Anti-hyperalgesic and anti-inflammatory effects of Ketorolac Tromethamine gel using pulsed ultrasound in inflamed rats

Archives of Pharmacal Research

Volumn 31, Issue 4, 2008, Pages 511-517

  Yang, Jae Heon ^a   Kim, Tae Youl ^b   Lee, Ji Hye ^c   Yoon, Se Won ^d   Yang, Kyu Ho ^e   Shin, Sang Chul ^e  

^a Woosuk University   (South Korea)

^b Dongshin University   (South Korea)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d Sunlin Hospital   (South Korea)

^e Chonnam National University   (South Korea)

Author keywords

Anti hyperalgesic; Anti inflammatory; Ketorolac tromethamine gel; Nociceptive flexor reflex; Phonophoretic transdermal delivery; Pulsed ultrasound

Indexed keywords

ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CARRAGEENAN; KETOROLAC TROMETAMOL;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; EDEMA; GEL; HYPERALGESIA; INTRADERMAL DRUG ADMINISTRATION; MALE; PAIN ASSESSMENT; PAIN THRESHOLD; PATHOPHYSIOLOGY; RAT; REACTION TIME; REFLEX; SPRAGUE DAWLEY RAT; TIME; ULTRASOUND;

ADMINISTRATION, CUTANEOUS; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; DISEASE MODELS, ANIMAL; EDEMA; GELS; HYPERALGESIA; KETOROLAC TROMETHAMINE; MALE; PAIN MEASUREMENT; PAIN THRESHOLD; PHONOPHORESIS; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; REFLEX; TIME FACTORS;

EID: 43049101077     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-001-1186-5     Document Type: Article

References (47)

1. Abramson, S. B. and Weissmann, G., The mechanisms of action of nonsteroidal anti-inflammatory drugs. Arthritis Rheum., 32, 1-9 (1989).
2. Anderson, C. R., Morris, R. L., Boeh, S.D., Panus, P. C., and Sembrowich, W. L., Effects of iontophoresis current magnitude and duration on dexamethasone deposition and localized drug retention. Phys. Ther., 83, 161-170 (2003).
3. Asano, J., Suisha, F., Takada, M., Kawasaki, N., and Miyazaki, S., Effect of pulsed output ultrasound on the transdermal absorption of indomethacin from an ointment in rats. Biol. Pharm. Bull., 20, 288-291 (1997).
4. Bare, A., McAnaw, M., and Pritchard, A., Phonophoretic delivery of 10% hydrocortisone through the epidermis of humans as determined by serum cortisol concentrations. Phys. Ther., 76, 738-749 (1996).
5. Behrens, B. J. and Michlovitz, S. L., Physical agents theory and practice for the physical therapist assistant, Yeongmun. Publishing. Company. Seoul. 95-102 (1996).
6. Bertolucci, L. E., Introduction of anti-inflammatory drugs by iontophoresis: Double blind study. J. Orthop. Sports. Phys. Ther., 4, 103-108 (1982).
7. Bommannan, D., Okuyama, H., Staufer, P., and Guy, R. H., Sonophoresis, I: the use of high frequency ultrasound to enhance transdermal drug delivery. Pharm. Res., 9, 559-564 (1992).
8. Cagnie, B., Vinck, E., Rimbaut, S., and Vanderstraeten, G., Phonophoresis versus topical application of ketoprofen: comparison between tissue and plasma levels. Phys. Ther., 83, 707-712 (2003).
9. Cesare, P. and McNaughton, P., Peripheral pain mechanisms. Curr. Opin. Neurobiol., 7, 493-499 (1997).
10. Chapman, V. and Dickenson, A. H., The spinal and peripheral roles of bradylcinin and prostaglandins in nociceptive processing in the rat. Eur. J. Pharmacol., 219, 427-433 (1992).
11. Chen, X., Tanner, K., and Levine, J. D., Mechanical sensitization of cutaneous C-fiber nociceptors by prostaglandin E2 in the rat. Neurosci. Lett., 267, 105-108 (1999).
12. Ciccone, C. D., Leggin, B. G., and Callamaro, J., Effects of ultrasound and trolamine salicylate phonophoresis on delayedonset muscle soreness. Phys. Ther., 71, 666-678 (1991).
13. Devor, M., Fovin-Lippman, R., and Raper, P., Corticosteroids suppress ectopic neural discharge originating in experimental neuromas. Pain., 22, 127-137 (1985).
14. Dirig, D. M., Isakson, P. C., and Yaksh, T. L., Effect of COX-1 and COX-2 inhibition on induction and maintenance of carrageenan-evoked thermal hyperalgesia in rats. J. Pharmacol Exp Ther., 285, 1031-1038 (1998).
15. Feltenstein, M. W., Schqhly, W., Warnick, J. E., Fischer, N. H., and Sufka, K. J., Anti-inflammatory and anti-hyperalgesic effects of sesquiterpene lactones from Magnolia and Bear's foot. Pharmacol. Biochem. Behav., 79, 299-302 (2004).
16. Fereira, S. H., Moncada, S., and Vane, J. R., Prostaglandin and the mechanism of analgesia produced by aspirin-like drugs. Br. J. Pharmacol., 49, 86-97 (1973).
17. Francischi, J. N., Chaves, C. T., Moura, A. C. L., Lima, A. S., Rocha, O. A., Ferreira-Alves, D. L., and Bakhle, Y. S., Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation. Br. J. Pharmacol., 137, 837-844 (2002).
18. Foldvari, M., Non-invasive administration of drugs through the skin: challenges in delivery system design. Pharm. Sci. Technol., 3, 417-425 (2000).
19. Herrero, J. F., Parrado, A., and Cervero, F., Central and peripheral actions of the NSAID Ketoprofen on spinal cord nociceptive reflexes. Neurophamcology, 36, 1425-1431 (1997).
20. Hsieh, Y. L., Effects of ultrasound and diclofenac phonophoresis on inflammatory pain relief: suppression of inducible nitric oxide synthase in arthritic rats. Phys. Ther., 86, 39-49 (2006).
21. Jadoul, A., Bouwstra, J., and Preat, V., Effects of iontophoresis and electroporation on the stratum corneum Review of the biophysical studies. Advanced Drug Delivery Reviews. Adv. Drug. Deliv. Rev., 35, 89-105 (1999).
22. Jane, E. C., Pandit, S., Santoro, J. C., Freund, C., Luell, S., Harris, G., Forrest, M. J., and Sitlani, A., Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation. J. Steroid Biochem. & Mol. Biol., 88, 191-201 (2004).
23. Jett, M. F., Rameshe, C. S., Brown, C. D., Chiu, S., Emmett, C., Voronin, T., Sun, T., Yang, C., Hunter, J. C., Eglen, R. M., and Johnson, R. M., Characterization of the Analgesic-Inflammatory Activities of Ketorolac and Its Enantiomers in the Rat. J. Pharmacol. Exp. Ther., 288, 1288-1297 (1999).
24. Kearns, G. L., Heacook, J., Daly, S. J., Singh, H., and Alander, S. W., Percutaneous lidocaine administration via a new iontophoresis system in children-tolerability and absence of systemic bioavailability. Pediatrics, 112, 578-582 (2003).
25. Kleinkort, J. A. and Wood, A. F., Phonophoresis with 1% versus 10% hydrocortisone. Phys. Mer. 55, 1320-1324 (1975).
26. Kozanoglu, E., Basaran, S., Guzel, R., and Guler-Uysal, F., Short term efficacy of ibuprofen phonophoresis versus continuous ultrasound therapy in knee osteoarthritis. Swiss. Med. Wkly. 14; 133(23-24), 333-338 (2003).
27. Lee, E. K., Shin, Y. H., and Lee, C. H., Anti-inflammatory activity of ketoprofen soft hydrogel. J. Kor. Pharm. Sci., 29, 137-143 (1999).
28. McCormack, K., Non-steroidal anti-inflammatory drugs and spinal nociceptive processing. Pain, 59, 943 (1994).
29. Matsuzaki, S., Hayashi, I., Nara, Y., Kamata, K., Yamanaka, M., Okamoto, H., Hoka, S., and Majima, M., Role of kinin and prostaglandin in cutaneous thermal nociception. Int. Immunopharmacol., 2, 2005-2012 (1969).
30. McElnay, J. C., Kennedy, T. A., and Harland, R., The influence of ultrasound on the percutaneous absorption of fluocinolone acetonide. Int. J. Pharm., 40, 105-110 (1987).
31. Median, V. M., Walmsley, A. D., and Irwin, W. J., Phonophoresis - is it a reality? Int. J. Pharm., 118, 129-149 (1995).
32. Merino, V., Kalia, Y. N., and Guy, R. H., Transdermal therapy and diagnosis by iontophoresis. Trends Biotehnol., 15, 288-290 (1997).
33. rd., Heidt, R. S. Jr., and Colosimo, A. J., Effects of iontophoretic versus injection administration of dexamethasone. Med. Sci. Sports Exerc., 34, 1294-1301 (2002).
34. Nyborg, W. L., Mechanisms, In: Nyborg, W. L., Ziskin, M. C., eds. Biological Effects of Ultrasound. NY Churchill Livingstone Inc., 23-33 (1985).
35. Penzes, T. P., Blazs, G., Aigner, Z., Falkay, G., and Eros, I., Topical absorption of piroxicam from organogels - in vitro and in vivo correlations. Int. J. Pharm., 298, 47-54 (2005).
36. Riviere, J. E. and Heit, M. C., Electrically-assisted transdermal drug delivery. Pharm. Res., 14, 687-697 (1997).
37. Samad, T. A., Moore, K. A., Sapirstein, A., Billet, S., Allchorne, A., Poole, S., Bonventre, J. V., and Woolf, C. J., Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature, 410, 471-475 (2001).
38. Schrier, D. J., Moniot, S., Gluckman, M. I., and Gibertson, R. B., The topical anti-inflammatory effects of a topical preparation of meclofenamic acid on carrageenan-induced footpad swelling in mice. J. Pharm. Pharmcol., 39, 57 (1987).
39. Seybold, V. S., Jia, Y. P., and Abrahams, L. G., Cyclo-oxygenase-2 contributes to central sensitization in rats with peripheral inflammation. Pain, 105, 47-55 (2003).
40. Shin, S. M. and Choi, J. K., Effect of indomethacin phonophoresis on the relief of temporomandibular joint pain. Cranio, 15, 345-348 (1997).
41. Snels, I. A., Beckerman, H., Twisk, J. W., Dekker, J. H., PeterDe, Koning, Koppe, P. A., Lankhorst, G. J., and Bouter, L. M., Effect of triamcinolone acetonide injections on hemiplegic shoulder pain; A randomized clinical trial. Stroke, 31, 2396-2401 (2000).
42. Tyle, P. and Agrawala, P., Drug delivery by phonophoresis. Pharm. Res., 6, 355-359 (1989).
43. Vane, J. R., Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biology, 231, 232-235 (1971).
44. Vlak, T., Comparative study of the efficacy of ultrasound and sonophoresis in the treatment of painful shouder syndrome. Reumatizam., 46, 5-11 (1999).
45. Varghese, E. and Khar, R. K., Enhanced skin permeation of diclofenac by iontophoresis: in vitro and in vivo studies. J. Control. Release, 38, 21-27 (1996).
46. Yang, J. H., Kim, D. K., Kim, T. Y., Kim, G. Y., and Shin, S. C., Anti-inflammatory effects by transdermal application of triamcinolone acetonide gel using phonophoresis in rats. Int. J. Pharm., 302, 39-46 (2005).
47. Zhang, R., Lao, L., Wang, X., Ren, K., and Berman, B. B., Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory rats. Pharmacol. Biochem. Behav., 78, 793-797 (2004).