메뉴 건너뛰기




Volumn 17, Issue 5-6, 2003, Pages 443-449

Comparison of cholesterol-lowering efficacy and anti-atherogenic properties of hydrogenated versus non-hydrogenated (Phytrol™) tall oil-derived phytosterols in Apo E-deficient mice

Author keywords

Apo E KO mice; Atherosclerosis; Plant sterols and stanols; Plasma cholesterol

Indexed keywords

APOLIPOPROTEIN E; CAMPESTEROL; FCP 3P1; FCP 3P2; HYPOCHOLESTEROLEMIC AGENT; PHYTOSTEROL; PHYTROL; SITOSTANOL; SITOSTEROL; UNCLASSIFIED DRUG;

EID: 1542719737     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:CARD.0000015859.37581.f1     Document Type: Article
Times cited : (17)

References (32)
  • 1
    • 0023025526 scopus 로고
    • Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT)
    • Stamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT). JAMA 1986;256:2823-2828.
    • (1986) JAMA , vol.256 , pp. 2823-2828
    • Stamler, J.1    Wentworth, D.2    Neaton, J.D.3
  • 3
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
    • Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001;285:2486-2491.
    • (2001) JAMA , vol.285 , pp. 2486-2491
  • 4
    • 0028181730 scopus 로고
    • By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?
    • Law MR, Wald NJ, Thompson SG. By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease? BMJ 1994;308:367-372.
    • (1994) BMJ , vol.308 , pp. 367-372
    • Law, M.R.1    Wald, N.J.2    Thompson, S.G.3
  • 5
    • 0028822216 scopus 로고
    • Serum cholesterol lowering by sitostanol ester margarine in a mildly hypercholesterolemic random population
    • Miettinen TA, Puska P, Gylling H, Vanhanen H, Vartiainen E. Serum cholesterol lowering by sitostanol ester margarine in a mildly hypercholesterolemic random population. N Engl J Med 1995;333:1308-1312.
    • (1995) N Engl J Med , vol.333 , pp. 1308-1312
    • Miettinen, T.A.1    Puska, P.2    Gylling, H.3    Vanhanen, H.4    Vartiainen, E.5
  • 6
    • 0032894986 scopus 로고    scopus 로고
    • Cholesterol reduction by different plant stanol mixtures and with variable fat intake
    • Gylling H, Miettinen TA. Cholesterol reduction by different plant stanol mixtures and with variable fat intake. Metabolism 1999;48:575-580.
    • (1999) Metabolism , vol.48 , pp. 575-580
    • Gylling, H.1    Miettinen, T.A.2
  • 7
    • 0034020057 scopus 로고    scopus 로고
    • Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner
    • Hallikainen MA, Sarkkinen ES, Uusitupa MI. Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner. J Nutr 2000;130:767-776.
    • (2000) J Nutr , vol.130 , pp. 767-776
    • Hallikainen, M.A.1    Sarkkinen, E.S.2    Uusitupa, M.I.3
  • 8
    • 0033914509 scopus 로고    scopus 로고
    • Plant stanol ester margarine lowers serum total and low-density lipoprotein cholesterol concentrations of healthy children: The STRIP project. Special Turku Coronary Risk Factors Intervention Project
    • Tammi A, Ronnemaa T, Gylling H, et al. Plant stanol ester margarine lowers serum total and low-density lipoprotein cholesterol concentrations of healthy children: The STRIP project. Special Turku Coronary Risk Factors Intervention Project. J Pediatr 2000;136:503-510.
    • (2000) J Pediatr , vol.136 , pp. 503-510
    • Tammi, A.1    Ronnemaa, T.2    Gylling, H.3
  • 9
    • 0025963444 scopus 로고
    • Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol
    • Heinemann T, Kullak-Ublick GA, Pietruck B, von Bergmann K. Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol. Eur J Clin Pharmacol 1991;40(Suppl 1):S59-S63.
    • (1991) Eur J Clin Pharmacol , vol.40 , Issue.1 SUPPL.
    • Heinemann, T.1    Kullak-Ublick, G.A.2    Pietruck, B.3    Von Bergmann, K.4
  • 10
    • 0032406294 scopus 로고    scopus 로고
    • Inhibition of cholesterol absorption by plant sterols for mass intervention
    • Ikeda I, Sugano M. Inhibition of cholesterol absorption by plant sterols for mass intervention. Curr Opin Lipidol 1998;9:527-531.
    • (1998) Curr Opin Lipidol , vol.9 , pp. 527-531
    • Ikeda, I.1    Sugano, M.2
  • 11
    • 0034712522 scopus 로고    scopus 로고
    • Plant sterol and stanol margarines and health
    • Law M. Plant sterol and stanol margarines and health. BMJ 2000;320:861-864.
    • (2000) BMJ , vol.320 , pp. 861-864
    • Law, M.1
  • 12
    • 0033765359 scopus 로고    scopus 로고
    • Flora pro.activ: A clinical and financial impact analysis
    • Philips C, Belsey J, Shindler J. Flora pro.activ: A clinical and financial impact analysis. J Med Econ 2000;3:61-76.
    • (2000) J Med Econ , vol.3 , pp. 61-76
    • Philips, C.1    Belsey, J.2    Shindler, J.3
  • 13
    • 0032763577 scopus 로고    scopus 로고
    • Effects of dietary phytosterols on cholesterol metabolism and atherosclerosis: Clinical and experimental evidence
    • Moghadasian MH, Frohlich JJ. Effects of dietary phytosterols on cholesterol metabolism and atherosclerosis: Clinical and experimental evidence. Am J Med 1999;107:588-594.
    • (1999) Am J Med , vol.107 , pp. 588-594
    • Moghadasian, M.H.1    Frohlich, J.J.2
  • 15
    • 0033528702 scopus 로고    scopus 로고
    • Proatherogenic and antiatherogenic effects of probucol and phytosterols in apolipoprotein E-deficient mice: Possible mechanisms of action
    • Moghadasian MH, McManus BM, Godin DV, Rodrigues B, Frohlich JJ. Proatherogenic and antiatherogenic effects of probucol and phytosterols in apolipoprotein E-deficient mice: Possible mechanisms of action. Circulation 1999;99:1733-1739.
    • (1999) Circulation , vol.99 , pp. 1733-1739
    • Moghadasian, M.H.1    McManus, B.M.2    Godin, D.V.3    Rodrigues, B.4    Frohlich, J.J.5
  • 16
    • 0026725757 scopus 로고
    • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    • Plump AS, Smith JD, Hayek T, et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 1992;71:343-353.
    • (1992) Cell , vol.71 , pp. 343-353
    • Plump, A.S.1    Smith, J.D.2    Hayek, T.3
  • 17
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    • Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992;468-471.
    • (1992) Science , pp. 468-471
    • Zhang, S.H.1    Reddick, R.L.2    Piedrahita, J.A.3    Maeda, N.4
  • 18
    • 0033049497 scopus 로고    scopus 로고
    • Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men
    • Jones PJ, Ntanios FY, Raeini-Sarjaz M, Vanstone CA. Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am J Clin Nutr 1999;69:1144-1150.
    • (1999) Am J Clin Nutr , vol.69 , pp. 1144-1150
    • Jones, P.J.1    Ntanios, F.Y.2    Raeini-Sarjaz, M.3    Vanstone, C.A.4
  • 19
    • 0017753145 scopus 로고
    • Comparison of hypocholesterolemic activity of beta-sitosterol and beta-sitostanol in rats
    • Sugano M, Morioka H, Ikeda IA. Comparison of hypocholesterolemic activity of beta-sitosterol and beta-sitostanol in rats. J Nutr 1977;107:2011-2019.
    • (1977) J Nutr , vol.107 , pp. 2011-2019
    • Sugano, M.1    Morioka, H.2    Ikeda, I.A.3
  • 20
    • 0000478507 scopus 로고
    • The effect of dietary alpha-sitosterol and alpha-sitostanol on the metabolism of cholesterol in rats
    • Ikeda I, Morioka H, Sugano M. The effect of dietary alpha-sitosterol and alpha-sitostanol on the metabolism of cholesterol in rats. Agric Biol Chem 1979;43:1927-1933.
    • (1979) Agric Biol Chem , vol.43 , pp. 1927-1933
    • Ikeda, I.1    Morioka, H.2    Sugano, M.3
  • 21
    • 0032920384 scopus 로고    scopus 로고
    • Dietary sitostanol reciprocally influences cholesterol absorption and biosynthesis in hamsters and rabbits
    • Nitanios FY, Jones PJH. Dietary sitostanol reciprocally influences cholesterol absorption and biosynthesis in hamsters and rabbits. Atherosclerosis 1999;143:341-351.
    • (1999) Atherosclerosis , vol.143 , pp. 341-351
    • Nitanios, F.Y.1    Jones, P.J.H.2
  • 22
    • 0031745196 scopus 로고    scopus 로고
    • Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects
    • Weststrate JA, Meijer GW. Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 1998;52:334-343.
    • (1998) Eur J Clin Nutr , vol.52 , pp. 334-343
    • Weststrate, J.A.1    Meijer, G.W.2
  • 23
    • 0032893986 scopus 로고    scopus 로고
    • Histologic, hematologic, and biochemical characteristics of apo E-deficient mice: Effects of dietary cholesterol and phytosterols
    • Moghadasian MH, Nguyen LB, Shefer S, McManus BM, Frohlich JJ. Histologic, hematologic, and biochemical characteristics of apo E-deficient mice: Effects of dietary cholesterol and phytosterols. Lab Invest 1999;79:355-364.
    • (1999) Lab Invest , vol.79 , pp. 355-364
    • Moghadasian, M.H.1    Nguyen, L.B.2    Shefer, S.3    McManus, B.M.4    Frohlich, J.J.5
  • 24
    • 0028146233 scopus 로고
    • Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption
    • Zhang SH, Reddick RL, Burkey B, Maeda N. Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption. J Clin Invest 1994;94:937-945.
    • (1994) J Clin Invest , vol.94 , pp. 937-945
    • Zhang, S.H.1    Reddick, R.L.2    Burkey, B.3    Maeda, N.4
  • 25
    • 17944371852 scopus 로고    scopus 로고
    • Pathophysiology of apolipoprotein E deficiency in mice: Relevance to apo E-related disorders in humans
    • Moghadasian MH, McManus BM, Nguyen LB, et al. Pathophysiology of apolipoprotein E deficiency in mice: Relevance to apo E-related disorders in humans. FASEB J 2001;15:2623-2630.
    • (2001) FASEB J , vol.15 , pp. 2623-2630
    • Moghadasian, M.H.1    McManus, B.M.2    Nguyen, L.B.3
  • 26
    • 0032961863 scopus 로고    scopus 로고
    • Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects
    • Hendriks HF, Weststrate JA, van Vliet T, Meijer GW. Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 1999;53:319-327.
    • (1999) Eur J Clin Nutr , vol.53 , pp. 319-327
    • Hendriks, H.F.1    Weststrate, J.A.2    Van Vliet, T.3    Meijer, G.W.4
  • 27
    • 0034020057 scopus 로고    scopus 로고
    • Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner
    • Hallikainen MA, Sarkkinen ES, Uusitupa MIJ. Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner. J Nutr 2000;130:767-776.
    • (2000) J Nutr , vol.130 , pp. 767-776
    • Hallikainen, M.A.1    Sarkkinen, E.S.2    Uusitupa, M.I.J.3
  • 28
    • 0036847484 scopus 로고    scopus 로고
    • Specificity of the commonly used enzymatic assay for plasma cholesterol determination
    • Moghadasian MH, Frohlich JJ, Scudamore CH. Specificity of the commonly used enzymatic assay for plasma cholesterol determination. J Clin Pathol 2002;55:859-861.
    • (2002) J Clin Pathol , vol.55 , pp. 859-861
    • Moghadasian, M.H.1    Frohlich, J.J.2    Scudamore, C.H.3
  • 29
    • 0034966879 scopus 로고    scopus 로고
    • Hepatic cholesterol and bile acid synthesis, low-density lipoprotein receptor function, and plasma and fecal sterol levels in mice: Effects of apolipoprotein E deficiency and probucol or phytosterol treatment
    • Moghadasian MH, Nguyen LB, Shefer S, Salen G, Batta AK, Frohlich JJ. Hepatic cholesterol and bile acid synthesis, low-density lipoprotein receptor function, and plasma and fecal sterol levels in mice: effects of apolipoprotein E deficiency and probucol or phytosterol treatment. Metabolism 2001;50:708-714.
    • (2001) Metabolism , vol.50 , pp. 708-714
    • Moghadasian, M.H.1    Nguyen, L.B.2    Shefer, S.3    Salen, G.4    Batta, A.K.5    Frohlich, J.J.6
  • 30
    • 0021248423 scopus 로고
    • Serum lipoproteins and lecithin: Cholesterol acyltransferase (LCAT) activity in hypercholesterolemic subjects given beta-sitosterol
    • Weisweiler P, Heinemann V, Schwandt P. Serum lipoproteins and lecithin: Cholesterol acyltransferase (LCAT) activity in hypercholesterolemic subjects given beta-sitosterol. Int Clin Pharmacol 1984;22:204-206.
    • (1984) Int Clin Pharmacol , vol.22 , pp. 204-206
    • Weisweiler, P.1    Heinemann, V.2    Schwandt, P.3
  • 32
    • 0028830069 scopus 로고
    • Lack of efficacy of low-dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterolemia
    • Denke MA. Lack of efficacy of low-dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterolemia. Am J Clin Nutr 1995;61:392-396.
    • (1995) Am J Clin Nutr , vol.61 , pp. 392-396
    • Denke, M.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.