Effects of iontophoresis current magnitude and duration on dexamethasone deposition and localized drug retention

Physical Therapy

Volumn 83, Issue 2, 2003, Pages 161-170

  Anderson, Carter R ^a   Morris, Russell L ^a   Boeh, Stephen D ^a   Panus, Peter C ^b   Sembrowich, Walter L ^a  

^a Birch Point Medical Inc   (United States)

^b EAST TENNESSEE STATE UNIVERSITY   (United States)

Author keywords

Cutaneous administration; Dexamethasone phosphate; Iontophoresis; Transdermal drug delivery

Indexed keywords

AGAROSE; CHLORIDE ION; DEXAMETHASONE; DEXAMETHASONE SODIUM PHOSPHATE;

ADULT; ARTICLE; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG RETENTION; ELECTRIC FIELD; FEMALE; HUMAN; HUMAN EXPERIMENT; ION CURRENT; ION EXCHANGE; IONTOPHORESIS; MALE; MODEL; MUSCULOSKELETAL DISEASE; NORMAL HUMAN; SKIN; VASOCONSTRICTION;

EID: 0037310931     PISSN: 00319023     EISSN: None     Source Type: Journal    
DOI: 10.1093/ptj/83.2.161     Document Type: Article

References (34)

1. Banga AK, Panus PC. Clinical applications of iontophoretic devices in rehabilitation medicine. Critical Reviews in Physical and Rehabilitation Medicine. 1998;10:147-179.
2. Costello CT, Jeske AH. Iontophoresis: applications in transdermal medication delivery. Phys Ther. 1995;75:554-563.
3. Li LC, Scudds RA. Iontophoresis: an overview of the mechanisms and clinical application. Arthritis Care Res. 1995;8:51-61.
4. Banta CA. A prospective, nonrandomized study of iontophoresis, wrist splinting, and anti-inflammatory medication in the treatment of early-mild carpal tunnel syndrome. J Occup Med. 1994;36:166-168.
5. Bertolucci LE. Introduction of anti-inflammatory drugs by iontophoresis: double blind study. J Orthop Sports Phys Ther. 1982;4:103-108.
6. Demirtas RN, Oner C. The treatment of lateral epicondylitis by iontophoresis of sodium salicylate and sodium diclofenac. Clin Rehabil. 1998;12:23-29.
7. Gudeman SD, Eisele SA, Heidt RS Jr, et al. Treatment of plantar fasciitis by iontophoresis of 0.4% dexamethasone: a randomized, double-blind, placebo-controlled study. Am J Sports Med. 1997;25:312-316.
8. Harris PR. Iontophoresis: clinical research in musculoskeletal inflammatory conditions. J Orthop Sports Phys Ther. 1982;4:109-112.
9. Hasson SH, Henderson GH, Daniels JC, Schieb DA. Exercise training and dexamethasone iontophoresis in rheumatoid arthritis: a case study. Physiotherapy Canada. 1991;43:11-14.
10. Japour CJ, Vohra R, Vohra PK, et al. Management of heel pain syndrome with acetic acid iontophoresis. J Am Podiatr Med Assoc. 1999;89:251-257.
11. Li LC, Scudds RA, Heck CS, Harth M. The efficacy of dexamethasone iontophoresis for the treatment of rheumatoid arthritic knees: a pilot study. Arthritis Care Res. 1996;9:126-132.
12. Glass JM, Stephen RL, Jacobson SC. The quantity and distribution of radiolabeled dexamethasone delivered to tissue by iontophoresis. Int J Dermatol. 1980;19:519-525.
13. James MP, Graham RM, English J. Percutaneous iontophoresis of prednisolone: a pharmacokinetic study. Clin Exp Dermatol. 1986;11:54-61.
14. Riviere JE, Monteiro Riviere NA, Inman AO. Determination of lidocaine concentrations in skin after transdermal iontophoresis: effects of vasoactive drugs. Pharm Res. 1992;9:211-214.
15. Singh P, Roberts MS. Iontophoretic transdermal delivery of salicylic acid and lidocaine to local subcutaneous structures. J Pharm Sci. 1993;82:127-131.
16. Blackford J, Doherty TJ, Ferslew KE, Panus PC. Iontophoresis of dexamethasone-phosphate into the equine tibiotarsal joint. J Vet Pharmacol Ther. 2000;23:229-236.
17. Smutok MA, Mayo MF, Gabaree CL, et al. Cathodic iontophoresis of dexamethasone-phosphate in human volunteers. J Orthop Sports Phys Ther. 2002;32:461-468.
18. McKenzie MA, Stoughton RB. Method for comparing percutaneous absorption of steroids. Arch Dermatol. 1962;86:88-90.
19. McKenzie MA. Percutaneous absorption of steroids. Arch Dermatol. 1962;86:91-94.
20. Crijns MB, Nater JP, van Oostveen F, van der Valk PG. Vasoconstrictor and the anti-inflammatory effects of 7 corticosteroids. Contact Dermatitis. 1984;11:108-111.
21. Noon JP, Evans CE, Haynes WG, et al. A comparison of techniques to assess skin blanching following the topical application of glucocorticoids. Br J Dermatol. 1996;134:837-842.
22. Sommer A, Veraart J, Neumann M, Kessels A. Evaluation of the vasoconstrictive effects of topical steroids by laser-Doppler-perfusion-imaging. Acta Derm Venereol. 1998;78:15-18.
23. Luong MS, Luong MP, Lok C, et al. Bioavailability evaluation of dermocorticoids using differential infrared thermography. Ann Dermatol Venereol. 2000;127:701-705.
24. Hornstein OP, Keller J, Boissevain F. Abnormalities of cutaneous microcirculation in atopic eczematics. Acta Derm Venereol Suppl (Stockh). 1992;176:86-89.
25. Physicians'Desk Reference. 56th ed. Montvale, NJ: Medical Economics Company Inc; 2002.
26. Anderson CR, Boeh SD, Morris RL, et al. Quantification of total dexamethasone-phosphate delivery by iontophoresis (PL-RR-155-F). Abstract of paper accepted for presentation at PT 2002: The Annual Conference and Exposition of the APTA, June 5-8, 2002. Available at: http://www.ptjournal.org/abstracts/pt2002/abstractsPt2002.cfm? pubNo=PL-RR-155-F.
27. Panus PC, Tober-Meyer B, Ferslew KE. Tissue extraction and high-performance liquid chromatographic determination of ketoprofen enantiomers. J Chromatogr B Biomed Sci Appl. 1998;705:295-302.
28. Panus PC, Ferslew KE, Tober-Meyer B, Kao RL. Ketoprofen tissue permeation in swine following cathodic iontophoresis. Phys Ther. 1999;79:40-49.
29. Ashburn MA, Streisand J, Zhang J, et al. The iontophoresis of fentanyl citrate in humans. Anesthesiology. 1995;82:1146-1153.
30. Gupta SK, Bernstein KJ, Noorduin H, et al. Fentanyl delivery from an electrotransport system: delivery is a function of total current, not duration of current. J Clin Pharmacol. 1998;38:951-958.
31. Grossmann M, Jamieson MJ, Kellogg DL Jr, et al. The effect of iontophoresis on the cutaneous vasculature: evidence for currentinduced hyperemia. Microvasc Res. 1995;50:444-452.
32. Riviere JE, Monteiro-Riviere NA, Rogers RA, et al. Pulsatile transdermal delivery of LHRH using electroporation: drug delivery and skin toxicology. J Control Release. 1995;36:229-233.
33. Singh P, Roberts MS. Effects of vasoconstriction on dermal pharmacokinetics and local tissue distribution of compounds. J Pharm Sci. 1994;83:783-791.
34. Guy RH, Hadgraft J, Bucks DA. Transdermal drug delivery and cutaneous metabolism. Xenobiotica. 1987;17:325-343.