778-788.
12. 2+ signalling. Isr J Med Sci 1995; 31: 42-48.
13. Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells. Cell 1975; 6: 331-343.
14. Gavrieli Y, Sherman Y, Ben-Sasson. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1991; 119: 493-501.
15. Enari M, Talanian RV, Wong WW, Nagata S. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 1996; 380: 723-726.
16. Schmitz I, Kirschhoff S, Krammer PH. Regulation of death receptor-mediated apoptosis pathways. Int J Biochem Cell Biol 2000; 32: 1123-1136.
17. Schuler M, Green DR. Mechanisms of p53-dependent apoptosis. Biochem Soc Trans 2001; 29: 684-688.
18. Borner C. The Bcl-2 protein family: Sensors and checkpoints for life-or-death decisions. Mol Immunol 2003; 39: 615-647.
19. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988; 106: 761-771.
20. Giard DJ, Aaronson SA, Todaro GJ, et al. In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst 1973; 51: 1417-1423.
21. Sakahira H, Enari M, Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 1998; 391: 96-99.
22. Ni R, Tomita Y, Matsuda K, et al. Fas-mediated apoptosis in primary cultured mouse hepatocytes. Exp Cell Res 1994; 215: 332-337.
23. Sung KJ, Paik EM, Jang KA, Suh HS, Choi JH. Apoptosis is induced by anti-Fas antibody alone in cultured human keratinocytes. J Dermatol 1997; 24: 427-434.
24. Jelaska A, Korn JH. Anti-Fas induces apoptosis and proliferation in human dermal fibroblasts: Differences between foreskin and adult fibroblasts. J Cell Physiol 1998; 175: 19-29.
25. Thornberry NA, Peterson EP, Zhao JJ, Howard AD, Griffin PR, Chapman KT. Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones. Biochemistry 1994; 33: 3934-3940.
26. Nicholson DW. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ 1999; 6: 1028-1042.
27. Kawakami A, Eguchi K. Involvement of apoptotic cell death in autoimmune diseases. Med Electron Microsc 2002; 35: 1-8.
28. Chung JH, Kwon OS, Eun HC, et al. Apoptosis in the pathogenesis of cutaneous lupus erythematosus. Am J Dermatopathol 1998; 20: 233-241.
29. Gniadecki R, Jemec GB, Thomsen BM, Hanse M. Relationship between keratinocyte adhesion and death: Anoikis in acantholytic diseases. Arch Dermatol Res 1998; 290: 528-532.
30. Milner Y, Métézeau P, Kiefer H, et al. Pemphigus - An autoimmune disease of the skin: Cell-cell separation versus membranal signaling and apoptosis in acantholysis. In: The Decade of Autoimmunity. Amsterdam: Y Schoenfeld, Elsevier Science 1999: 197-207.
31. Leverkus M, Yaar M, Gilchrest B. Fas/Fas ligand interaction contributes to UV-induced apoptosis in human keratinocytes. Exp Cell Res 1997; 232: 255-262.
32. Aragane Y, Kulms D, Metze D, et al. Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand C95L. J Cell Biol 1998; 140: 171-182.
33. Oishi M, Maeda K, Sugiyama S. Distribution of apoptosis-mediating Fas antigen in human skin and effects of anti-Fas monoclonal antibody on human epidermal keratinocyte and squamous cell carcinoma cell lines. Arch Dermatol Res 1994; 286: 396-407.
34. Sayama K, Yonehara S, Watanabe Y, Miki Y. Expression of Fas antigen on keratinocytes in vivo and induction of apoptosis in cultured keratinocytes. J Invest Dermatol 1994; 103: 330-334.
35. Evan G, Littlewood T. A matter of life and cell death. Science 1998; 281: 1317-1322.
36. Hall PA, McKee PH, Menage HD, Dover R, Lane DP. High levels of p53 protein in UV-irradiated normal human skin. Oncogene 1993; 8: 203-207.
37. Chen Q, Gong B, Almascan A. Distinct stages of cytochrome c release from mitochondria: Evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis. Cell Death Diff 2000; 7: 227-233.
38. Reich K, Brinck U, Letschert M, et al. Graft-versus-host disease-like immunophenotype and apoptotic keratinocyte death in paraneoplastic pemphigus. Br J Dermatol 1999; 141: 739-746.
39. Weiske J, Schöneberg T, Schröder W, Hatzfeld M, Tauber R, Huber O. The fate of desmosomal proteins in apoptotic cells. J Biol Chem 2001; 276: 41175-41181.
40. Meredith JE Jr, Fazeli B, Schwartz MA. The extracellular matrix as a cell survival factor. Mol Biol Cell 1993; 4: 953-961.
41. Frisch SM, Francis H. Disruption of epithelial cell matrix interactions induces apoptosis. J Cell Biol 1994; 124: 619-626.
42. Aoujdit F, Vuori K. Matrix attachment regulates Fas-induced apoptosis in endothelial cells: A role for c-Flip and implications for anoikis. J Cell Biol 2001; 152: 633-643.
43. Feliciani C, Toto P, Amerio P, et al. In vitro and in vivo expression of interleukin-1 alpha and tumor necrosis factor-alpha mRNA in pemphigus vulgaris: Interleukin-1 alpha and tumor necrosis factor-alpha are involved in acantholysis. J Invest Dermatol 2000; 114: 71-77.
44. Caproni M, Giomi B, Cardinali C, et al. Further support for a role for Th2-like cytokines in blister formation of pemphigus. Clin Immunol 2001; 98: 264-271.
45. Grando SA, Pittelkow MR, Shultz LD, Dmochowski M, Nguyen VT. Pemphigus: An unfolding story. J Invest Dermatol 2001; 117: 990-995.
46. Stanley JR, Nishikawa T, Diaz LA, Amagai M. Pemphigus: Is there another half of the story? J Invest Dermatol 2001; 116: 489-490.
47. Wehrli P, Viard I, Bullani R, Tschopp J, French LE. Death receptors in cutaneous biology and disease. J Invest Dermatol 2000; 115: 141-148.
48. Viard I, Wehrli P, Bullani R, et al. Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin. Science 1998; 282: 490-493.
49. Viard-Leveugle I, Bullani RR, Meda P, et al. Intracellular localization of keratinocyte Fas ligand explains lack of cytolytic activity under physiological conditions. J Biol Chem 2003; 278: 16183-16188.
50. Livingston DJ. In vitro and in vivo studies of ICE inhibitors. J Cell Biochem 1997; 64: 19-26.
51. Tewari M, Beidler DR, Dixit VM. CrmA-inhibitable cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein during Fas- and tumor necrosis factor-induced apoptosis. J Biol Chem 1995; 270: 18738-18741.
52. Clem RJ, Miller LK. Control of programmed cell death by the baculovirus genes p35 and IAP. Mol Cell Biol 1994; 14: 5212-5222.